Rattus norvegicus

0 known processes

Cldn18

claudin 18

Cldn18 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
programmed cell death GO:0012501 392 0.173
apoptotic process GO:0006915 381 0.101
regulation of apoptotic process GO:0042981 335 0.093
regulation of transcription dna templated GO:0006355 374 0.091
nucleic acid templated transcription GO:0097659 379 0.090
regulation of programmed cell death GO:0043067 341 0.089
response to inorganic substance GO:0010035 377 0.087
biological adhesion GO:0022610 110 0.085
response to acid chemical GO:0001101 222 0.085
regulation of nucleic acid templated transcription GO:1903506 380 0.084
regulation of multicellular organismal development GO:2000026 376 0.081
response to wounding GO:0009611 254 0.079
rna metabolic process GO:0016070 406 0.079
regulation of rna metabolic process GO:0051252 391 0.075
response to oxidative stress GO:0006979 186 0.073
transcription dna templated GO:0006351 377 0.073
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.070
response to ketone GO:1901654 182 0.070
Rat
response to peptide hormone GO:0043434 278 0.069
response to peptide GO:1901652 292 0.067
regulation of molecular function GO:0065009 398 0.061
positive regulation of cell proliferation GO:0008284 249 0.055
homeostatic process GO:0042592 331 0.054
rna biosynthetic process GO:0032774 380 0.053
regulation of cell differentiation GO:0045595 320 0.052
intracellular signal transduction GO:0035556 314 0.052
positive regulation of developmental process GO:0051094 283 0.051
regulation of cell proliferation GO:0042127 359 0.050
response to temperature stimulus GO:0009266 94 0.049
negative regulation of metabolic process GO:0009892 331 0.047
immune system process GO:0002376 204 0.047
protein complex subunit organization GO:0071822 302 0.046
cellular response to lipid GO:0071396 201 0.045
cation homeostasis GO:0055080 195 0.044
cellular amino acid metabolic process GO:0006520 107 0.043
response to oxygen levels GO:0070482 265 0.042
positive regulation of cell death GO:0010942 184 0.042
negative regulation of gene expression GO:0010629 199 0.041
locomotion GO:0040011 237 0.041
carboxylic acid metabolic process GO:0019752 289 0.041
gland development GO:0048732 155 0.041
negative regulation of cell death GO:0060548 229 0.041
regulation of protein metabolic process GO:0051246 289 0.040
protein phosphorylation GO:0006468 345 0.040
regulation of cellular protein metabolic process GO:0032268 267 0.039
transcription from rna polymerase ii promoter GO:0006366 252 0.039
cellular component assembly GO:0022607 360 0.039
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.038
wound healing GO:0042060 122 0.038
positive regulation of rna biosynthetic process GO:1902680 197 0.038
reproductive process GO:0022414 372 0.038
Rat
response to extracellular stimulus GO:0009991 380 0.038
chemical homeostasis GO:0048878 292 0.038
cellular response to endogenous stimulus GO:0071495 377 0.038
regulation of rna biosynthetic process GO:2001141 381 0.037
positive regulation of biosynthetic process GO:0009891 319 0.036
negative regulation of programmed cell death GO:0043069 183 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.036
positive regulation of gene expression GO:0010628 244 0.036
reproduction GO:0000003 245 0.035
positive regulation of cell communication GO:0010647 271 0.035
oxoacid metabolic process GO:0043436 290 0.035
response to decreased oxygen levels GO:0036293 237 0.034
positive regulation of molecular function GO:0044093 230 0.033
positive regulation of apoptotic process GO:0043065 154 0.033
positive regulation of response to stimulus GO:0048584 285 0.033
cellular catabolic process GO:0044248 295 0.033
cellular component biogenesis GO:0044085 368 0.033
organ regeneration GO:0031100 101 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
multicellular organism reproduction GO:0032504 233 0.031
response to reactive oxygen species GO:0000302 120 0.031
anatomical structure morphogenesis GO:0009653 298 0.031
cell activation GO:0001775 97 0.031
positive regulation of cell differentiation GO:0045597 217 0.031
regulation of signal transduction GO:0009966 318 0.031
negative regulation of apoptotic process GO:0043066 181 0.030
positive regulation of secretion by cell GO:1903532 128 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.030
cell adhesion GO:0007155 110 0.030
negative regulation of multicellular organismal process GO:0051241 203 0.030
positive regulation of nucleic acid templated transcription GO:1903508 197 0.029
regulation of immune system process GO:0002682 123 0.029
proteolysis GO:0006508 175 0.029
single organism reproductive process GO:0044702 297 0.029
positive regulation of cellular biosynthetic process GO:0031328 295 0.029
positive regulation of secretion GO:0051047 140 0.029
negative regulation of cellular biosynthetic process GO:0031327 161 0.029
secretion by cell GO:0032940 248 0.029
organ morphogenesis GO:0009887 75 0.029
positive regulation of catalytic activity GO:0043085 184 0.028
positive regulation of signaling GO:0023056 270 0.028
cellular response to hormone stimulus GO:0032870 247 0.028
regulation of catalytic activity GO:0050790 304 0.027
regulation of cellular amine metabolic process GO:0033238 8 0.027
single organism cell adhesion GO:0098602 46 0.027
regeneration GO:0031099 163 0.027
cell projection organization GO:0030030 302 0.027
synaptic transmission GO:0007268 235 0.027
amine metabolic process GO:0009308 38 0.027
tissue development GO:0009888 252 0.027
defense response GO:0006952 194 0.027
signal transduction by phosphorylation GO:0023014 144 0.026
neurological system process GO:0050877 219 0.025
inflammatory response GO:0006954 150 0.025
organic acid metabolic process GO:0006082 292 0.025
peptidyl tyrosine phosphorylation GO:0018108 72 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.025
leukocyte activation GO:0045321 76 0.025
response to corticosteroid GO:0031960 235 0.024
positive regulation of nervous system development GO:0051962 178 0.024
response to hypoxia GO:0001666 231 0.024
ossification GO:0001503 70 0.024
positive regulation of programmed cell death GO:0043068 157 0.024
cellular amine metabolic process GO:0044106 38 0.023
regulation of nervous system development GO:0051960 264 0.023
regulation of cell adhesion GO:0030155 52 0.023
neuron differentiation GO:0030182 368 0.023
regulation of protein phosphorylation GO:0001932 183 0.023
regulation of neurogenesis GO:0050767 247 0.023
response to other organism GO:0051707 220 0.023
response to nutrient levels GO:0031667 370 0.023
regulation of body fluid levels GO:0050878 90 0.022
cellular response to nitrogen compound GO:1901699 210 0.022
regulation of cell development GO:0060284 263 0.022
regulation of mapk cascade GO:0043408 116 0.022
growth GO:0040007 165 0.022
positive regulation of cell development GO:0010720 176 0.022
positive regulation of protein phosphorylation GO:0001934 135 0.022
protein autophosphorylation GO:0046777 66 0.022
response to mechanical stimulus GO:0009612 134 0.022
cellular calcium ion homeostasis GO:0006874 160 0.022
anion transport GO:0006820 178 0.022
response to bacterium GO:0009617 200 0.022
secretion GO:0046903 307 0.021
positive regulation of mapk cascade GO:0043410 92 0.021
saliva secretion GO:0046541 3 0.021
cell type specific apoptotic process GO:0097285 134 0.021
regulation of cellular component organization GO:0051128 368 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
regulation of protein modification process GO:0031399 194 0.021
regulation of cell activation GO:0050865 50 0.021
positive regulation of cellular component organization GO:0051130 200 0.021
organic substance catabolic process GO:1901575 316 0.021
positive regulation of multicellular organismal process GO:0051240 387 0.020
positive regulation of hydrolase activity GO:0051345 86 0.020
response to glucocorticoid GO:0051384 223 0.020
cellular response to peptide GO:1901653 133 0.020
response to radiation GO:0009314 137 0.020
epithelium development GO:0060429 96 0.020
mapk cascade GO:0000165 140 0.020
catabolic process GO:0009056 351 0.019
central nervous system development GO:0007417 311 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
regulation of cellular localization GO:0060341 263 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
liver development GO:0001889 90 0.019
organelle organization GO:0006996 266 0.019
protein transport GO:0015031 132 0.019
positive regulation of intracellular signal transduction GO:1902533 138 0.018
regulation of response to external stimulus GO:0032101 106 0.018
cellular cation homeostasis GO:0030003 180 0.018
neuron development GO:0048666 286 0.018
carbohydrate derivative metabolic process GO:1901135 346 0.018
cellular homeostasis GO:0019725 252 0.018
tongue morphogenesis GO:0043587 3 0.018
protein complex biogenesis GO:0070271 263 0.018
negative regulation of rna metabolic process GO:0051253 123 0.018
positive regulation of rna metabolic process GO:0051254 203 0.018
cellular response to oxygen containing compound GO:1901701 386 0.018
positive regulation of hormone secretion GO:0046887 65 0.018
negative regulation of signaling GO:0023057 157 0.017
amine transport GO:0015837 57 0.017
hepaticobiliary system development GO:0061008 90 0.017
divalent inorganic cation homeostasis GO:0072507 165 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
protein complex assembly GO:0006461 263 0.017
glial cell differentiation GO:0010001 65 0.017
cell migration GO:0016477 197 0.017
macromolecular complex assembly GO:0065003 273 0.017
vesicle mediated transport GO:0016192 181 0.017
response to estradiol GO:0032355 164 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.017
s shaped body morphogenesis GO:0072050 2 0.017
regulation of system process GO:0044057 208 0.017
positive regulation of phosphorylation GO:0042327 177 0.017
aromatic compound catabolic process GO:0019439 168 0.017
regulation of membrane potential GO:0042391 110 0.017
ion homeostasis GO:0050801 212 0.016
immune response GO:0006955 104 0.016
regulation of response to wounding GO:1903034 69 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
negative regulation of rna biosynthetic process GO:1902679 118 0.016
cellular component movement GO:0006928 248 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
single organism behavior GO:0044708 130 0.016
single organism cellular localization GO:1902580 102 0.016
regulation of locomotion GO:0040012 148 0.016
positive regulation of protein modification process GO:0031401 142 0.016
cellular chemical homeostasis GO:0055082 247 0.016
blood coagulation GO:0007596 26 0.016
transmembrane transport GO:0055085 412 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
cellular response to stress GO:0033554 269 0.016
neuron projection development GO:0031175 273 0.016
urinary tract smooth muscle contraction GO:0014848 4 0.015
regulation of hormone levels GO:0010817 187 0.015
cell cell signaling GO:0007267 335 0.015
response to biotic stimulus GO:0009607 226 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
carbohydrate derivative catabolic process GO:1901136 147 0.015
response to nutrient GO:0007584 248 0.015
signal release GO:0023061 145 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
lymphocyte activation GO:0046649 43 0.015
negative regulation of transcription dna templated GO:0045892 116 0.015
positive regulation of transport GO:0051050 245 0.015
cellular ion homeostasis GO:0006873 184 0.015
metal ion homeostasis GO:0055065 186 0.015
axis specification GO:0009798 4 0.015
regulation of phosphorylation GO:0042325 248 0.015
macromolecule localization GO:0033036 252 0.015
single organism biosynthetic process GO:0044711 342 0.015
negative regulation of cell communication GO:0010648 158 0.015
brain development GO:0007420 247 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
regulation of kinase activity GO:0043549 117 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
regulation of response to stress GO:0080134 126 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.014
positive regulation of response to wounding GO:1903036 34 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
negative regulation of developmental process GO:0051093 125 0.014
nitrogen compound transport GO:0071705 229 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
regulation of hydrolase activity GO:0051336 143 0.014
aging GO:0007568 241 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
regulation of saliva secretion GO:0046877 3 0.014
cation transport GO:0006812 382 0.014
negative regulation of biosynthetic process GO:0009890 168 0.014
single organism catabolic process GO:0044712 283 0.014
action potential GO:0001508 54 0.014
cellular ketone metabolic process GO:0042180 51 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
estrous cycle phase GO:0060206 15 0.014
cellular divalent inorganic cation homeostasis GO:0072503 162 0.014
purine containing compound metabolic process GO:0072521 253 0.013
regulation of secretion by cell GO:1903530 208 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
sensory perception GO:0007600 101 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
response to external biotic stimulus GO:0043207 221 0.013
positive regulation of signal transduction GO:0009967 175 0.013
ras protein signal transduction GO:0007265 29 0.013
protein oligomerization GO:0051259 191 0.013
single organismal cell cell adhesion GO:0016337 42 0.013
embryonic skeletal system development GO:0048706 3 0.013
regulation of cell motility GO:2000145 131 0.013
regulation of establishment of planar polarity GO:0090175 2 0.013
sexual reproduction GO:0019953 148 0.013
protein maturation GO:0051604 68 0.013
cellular response to peptide hormone stimulus GO:0071375 120 0.013
organophosphate catabolic process GO:0046434 148 0.013
cell motility GO:0048870 202 0.013
regulation of homotypic cell cell adhesion GO:0034110 4 0.013
epithelial cell differentiation GO:0030855 71 0.013
multi organism reproductive process GO:0044703 262 0.013
Rat
nucleotide metabolic process GO:0009117 279 0.013
regulation of synaptic transmission GO:0050804 141 0.013
negative regulation of protein metabolic process GO:0051248 114 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
comma shaped body morphogenesis GO:0072049 2 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
positive regulation of protein kinase activity GO:0045860 73 0.012
response to metal ion GO:0010038 253 0.012
developmental process involved in reproduction GO:0003006 159 0.012
multicellular organism growth GO:0035264 1 0.012
rhythmic process GO:0048511 156 0.012
Rat
establishment of anatomical structure orientation GO:0048560 1 0.012
negative regulation of transport GO:0051051 136 0.012
chromosome segregation GO:0007059 2 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
protein localization GO:0008104 191 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
regulation of vasoconstriction GO:0019229 44 0.012
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
establishment of tissue polarity GO:0007164 2 0.012
response to progesterone GO:0032570 48 0.012
Rat
organic anion transport GO:0015711 132 0.012
sulfur compound metabolic process GO:0006790 70 0.012
response to retinoic acid GO:0032526 63 0.012
ribose phosphate metabolic process GO:0019693 235 0.012
asymmetric stem cell division GO:0098722 2 0.011
cellular macromolecule localization GO:0070727 122 0.011
regulation of ossification GO:0030278 32 0.011
positive regulation of saliva secretion GO:0046878 3 0.011
ribonucleoside monophosphate metabolic process GO:0009161 88 0.011
metestrus GO:0060210 1 0.011
nucleoside monophosphate metabolic process GO:0009123 93 0.011
bmp signaling pathway GO:0030509 4 0.011
regulation of neuron apoptotic process GO:0043523 83 0.011
cognition GO:0050890 92 0.011
cytoplasmic transport GO:0016482 115 0.011
single organism organelle organization GO:1902589 180 0.011
protein processing GO:0016485 68 0.011
cellular modified amino acid metabolic process GO:0006575 61 0.011
hair cycle GO:0042633 3 0.011
regulation of blood coagulation GO:0030193 9 0.011
regulation of cell migration GO:0030334 128 0.011
response to ethanol GO:0045471 162 0.011
divalent metal ion transport GO:0070838 132 0.011
regulation of anatomical structure size GO:0090066 135 0.011
behavior GO:0007610 205 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
sensory organ development GO:0007423 74 0.011
hemopoiesis GO:0030097 34 0.011
meiotic cell cycle process GO:1903046 3 0.011
cellular response to corticosteroid stimulus GO:0071384 69 0.011
positive regulation of phosphate metabolic process GO:0045937 262 0.011
heterocycle catabolic process GO:0046700 167 0.011
regulation of cell projection organization GO:0031344 175 0.011
urogenital system development GO:0001655 78 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
metanephric comma shaped body morphogenesis GO:0072278 2 0.011
secretion by tissue GO:0032941 37 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
hormone secretion GO:0046879 115 0.011
neuron death GO:0070997 127 0.011
response to lipopolysaccharide GO:0032496 191 0.011
gamete generation GO:0007276 124 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
response to heat GO:0009408 60 0.011
gliogenesis GO:0042063 93 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
regulation of leukocyte proliferation GO:0070663 26 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
nucleoside metabolic process GO:0009116 179 0.010
actin filament based process GO:0030029 86 0.010
establishment of protein localization GO:0045184 141 0.010
negative regulation of molecular function GO:0044092 133 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.010
regulation of organelle organization GO:0033043 80 0.010
regulation of transferase activity GO:0051338 123 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
urinary bladder smooth muscle contraction GO:0014832 4 0.010
response to estrogen GO:0043627 232 0.010
head development GO:0060322 247 0.010
regulation of stem cell differentiation GO:2000736 2 0.010
organophosphate metabolic process GO:0019637 370 0.010

Cldn18 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.050
nervous system disease DOID:863 0 0.050
sensory system disease DOID:0050155 0 0.016