Rattus norvegicus

172 known processes

Eif2b5

eukaryotic translation initiation factor 2B, subunit 5 epsilon

Eif2b5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of translational initiation GO:0045947 5 0.966
negative regulation of translation in response to stress GO:0032055 5 0.669
response to heat GO:0009408 60 0.286
response to temperature stimulus GO:0009266 94 0.227
nucleoside phosphate metabolic process GO:0006753 283 0.214
negative regulation of metabolic process GO:0009892 331 0.175
regulation of translation in response to stress GO:0043555 5 0.174
response to monosaccharide GO:0034284 159 0.160
response to hexose GO:0009746 144 0.159
nucleobase containing small molecule metabolic process GO:0055086 316 0.143
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.136
regulation of translation GO:0006417 27 0.128
nucleotide metabolic process GO:0009117 279 0.119
response to peptide GO:1901652 292 0.116
rna metabolic process GO:0016070 406 0.104
response to glucose GO:0009749 136 0.086
response to peptide hormone GO:0043434 278 0.076
negative regulation of cellular metabolic process GO:0031324 281 0.069
transcription dna templated GO:0006351 377 0.067
negative regulation of protein metabolic process GO:0051248 114 0.065
purine nucleotide metabolic process GO:0006163 229 0.064
translation GO:0006412 35 0.064
organophosphate metabolic process GO:0019637 370 0.063
response to carbohydrate GO:0009743 183 0.059
regulation of rna biosynthetic process GO:2001141 381 0.056
regulation of cellular protein metabolic process GO:0032268 267 0.054
glycosyl compound metabolic process GO:1901657 182 0.054
vesicle mediated transport GO:0016192 181 0.053
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.051
negative regulation of cellular protein metabolic process GO:0032269 106 0.051
rna biosynthetic process GO:0032774 380 0.051
cellular response to stress GO:0033554 269 0.051
single organism biosynthetic process GO:0044711 342 0.050
regulation of catalytic activity GO:0050790 304 0.049
positive regulation of transcription dna templated GO:0045893 197 0.048
ribonucleoside triphosphate catabolic process GO:0009203 122 0.046
ribonucleotide biosynthetic process GO:0009260 85 0.045
negative regulation of biosynthetic process GO:0009890 168 0.044
response to decreased oxygen levels GO:0036293 237 0.044
regulation of molecular function GO:0065009 398 0.043
single organism catabolic process GO:0044712 283 0.042
regulation of rna metabolic process GO:0051252 391 0.041
reproductive process GO:0022414 372 0.041
Human
negative regulation of macromolecule metabolic process GO:0010605 260 0.040
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.039
regeneration GO:0031099 163 0.039
regulation of purine nucleotide metabolic process GO:1900542 115 0.039
organophosphate biosynthetic process GO:0090407 143 0.038
regulation of protein metabolic process GO:0051246 289 0.038
nucleic acid templated transcription GO:0097659 379 0.038
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.038
purine containing compound metabolic process GO:0072521 253 0.038
positive regulation of rna metabolic process GO:0051254 203 0.037
positive regulation of gene expression GO:0010628 244 0.037
carbohydrate derivative metabolic process GO:1901135 346 0.037
ribonucleotide metabolic process GO:0009259 231 0.036
negative regulation of multicellular organismal process GO:0051241 203 0.036
response to inorganic substance GO:0010035 377 0.036
positive regulation of nucleic acid templated transcription GO:1903508 197 0.033
positive regulation of phosphate metabolic process GO:0045937 262 0.033
regulation of transcription dna templated GO:0006355 374 0.033
positive regulation of biosynthetic process GO:0009891 319 0.032
response to oxygen levels GO:0070482 265 0.032
positive regulation of nucleotide metabolic process GO:0045981 91 0.031
ribonucleoside metabolic process GO:0009119 174 0.031
negative regulation of gene expression GO:0010629 199 0.030
ribose phosphate metabolic process GO:0019693 235 0.030
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.030
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.030
transcription from rna polymerase ii promoter GO:0006366 252 0.029
regulation of hydrolase activity GO:0051336 143 0.029
catabolic process GO:0009056 351 0.029
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.028
negative regulation of cell death GO:0060548 229 0.028
regulation of nucleotide catabolic process GO:0030811 65 0.028
gonad development GO:0008406 104 0.028
Human
organ regeneration GO:0031100 101 0.027
nucleoside metabolic process GO:0009116 179 0.027
response to nutrient GO:0007584 248 0.027
reproduction GO:0000003 245 0.026
Human
development of primary sexual characteristics GO:0045137 107 0.026
Human
regulation of purine nucleotide catabolic process GO:0033121 65 0.026
response to hypoxia GO:0001666 231 0.026
regulation of cell proliferation GO:0042127 359 0.026
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.026
establishment of protein localization GO:0045184 141 0.026
nucleotide biosynthetic process GO:0009165 98 0.025
central nervous system development GO:0007417 311 0.024
Human
positive regulation of phosphorus metabolic process GO:0010562 262 0.024
nucleoside catabolic process GO:0009164 126 0.023
purine ribonucleoside metabolic process GO:0046128 168 0.023
negative regulation of molecular function GO:0044092 133 0.023
regulation of nucleic acid templated transcription GO:1903506 380 0.023
locomotion GO:0040011 237 0.022
regulation of membrane potential GO:0042391 110 0.022
Human
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.022
purine ribonucleotide biosynthetic process GO:0009152 81 0.022
regulation of translational initiation in response to stress GO:0043558 4 0.022
negative regulation of cellular biosynthetic process GO:0031327 161 0.022
multicellular organismal reproductive process GO:0048609 233 0.021
Human
regulation of multicellular organismal development GO:2000026 376 0.021
regulation of nucleotide metabolic process GO:0006140 117 0.021
positive regulation of cellular component organization GO:0051130 200 0.020
purine nucleotide biosynthetic process GO:0006164 83 0.020
dna metabolic process GO:0006259 96 0.020
secretion GO:0046903 307 0.020
cellular nitrogen compound catabolic process GO:0044270 163 0.020
regulation of neurogenesis GO:0050767 247 0.020
action potential GO:0001508 54 0.020
Human
negative regulation of phosphate metabolic process GO:0045936 80 0.020
response to metal ion GO:0010038 253 0.020
regulation of phosphorus metabolic process GO:0051174 349 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
organonitrogen compound biosynthetic process GO:1901566 167 0.019
nucleoside phosphate catabolic process GO:1901292 140 0.019
ribose phosphate biosynthetic process GO:0046390 87 0.019
negative regulation of transport GO:0051051 136 0.019
receptor mediated endocytosis GO:0006898 42 0.019
response to external biotic stimulus GO:0043207 221 0.019
cell migration GO:0016477 197 0.018
regulation of phosphate metabolic process GO:0019220 349 0.018
positive regulation of hydrolase activity GO:0051345 86 0.018
carbohydrate derivative biosynthetic process GO:1901137 124 0.018
nucleoside phosphate biosynthetic process GO:1901293 102 0.018
ribonucleoside triphosphate metabolic process GO:0009199 141 0.018
rhythmic process GO:0048511 156 0.018
Human
regulation of cellular component organization GO:0051128 368 0.018
cellular homeostasis GO:0019725 252 0.018
secretion by cell GO:0032940 248 0.018
programmed cell death GO:0012501 392 0.017
macromolecule localization GO:0033036 252 0.017
response to ethanol GO:0045471 162 0.017
negative regulation of cell proliferation GO:0008285 119 0.017
cation transport GO:0006812 382 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
chemical homeostasis GO:0048878 292 0.017
protein localization to organelle GO:0033365 57 0.016
ncrna metabolic process GO:0034660 8 0.016
macromolecular complex assembly GO:0065003 273 0.016
neuron projection development GO:0031175 273 0.016
neurological system process GO:0050877 219 0.016
Human
single organism organelle organization GO:1902589 180 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
response to extracellular stimulus GO:0009991 380 0.016
purine nucleoside triphosphate catabolic process GO:0009146 122 0.016
purine containing compound catabolic process GO:0072523 138 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
protein maturation GO:0051604 68 0.016
response to oxidative stress GO:0006979 186 0.015
ras protein signal transduction GO:0007265 29 0.015
nucleoside monophosphate biosynthetic process GO:0009124 28 0.015
response to biotic stimulus GO:0009607 226 0.015
apoptotic process GO:0006915 381 0.015
heart morphogenesis GO:0003007 3 0.015
regulation of catabolic process GO:0009894 113 0.015
protein transport GO:0015031 132 0.015
negative regulation of phosphorus metabolic process GO:0010563 80 0.015
cellular component movement GO:0006928 248 0.015
response to other organism GO:0051707 220 0.015
organic substance catabolic process GO:1901575 316 0.014
growth GO:0040007 165 0.014
transmission of nerve impulse GO:0019226 42 0.014
Human
response to nutrient levels GO:0031667 370 0.014
cellular macromolecule localization GO:0070727 122 0.014
intracellular signal transduction GO:0035556 314 0.014
positive regulation of cellular catabolic process GO:0031331 71 0.014
organophosphate catabolic process GO:0046434 148 0.014
cellular catabolic process GO:0044248 295 0.014
reproductive structure development GO:0048608 128 0.014
Human
cytoplasmic transport GO:0016482 115 0.014
cellular response to oxygen containing compound GO:1901701 386 0.014
single organism cellular localization GO:1902580 102 0.014
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 3 0.014
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 4 0.014
response to acid chemical GO:0001101 222 0.014
neuron differentiation GO:0030182 368 0.013
developmental process involved in reproduction GO:0003006 159 0.013
Human
purine nucleotide catabolic process GO:0006195 136 0.013
single organism intracellular transport GO:1902582 166 0.013
cell projection organization GO:0030030 302 0.013
defense response GO:0006952 194 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
negative regulation of cell development GO:0010721 82 0.013
synaptic transmission GO:0007268 235 0.013
ribonucleoside monophosphate metabolic process GO:0009161 88 0.013
positive regulation of protein modification process GO:0031401 142 0.013
regulation of signal transduction GO:0009966 318 0.013
ion homeostasis GO:0050801 212 0.013
negative regulation of cell differentiation GO:0045596 99 0.013
regulation of immune system process GO:0002682 123 0.013
organonitrogen compound catabolic process GO:1901565 179 0.013
translational initiation GO:0006413 8 0.013
nucleoside triphosphate metabolic process GO:0009141 144 0.013
protein complex biogenesis GO:0070271 263 0.013
immune system process GO:0002376 204 0.012
cell cycle GO:0007049 101 0.012
multi multicellular organism process GO:0044706 138 0.012
multicellular organism reproduction GO:0032504 233 0.012
Human
regulation of body fluid levels GO:0050878 90 0.012
regulation of programmed cell death GO:0043067 341 0.012
purine nucleoside monophosphate metabolic process GO:0009126 84 0.012
protein secretion GO:0009306 34 0.012
response to cytokine GO:0034097 215 0.012
regulation of ion transport GO:0043269 245 0.012
regulation of phosphorylation GO:0042325 248 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
multicellular organismal signaling GO:0035637 44 0.012
Human
response to amine GO:0014075 46 0.012
positive regulation of protein metabolic process GO:0051247 178 0.011
reproductive system development GO:0061458 128 0.011
Human
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
endocytosis GO:0006897 84 0.011
regulation of nucleoside metabolic process GO:0009118 66 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
maintenance of location GO:0051235 17 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
muscle system process GO:0003012 115 0.011
trna metabolic process GO:0006399 4 0.011
regulation of cell differentiation GO:0045595 320 0.011
sex differentiation GO:0007548 113 0.011
Human
organic acid metabolic process GO:0006082 292 0.011
macromolecular complex subunit organization GO:0043933 339 0.011
organelle organization GO:0006996 266 0.011
cellular amine metabolic process GO:0044106 38 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
regulation of nervous system development GO:0051960 264 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
neuron apoptotic process GO:0051402 88 0.011
guanosine containing compound metabolic process GO:1901068 74 0.010
negative regulation of cell communication GO:0010648 158 0.010
potassium ion transport GO:0006813 97 0.010
response to vitamin GO:0033273 131 0.010
negative regulation of transcription dna templated GO:0045892 116 0.010
transmembrane transport GO:0055085 412 0.010
amine metabolic process GO:0009308 38 0.010
positive regulation of rna biosynthetic process GO:1902680 197 0.010
neuromuscular synaptic transmission GO:0007274 2 0.010
cellular protein localization GO:0034613 122 0.010
bmp signaling pathway GO:0030509 4 0.010

Eif2b5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.030
carbohydrate metabolic disorder DOID:2978 0 0.030
inherited metabolic disorder DOID:655 0 0.030
disease of anatomical entity DOID:7 0 0.013
musculoskeletal system disease DOID:17 0 0.013