Rattus norvegicus

0 known processes

Arhgef5

Rho guanine nucleotide exchange factor (GEF) 5

(Aliases: Tim1)

Arhgef5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of signal transduction GO:0009966 318 0.072
Rat
transcription dna templated GO:0006351 377 0.067
regulation of protein metabolic process GO:0051246 289 0.066
organic acid metabolic process GO:0006082 292 0.062
nucleic acid templated transcription GO:0097659 379 0.062
regulation of phosphorylation GO:0042325 248 0.062
negative regulation of metabolic process GO:0009892 331 0.062
regulation of protein modification process GO:0031399 194 0.060
positive regulation of cell communication GO:0010647 271 0.058
cellular component assembly GO:0022607 360 0.054
Rat
regulation of rna metabolic process GO:0051252 391 0.053
protein phosphorylation GO:0006468 345 0.051
apoptotic process GO:0006915 381 0.050
negative regulation of cellular metabolic process GO:0031324 281 0.050
rna biosynthetic process GO:0032774 380 0.048
negative regulation of macromolecule metabolic process GO:0010605 260 0.046
regulation of transcription dna templated GO:0006355 374 0.046
regulation of phosphate metabolic process GO:0019220 349 0.045
Rat
regulation of cellular component organization GO:0051128 368 0.045
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.044
intracellular signal transduction GO:0035556 314 0.043
regulation of programmed cell death GO:0043067 341 0.043
regulation of cellular ketone metabolic process GO:0010565 27 0.043
regulation of intracellular signal transduction GO:1902531 218 0.042
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.042
cellular amino acid metabolic process GO:0006520 107 0.042
regulation of molecular function GO:0065009 398 0.042
Rat
regulation of cellular protein metabolic process GO:0032268 267 0.041
cellular response to oxygen containing compound GO:1901701 386 0.040
oxoacid metabolic process GO:0043436 290 0.039
regulation of cellular amine metabolic process GO:0033238 8 0.039
regulation of phosphorus metabolic process GO:0051174 349 0.038
Rat
regulation of cell proliferation GO:0042127 359 0.037
carboxylic acid metabolic process GO:0019752 289 0.037
transcription from rna polymerase ii promoter GO:0006366 252 0.037
cellular component biogenesis GO:0044085 368 0.036
Rat
positive regulation of cell proliferation GO:0008284 249 0.036
rna metabolic process GO:0016070 406 0.036
regulation of cell differentiation GO:0045595 320 0.036
cellular amine metabolic process GO:0044106 38 0.034
cellular ketone metabolic process GO:0042180 51 0.034
programmed cell death GO:0012501 392 0.034
brain development GO:0007420 247 0.034
positive regulation of signal transduction GO:0009967 175 0.033
reproductive process GO:0022414 372 0.033
regulation of nervous system development GO:0051960 264 0.031
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.031
Rat
amine metabolic process GO:0009308 38 0.031
response to inorganic substance GO:0010035 377 0.030
regulation of catalytic activity GO:0050790 304 0.030
Rat
cellular response to endogenous stimulus GO:0071495 377 0.030
regulation of protein phosphorylation GO:0001932 183 0.030
positive regulation of molecular function GO:0044093 230 0.029
Rat
positive regulation of response to stimulus GO:0048584 285 0.029
cellular response to hormone stimulus GO:0032870 247 0.029
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.029
negative regulation of gene expression GO:0010629 199 0.029
circulatory system process GO:0003013 183 0.029
mapk cascade GO:0000165 140 0.028
single organism biosynthetic process GO:0044711 342 0.028
positive regulation of protein modification process GO:0031401 142 0.028
response to oxygen levels GO:0070482 265 0.028
regulation of rna biosynthetic process GO:2001141 381 0.028
response to hypoxia GO:0001666 231 0.027
regulation of neurogenesis GO:0050767 247 0.027
multi organism reproductive process GO:0044703 262 0.027
homeostatic process GO:0042592 331 0.027
catabolic process GO:0009056 351 0.027
Rat
negative regulation of programmed cell death GO:0043069 183 0.027
regeneration GO:0031099 163 0.027
positive regulation of transcription dna templated GO:0045893 197 0.027
positive regulation of cell development GO:0010720 176 0.026
regulation of neuron differentiation GO:0045664 208 0.026
positive regulation of cellular protein metabolic process GO:0032270 167 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
positive regulation of multicellular organismal process GO:0051240 387 0.026
single organism reproductive process GO:0044702 297 0.026
response to nutrient levels GO:0031667 370 0.026
negative regulation of cell communication GO:0010648 158 0.026
negative regulation of biosynthetic process GO:0009890 168 0.025
regulation of apoptotic process GO:0042981 335 0.025
response to peptide hormone GO:0043434 278 0.025
macromolecular complex subunit organization GO:0043933 339 0.025
Rat
positive regulation of biosynthetic process GO:0009891 319 0.025
regulation of multicellular organismal development GO:2000026 376 0.025
protein complex subunit organization GO:0071822 302 0.025
Rat
response to decreased oxygen levels GO:0036293 237 0.024
positive regulation of phosphorylation GO:0042327 177 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.024
single organism intracellular transport GO:1902582 166 0.024
peptidyl amino acid modification GO:0018193 126 0.024
cellular catabolic process GO:0044248 295 0.024
Rat
positive regulation of signaling GO:0023056 270 0.023
transmembrane transport GO:0055085 412 0.023
protein complex biogenesis GO:0070271 263 0.023
protein oligomerization GO:0051259 191 0.023
chemical homeostasis GO:0048878 292 0.023
locomotion GO:0040011 237 0.023
cellular response to nitrogen compound GO:1901699 210 0.023
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.023
regulation of system process GO:0044057 208 0.023
cellular chemical homeostasis GO:0055082 247 0.023
regulation of cell projection organization GO:0031344 175 0.023
multi multicellular organism process GO:0044706 138 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.022
organelle organization GO:0006996 266 0.022
Rat
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.022
Rat
regulation of kinase activity GO:0043549 117 0.022
protein complex assembly GO:0006461 263 0.022
multicellular organismal reproductive process GO:0048609 233 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
anatomical structure morphogenesis GO:0009653 298 0.022
regulation of canonical wnt signaling pathway GO:0060828 4 0.022
organophosphate metabolic process GO:0019637 370 0.022
Rat
positive regulation of cell differentiation GO:0045597 217 0.021
head development GO:0060322 247 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
Rat
nitrogen compound transport GO:0071705 229 0.021
neuron differentiation GO:0030182 368 0.021
cation homeostasis GO:0055080 195 0.021
neuron projection development GO:0031175 273 0.021
response to extracellular stimulus GO:0009991 380 0.021
multicellular organism reproduction GO:0032504 233 0.021
regulation of cell development GO:0060284 263 0.021
ion transmembrane transport GO:0034220 365 0.021
secretion GO:0046903 307 0.021
negative regulation of cellular protein metabolic process GO:0032269 106 0.021
central nervous system development GO:0007417 311 0.021
cellular response to lipid GO:0071396 201 0.021
anion transport GO:0006820 178 0.020
cation transport GO:0006812 382 0.020
cell projection organization GO:0030030 302 0.020
cellular homeostasis GO:0019725 252 0.020
positive regulation of phosphate metabolic process GO:0045937 262 0.020
Rat
positive regulation of developmental process GO:0051094 283 0.020
cell adhesion GO:0007155 110 0.020
response to estrogen GO:0043627 232 0.020
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
Rat
intracellular transport GO:0046907 185 0.020
negative regulation of cell death GO:0060548 229 0.020
response to vitamin GO:0033273 131 0.020
response to peptide GO:1901652 292 0.020
cellular response to organic cyclic compound GO:0071407 202 0.020
positive regulation of gene expression GO:0010628 244 0.020
cellular cation homeostasis GO:0030003 180 0.019
ion homeostasis GO:0050801 212 0.019
negative regulation of transcription dna templated GO:0045892 116 0.019
signal transduction by phosphorylation GO:0023014 144 0.019
cellular component morphogenesis GO:0032989 155 0.019
regulation of protein kinase activity GO:0045859 105 0.019
localization of cell GO:0051674 202 0.019
response to cytokine GO:0034097 215 0.019
response to nutrient GO:0007584 248 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
positive regulation of cellular component organization GO:0051130 200 0.019
Rat
peptidyl tyrosine phosphorylation GO:0018108 72 0.019
negative regulation of cellular biosynthetic process GO:0031327 161 0.019
positive regulation of protein phosphorylation GO:0001934 135 0.019
cellular response to peptide GO:1901653 133 0.019
macromolecular complex assembly GO:0065003 273 0.018
positive regulation of neurogenesis GO:0050769 165 0.018
positive regulation of programmed cell death GO:0043068 157 0.018
necroptotic process GO:0070266 2 0.018
tissue development GO:0009888 252 0.018
positive regulation of cell death GO:0010942 184 0.018
positive regulation of protein metabolic process GO:0051247 178 0.018
enzyme linked receptor protein signaling pathway GO:0007167 116 0.018
negative regulation of signaling GO:0023057 157 0.018
immune system process GO:0002376 204 0.018
cellular component movement GO:0006928 248 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.018
response to ketone GO:1901654 182 0.018
response to growth factor GO:0070848 189 0.017
vesicle mediated transport GO:0016192 181 0.017
positive regulation of rna biosynthetic process GO:1902680 197 0.017
response to metal ion GO:0010038 253 0.017
regulation of transferase activity GO:0051338 123 0.017
reproduction GO:0000003 245 0.017
regulation of cellular localization GO:0060341 263 0.017
protein localization GO:0008104 191 0.017
blood circulation GO:0008015 183 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
regulation of neuron projection development GO:0010975 161 0.017
cellular response to stress GO:0033554 269 0.017
wound healing GO:0042060 122 0.017
action potential GO:0001508 54 0.017
response to bacterium GO:0009617 200 0.017
negative regulation of molecular function GO:0044092 133 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
cell motility GO:0048870 202 0.017
cellular metal ion homeostasis GO:0006875 172 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
proteolysis GO:0006508 175 0.016
neuron development GO:0048666 286 0.016
response to wounding GO:0009611 254 0.016
response to carbohydrate GO:0009743 183 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
regulation of neuron death GO:1901214 115 0.016
carbohydrate derivative metabolic process GO:1901135 346 0.016
Rat
calcium ion homeostasis GO:0055074 162 0.016
growth GO:0040007 165 0.016
programmed necrotic cell death GO:0097300 2 0.016
regulation of map kinase activity GO:0043405 53 0.016
reproductive system development GO:0061458 128 0.016
response to reactive oxygen species GO:0000302 120 0.016
positive regulation of nervous system development GO:0051962 178 0.016
cellular ion homeostasis GO:0006873 184 0.016
liver development GO:0001889 90 0.016
cell migration GO:0016477 197 0.016
response to oxidative stress GO:0006979 186 0.016
macromolecule localization GO:0033036 252 0.016
cellular response to external stimulus GO:0071496 118 0.016
muscle cell proliferation GO:0033002 84 0.015
single organism organelle organization GO:1902589 180 0.015
Rat
positive regulation of rna metabolic process GO:0051254 203 0.015
metal ion homeostasis GO:0055065 186 0.015
organic substance catabolic process GO:1901575 316 0.015
Rat
response to estradiol GO:0032355 164 0.015
negative regulation of phosphorus metabolic process GO:0010563 80 0.015
nucleotide metabolic process GO:0009117 279 0.015
Rat
cellular protein localization GO:0034613 122 0.015
peptidyl tyrosine modification GO:0018212 72 0.015
lipid metabolic process GO:0006629 283 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.015
organic anion transport GO:0015711 132 0.015
cell type specific apoptotic process GO:0097285 134 0.015
positive regulation of transport GO:0051050 245 0.015
female pregnancy GO:0007565 122 0.015
neurological system process GO:0050877 219 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.015
cellular calcium ion homeostasis GO:0006874 160 0.015
negative regulation of protein metabolic process GO:0051248 114 0.015
mesoderm development GO:0007498 2 0.014
response to acid chemical GO:0001101 222 0.014
aging GO:0007568 241 0.014
rhythmic process GO:0048511 156 0.014
g protein coupled receptor signaling pathway GO:0007186 242 0.014
response to corticosteroid GO:0031960 235 0.014
behavior GO:0007610 205 0.014
regulation of anatomical structure size GO:0090066 135 0.014
developmental process involved in reproduction GO:0003006 159 0.014
positive regulation of intracellular signal transduction GO:1902533 138 0.014
immune effector process GO:0002252 53 0.014
cellular response to peptide hormone stimulus GO:0071375 120 0.014
regulation of smooth muscle cell proliferation GO:0048660 75 0.014
response to glucocorticoid GO:0051384 223 0.014
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
Rat
metal ion transport GO:0030001 289 0.013
regulation of immune system process GO:0002682 123 0.013
multicellular organismal signaling GO:0035637 44 0.013
protein heterooligomerization GO:0051291 89 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
regulation of protein serine threonine kinase activity GO:0071900 64 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
regulation of blood circulation GO:1903522 110 0.013
purine containing compound metabolic process GO:0072521 253 0.013
Rat
regulation of membrane potential GO:0042391 110 0.013
chromosome segregation GO:0007059 2 0.013
regulation of cytokine production GO:0001817 56 0.013
nucleoside phosphate metabolic process GO:0006753 283 0.013
Rat
positive regulation of mapk cascade GO:0043410 92 0.013
axis specification GO:0009798 4 0.013
hepaticobiliary system development GO:0061008 90 0.013
gamete generation GO:0007276 124 0.013
sexual reproduction GO:0019953 148 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
negative regulation of transport GO:0051051 136 0.013
single organism behavior GO:0044708 130 0.013
cytokine production GO:0001816 61 0.013
negative regulation of signal transduction GO:0009968 83 0.013
anterior posterior pattern specification GO:0009952 1 0.013
ras protein signal transduction GO:0007265 29 0.013
cell cell signaling GO:0007267 335 0.012
cellular response to acid chemical GO:0071229 75 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
eye morphogenesis GO:0048592 4 0.012
cellular divalent inorganic cation homeostasis GO:0072503 162 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.012
cofactor metabolic process GO:0051186 95 0.012
single organism cellular localization GO:1902580 102 0.012
neuronal action potential GO:0019228 35 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.012
regulation of hydrolase activity GO:0051336 143 0.012
Rat
synaptic transmission GO:0007268 235 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
negative regulation of rna metabolic process GO:0051253 123 0.012
organ regeneration GO:0031100 101 0.012
organic hydroxy compound metabolic process GO:1901615 115 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
cellular response to steroid hormone stimulus GO:0071383 93 0.012
inorganic ion transmembrane transport GO:0098660 229 0.012
cytoplasmic transport GO:0016482 115 0.012
positive regulation of transferase activity GO:0051347 81 0.011
carbohydrate homeostasis GO:0033500 75 0.011
urogenital system development GO:0001655 78 0.011
regulation of hormone levels GO:0010817 187 0.011
response to alkaloid GO:0043279 132 0.011
cardiac chamber development GO:0003205 1 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
response to toxic substance GO:0009636 133 0.011
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.011
regulation of dendrite development GO:0050773 59 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
sequestering of calcium ion GO:0051208 8 0.011
positive regulation of protein kinase activity GO:0045860 73 0.011
negative regulation of developmental process GO:0051093 125 0.011
renal system development GO:0072001 67 0.011
regulation of locomotion GO:0040012 148 0.011
protein homooligomerization GO:0051260 91 0.011
defense response GO:0006952 194 0.011
transmission of nerve impulse GO:0019226 42 0.011
embryonic pattern specification GO:0009880 1 0.011
organic cyclic compound catabolic process GO:1901361 175 0.011
Rat
cellular macromolecule localization GO:0070727 122 0.011
hematopoietic progenitor cell differentiation GO:0002244 2 0.011
actin filament based process GO:0030029 86 0.011
Rat
cardiac muscle cell contraction GO:0086003 10 0.011
response to radiation GO:0009314 137 0.011
sex differentiation GO:0007548 113 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
forebrain development GO:0030900 98 0.011
regulation of tube size GO:0035150 89 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
Rat
secretion by cell GO:0032940 248 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
regulation of mapk cascade GO:0043408 116 0.011
smooth muscle cell proliferation GO:0048659 77 0.011
biological adhesion GO:0022610 110 0.011
sequestering of metal ion GO:0051238 9 0.011
male gamete generation GO:0048232 99 0.011
positive regulation of kinase activity GO:0033674 77 0.011
regulation of cell motility GO:2000145 131 0.010
multicellular organism growth GO:0035264 1 0.010
cellular response to metal ion GO:0071248 55 0.010
positive regulation of map kinase activity GO:0043406 46 0.010
cell part morphogenesis GO:0032990 123 0.010
amide transport GO:0042886 105 0.010
leukocyte activation GO:0045321 76 0.010
regulation of blood vessel size GO:0050880 89 0.010
regulation of stem cell differentiation GO:2000736 2 0.010
regulation of cell migration GO:0030334 128 0.010
spermatogenesis GO:0007283 99 0.010
cell projection morphogenesis GO:0048858 123 0.010
response to ethanol GO:0045471 162 0.010
negative regulation of cell differentiation GO:0045596 99 0.010
circulatory system development GO:0072359 134 0.010
oxidation reduction process GO:0055114 304 0.010
organonitrogen compound biosynthetic process GO:1901566 167 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.010
cellular response to mechanical stimulus GO:0071260 48 0.010
cation transmembrane transport GO:0098655 263 0.010
dephosphorylation GO:0016311 98 0.010
regulation of neuron apoptotic process GO:0043523 83 0.010

Arhgef5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
nervous system disease DOID:863 0 0.019
disease of metabolism DOID:0014667 0 0.019
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
cardiovascular system disease DOID:1287 0 0.015
musculoskeletal system disease DOID:17 0 0.014
organ system cancer DOID:0050686 0 0.013
muscular disease DOID:0080000 0 0.012
central nervous system disease DOID:331 0 0.011
inherited metabolic disorder DOID:655 0 0.011
sensory system disease DOID:0050155 0 0.011