Rattus norvegicus

100 known processes

Traf2

Tnf receptor-associated factor 2

Traf2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 289 0.084
rna metabolic process GO:0016070 406 0.076
regulation of transcription dna templated GO:0006355 374 0.072
regulation of nucleic acid templated transcription GO:1903506 380 0.067
macromolecule localization GO:0033036 252 0.063
oxoacid metabolic process GO:0043436 290 0.063
transcription dna templated GO:0006351 377 0.058
regulation of phosphate metabolic process GO:0019220 349 0.058
rna biosynthetic process GO:0032774 380 0.057
organic acid metabolic process GO:0006082 292 0.057
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.056
nucleic acid templated transcription GO:0097659 379 0.053
regulation of rna metabolic process GO:0051252 391 0.053
protein phosphorylation GO:0006468 345 0.052
regulation of signal transduction GO:0009966 318 0.052
cation transport GO:0006812 382 0.049
intracellular signal transduction GO:0035556 314 0.049
positive regulation of nucleic acid templated transcription GO:1903508 197 0.046
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.045
programmed cell death GO:0012501 392 0.044
regulation of rna biosynthetic process GO:2001141 381 0.044
regulation of programmed cell death GO:0043067 341 0.044
cellular catabolic process GO:0044248 295 0.042
apoptotic process GO:0006915 381 0.042
single organism biosynthetic process GO:0044711 342 0.042
cellular amino acid metabolic process GO:0006520 107 0.041
positive regulation of gene expression GO:0010628 244 0.040
regulation of phosphorus metabolic process GO:0051174 349 0.040
regulation of cellular localization GO:0060341 263 0.039
cell cell signaling GO:0007267 335 0.038
organophosphate metabolic process GO:0019637 370 0.038
positive regulation of cell communication GO:0010647 271 0.037
regulation of cell proliferation GO:0042127 359 0.037
regulation of molecular function GO:0065009 398 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.036
positive regulation of signaling GO:0023056 270 0.035
organonitrogen compound biosynthetic process GO:1901566 167 0.035
organic substance catabolic process GO:1901575 316 0.035
secretion GO:0046903 307 0.035
regulation of cell differentiation GO:0045595 320 0.035
response to inorganic substance GO:0010035 377 0.034
regulation of cellular protein metabolic process GO:0032268 267 0.034
positive regulation of transcription dna templated GO:0045893 197 0.034
carbohydrate derivative metabolic process GO:1901135 346 0.034
ribonucleotide metabolic process GO:0009259 231 0.033
regulation of cellular ketone metabolic process GO:0010565 27 0.032
positive regulation of cellular biosynthetic process GO:0031328 295 0.032
central nervous system development GO:0007417 311 0.032
transcription from rna polymerase ii promoter GO:0006366 252 0.032
regulation of cellular component organization GO:0051128 368 0.032
multicellular organism reproduction GO:0032504 233 0.031
nitrogen compound transport GO:0071705 229 0.031
regulation of secretion GO:0051046 224 0.030
regulation of apoptotic process GO:0042981 335 0.030
purine nucleotide metabolic process GO:0006163 229 0.030
nucleoside phosphate metabolic process GO:0006753 283 0.030
regulation of cellular amine metabolic process GO:0033238 8 0.030
positive regulation of rna biosynthetic process GO:1902680 197 0.030
regulation of catalytic activity GO:0050790 304 0.030
catabolic process GO:0009056 351 0.030
response to external biotic stimulus GO:0043207 221 0.030
head development GO:0060322 247 0.029
cellular component biogenesis GO:0044085 368 0.029
cellular amine metabolic process GO:0044106 38 0.029
cellular response to oxygen containing compound GO:1901701 386 0.029
negative regulation of cellular metabolic process GO:0031324 281 0.029
negative regulation of macromolecule metabolic process GO:0010605 260 0.028
negative regulation of metabolic process GO:0009892 331 0.028
purine containing compound metabolic process GO:0072521 253 0.028
regulation of phosphorylation GO:0042325 248 0.028
positive regulation of nervous system development GO:0051962 178 0.027
positive regulation of response to stimulus GO:0048584 285 0.027
alpha amino acid metabolic process GO:1901605 71 0.027
brain development GO:0007420 247 0.027
organelle organization GO:0006996 266 0.027
cellular ketone metabolic process GO:0042180 51 0.026
negative regulation of signaling GO:0023057 157 0.026
response to bacterium GO:0009617 200 0.026
response to nutrient levels GO:0031667 370 0.026
positive regulation of multicellular organismal process GO:0051240 387 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
positive regulation of rna metabolic process GO:0051254 203 0.025
macromolecular complex assembly GO:0065003 273 0.025
nucleobase containing small molecule metabolic process GO:0055086 316 0.025
positive regulation of phosphate metabolic process GO:0045937 262 0.025
cellular response to stress GO:0033554 269 0.025
amine metabolic process GO:0009308 38 0.025
response to extracellular stimulus GO:0009991 380 0.025
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.025
homeostatic process GO:0042592 331 0.025
positive regulation of cell proliferation GO:0008284 249 0.025
cellular component assembly GO:0022607 360 0.025
ribose phosphate metabolic process GO:0019693 235 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
positive regulation of developmental process GO:0051094 283 0.024
neuron differentiation GO:0030182 368 0.024
metal ion transport GO:0030001 289 0.024
regulation of nervous system development GO:0051960 264 0.024
multi organism reproductive process GO:0044703 262 0.024
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.023
anterior posterior pattern specification GO:0009952 1 0.023
positive regulation of phosphorus metabolic process GO:0010562 262 0.023
tissue development GO:0009888 252 0.023
negative regulation of cell communication GO:0010648 158 0.023
transmembrane transport GO:0055085 412 0.023
regulation of intracellular signal transduction GO:1902531 218 0.022
positive regulation of molecular function GO:0044093 230 0.022
reproductive process GO:0022414 372 0.022
regulation of protein metabolic process GO:0051246 289 0.022
embryonic pattern specification GO:0009880 1 0.022
immune system process GO:0002376 204 0.022
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.022
response to biotic stimulus GO:0009607 226 0.022
carboxylic acid biosynthetic process GO:0046394 83 0.022
organophosphate biosynthetic process GO:0090407 143 0.022
response to acid chemical GO:0001101 222 0.022
secretion by cell GO:0032940 248 0.021
regulation of multicellular organismal development GO:2000026 376 0.021
protein complex biogenesis GO:0070271 263 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
regulation of cell development GO:0060284 263 0.021
purine ribonucleotide metabolic process GO:0009150 227 0.021
regulation of neuron differentiation GO:0045664 208 0.021
macromolecular complex subunit organization GO:0043933 339 0.021
nucleotide metabolic process GO:0009117 279 0.021
response to other organism GO:0051707 220 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
vesicle mediated transport GO:0016192 181 0.020
cytoplasmic transport GO:0016482 115 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
regulation of neurogenesis GO:0050767 247 0.020
single organism catabolic process GO:0044712 283 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
response to molecule of bacterial origin GO:0002237 194 0.020
cell projection organization GO:0030030 302 0.020
negative regulation of response to stimulus GO:0048585 155 0.020
reproduction GO:0000003 245 0.020
regulation of protein modification process GO:0031399 194 0.019
regulation of ion transport GO:0043269 245 0.019
anatomical structure morphogenesis GO:0009653 298 0.019
protein localization GO:0008104 191 0.019
intracellular transport GO:0046907 185 0.019
single organism reproductive process GO:0044702 297 0.019
negative regulation of transport GO:0051051 136 0.019
proteolysis GO:0006508 175 0.019
regulation of proteasomal protein catabolic process GO:0061136 4 0.019
neuron projection development GO:0031175 273 0.019
positive regulation of signal transduction GO:0009967 175 0.019
regulation of secretion by cell GO:1903530 208 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
axis specification GO:0009798 4 0.019
chemical homeostasis GO:0048878 292 0.019
response to metal ion GO:0010038 253 0.019
positive regulation of cellular component organization GO:0051130 200 0.018
negative regulation of apoptotic process GO:0043066 181 0.018
response to lipopolysaccharide GO:0032496 191 0.018
negative regulation of transcription dna templated GO:0045892 116 0.018
neurological system process GO:0050877 219 0.018
single organism organelle organization GO:1902589 180 0.018
negative regulation of multicellular organismal process GO:0051241 203 0.018
glycosyl compound metabolic process GO:1901657 182 0.018
organic acid biosynthetic process GO:0016053 83 0.018
ion transmembrane transport GO:0034220 365 0.018
single organism intracellular transport GO:1902582 166 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
small gtpase mediated signal transduction GO:0007264 36 0.017
response to oxygen levels GO:0070482 265 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
small molecule biosynthetic process GO:0044283 124 0.017
cellular lipid metabolic process GO:0044255 208 0.017
positive regulation of protein modification process GO:0031401 142 0.017
positive regulation of cell death GO:0010942 184 0.017
glycosyl compound catabolic process GO:1901658 126 0.017
cellular homeostasis GO:0019725 252 0.017
heart morphogenesis GO:0003007 3 0.017
lipid metabolic process GO:0006629 283 0.016
positive regulation of secretion GO:0051047 140 0.016
neuron development GO:0048666 286 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
regulation of cell projection organization GO:0031344 175 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
positive regulation of transport GO:0051050 245 0.016
positive regulation of cell development GO:0010720 176 0.016
gastrulation GO:0007369 2 0.016
positive regulation of phosphorylation GO:0042327 177 0.016
cellular component morphogenesis GO:0032989 155 0.016
cellular amino acid biosynthetic process GO:0008652 32 0.016
blood circulation GO:0008015 183 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
circulatory system process GO:0003013 183 0.015
cellular response to lipid GO:0071396 201 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
regulation of purine nucleotide metabolic process GO:1900542 115 0.015
anion transport GO:0006820 178 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
purine nucleotide biosynthetic process GO:0006164 83 0.015
aging GO:0007568 241 0.015
ribonucleotide biosynthetic process GO:0009260 85 0.015
regulation of kinase activity GO:0043549 117 0.015
regulation of locomotion GO:0040012 148 0.015
locomotion GO:0040011 237 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
regulation of protein transport GO:0051223 68 0.015
asymmetric protein localization GO:0008105 2 0.015
cellular component movement GO:0006928 248 0.015
response to cytokine GO:0034097 215 0.015
amide transport GO:0042886 105 0.015
carboxylic acid transport GO:0046942 115 0.015
regulation of anatomical structure size GO:0090066 135 0.015
cation transmembrane transport GO:0098655 263 0.015
heart process GO:0003015 57 0.014
protein complex subunit organization GO:0071822 302 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
response to monosaccharide GO:0034284 159 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
eye morphogenesis GO:0048592 4 0.014
negative regulation of developmental process GO:0051093 125 0.014
ras protein signal transduction GO:0007265 29 0.014
b cell differentiation GO:0030183 2 0.014
regulation of hormone levels GO:0010817 187 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
negative regulation of rna metabolic process GO:0051253 123 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
divalent inorganic cation transport GO:0072511 134 0.014
response to hexose GO:0009746 144 0.014
mapk cascade GO:0000165 140 0.014
cellular chemical homeostasis GO:0055082 247 0.014
calcium ion transport GO:0006816 131 0.014
localization of cell GO:0051674 202 0.014
cellular cation homeostasis GO:0030003 180 0.014
regulation of membrane potential GO:0042391 110 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
nucleoside metabolic process GO:0009116 179 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
response to alkaloid GO:0043279 132 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
spermatogenesis GO:0007283 99 0.013
behavior GO:0007610 205 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
cell migration GO:0016477 197 0.013
protein complex assembly GO:0006461 263 0.013
sexual reproduction GO:0019953 148 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
negative regulation of gene expression GO:0010629 199 0.013
synaptic transmission GO:0007268 235 0.013
regulation of canonical wnt signaling pathway GO:0060828 4 0.013
growth GO:0040007 165 0.013
heart contraction GO:0060047 57 0.013
nucleoside phosphate biosynthetic process GO:1901293 102 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
cellular macromolecule localization GO:0070727 122 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
regulation of transferase activity GO:0051338 123 0.013
peptide transport GO:0015833 97 0.013
protein oligomerization GO:0051259 191 0.013
regulation of peptide transport GO:0090087 87 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
inorganic cation transmembrane transport GO:0098662 202 0.013
multicellular organism growth GO:0035264 1 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
cation homeostasis GO:0055080 195 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
regulation of immune system process GO:0002682 123 0.012
carbohydrate derivative catabolic process GO:1901136 147 0.012
regulation of establishment of protein localization GO:0070201 69 0.012
heterocycle catabolic process GO:0046700 167 0.012
response to nutrient GO:0007584 248 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
response to carbohydrate GO:0009743 183 0.012
response to hypoxia GO:0001666 231 0.012
regulation of protein localization GO:0032880 81 0.012
protein transport GO:0015031 132 0.012
purine ribonucleotide biosynthetic process GO:0009152 81 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
defense response GO:0006952 194 0.012
regulation of mapk cascade GO:0043408 116 0.012
cell type specific apoptotic process GO:0097285 134 0.012
coenzyme metabolic process GO:0006732 86 0.012
response to wounding GO:0009611 254 0.012
oxidation reduction process GO:0055114 304 0.012
divalent metal ion transport GO:0070838 132 0.012
response to decreased oxygen levels GO:0036293 237 0.012
cellular ion homeostasis GO:0006873 184 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
developmental process involved in reproduction GO:0003006 159 0.012
cell growth GO:0016049 104 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
peptidyl amino acid modification GO:0018193 126 0.012
rhythmic process GO:0048511 156 0.011
regulation of metal ion transport GO:0010959 118 0.011
negative regulation of cell death GO:0060548 229 0.011
chromosome segregation GO:0007059 2 0.011
lipid transport GO:0006869 61 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
nucleotide biosynthetic process GO:0009165 98 0.011
response to glucose GO:0009749 136 0.011
hormone transport GO:0009914 121 0.011
negative regulation of cellular biosynthetic process GO:0031327 161 0.011
response to corticosteroid GO:0031960 235 0.011
negative regulation of molecular function GO:0044092 133 0.011
response to toxic substance GO:0009636 133 0.011
gamete generation GO:0007276 124 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
male gamete generation GO:0048232 99 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
purine containing compound catabolic process GO:0072523 138 0.011
metal ion homeostasis GO:0055065 186 0.011
response to growth factor GO:0070848 189 0.011
rna localization GO:0006403 4 0.011
aromatic compound catabolic process GO:0019439 168 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
nucleotide catabolic process GO:0009166 139 0.011
organic anion transport GO:0015711 132 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
cardiac muscle contraction GO:0060048 27 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
cellular response to organic cyclic compound GO:0071407 202 0.011
muscle organ morphogenesis GO:0048644 1 0.011
positive regulation of ion transport GO:0043270 94 0.011
ion homeostasis GO:0050801 212 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
embryonic axis specification GO:0000578 1 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
cofactor metabolic process GO:0051186 95 0.011
regulation of hydrolase activity GO:0051336 143 0.011
single organism cellular localization GO:1902580 102 0.011
response to ketone GO:1901654 182 0.011
cellular response to hormone stimulus GO:0032870 247 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
negative regulation of nucleic acid templated transcription GO:1903507 117 0.010
regulation of neuron projection development GO:0010975 161 0.010
establishment of protein localization GO:0045184 141 0.010
response to peptide GO:1901652 292 0.010
muscle system process GO:0003012 115 0.010
cellular modified amino acid metabolic process GO:0006575 61 0.010
positive regulation of immune system process GO:0002684 90 0.010
regulation of peptide secretion GO:0002791 82 0.010
regulation of response to stress GO:0080134 126 0.010
nucleoside phosphate catabolic process GO:1901292 140 0.010
circulatory system development GO:0072359 134 0.010
organic acid transport GO:0015849 116 0.010
dephosphorylation GO:0016311 98 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
purine ribonucleoside metabolic process GO:0046128 168 0.010
adult locomotory behavior GO:0008344 4 0.010
maintenance of location GO:0051235 17 0.010
cellular response to growth factor stimulus GO:0071363 162 0.010
positive regulation of secretion by cell GO:1903532 128 0.010
positive regulation of protein phosphorylation GO:0001934 135 0.010
regulation of protein kinase activity GO:0045859 105 0.010
purine nucleoside metabolic process GO:0042278 169 0.010
lipid localization GO:0010876 62 0.010
response to oxidative stress GO:0006979 186 0.010

Traf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.015
muscular disease DOID:0080000 0 0.015
disease of anatomical entity DOID:7 0 0.015
musculoskeletal system disease DOID:17 0 0.015
muscle tissue disease DOID:66 0 0.015
disease of metabolism DOID:0014667 0 0.015
nervous system disease DOID:863 0 0.013
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011