Rattus norvegicus

13 known processes

Arhgef1

Rho guanine nucleotide exchange factor (GEF) 1

(Aliases: MGC108950,Lsc)

Arhgef1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of mrna splicing via spliceosome GO:0048024 3 0.234
macromolecular complex subunit organization GO:0043933 339 0.128
g protein coupled receptor signaling pathway GO:0007186 242 0.112
negative regulation of cell cycle g1 s phase transition GO:1902807 2 0.111
neuron projection development GO:0031175 273 0.110
response to metal ion GO:0010038 253 0.097
negative regulation of transcription dna templated GO:0045892 116 0.095
regulation of molecular function GO:0065009 398 0.094
protein phosphorylation GO:0006468 345 0.092
transcription dna templated GO:0006351 377 0.088
regulation of cell cycle g1 s phase transition GO:1902806 7 0.088
regulation of cellular localization GO:0060341 263 0.081
positive regulation of biosynthetic process GO:0009891 319 0.080
purine containing compound metabolic process GO:0072521 253 0.080
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.079
purine ribonucleoside catabolic process GO:0046130 124 0.069
organelle organization GO:0006996 266 0.069
regulation of nucleic acid templated transcription GO:1903506 380 0.068
cellular homeostasis GO:0019725 252 0.066
positive regulation of rna metabolic process GO:0051254 203 0.063
regulation of rna metabolic process GO:0051252 391 0.063
positive regulation of transport GO:0051050 245 0.061
homeostatic process GO:0042592 331 0.060
regulation of intracellular signal transduction GO:1902531 218 0.059
protein complex biogenesis GO:0070271 263 0.059
regulation of signal transduction GO:0009966 318 0.058
negative regulation of cellular metabolic process GO:0031324 281 0.056
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.055
intracellular signal transduction GO:0035556 314 0.054
response to other organism GO:0051707 220 0.054
regulation of multicellular organismal development GO:2000026 376 0.052
cell cycle GO:0007049 101 0.051
neuron differentiation GO:0030182 368 0.051
organophosphate catabolic process GO:0046434 148 0.050
positive regulation of gene expression GO:0010628 244 0.050
macromolecule localization GO:0033036 252 0.049
cellular component assembly GO:0022607 360 0.049
nucleobase containing small molecule metabolic process GO:0055086 316 0.046
regulation of cell cycle GO:0051726 73 0.044
cell cycle g1 s phase transition GO:0044843 13 0.044
cytoskeleton organization GO:0007010 111 0.041
macromolecular complex assembly GO:0065003 273 0.041
nucleotide catabolic process GO:0009166 139 0.041
positive regulation of cell communication GO:0010647 271 0.040
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.039
cellular chemical homeostasis GO:0055082 247 0.039
cellular component biogenesis GO:0044085 368 0.038
positive regulation of secretion GO:0051047 140 0.038
regulation of phosphate metabolic process GO:0019220 349 0.037
negative regulation of signaling GO:0023057 157 0.037
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.037
nucleoside metabolic process GO:0009116 179 0.036
chromatin assembly or disassembly GO:0006333 1 0.036
ribonucleotide metabolic process GO:0009259 231 0.036
regulation of protein phosphorylation GO:0001932 183 0.035
purine ribonucleotide metabolic process GO:0009150 227 0.035
brain development GO:0007420 247 0.035
negative regulation of transport GO:0051051 136 0.035
regulation of cell proliferation GO:0042127 359 0.035
response to biotic stimulus GO:0009607 226 0.035
response to temperature stimulus GO:0009266 94 0.035
regulation of rna biosynthetic process GO:2001141 381 0.035
cellular response to endogenous stimulus GO:0071495 377 0.035
regulation of protein kinase activity GO:0045859 105 0.034
negative regulation of rna metabolic process GO:0051253 123 0.034
regulation of protein localization GO:0032880 81 0.034
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.034
atp catabolic process GO:0006200 54 0.034
central nervous system development GO:0007417 311 0.034
response to external biotic stimulus GO:0043207 221 0.033
peptidyl amino acid modification GO:0018193 126 0.033
purine nucleoside monophosphate catabolic process GO:0009128 55 0.033
positive regulation of phosphate metabolic process GO:0045937 262 0.033
carbohydrate derivative catabolic process GO:1901136 147 0.033
regulation of cellular component organization GO:0051128 368 0.033
immune system process GO:0002376 204 0.032
reproduction GO:0000003 245 0.032
Worm
regulation of catalytic activity GO:0050790 304 0.032
response to radiation GO:0009314 137 0.032
cellular component movement GO:0006928 248 0.032
negative regulation of cellular biosynthetic process GO:0031327 161 0.031
single organism organelle organization GO:1902589 180 0.031
activation of mapkkk activity GO:0000185 1 0.031
negative regulation of cell communication GO:0010648 158 0.030
protein complex assembly GO:0006461 263 0.030
secretion by cell GO:0032940 248 0.030
purine nucleotide metabolic process GO:0006163 229 0.030
response to peptide GO:1901652 292 0.030
single organism reproductive process GO:0044702 297 0.029
ribonucleoside triphosphate metabolic process GO:0009199 141 0.029
negative regulation of nucleic acid templated transcription GO:1903507 117 0.029
response to wounding GO:0009611 254 0.028
organophosphate metabolic process GO:0019637 370 0.028
negative regulation of macromolecule metabolic process GO:0010605 260 0.028
positive regulation of nucleic acid templated transcription GO:1903508 197 0.028
regulation of homeostatic process GO:0032844 101 0.028
tube formation GO:0035148 3 0.028
response to inorganic substance GO:0010035 377 0.027
response to oxidative stress GO:0006979 186 0.027
purine nucleotide catabolic process GO:0006195 136 0.027
cell cycle checkpoint GO:0000075 2 0.027
negative regulation of cell cycle phase transition GO:1901988 4 0.027
glutamate receptor signaling pathway GO:0007215 43 0.027
cytosolic calcium ion homeostasis GO:0051480 140 0.027
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.027
cellular response to stress GO:0033554 269 0.026
protein oligomerization GO:0051259 191 0.026
purine containing compound catabolic process GO:0072523 138 0.026
carbohydrate derivative metabolic process GO:1901135 346 0.026
regulation of phosphorylation GO:0042325 248 0.026
mitotic cell cycle GO:0000278 49 0.026
regulation of cell development GO:0060284 263 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.026
positive regulation of intracellular signal transduction GO:1902533 138 0.026
positive regulation of transcription dna templated GO:0045893 197 0.026
cellular response to organonitrogen compound GO:0071417 197 0.026
regulation of phosphorus metabolic process GO:0051174 349 0.025
sensory perception GO:0007600 101 0.025
Worm
negative regulation of biosynthetic process GO:0009890 168 0.024
vasculogenesis GO:0001570 3 0.024
metal ion homeostasis GO:0055065 186 0.024
regulation of neurogenesis GO:0050767 247 0.024
calcium ion homeostasis GO:0055074 162 0.024
ribonucleoside triphosphate catabolic process GO:0009203 122 0.024
negative regulation of rna biosynthetic process GO:1902679 118 0.024
endocytosis GO:0006897 84 0.024
peptide biosynthetic process GO:0043043 3 0.023
response to cytokine GO:0034097 215 0.023
regulation of nervous system development GO:0051960 264 0.023
cytoplasmic transport GO:0016482 115 0.023
ras protein signal transduction GO:0007265 29 0.023
spindle organization GO:0007051 2 0.023
regulation of cell differentiation GO:0045595 320 0.022
small gtpase mediated signal transduction GO:0007264 36 0.022
secretion GO:0046903 307 0.022
cell projection organization GO:0030030 302 0.022
rna metabolic process GO:0016070 406 0.022
response to transforming growth factor beta GO:0071559 46 0.022
regulation of receptor recycling GO:0001919 6 0.022
positive regulation of protein phosphorylation GO:0001934 135 0.022
positive regulation of molecular function GO:0044093 230 0.021
calcium ion transport GO:0006816 131 0.021
nucleotide metabolic process GO:0009117 279 0.021
nucleocytoplasmic transport GO:0006913 48 0.021
mapk cascade GO:0000165 140 0.021
mitotic cell cycle process GO:1903047 35 0.021
neurological system process GO:0050877 219 0.021
Worm
purine ribonucleoside metabolic process GO:0046128 168 0.021
regulation of locomotion GO:0040012 148 0.021
negative regulation of protein metabolic process GO:0051248 114 0.021
ribonucleotide catabolic process GO:0009261 136 0.021
rna biosynthetic process GO:0032774 380 0.020
protein localization GO:0008104 191 0.020
amine metabolic process GO:0009308 38 0.020
vesicle mediated transport GO:0016192 181 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
Worm
positive regulation of signaling GO:0023056 270 0.020
cellular cation homeostasis GO:0030003 180 0.019
defense response GO:0006952 194 0.019
locomotion GO:0040011 237 0.019
Worm
nucleoside phosphate metabolic process GO:0006753 283 0.019
multicellular organism reproduction GO:0032504 233 0.019
Worm
divalent inorganic cation homeostasis GO:0072507 165 0.019
cellular metal ion homeostasis GO:0006875 172 0.019
tissue development GO:0009888 252 0.019
chemical homeostasis GO:0048878 292 0.019
response to lipopolysaccharide GO:0032496 191 0.019
cellular calcium ion homeostasis GO:0006874 160 0.018
response to ammonium ion GO:0060359 71 0.018
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.018
nucleobase containing compound catabolic process GO:0034655 152 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
protein complex subunit organization GO:0071822 302 0.018
cellular divalent inorganic cation homeostasis GO:0072503 162 0.018
negative regulation of metabolic process GO:0009892 331 0.018
ion homeostasis GO:0050801 212 0.017
cation homeostasis GO:0055080 195 0.017
apoptotic process GO:0006915 381 0.017
reproductive process GO:0022414 372 0.017
Worm
embryo development GO:0009790 49 0.017
Worm
multi organism reproductive process GO:0044703 262 0.017
Worm
cellular ion homeostasis GO:0006873 184 0.017
neuron development GO:0048666 286 0.017
negative regulation of response to stimulus GO:0048585 155 0.017
atp metabolic process GO:0046034 72 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
cellular response to peptide GO:1901653 133 0.017
programmed cell death GO:0012501 392 0.017
positive regulation of apoptotic process GO:0043065 154 0.017
response to hydrogen peroxide GO:0042542 89 0.016
regulation of neuron differentiation GO:0045664 208 0.016
nucleoside triphosphate catabolic process GO:0009143 123 0.016
heterocycle catabolic process GO:0046700 167 0.016
positive regulation of rna biosynthetic process GO:1902680 197 0.016
negative regulation of gene expression GO:0010629 199 0.016
dna metabolic process GO:0006259 96 0.016
cellular amine metabolic process GO:0044106 38 0.016
defense response to gram negative bacterium GO:0050829 3 0.016
signal transduction by phosphorylation GO:0023014 144 0.016
positive regulation of cell death GO:0010942 184 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
regulation of cellular protein metabolic process GO:0032268 267 0.015
regulation of purine nucleotide metabolic process GO:1900542 115 0.015
catabolic process GO:0009056 351 0.015
ion transmembrane transport GO:0034220 365 0.015
regulation of secretion GO:0051046 224 0.015
asymmetric protein localization GO:0008105 2 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
regulation of cell projection organization GO:0031344 175 0.015
regulation of transcription dna templated GO:0006355 374 0.015
mammary gland epithelium development GO:0061180 1 0.015
inflammatory response GO:0006954 150 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
ribonucleoside monophosphate metabolic process GO:0009161 88 0.015
cellular protein localization GO:0034613 122 0.015
lipid metabolic process GO:0006629 283 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
heart morphogenesis GO:0003007 3 0.014
actin filament organization GO:0007015 42 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
response to estrogen GO:0043627 232 0.014
cellular macromolecule localization GO:0070727 122 0.014
actin filament based process GO:0030029 86 0.014
negative regulation of phosphorylation GO:0042326 57 0.014
regulation of response to stress GO:0080134 126 0.014
carboxylic acid metabolic process GO:0019752 289 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
hematopoietic or lymphoid organ development GO:0048534 36 0.014
aromatic compound catabolic process GO:0019439 168 0.014
regulation of growth GO:0040008 105 0.014
nucleoside triphosphate metabolic process GO:0009141 144 0.013
dna integrity checkpoint GO:0031570 2 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
transmembrane transport GO:0055085 412 0.013
head development GO:0060322 247 0.013
single organism intracellular transport GO:1902582 166 0.013
lipid transport GO:0006869 61 0.013
positive regulation of cell development GO:0010720 176 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.013
regulation of small gtpase mediated signal transduction GO:0051056 48 0.013
sensory organ development GO:0007423 74 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
forebrain development GO:0030900 98 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.013
regulation of neuron projection development GO:0010975 161 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
negative regulation of cell development GO:0010721 82 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
mitotic spindle organization GO:0007052 2 0.013
positive regulation of cell proliferation GO:0008284 249 0.012
response to light stimulus GO:0009416 52 0.012
response to carbohydrate GO:0009743 183 0.012
response to bacterium GO:0009617 200 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
heart development GO:0007507 72 0.012
regulation of protein serine threonine kinase activity GO:0071900 64 0.012
regulation of ion transport GO:0043269 245 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
nucleoside monophosphate catabolic process GO:0009125 56 0.012
cell morphogenesis GO:0000902 142 0.012
rna splicing via transesterification reactions GO:0000375 7 0.012
aging GO:0007568 241 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
nucleoside catabolic process GO:0009164 126 0.012
divalent metal ion transport GO:0070838 132 0.012
regulation of the force of heart contraction by chemical signal GO:0003057 2 0.012
histone modification GO:0016570 30 0.012
negative regulation of protein phosphorylation GO:0001933 44 0.012
negative regulation of cell differentiation GO:0045596 99 0.012
transcription from rna polymerase ii promoter GO:0006366 252 0.012
anatomical structure morphogenesis GO:0009653 298 0.011
nucleic acid templated transcription GO:0097659 379 0.011
positive regulation of response to stimulus GO:0048584 285 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
innate immune response GO:0045087 35 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
regulation of membrane potential GO:0042391 110 0.011
positive regulation of kinase activity GO:0033674 77 0.011
female pregnancy GO:0007565 122 0.011
regulation of immune response GO:0050776 55 0.011
muscle system process GO:0003012 115 0.011
organic substance catabolic process GO:1901575 316 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
regulation of cell cycle process GO:0010564 31 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
positive regulation of nervous system development GO:0051962 178 0.011
response to acid chemical GO:0001101 222 0.011
regulation of cell motility GO:2000145 131 0.011
receptor metabolic process GO:0043112 18 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
cell motility GO:0048870 202 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
cellular response to hormone stimulus GO:0032870 247 0.011
regulation of transferase activity GO:0051338 123 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.010
axis specification GO:0009798 4 0.010
response to camp GO:0051591 91 0.010
regulation of embryonic development GO:0045995 2 0.010
cellular response to abiotic stimulus GO:0071214 85 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
negative regulation of neuron differentiation GO:0045665 62 0.010
regulation of cellular component biogenesis GO:0044087 86 0.010
ribonucleoside monophosphate catabolic process GO:0009158 55 0.010
response to potassium ion GO:0035864 9 0.010
negative regulation of multicellular organismal process GO:0051241 203 0.010
single organism behavior GO:0044708 130 0.010
Worm
liver development GO:0001889 90 0.010
regulation of cellular ketone metabolic process GO:0010565 27 0.010
regulation of establishment of protein localization GO:0070201 69 0.010

Arhgef1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
musculoskeletal system disease DOID:17 0 0.020
nervous system disease DOID:863 0 0.011