Rattus norvegicus

11 known processes

Sec61a1

Sec61 alpha 1 subunit (S. cerevisiae)

(Aliases: Sec61a)

Sec61a1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of behavior GO:0048520 38 0.591
vesicle mediated transport GO:0016192 181 0.446
cellular protein catabolic process GO:0044257 19 0.435
regulation of behavior GO:0050795 61 0.383
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 1 0.343
regulation of secretion GO:0051046 224 0.284
regulation of blood vessel size GO:0050880 89 0.261
intracellular transport GO:0046907 185 0.244
regulation of chemotaxis GO:0050920 29 0.223
positive regulation of secretion by cell GO:1903532 128 0.220
endocytosis GO:0006897 84 0.198
secretion by cell GO:0032940 248 0.193
exocytosis GO:0006887 60 0.169
behavior GO:0007610 205 0.169
positive regulation of protein secretion GO:0050714 19 0.163
macromolecular complex subunit organization GO:0043933 339 0.159
protein complex biogenesis GO:0070271 263 0.150
cellular cation homeostasis GO:0030003 180 0.148
response to hypoxia GO:0001666 231 0.147
positive regulation of protein transport GO:0051222 41 0.146
anatomical structure morphogenesis GO:0009653 298 0.146
blood circulation GO:0008015 183 0.144
carbohydrate metabolic process GO:0005975 130 0.140
sensory organ development GO:0007423 74 0.134
reproductive process GO:0022414 372 0.130
protein complex assembly GO:0006461 263 0.127
cellular component assembly GO:0022607 360 0.122
protein complex subunit organization GO:0071822 302 0.118
retinoic acid receptor signaling pathway GO:0048384 7 0.110
regulation of endocytosis GO:0030100 42 0.105
neuromuscular process GO:0050905 2 0.105
circulatory system development GO:0072359 134 0.097
cytoskeleton organization GO:0007010 111 0.096
regulation of cell motility GO:2000145 131 0.095
secretion GO:0046903 307 0.087
cellular response to stress GO:0033554 269 0.087
vasoconstriction GO:0042310 54 0.085
positive regulation of secretion GO:0051047 140 0.083
er associated ubiquitin dependent protein catabolic process GO:0030433 1 0.083
organic substance catabolic process GO:1901575 316 0.083
organelle organization GO:0006996 266 0.082
regulation of tube size GO:0035150 89 0.081
cell morphogenesis GO:0000902 142 0.081
cellular macromolecule catabolic process GO:0044265 29 0.081
regulation of catalytic activity GO:0050790 304 0.081
proteasomal protein catabolic process GO:0010498 8 0.081
vascular process in circulatory system GO:0003018 96 0.078
regulation of apoptotic process GO:0042981 335 0.077
head development GO:0060322 247 0.075
macromolecule catabolic process GO:0009057 58 0.075
regulation of molecular function GO:0065009 398 0.073
neurological system process GO:0050877 219 0.073
cellular chemical homeostasis GO:0055082 247 0.071
positive regulation of transport GO:0051050 245 0.071
cellular metal ion homeostasis GO:0006875 172 0.070
carbohydrate derivative metabolic process GO:1901135 346 0.070
multicellular organism growth GO:0035264 1 0.070
negative regulation of cell death GO:0060548 229 0.067
cellular response to nitrogen compound GO:1901699 210 0.065
muscle structure development GO:0061061 87 0.065
regulation of vesicle mediated transport GO:0060627 81 0.063
single organism organelle organization GO:1902589 180 0.063
regulation of translation GO:0006417 27 0.063
establishment of protein localization GO:0045184 141 0.062
positive regulation of endocytosis GO:0045807 28 0.062
macromolecular complex assembly GO:0065003 273 0.060
regulation of cell morphogenesis GO:0022604 77 0.058
negative regulation of rna splicing GO:0033119 3 0.058
positive regulation of cytokine secretion GO:0050715 9 0.057
central nervous system development GO:0007417 311 0.057
response to inorganic substance GO:0010035 377 0.057
regulation of dendrite development GO:0050773 59 0.057
ion homeostasis GO:0050801 212 0.056
muscle cell differentiation GO:0042692 52 0.056
protein transport GO:0015031 132 0.054
response to other organism GO:0051707 220 0.053
lipid localization GO:0010876 62 0.053
positive regulation of protein metabolic process GO:0051247 178 0.053
cellular response to organonitrogen compound GO:0071417 197 0.052
regulation of signal transduction GO:0009966 318 0.052
regulation of anatomical structure morphogenesis GO:0022603 141 0.051
carbohydrate derivative biosynthetic process GO:1901137 124 0.051
circulatory system process GO:0003013 183 0.051
glycoprotein biosynthetic process GO:0009101 19 0.050
homeostatic process GO:0042592 331 0.050
chemical homeostasis GO:0048878 292 0.050
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 7 0.049
cellular ion homeostasis GO:0006873 184 0.048
protein folding GO:0006457 12 0.048
regulation of programmed cell death GO:0043067 341 0.047
regulation of hormone levels GO:0010817 187 0.047
positive regulation of cell differentiation GO:0045597 217 0.046
multicellular organism reproduction GO:0032504 233 0.045
cellular component biogenesis GO:0044085 368 0.045
cellular catabolic process GO:0044248 295 0.045
positive regulation of gene expression GO:0010628 244 0.045
cardiovascular system development GO:0072358 134 0.045
cation transport GO:0006812 382 0.045
regulation of cell migration GO:0030334 128 0.044
regulation of secretion by cell GO:1903530 208 0.044
single organism cell adhesion GO:0098602 46 0.044
actin filament bundle organization GO:0061572 19 0.044
positive regulation of cellular component organization GO:0051130 200 0.043
proteolysis GO:0006508 175 0.043
macromolecule glycosylation GO:0043413 14 0.043
regulation of cellular protein metabolic process GO:0032268 267 0.042
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.042
cell adhesion GO:0007155 110 0.042
positive regulation of blood circulation GO:1903524 65 0.041
negative regulation of neurogenesis GO:0050768 78 0.041
positive regulation of response to stimulus GO:0048584 285 0.041
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.041
apoptotic process GO:0006915 381 0.041
organelle inheritance GO:0048308 2 0.040
cellular response to endogenous stimulus GO:0071495 377 0.040
startle response GO:0001964 2 0.040
response to endoplasmic reticulum stress GO:0034976 10 0.040
protein secretion GO:0009306 34 0.040
response to estradiol GO:0032355 164 0.039
gamete generation GO:0007276 124 0.039
ear development GO:0043583 21 0.039
positive regulation of biosynthetic process GO:0009891 319 0.039
alpha amino acid metabolic process GO:1901605 71 0.038
lipid storage GO:0019915 1 0.038
glycosyl compound metabolic process GO:1901657 182 0.038
regulation of cellular localization GO:0060341 263 0.038
regulation of protein secretion GO:0050708 28 0.038
brain development GO:0007420 247 0.037
regulation of phagocytosis GO:0050764 13 0.037
chemosensory behavior GO:0007635 2 0.036
cellular response to oxygen containing compound GO:1901701 386 0.036
regulation of system process GO:0044057 208 0.036
metal ion homeostasis GO:0055065 186 0.035
fatty acid oxidation GO:0019395 29 0.035
response to oxygen levels GO:0070482 265 0.035
positive regulation of cellular protein metabolic process GO:0032270 167 0.035
regulation of response to stress GO:0080134 126 0.034
protein catabolic process GO:0030163 30 0.034
multicellular organismal reproductive process GO:0048609 233 0.034
heterocycle catabolic process GO:0046700 167 0.033
positive regulation of cytoskeleton organization GO:0051495 26 0.033
protein oligomerization GO:0051259 191 0.033
cellular amino acid metabolic process GO:0006520 107 0.032
regulation of exocytosis GO:0017157 37 0.032
response to metal ion GO:0010038 253 0.032
cellular protein complex assembly GO:0043623 44 0.032
cellular response to oxygen levels GO:0071453 60 0.032
regulation of proteasomal protein catabolic process GO:0061136 4 0.032
dna metabolic process GO:0006259 96 0.032
heart morphogenesis GO:0003007 3 0.032
regulation of multicellular organismal development GO:2000026 376 0.031
negative regulation of developmental process GO:0051093 125 0.031
single organism catabolic process GO:0044712 283 0.031
endoplasmic reticulum unfolded protein response GO:0030968 2 0.031
cellular amine metabolic process GO:0044106 38 0.031
positive regulation of chemotaxis GO:0050921 23 0.031
negative regulation of fertilization GO:0060467 1 0.031
single organism carbohydrate metabolic process GO:0044723 118 0.031
single organism behavior GO:0044708 130 0.030
cation homeostasis GO:0055080 195 0.030
response to axon injury GO:0048678 59 0.030
cellular response to unfolded protein GO:0034620 2 0.030
posttranscriptional regulation of gene expression GO:0010608 37 0.030
protein localization GO:0008104 191 0.029
syncytium formation by plasma membrane fusion GO:0000768 3 0.029
regulation of protein metabolic process GO:0051246 289 0.029
phagocytosis GO:0006909 17 0.028
response to oxidative stress GO:0006979 186 0.028
response to electrical stimulus GO:0051602 56 0.028
nucleobase containing small molecule metabolic process GO:0055086 316 0.028
organic acid transport GO:0015849 116 0.028
regulation of cell differentiation GO:0045595 320 0.028
positive regulation of immunoglobulin production GO:0002639 4 0.028
divalent metal ion transport GO:0070838 132 0.027
locomotion GO:0040011 237 0.027
protein glycosylation GO:0006486 14 0.027
heart development GO:0007507 72 0.027
programmed cell death GO:0012501 392 0.027
regulation of cell substrate adhesion GO:0010810 18 0.027
positive regulation of molecular function GO:0044093 230 0.027
response to decreased oxygen levels GO:0036293 237 0.026
detection of visible light GO:0009584 3 0.026
stress activated protein kinase signaling cascade GO:0031098 37 0.026
nucleotide catabolic process GO:0009166 139 0.026
carboxylic acid transport GO:0046942 115 0.026
chromosome segregation GO:0007059 2 0.025
golgi vesicle transport GO:0048193 22 0.025
regulation of neuron projection development GO:0010975 161 0.025
response to carbohydrate GO:0009743 183 0.025
muscle tissue development GO:0060537 58 0.024
regulation of actin nucleation GO:0051125 2 0.024
triglyceride homeostasis GO:0070328 2 0.024
cellular response to starvation GO:0009267 27 0.024
positive regulation of cell communication GO:0010647 271 0.024
intracellular signal transduction GO:0035556 314 0.024
anion transport GO:0006820 178 0.023
positive regulation of rna metabolic process GO:0051254 203 0.023
modification dependent protein catabolic process GO:0019941 14 0.023
positive regulation of signal transduction GO:0009967 175 0.023
negative regulation of nervous system development GO:0051961 79 0.023
multi organism reproductive process GO:0044703 262 0.023
reproduction GO:0000003 245 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.022
inner ear development GO:0048839 21 0.022
anatomical structure formation involved in morphogenesis GO:0048646 83 0.022
biological adhesion GO:0022610 110 0.022
positive regulation of phagocytosis GO:0050766 9 0.022
cellular divalent inorganic cation homeostasis GO:0072503 162 0.022
actin cytoskeleton organization GO:0030036 73 0.022
positive regulation of cellular component biogenesis GO:0044089 55 0.022
regulation of blood circulation GO:1903522 110 0.022
appendage morphogenesis GO:0035107 4 0.022
positive regulation of cell proliferation GO:0008284 249 0.022
cellular response to metal ion GO:0071248 55 0.022
cellular component morphogenesis GO:0032989 155 0.022
macromolecule localization GO:0033036 252 0.021
regulation of plasma lipoprotein particle levels GO:0097006 3 0.021
amino acid transport GO:0006865 70 0.021
cellular homeostasis GO:0019725 252 0.020
regulation of neuron differentiation GO:0045664 208 0.020
aging GO:0007568 241 0.020
regulation of cellular component organization GO:0051128 368 0.020
platelet aggregation GO:0070527 4 0.020
syncytium formation GO:0006949 4 0.020
lipid oxidation GO:0034440 30 0.020
positive regulation of nucleic acid templated transcription GO:1903508 197 0.020
blood vessel morphogenesis GO:0048514 58 0.020
neuron differentiation GO:0030182 368 0.020
reproductive structure development GO:0048608 128 0.020
activation of phospholipase d activity GO:0031584 2 0.020
neuron projection development GO:0031175 273 0.020
regulation of dendritic spine development GO:0060998 16 0.020
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.019
myoblast fusion GO:0007520 2 0.019
response to wounding GO:0009611 254 0.019
dendrite development GO:0016358 72 0.019
embryonic appendage morphogenesis GO:0035113 4 0.019
ribonucleoside metabolic process GO:0009119 174 0.019
folic acid containing compound metabolic process GO:0006760 10 0.019
cell cycle GO:0007049 101 0.018
organic cyclic compound catabolic process GO:1901361 175 0.018
epidermal growth factor receptor signaling pathway GO:0007173 23 0.018
response to alkaloid GO:0043279 132 0.018
negative regulation of synaptic transmission GO:0050805 29 0.018
muscle system process GO:0003012 115 0.018
sleep GO:0030431 30 0.018
regulation of systemic arterial blood pressure GO:0003073 30 0.018
olfactory behavior GO:0042048 2 0.018
glycoprotein metabolic process GO:0009100 24 0.018
apoptotic signaling pathway GO:0097190 27 0.018
regulation of canonical wnt signaling pathway GO:0060828 4 0.018
steroid metabolic process GO:0008202 73 0.018
regulation of cysteine type endopeptidase activity GO:2000116 32 0.017
regulation of hydrolase activity GO:0051336 143 0.017
response to external biotic stimulus GO:0043207 221 0.017
amine metabolic process GO:0009308 38 0.017
sexual reproduction GO:0019953 148 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
regulation of cell adhesion GO:0030155 52 0.017
regulation of meiotic cell cycle GO:0051445 3 0.017
auditory receptor cell differentiation GO:0042491 2 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.017
response to nicotine GO:0035094 51 0.017
muscle contraction GO:0006936 88 0.017
negative regulation of cell differentiation GO:0045596 99 0.017
maintenance of location GO:0051235 17 0.017
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.017
cellular macromolecular complex assembly GO:0034622 58 0.017
modification dependent macromolecule catabolic process GO:0043632 14 0.017
calcium ion homeostasis GO:0055074 162 0.017
smooth muscle cell proliferation GO:0048659 77 0.017
response to testosterone GO:0033574 55 0.017
single organism intracellular transport GO:1902582 166 0.017
organic hydroxy compound transport GO:0015850 77 0.017
positive regulation of cellular biosynthetic process GO:0031328 295 0.016
hormone metabolic process GO:0042445 69 0.016
response to nutrient levels GO:0031667 370 0.016
organic anion transport GO:0015711 132 0.016
spindle organization GO:0007051 2 0.016
reproductive system development GO:0061458 128 0.016
biphenyl catabolic process GO:0070980 2 0.016
rna catabolic process GO:0006401 3 0.016
calcium ion transport GO:0006816 131 0.016
extracellular structure organization GO:0043062 13 0.016
nucleoside metabolic process GO:0009116 179 0.016
nucleotide metabolic process GO:0009117 279 0.016
signal release GO:0023061 145 0.016
positive regulation of cytoplasmic transport GO:1903651 32 0.016
negative regulation of gene expression GO:0010629 199 0.016
cytosolic calcium ion homeostasis GO:0051480 140 0.016
response to nutrient GO:0007584 248 0.016
reactive oxygen species biosynthetic process GO:1903409 8 0.016
positive regulation of response to external stimulus GO:0032103 51 0.016
response to purine containing compound GO:0014074 126 0.015
eye morphogenesis GO:0048592 4 0.015
positive regulation of hydrolase activity GO:0051345 86 0.015
positive regulation of cell motility GO:2000147 97 0.015
purine containing compound catabolic process GO:0072523 138 0.015
camera type eye development GO:0043010 48 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
cardiocyte differentiation GO:0035051 22 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
sex differentiation GO:0007548 113 0.015
vesicle docking involved in exocytosis GO:0006904 4 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
ubiquitin dependent protein catabolic process GO:0006511 14 0.014
regulation of proteolysis GO:0030162 66 0.014
mapk cascade GO:0000165 140 0.014
vesicle organization GO:0016050 29 0.014
regulation of nervous system development GO:0051960 264 0.014
regulation of fatty acid transport GO:2000191 10 0.014
developmental process involved in reproduction GO:0003006 159 0.014
cellular response to inorganic substance GO:0071241 65 0.014
actin nucleation GO:0045010 2 0.014
single organism biosynthetic process GO:0044711 342 0.014
organophosphate metabolic process GO:0019637 370 0.014
transmembrane transport GO:0055085 412 0.014
regulation of immune system process GO:0002682 123 0.014
hepaticobiliary system development GO:0061008 90 0.014
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.014
cellular response to hypoxia GO:0071456 51 0.014
negative regulation of cell development GO:0010721 82 0.014
regulation of locomotion GO:0040012 148 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
lipid transport GO:0006869 61 0.013
regulation of cellular component biogenesis GO:0044087 86 0.013
regulation of anatomical structure size GO:0090066 135 0.013
positive regulation of developmental process GO:0051094 283 0.013
long chain fatty acid transport GO:0015909 14 0.013
male gamete generation GO:0048232 99 0.013
immune system development GO:0002520 41 0.013
single organism reproductive process GO:0044702 297 0.013
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.013
divalent inorganic cation transport GO:0072511 134 0.013
limb morphogenesis GO:0035108 4 0.013
purine nucleoside monophosphate catabolic process GO:0009128 55 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
gland development GO:0048732 155 0.013
androgen metabolic process GO:0008209 14 0.013
positive regulation of cell death GO:0010942 184 0.013
protein n linked glycosylation GO:0006487 2 0.013
regulation of phosphate metabolic process GO:0019220 349 0.013
regulation of response to external stimulus GO:0032101 106 0.013
plasma lipoprotein particle clearance GO:0034381 3 0.013
carboxylic acid metabolic process GO:0019752 289 0.013
membrane organization GO:0061024 94 0.013
oxoacid metabolic process GO:0043436 290 0.012
single fertilization GO:0007338 3 0.012
blood vessel development GO:0001568 69 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
regulation of neurogenesis GO:0050767 247 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
regulation of ion transport GO:0043269 245 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.012
regulation of developmental growth GO:0048638 45 0.012
ion transmembrane transport GO:0034220 365 0.012
positive regulation of organelle organization GO:0010638 48 0.012
arp2 3 complex mediated actin nucleation GO:0034314 2 0.012
anion transmembrane transport GO:0098656 77 0.012
cytoplasmic transport GO:0016482 115 0.012
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.012
regulation of cellular amine metabolic process GO:0033238 8 0.011
regulation of phosphorylation GO:0042325 248 0.011
regulation of cell cycle g2 m phase transition GO:1902749 4 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
chromosome condensation GO:0030261 3 0.011
regulation of phosphorus metabolic process GO:0051174 349 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
microtubule based process GO:0007017 36 0.011
hormone biosynthetic process GO:0042446 25 0.011
regulation of cell projection organization GO:0031344 175 0.011
erbb signaling pathway GO:0038127 23 0.011
glycosylation GO:0070085 20 0.011
positive regulation of exocytosis GO:0045921 19 0.011
cell junction assembly GO:0034329 18 0.011
peptide hormone secretion GO:0030072 84 0.011
wound healing GO:0042060 122 0.011
hemopoiesis GO:0030097 34 0.011
cell projection morphogenesis GO:0048858 123 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.011
regulation of metal ion transport GO:0010959 118 0.011
response to ketone GO:1901654 182 0.011
calcium ion dependent exocytosis GO:0017156 16 0.011
actin filament based process GO:0030029 86 0.011
regulation of cell proliferation GO:0042127 359 0.010
positive regulation of apoptotic process GO:0043065 154 0.010
oxidation reduction process GO:0055114 304 0.010
response to biotic stimulus GO:0009607 226 0.010
positive regulation of vasoconstriction GO:0045907 31 0.010
catabolic process GO:0009056 351 0.010
coagulation GO:0050817 28 0.010
negative regulation of protein modification by small protein conjugation or removal GO:1903321 4 0.010
liver development GO:0001889 90 0.010
metal ion transport GO:0030001 289 0.010
locomotion involved in locomotory behavior GO:0031987 2 0.010
neuron development GO:0048666 286 0.010
regulation of cytoskeleton organization GO:0051493 49 0.010
hematopoietic progenitor cell differentiation GO:0002244 2 0.010
cellular response to oxidative stress GO:0034599 76 0.010
regulation of endopeptidase activity GO:0052548 51 0.010
acylglycerol homeostasis GO:0055090 2 0.010
negative regulation of systemic arterial blood pressure GO:0003085 4 0.010
positive regulation of protein modification process GO:0031401 142 0.010
regulation of lipid storage GO:0010883 1 0.010

Sec61a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.091
disease of anatomical entity DOID:7 0 0.085
musculoskeletal system disease DOID:17 0 0.085
nervous system disease DOID:863 0 0.052
cancer DOID:162 0 0.032
connective tissue disease DOID:65 0 0.024
sensory system disease DOID:0050155 0 0.022
central nervous system disease DOID:331 0 0.019
bone development disease DOID:0080006 0 0.019
bone disease DOID:0080001 0 0.019
breast cancer DOID:1612 0 0.010
thoracic cancer DOID:5093 0 0.010
organ system cancer DOID:0050686 0 0.010