Rattus norvegicus

0 known processes

Cldn2

claudin 2

(Aliases: RGD1560247)

Cldn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
modified amino acid transport GO:0072337 12 0.234
anion transport GO:0006820 178 0.189
carboxylic acid transport GO:0046942 115 0.174
transmembrane transport GO:0055085 412 0.158
drug transmembrane transport GO:0006855 13 0.136
carboxylic acid metabolic process GO:0019752 289 0.129
amino acid transport GO:0006865 70 0.113
organic anion transport GO:0015711 132 0.107
oligopeptide transport GO:0006857 4 0.096
monocarboxylic acid transport GO:0015718 52 0.095
organic acid transport GO:0015849 116 0.084
metal ion transport GO:0030001 289 0.075
cellular amino acid metabolic process GO:0006520 107 0.073
cation transport GO:0006812 382 0.071
organic acid metabolic process GO:0006082 292 0.070
response to inorganic substance GO:0010035 377 0.063
intracellular signal transduction GO:0035556 314 0.061
oxoacid metabolic process GO:0043436 290 0.061
cellular response to endogenous stimulus GO:0071495 377 0.056
cellular ketone metabolic process GO:0042180 51 0.056
monovalent inorganic cation transport GO:0015672 172 0.053
carboxylic acid biosynthetic process GO:0046394 83 0.050
protein phosphorylation GO:0006468 345 0.050
positive regulation of cell death GO:0010942 184 0.050
response to corticosteroid GO:0031960 235 0.048
response to glucocorticoid GO:0051384 223 0.047
negative regulation of metabolic process GO:0009892 331 0.047
regulation of hormone levels GO:0010817 187 0.047
regulation of cellular ketone metabolic process GO:0010565 27 0.047
head development GO:0060322 247 0.047
regulation of molecular function GO:0065009 398 0.044
anion transmembrane transport GO:0098656 77 0.044
macromolecular complex assembly GO:0065003 273 0.043
choline transport GO:0015871 4 0.043
negative regulation of cellular metabolic process GO:0031324 281 0.043
multicellular organism reproduction GO:0032504 233 0.042
regulation of protein metabolic process GO:0051246 289 0.042
regulation of membrane potential GO:0042391 110 0.041
response to peptide GO:1901652 292 0.040
tissue development GO:0009888 252 0.039
cellular amine metabolic process GO:0044106 38 0.039
regulation of secretion GO:0051046 224 0.038
regeneration GO:0031099 163 0.037
lipid localization GO:0010876 62 0.037
amide transport GO:0042886 105 0.036
cellular component biogenesis GO:0044085 368 0.036
regulation of cellular amino acid metabolic process GO:0006521 2 0.036
secretion by cell GO:0032940 248 0.035
glutathione transport GO:0034635 2 0.035
nitrogen compound transport GO:0071705 229 0.035
lipid transport GO:0006869 61 0.035
macromolecule localization GO:0033036 252 0.034
organic hydroxy compound transport GO:0015850 77 0.033
response to toxic substance GO:0009636 133 0.033
lipid metabolic process GO:0006629 283 0.032
regulation of intracellular signal transduction GO:1902531 218 0.032
proteolysis GO:0006508 175 0.032
small molecule biosynthetic process GO:0044283 124 0.031
organic acid biosynthetic process GO:0016053 83 0.031
cell cell signaling GO:0007267 335 0.031
regulation of cellular amine metabolic process GO:0033238 8 0.031
bile acid and bile salt transport GO:0015721 12 0.030
amine metabolic process GO:0009308 38 0.030
regulation of phosphorylation GO:0042325 248 0.030
inorganic ion transmembrane transport GO:0098660 229 0.030
single organism biosynthetic process GO:0044711 342 0.030
positive regulation of phosphorus metabolic process GO:0010562 262 0.029
negative regulation of macromolecule metabolic process GO:0010605 260 0.029
secretion GO:0046903 307 0.029
regulation of rna metabolic process GO:0051252 391 0.029
central nervous system development GO:0007417 311 0.029
brain development GO:0007420 247 0.028
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.028
response to metal ion GO:0010038 253 0.028
macromolecular complex subunit organization GO:0043933 339 0.028
homeostatic process GO:0042592 331 0.028
single organism intracellular transport GO:1902582 166 0.028
intracellular transport GO:0046907 185 0.028
negative regulation of molecular function GO:0044092 133 0.028
regulation of cell proliferation GO:0042127 359 0.027
sodium ion transport GO:0006814 82 0.027
hormone transport GO:0009914 121 0.027
regulation of phosphate metabolic process GO:0019220 349 0.027
cellular response to organonitrogen compound GO:0071417 197 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.027
cation transmembrane transport GO:0098655 263 0.027
protein oligomerization GO:0051259 191 0.027
protein complex assembly GO:0006461 263 0.026
cellular response to stress GO:0033554 269 0.026
rna biosynthetic process GO:0032774 380 0.026
negative regulation of cell communication GO:0010648 158 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.025
organelle organization GO:0006996 266 0.025
endocytosis GO:0006897 84 0.025
camera type eye development GO:0043010 48 0.025
response to external biotic stimulus GO:0043207 221 0.025
muscle system process GO:0003012 115 0.025
organic hydroxy compound metabolic process GO:1901615 115 0.025
cellular catabolic process GO:0044248 295 0.024
response to heat GO:0009408 60 0.024
cellular component assembly GO:0022607 360 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
protein complex subunit organization GO:0071822 302 0.023
innate immune response GO:0045087 35 0.023
chemical homeostasis GO:0048878 292 0.023
cellular response to oxygen containing compound GO:1901701 386 0.023
negative regulation of protein metabolic process GO:0051248 114 0.023
regulation of catalytic activity GO:0050790 304 0.023
regulation of hydrolase activity GO:0051336 143 0.023
regulation of signal transduction GO:0009966 318 0.022
response to vitamin GO:0033273 131 0.022
reproduction GO:0000003 245 0.022
regulation of transferase activity GO:0051338 123 0.022
positive regulation of programmed cell death GO:0043068 157 0.022
response to nutrient levels GO:0031667 370 0.022
muscle contraction GO:0006936 88 0.022
regulation of secretion by cell GO:1903530 208 0.021
catabolic process GO:0009056 351 0.021
drug transport GO:0015893 18 0.021
sodium independent organic anion transport GO:0043252 2 0.021
response to vitamin d GO:0033280 34 0.021
cellular lipid metabolic process GO:0044255 208 0.021
response to oxidative stress GO:0006979 186 0.021
rna metabolic process GO:0016070 406 0.020
negative regulation of intracellular signal transduction GO:1902532 38 0.020
reproductive process GO:0022414 372 0.020
Rat
dna metabolic process GO:0006259 96 0.020
blood circulation GO:0008015 183 0.020
negative regulation of signaling GO:0023057 157 0.020
protein transport GO:0015031 132 0.020
monocarboxylic acid metabolic process GO:0032787 152 0.020
multi organism reproductive process GO:0044703 262 0.020
Rat
establishment of protein localization GO:0045184 141 0.020
cellular response to organic cyclic compound GO:0071407 202 0.019
reactive oxygen species metabolic process GO:0072593 37 0.019
single organism catabolic process GO:0044712 283 0.019
alpha amino acid metabolic process GO:1901605 71 0.019
positive regulation of multicellular organismal process GO:0051240 387 0.019
response to ketone GO:1901654 182 0.019
Rat
carnitine transport GO:0015879 1 0.019
negative regulation of phosphorus metabolic process GO:0010563 80 0.019
ion homeostasis GO:0050801 212 0.019
reactive nitrogen species metabolic process GO:2001057 1 0.019
regulation of cellular component organization GO:0051128 368 0.019
negative regulation of response to stimulus GO:0048585 155 0.018
anatomical structure morphogenesis GO:0009653 298 0.018
eye development GO:0001654 50 0.018
chemosensory behavior GO:0007635 2 0.018
intestinal absorption GO:0050892 3 0.018
positive regulation of cell communication GO:0010647 271 0.018
small gtpase mediated signal transduction GO:0007264 36 0.018
nucleobase containing compound catabolic process GO:0034655 152 0.018
response to cytokine GO:0034097 215 0.018
positive regulation of signal transduction GO:0009967 175 0.018
positive regulation of cellular biosynthetic process GO:0031328 295 0.018
regulation of cell growth GO:0001558 85 0.018
negative regulation of catalytic activity GO:0043086 103 0.017
cofactor metabolic process GO:0051186 95 0.017
ion transmembrane transport GO:0034220 365 0.017
regulation of mapk cascade GO:0043408 116 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.017
negative regulation of gene expression GO:0010629 199 0.017
programmed cell death GO:0012501 392 0.017
establishment or maintenance of transmembrane electrochemical gradient GO:0010248 1 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
regulation of calcium ion transport GO:0051924 77 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
response to acid chemical GO:0001101 222 0.017
growth GO:0040007 165 0.016
transcription from rna polymerase ii promoter GO:0006366 252 0.016
peptide transport GO:0015833 97 0.016
positive regulation of catalytic activity GO:0043085 184 0.016
sodium ion transmembrane transport GO:0035725 67 0.016
organic substance catabolic process GO:1901575 316 0.016
regulation of cellular protein metabolic process GO:0032268 267 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
lipid biosynthetic process GO:0008610 128 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
ras protein signal transduction GO:0007265 29 0.015
gastrulation GO:0007369 2 0.015
mapk cascade GO:0000165 140 0.015
transmission of nerve impulse GO:0019226 42 0.015
circadian rhythm GO:0007623 88 0.015
Rat
amino acid transmembrane transport GO:0003333 33 0.015
nucleoside catabolic process GO:0009164 126 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
regulation of phosphorus metabolic process GO:0051174 349 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.015
regulation of locomotion GO:0040012 148 0.015
negative regulation of signal transduction GO:0009968 83 0.015
peptidyl tyrosine phosphorylation GO:0018108 72 0.015
response to decreased oxygen levels GO:0036293 237 0.015
long chain fatty acid metabolic process GO:0001676 32 0.015
regulation of ion transport GO:0043269 245 0.015
protein maturation GO:0051604 68 0.015
antibiotic transport GO:0042891 2 0.015
regulation of rna biosynthetic process GO:2001141 381 0.015
positive regulation of nucleic acid templated transcription GO:1903508 197 0.015
negative regulation of osteoblast differentiation GO:0045668 2 0.015
sensory perception GO:0007600 101 0.015
regulation of cellular localization GO:0060341 263 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
olfactory behavior GO:0042048 2 0.014
negative regulation of multicellular organismal process GO:0051241 203 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
signal release GO:0023061 145 0.014
single organism carbohydrate metabolic process GO:0044723 118 0.014
protein complex biogenesis GO:0070271 263 0.014
response to peptide hormone GO:0043434 278 0.014
response to molecule of fungal origin GO:0002238 3 0.014
sensory organ development GO:0007423 74 0.014
positive regulation of signaling GO:0023056 270 0.014
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
negative regulation of phosphorylation GO:0042326 57 0.014
single organism organelle organization GO:1902589 180 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
cellular protein localization GO:0034613 122 0.014
positive regulation of cellular component organization GO:0051130 200 0.014
vesicle mediated transport GO:0016192 181 0.014
response to nutrient GO:0007584 248 0.014
regulation of defense response GO:0031347 68 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.014
positive regulation of protein modification process GO:0031401 142 0.014
response to extracellular stimulus GO:0009991 380 0.014
cellular nitrogen compound catabolic process GO:0044270 163 0.014
male gamete generation GO:0048232 99 0.014
aging GO:0007568 241 0.013
positive regulation of protein kinase activity GO:0045860 73 0.013
lens development in camera type eye GO:0002088 13 0.013
positive regulation of molecular function GO:0044093 230 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
positive regulation of gene expression GO:0010628 244 0.013
cellular component movement GO:0006928 248 0.013
negative regulation of phosphate metabolic process GO:0045936 80 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
apoptotic process GO:0006915 381 0.013
tripeptide transport GO:0042939 2 0.013
carbohydrate derivative metabolic process GO:1901135 346 0.013
cellular modified amino acid metabolic process GO:0006575 61 0.013
membrane organization GO:0061024 94 0.013
response to hypoxia GO:0001666 231 0.013
regulation of map kinase activity GO:0043405 53 0.012
regulation of protein modification process GO:0031399 194 0.012
cell projection organization GO:0030030 302 0.012
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.012
positive regulation of long term synaptic potentiation GO:1900273 4 0.012
multicellular organismal signaling GO:0035637 44 0.012
action potential GO:0001508 54 0.012
negative regulation of transport GO:0051051 136 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
nucleic acid templated transcription GO:0097659 379 0.012
sulfur compound transport GO:0072348 8 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
icosanoid metabolic process GO:0006690 38 0.012
inorganic cation transmembrane transport GO:0098662 202 0.012
intracellular protein transport GO:0006886 79 0.012
response to carbohydrate GO:0009743 183 0.012
non canonical wnt signaling pathway GO:0035567 3 0.012
regulation of metal ion transport GO:0010959 118 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
potassium ion transport GO:0006813 97 0.012
mesoderm morphogenesis GO:0048332 1 0.012
regulation of system process GO:0044057 208 0.012
neuronal action potential GO:0019228 35 0.012
regulation of transcription dna templated GO:0006355 374 0.012
lens fiber cell differentiation GO:0070306 3 0.012
defense response GO:0006952 194 0.011
regulation of growth GO:0040008 105 0.011
reproductive system development GO:0061458 128 0.011
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.011
regulation of blood circulation GO:1903522 110 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
response to amine GO:0014075 46 0.011
cellular macromolecule localization GO:0070727 122 0.011
response to reactive oxygen species GO:0000302 120 0.011
response to temperature stimulus GO:0009266 94 0.011
neurotransmitter uptake GO:0001504 3 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
transcription dna templated GO:0006351 377 0.011
negative regulation of cellular biosynthetic process GO:0031327 161 0.011
divalent inorganic cation transport GO:0072511 134 0.011
olfactory learning GO:0008355 1 0.011
cell cycle GO:0007049 101 0.011
negative regulation of developmental process GO:0051093 125 0.011
anterior posterior pattern specification GO:0009952 1 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
rhythmic process GO:0048511 156 0.011
Rat
purine ribonucleoside catabolic process GO:0046130 124 0.011
heterocycle catabolic process GO:0046700 167 0.011
regulation of muscle system process GO:0090257 79 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
cell morphogenesis GO:0000902 142 0.011
cytoplasmic transport GO:0016482 115 0.011
sensory perception of bitter taste GO:0050913 4 0.011
regulation of cell differentiation GO:0045595 320 0.011
cellular response to peptide GO:1901653 133 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
carbohydrate metabolic process GO:0005975 130 0.011
cellular amide metabolic process GO:0043603 44 0.011
lipid storage GO:0019915 1 0.011
protein homooligomerization GO:0051260 91 0.011
single organism cellular localization GO:1902580 102 0.011
mesoderm development GO:0007498 2 0.011
regulation of apoptotic process GO:0042981 335 0.011
gtp metabolic process GO:0046039 72 0.011
gland development GO:0048732 155 0.011
cellular chemical homeostasis GO:0055082 247 0.011
eye morphogenesis GO:0048592 4 0.010
activation of phospholipase d activity GO:0031584 2 0.010
glycosyl compound metabolic process GO:1901657 182 0.010
response to ammonium ion GO:0060359 71 0.010
organophosphate metabolic process GO:0019637 370 0.010
neuron development GO:0048666 286 0.010
neuromuscular process GO:0050905 2 0.010
bile acid biosynthetic process GO:0006699 3 0.010
salivary gland development GO:0007431 3 0.010
cell cycle process GO:0022402 57 0.010
cell growth GO:0016049 104 0.010
multi multicellular organism process GO:0044706 138 0.010
Rat
regulation of programmed cell death GO:0043067 341 0.010
coenzyme metabolic process GO:0006732 86 0.010
tissue regeneration GO:0042246 36 0.010
regulation of endocytosis GO:0030100 42 0.010
response to wounding GO:0009611 254 0.010
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.010
positive regulation of response to stimulus GO:0048584 285 0.010
nucleoside phosphate metabolic process GO:0006753 283 0.010
activation of protein kinase activity GO:0032147 47 0.010
regulation of tube size GO:0035150 89 0.010
spermatogenesis GO:0007283 99 0.010
dopamine transport GO:0015872 18 0.010
skin morphogenesis GO:0043589 2 0.010

Cldn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
nervous system disease DOID:863 0 0.040
sensory system disease DOID:0050155 0 0.023
vascular disease DOID:178 0 0.021
cardiovascular system disease DOID:1287 0 0.021
disease of metabolism DOID:0014667 0 0.019
eye and adnexa disease DOID:1492 0 0.017
eye disease DOID:5614 0 0.016
central nervous system disease DOID:331 0 0.016
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011