Rattus norvegicus

0 known processes

Vcl

vinculin

Vcl biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
gap junction assembly GO:0016264 2 0.129
Rat
cardiovascular system development GO:0072358 134 0.087
single organism catabolic process GO:0044712 283 0.078
catabolic process GO:0009056 351 0.077
nucleotide metabolic process GO:0009117 279 0.070
nucleobase containing small molecule metabolic process GO:0055086 316 0.070
circulatory system development GO:0072359 134 0.066
cellular component movement GO:0006928 248 0.060
organic substance catabolic process GO:1901575 316 0.057
aromatic compound catabolic process GO:0019439 168 0.053
purine ribonucleoside catabolic process GO:0046130 124 0.053
response to nutrient levels GO:0031667 370 0.049
glycosyl compound metabolic process GO:1901657 182 0.048
purine nucleotide metabolic process GO:0006163 229 0.047
tissue development GO:0009888 252 0.047
ribonucleoside metabolic process GO:0009119 174 0.046
response to extracellular stimulus GO:0009991 380 0.046
brain development GO:0007420 247 0.046
cellular ketone metabolic process GO:0042180 51 0.045
organonitrogen compound catabolic process GO:1901565 179 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.044
aging GO:0007568 241 0.043
Rat
purine containing compound metabolic process GO:0072521 253 0.042
purine nucleoside metabolic process GO:0042278 169 0.042
divalent inorganic cation homeostasis GO:0072507 165 0.041
ribose phosphate metabolic process GO:0019693 235 0.041
cellular component biogenesis GO:0044085 368 0.041
Rat
regulation of cellular component organization GO:0051128 368 0.041
protein complex subunit organization GO:0071822 302 0.041
Rat
purine nucleoside triphosphate metabolic process GO:0009144 141 0.041
nucleoside catabolic process GO:0009164 126 0.040
cellular cation homeostasis GO:0030003 180 0.040
cation transport GO:0006812 382 0.039
ribonucleoside catabolic process GO:0042454 126 0.039
carbohydrate derivative catabolic process GO:1901136 147 0.039
organophosphate metabolic process GO:0019637 370 0.038
regulation of cellular amino acid metabolic process GO:0006521 2 0.037
anterior posterior pattern specification GO:0009952 1 0.037
metal ion transport GO:0030001 289 0.037
cellular homeostasis GO:0019725 252 0.037
cellular catabolic process GO:0044248 295 0.037
purine ribonucleotide catabolic process GO:0009154 136 0.037
gastrulation GO:0007369 2 0.036
organic acid metabolic process GO:0006082 292 0.036
cellular calcium ion homeostasis GO:0006874 160 0.036
neuron differentiation GO:0030182 368 0.035
Rat Fly
regulation of hydrolase activity GO:0051336 143 0.035
calcium ion homeostasis GO:0055074 162 0.035
glycosyl compound catabolic process GO:1901658 126 0.034
nucleoside phosphate metabolic process GO:0006753 283 0.034
head development GO:0060322 247 0.034
heart morphogenesis GO:0003007 3 0.033
positive regulation of transport GO:0051050 245 0.033
organic cyclic compound catabolic process GO:1901361 175 0.033
cellular amino acid metabolic process GO:0006520 107 0.033
cellular response to oxygen containing compound GO:1901701 386 0.032
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.032
regulation of cellular ketone metabolic process GO:0010565 27 0.030
single organism biosynthetic process GO:0044711 342 0.030
response to decreased oxygen levels GO:0036293 237 0.030
oxoacid metabolic process GO:0043436 290 0.030
ion homeostasis GO:0050801 212 0.030
chemical homeostasis GO:0048878 292 0.029
ribonucleoside triphosphate catabolic process GO:0009203 122 0.029
positive regulation of cellular component organization GO:0051130 200 0.029
ribonucleotide metabolic process GO:0009259 231 0.029
purine nucleoside catabolic process GO:0006152 124 0.029
positive regulation of molecular function GO:0044093 230 0.029
purine containing compound catabolic process GO:0072523 138 0.029
nucleoside metabolic process GO:0009116 179 0.029
neuron development GO:0048666 286 0.029
Rat Fly
protein complex biogenesis GO:0070271 263 0.028
Rat
calcium ion transport GO:0006816 131 0.028
cellular nitrogen compound catabolic process GO:0044270 163 0.028
negative regulation of metabolic process GO:0009892 331 0.028
transcription dna templated GO:0006351 377 0.028
carboxylic acid metabolic process GO:0019752 289 0.027
multicellular organismal reproductive process GO:0048609 233 0.027
Rat
response to estrogen GO:0043627 232 0.027
Rat
cellular ion homeostasis GO:0006873 184 0.027
organelle organization GO:0006996 266 0.026
ribonucleoside triphosphate metabolic process GO:0009199 141 0.026
negative regulation of cardiac muscle tissue development GO:0055026 3 0.026
regulation of cell proliferation GO:0042127 359 0.026
response to nutrient GO:0007584 248 0.026
regulation of cellular amine metabolic process GO:0033238 8 0.026
regulation of neuron projection development GO:0010975 161 0.026
muscle contraction GO:0006936 88 0.025
cellular response to stress GO:0033554 269 0.025
Rat
cation homeostasis GO:0055080 195 0.025
nucleobase containing compound catabolic process GO:0034655 152 0.025
positive regulation of cell communication GO:0010647 271 0.025
heterocycle catabolic process GO:0046700 167 0.025
central nervous system development GO:0007417 311 0.024
regulation of multicellular organismal development GO:2000026 376 0.024
nucleotide catabolic process GO:0009166 139 0.024
cell projection organization GO:0030030 302 0.024
Rat Fly
transmembrane transport GO:0055085 412 0.024
regulation of phosphate metabolic process GO:0019220 349 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.024
embryonic pattern specification GO:0009880 1 0.023
reproductive process GO:0022414 372 0.023
Rat
purine nucleotide catabolic process GO:0006195 136 0.023
response to vitamin GO:0033273 131 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.023
positive regulation of signaling GO:0023056 270 0.023
ion transmembrane transport GO:0034220 365 0.023
positive regulation of cellular amine metabolic process GO:0033240 3 0.023
female pregnancy GO:0007565 122 0.023
positive regulation of phosphate metabolic process GO:0045937 262 0.023
nucleoside triphosphate metabolic process GO:0009141 144 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
regulation of mapk cascade GO:0043408 116 0.022
neuron projection development GO:0031175 273 0.022
Rat Fly
positive regulation of biosynthetic process GO:0009891 319 0.022
regulation of catabolic process GO:0009894 113 0.022
multi organism reproductive process GO:0044703 262 0.022
muscle tissue development GO:0060537 58 0.022
macromolecular complex subunit organization GO:0043933 339 0.021
Rat
macromolecule localization GO:0033036 252 0.021
metal ion homeostasis GO:0055065 186 0.021
regulation of transcription dna templated GO:0006355 374 0.021
regulation of cell differentiation GO:0045595 320 0.021
cellular amine metabolic process GO:0044106 38 0.021
cation transmembrane transport GO:0098655 263 0.021
homeostatic process GO:0042592 331 0.021
response to hypoxia GO:0001666 231 0.021
regulation of programmed cell death GO:0043067 341 0.021
cellular divalent inorganic cation homeostasis GO:0072503 162 0.020
intracellular signal transduction GO:0035556 314 0.020
regulation of signal transduction GO:0009966 318 0.020
protein phosphorylation GO:0006468 345 0.020
regulation of molecular function GO:0065009 398 0.020
establishment of protein localization GO:0045184 141 0.020
cellular metal ion homeostasis GO:0006875 172 0.020
multicellular organismal signaling GO:0035637 44 0.020
carbohydrate derivative metabolic process GO:1901135 346 0.020
purine nucleoside triphosphate catabolic process GO:0009146 122 0.020
macromolecular complex assembly GO:0065003 273 0.020
Rat
regulation of neuron differentiation GO:0045664 208 0.020
cellular chemical homeostasis GO:0055082 247 0.020
regulation of ion transport GO:0043269 245 0.020
regulation of phosphorus metabolic process GO:0051174 349 0.020
mesoderm development GO:0007498 2 0.020
nucleoside phosphate catabolic process GO:1901292 140 0.020
negative regulation of cell death GO:0060548 229 0.020
protein oligomerization GO:0051259 191 0.020
Rat
ras protein signal transduction GO:0007265 29 0.020
regulation of protein modification process GO:0031399 194 0.020
regulation of cell development GO:0060284 263 0.019
negative regulation of multicellular organismal process GO:0051241 203 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
reactive oxygen species metabolic process GO:0072593 37 0.019
blood circulation GO:0008015 183 0.019
blood vessel morphogenesis GO:0048514 58 0.019
regulation of blood circulation GO:1903522 110 0.019
cell adhesion GO:0007155 110 0.019
purine ribonucleoside metabolic process GO:0046128 168 0.019
single organism organelle organization GO:1902589 180 0.019
cell migration GO:0016477 197 0.019
heart development GO:0007507 72 0.019
cell activation GO:0001775 97 0.019
axis specification GO:0009798 4 0.019
nucleic acid templated transcription GO:0097659 379 0.018
reproduction GO:0000003 245 0.018
Rat
inorganic ion transmembrane transport GO:0098660 229 0.018
regulation of endocytosis GO:0030100 42 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
multicellular organism reproduction GO:0032504 233 0.018
Rat
regulation of nervous system development GO:0051960 264 0.018
organophosphate catabolic process GO:0046434 148 0.018
cellular component assembly GO:0022607 360 0.018
Rat
response to bacterium GO:0009617 200 0.018
regulation of nucleotide metabolic process GO:0006140 117 0.018
transcription from rna polymerase ii promoter GO:0006366 252 0.018
locomotion GO:0040011 237 0.018
muscle system process GO:0003012 115 0.017
negative regulation of cell differentiation GO:0045596 99 0.017
vasculature development GO:0001944 70 0.017
protein heterooligomerization GO:0051291 89 0.017
Rat
regulation of phosphorylation GO:0042325 248 0.017
positive regulation of endocytosis GO:0045807 28 0.017
regulation of cellular localization GO:0060341 263 0.017
heterotypic cell cell adhesion GO:0034113 2 0.017
regulation of cell projection organization GO:0031344 175 0.017
epithelium development GO:0060429 96 0.017
circulatory system process GO:0003013 183 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
apoptotic process GO:0006915 381 0.017
purine nucleoside monophosphate catabolic process GO:0009128 55 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.016
localization of cell GO:0051674 202 0.016
formation of primary germ layer GO:0001704 1 0.016
negative regulation of neuron differentiation GO:0045665 62 0.016
positive regulation of programmed cell death GO:0043068 157 0.016
cellular response to lipid GO:0071396 201 0.016
cell cycle GO:0007049 101 0.016
regulation of catalytic activity GO:0050790 304 0.016
regulation of locomotion GO:0040012 148 0.016
response to activity GO:0014823 73 0.016
g protein coupled receptor signaling pathway GO:0007186 242 0.016
regulation of g0 to g1 transition GO:0070316 3 0.016
positive regulation of cellular protein metabolic process GO:0032270 167 0.016
positive regulation of multicellular organismal process GO:0051240 387 0.016
neuron projection regeneration GO:0031102 35 0.016
Rat
endocytosis GO:0006897 84 0.016
Fly
anatomical structure formation involved in morphogenesis GO:0048646 83 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
gland development GO:0048732 155 0.015
atp catabolic process GO:0006200 54 0.015
regulation of system process GO:0044057 208 0.015
response to carbohydrate GO:0009743 183 0.015
organ morphogenesis GO:0009887 75 0.015
Rat
salivary gland morphogenesis GO:0007435 1 0.015
negative regulation of transport GO:0051051 136 0.015
negative regulation of nervous system development GO:0051961 79 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
defense response GO:0006952 194 0.015
ribonucleotide catabolic process GO:0009261 136 0.015
blood vessel development GO:0001568 69 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
regulation of transmembrane transport GO:0034762 122 0.014
regulation of anatomical structure size GO:0090066 135 0.014
divalent inorganic cation transport GO:0072511 134 0.014
response to oxygen levels GO:0070482 265 0.014
regulation of purine nucleotide metabolic process GO:1900542 115 0.014
secretion by cell GO:0032940 248 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.014
single organism reproductive process GO:0044702 297 0.014
Rat
negative regulation of cell proliferation GO:0008285 119 0.014
divalent metal ion transport GO:0070838 132 0.014
multicellular organism growth GO:0035264 1 0.014
response to estradiol GO:0032355 164 0.014
oxidation reduction process GO:0055114 304 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
regulation of apoptotic process GO:0042981 335 0.014
regulation of vesicle mediated transport GO:0060627 81 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
female sex differentiation GO:0046660 59 0.014
Rat
regulation of homeostatic process GO:0032844 101 0.014
anatomical structure morphogenesis GO:0009653 298 0.014
Rat Fly
actin filament depolymerization GO:0030042 3 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
synaptic transmission GO:0007268 235 0.014
proteolysis GO:0006508 175 0.014
signal transduction by phosphorylation GO:0023014 144 0.014
purine nucleoside monophosphate metabolic process GO:0009126 84 0.014
regulation of rna biosynthetic process GO:2001141 381 0.014
biological adhesion GO:0022610 110 0.014
programmed cell death GO:0012501 392 0.014
regulation of cell morphogenesis GO:0022604 77 0.014
negative regulation of macromolecule metabolic process GO:0010605 260 0.014
single organism cellular localization GO:1902580 102 0.013
regulation of nucleic acid templated transcription GO:1903506 380 0.013
amine metabolic process GO:0009308 38 0.013
response to other organism GO:0051707 220 0.013
negative regulation of programmed cell death GO:0043069 183 0.013
single organismal cell cell adhesion GO:0016337 42 0.013
cardiac muscle tissue development GO:0048738 26 0.013
rhythmic process GO:0048511 156 0.013
Rat
regulation of intracellular signal transduction GO:1902531 218 0.013
cellular response to alcohol GO:0097306 87 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
secretion GO:0046903 307 0.013
rna biosynthetic process GO:0032774 380 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
vesicle mediated transport GO:0016192 181 0.013
Fly
response to wounding GO:0009611 254 0.013
Rat
action potential GO:0001508 54 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
positive regulation of ion transport GO:0043270 94 0.013
ribonucleoside monophosphate metabolic process GO:0009161 88 0.013
regulation of membrane potential GO:0042391 110 0.013
actin filament based process GO:0030029 86 0.013
regulation of transferase activity GO:0051338 123 0.013
nucleoside monophosphate metabolic process GO:0009123 93 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
regulation of small gtpase mediated signal transduction GO:0051056 48 0.013
positive regulation of protein modification process GO:0031401 142 0.013
inorganic cation transmembrane transport GO:0098662 202 0.013
actin filament based movement GO:0030048 16 0.013
regulation of cellular component movement GO:0051270 150 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
rho protein signal transduction GO:0007266 11 0.013
negative regulation of cellular metabolic process GO:0031324 281 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
muscle structure development GO:0061061 87 0.012
tissue morphogenesis GO:0048729 22 0.012
cell motility GO:0048870 202 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
cell cell junction organization GO:0045216 20 0.012
Rat
cytosolic calcium ion homeostasis GO:0051480 140 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
gonad development GO:0008406 104 0.012
Rat
positive regulation of developmental process GO:0051094 283 0.012
positive regulation of nervous system development GO:0051962 178 0.012
protein transport GO:0015031 132 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
organic hydroxy compound transport GO:0015850 77 0.012
regulation of rna metabolic process GO:0051252 391 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
ribonucleoside monophosphate catabolic process GO:0009158 55 0.012
mesoderm morphogenesis GO:0048332 1 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
regulation of cellular protein metabolic process GO:0032268 267 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
positive regulation of cell death GO:0010942 184 0.011
cell morphogenesis GO:0000902 142 0.011
Fly
positive regulation of neurogenesis GO:0050769 165 0.011
single organism membrane organization GO:0044802 74 0.011
cardiocyte differentiation GO:0035051 22 0.011
multicellular organismal homeostasis GO:0048871 49 0.011
positive regulation of transferase activity GO:0051347 81 0.011
cell cell signaling GO:0007267 335 0.011
response to hexose GO:0009746 144 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
nucleoside monophosphate catabolic process GO:0009125 56 0.011
neuronal action potential GO:0019228 35 0.011
glucan metabolic process GO:0044042 23 0.011
camera type eye morphogenesis GO:0048593 2 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
negative regulation of cell development GO:0010721 82 0.011
negative regulation of gene expression GO:0010629 199 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
regulation of nucleoside metabolic process GO:0009118 66 0.011
regulation of heart contraction GO:0008016 48 0.011
multi multicellular organism process GO:0044706 138 0.011
striated muscle tissue development GO:0014706 58 0.011
embryonic axis specification GO:0000578 1 0.010
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
transmission of nerve impulse GO:0019226 42 0.010
vascular process in circulatory system GO:0003018 96 0.010
regulation of reactive oxygen species metabolic process GO:2000377 26 0.010
generation of precursor metabolites and energy GO:0006091 62 0.010
synaptic growth at neuromuscular junction GO:0051124 1 0.010
positive regulation of rna metabolic process GO:0051254 203 0.010
negative regulation of organ growth GO:0046621 3 0.010
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.010
negative regulation of intracellular signal transduction GO:1902532 38 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
cellular macromolecule localization GO:0070727 122 0.010
regulation of protein kinase activity GO:0045859 105 0.010
rna metabolic process GO:0016070 406 0.010
actin cytoskeleton organization GO:0030036 73 0.010
regulation of cellular component biogenesis GO:0044087 86 0.010
regulation of cell migration GO:0030334 128 0.010
response to monosaccharide GO:0034284 159 0.010
regulation of muscle contraction GO:0006937 53 0.010
platelet aggregation GO:0070527 4 0.010
response to glucose GO:0009749 136 0.010
negative regulation of secretion GO:0051048 82 0.010

Vcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 0 0.028
disease of anatomical entity DOID:7 0 0.028
musculoskeletal system disease DOID:17 0 0.028
muscle tissue disease DOID:66 0 0.028
nervous system disease DOID:863 0 0.024
sensory system disease DOID:0050155 0 0.020
eye and adnexa disease DOID:1492 0 0.015
eye disease DOID:5614 0 0.015
cardiovascular system disease DOID:1287 0 0.012