Rattus norvegicus

20 known processes

Cldn4

claudin 4

Cldn4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron development GO:0048666 286 0.177
multi organism reproductive process GO:0044703 262 0.116
cellular component assembly GO:0022607 360 0.110
reproductive process GO:0022414 372 0.109
intracellular signal transduction GO:0035556 314 0.108
anatomical structure morphogenesis GO:0009653 298 0.105
neurological system process GO:0050877 219 0.104
response to inorganic substance GO:0010035 377 0.090
regulation of catalytic activity GO:0050790 304 0.089
response to bacterium GO:0009617 200 0.088
cellular response to oxygen containing compound GO:1901701 386 0.087
blood circulation GO:0008015 183 0.087
cellular component biogenesis GO:0044085 368 0.087
tissue development GO:0009888 252 0.086
single organism reproductive process GO:0044702 297 0.072
neuron differentiation GO:0030182 368 0.071
regulation of phosphate metabolic process GO:0019220 349 0.070
positive regulation of phosphate metabolic process GO:0045937 262 0.067
cellular component morphogenesis GO:0032989 155 0.066
regulation of system process GO:0044057 208 0.065
regulation of protein metabolic process GO:0051246 289 0.064
cellular response to peptide GO:1901653 133 0.062
macromolecular complex subunit organization GO:0043933 339 0.060
cell projection organization GO:0030030 302 0.058
macromolecular complex assembly GO:0065003 273 0.057
regulation of molecular function GO:0065009 398 0.056
carboxylic acid metabolic process GO:0019752 289 0.054
cellular component movement GO:0006928 248 0.054
cellular response to endogenous stimulus GO:0071495 377 0.053
response to wounding GO:0009611 254 0.053
regulation of multicellular organismal development GO:2000026 376 0.052
locomotion GO:0040011 237 0.051
regulation of cellular amino acid metabolic process GO:0006521 2 0.048
protein complex biogenesis GO:0070271 263 0.047
secretion GO:0046903 307 0.047
single organism catabolic process GO:0044712 283 0.047
multicellular organism reproduction GO:0032504 233 0.047
nucleobase containing small molecule metabolic process GO:0055086 316 0.044
response to ketone GO:1901654 182 0.044
response to metal ion GO:0010038 253 0.043
aging GO:0007568 241 0.042
regulation of cell projection organization GO:0031344 175 0.042
epithelial cell differentiation GO:0030855 71 0.041
organonitrogen compound catabolic process GO:1901565 179 0.041
protein complex subunit organization GO:0071822 302 0.041
sexual reproduction GO:0019953 148 0.041
nucleotide metabolic process GO:0009117 279 0.040
cell morphogenesis GO:0000902 142 0.039
positive regulation of programmed cell death GO:0043068 157 0.038
cellular catabolic process GO:0044248 295 0.037
behavior GO:0007610 205 0.037
action potential GO:0001508 54 0.037
cellular amino acid metabolic process GO:0006520 107 0.037
multicellular organismal reproductive process GO:0048609 233 0.037
regulation of anatomical structure morphogenesis GO:0022603 141 0.036
regulation of nervous system development GO:0051960 264 0.036
synaptic transmission GO:0007268 235 0.036
cell morphogenesis involved in differentiation GO:0000904 119 0.035
neuron projection development GO:0031175 273 0.034
response to oxidative stress GO:0006979 186 0.034
sensory perception GO:0007600 101 0.034
cytoskeleton organization GO:0007010 111 0.033
single organism biosynthetic process GO:0044711 342 0.033
regulation of protein modification process GO:0031399 194 0.033
response to lipopolysaccharide GO:0032496 191 0.033
protein phosphorylation GO:0006468 345 0.033
cellular ketone metabolic process GO:0042180 51 0.033
organic substance catabolic process GO:1901575 316 0.033
positive regulation of response to stimulus GO:0048584 285 0.032
carbohydrate derivative metabolic process GO:1901135 346 0.032
oxoacid metabolic process GO:0043436 290 0.032
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
response to estrogen GO:0043627 232 0.032
glycosyl compound metabolic process GO:1901657 182 0.032
purine nucleotide metabolic process GO:0006163 229 0.032
response to hydrogen peroxide GO:0042542 89 0.031
membrane organization GO:0061024 94 0.031
reproductive system development GO:0061458 128 0.031
wound healing GO:0042060 122 0.031
cellular response to stress GO:0033554 269 0.031
regulation of protein phosphorylation GO:0001932 183 0.030
regulation of neuron differentiation GO:0045664 208 0.030
protein complex assembly GO:0006461 263 0.030
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.030
signal transduction by phosphorylation GO:0023014 144 0.030
heterocycle catabolic process GO:0046700 167 0.029
purine nucleoside triphosphate metabolic process GO:0009144 141 0.029
regulation of neuron projection development GO:0010975 161 0.029
nucleic acid templated transcription GO:0097659 379 0.029
hormone metabolic process GO:0042445 69 0.029
single organism organelle organization GO:1902589 180 0.028
response to radiation GO:0009314 137 0.028
nucleoside metabolic process GO:0009116 179 0.028
regulation of immune response to tumor cell GO:0002837 3 0.027
chemical homeostasis GO:0048878 292 0.027
organic cyclic compound catabolic process GO:1901361 175 0.027
purine containing compound metabolic process GO:0072521 253 0.027
purine ribonucleotide metabolic process GO:0009150 227 0.027
regulation of immune system process GO:0002682 123 0.027
positive regulation of locomotion GO:0040017 102 0.027
gamete generation GO:0007276 124 0.027
positive regulation of cell development GO:0010720 176 0.027
apoptotic process GO:0006915 381 0.027
regulation of cell differentiation GO:0045595 320 0.027
single organism membrane organization GO:0044802 74 0.026
organelle organization GO:0006996 266 0.026
regulation of cell development GO:0060284 263 0.026
regulation of neurogenesis GO:0050767 247 0.026
positive regulation of cellular component organization GO:0051130 200 0.026
positive regulation of neurogenesis GO:0050769 165 0.026
cellular response to tumor necrosis factor GO:0071356 46 0.025
epithelium development GO:0060429 96 0.025
cellular response to nitrogen compound GO:1901699 210 0.025
positive regulation of catalytic activity GO:0043085 184 0.025
ribonucleoside metabolic process GO:0009119 174 0.025
positive regulation of cell projection organization GO:0031346 111 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.025
ribonucleotide metabolic process GO:0009259 231 0.025
immune system process GO:0002376 204 0.025
glial cell differentiation GO:0010001 65 0.025
response to acid chemical GO:0001101 222 0.025
regulation of cellular amine metabolic process GO:0033238 8 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
secretion by cell GO:0032940 248 0.024
rna biosynthetic process GO:0032774 380 0.024
nucleoside phosphate metabolic process GO:0006753 283 0.024
regulation of synaptic transmission GO:0050804 141 0.024
urogenital system development GO:0001655 78 0.024
regulation of intracellular signal transduction GO:1902531 218 0.024
regulation of phosphorylation GO:0042325 248 0.024
ribose phosphate metabolic process GO:0019693 235 0.024
cellular response to peptide hormone stimulus GO:0071375 120 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
negative regulation of macromolecule metabolic process GO:0010605 260 0.023
positive regulation of gene expression GO:0010628 244 0.023
proteolysis GO:0006508 175 0.023
circulatory system process GO:0003013 183 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.022
purine ribonucleoside metabolic process GO:0046128 168 0.022
catabolic process GO:0009056 351 0.022
response to other organism GO:0051707 220 0.022
metal ion transport GO:0030001 289 0.022
positive regulation of molecular function GO:0044093 230 0.022
cellular response to lipid GO:0071396 201 0.022
response to alkaloid GO:0043279 132 0.022
cell motility GO:0048870 202 0.021
regulation of membrane potential GO:0042391 110 0.021
purine containing compound catabolic process GO:0072523 138 0.021
negative regulation of protein metabolic process GO:0051248 114 0.021
cell projection morphogenesis GO:0048858 123 0.021
regulation of signal transduction GO:0009966 318 0.021
female pregnancy GO:0007565 122 0.021
homeostatic process GO:0042592 331 0.021
response to estradiol GO:0032355 164 0.021
protein oligomerization GO:0051259 191 0.021
axon development GO:0061564 96 0.021
macromolecule localization GO:0033036 252 0.021
regulation of apoptotic process GO:0042981 335 0.021
purine nucleoside metabolic process GO:0042278 169 0.021
defense response GO:0006952 194 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
myelination GO:0042552 39 0.020
regulation of cellular component organization GO:0051128 368 0.020
regulation of hormone levels GO:0010817 187 0.020
organophosphate catabolic process GO:0046434 148 0.020
ras protein signal transduction GO:0007265 29 0.020
negative regulation of phosphorus metabolic process GO:0010563 80 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.020
positive regulation of cell differentiation GO:0045597 217 0.020
negative regulation of response to stimulus GO:0048585 155 0.020
developmental process involved in reproduction GO:0003006 159 0.020
response to toxic substance GO:0009636 133 0.020
localization of cell GO:0051674 202 0.019
response to monosaccharide GO:0034284 159 0.019
regulation of secretion GO:0051046 224 0.019
regulation of protein kinase activity GO:0045859 105 0.019
cellular response to hormone stimulus GO:0032870 247 0.019
regulation of mapk cascade GO:0043408 116 0.019
regulation of cellular component biogenesis GO:0044087 86 0.019
response to molecule of bacterial origin GO:0002237 194 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
nucleoside catabolic process GO:0009164 126 0.019
response to extracellular stimulus GO:0009991 380 0.019
positive regulation of signaling GO:0023056 270 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
gland development GO:0048732 155 0.018
negative regulation of cellular metabolic process GO:0031324 281 0.018
ribonucleoside monophosphate metabolic process GO:0009161 88 0.018
synaptic growth at neuromuscular junction GO:0051124 1 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.018
cell part morphogenesis GO:0032990 123 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.018
programmed cell death GO:0012501 392 0.018
brain development GO:0007420 247 0.018
regulation of cellular component movement GO:0051270 150 0.018
organophosphate metabolic process GO:0019637 370 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
regulation of cell motility GO:2000145 131 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.017
cytokine biosynthetic process GO:0042089 3 0.017
mapk cascade GO:0000165 140 0.017
cation transport GO:0006812 382 0.017
cellular calcium ion homeostasis GO:0006874 160 0.017
positive regulation of protein modification process GO:0031401 142 0.017
regulation of cell migration GO:0030334 128 0.017
regulation of tube size GO:0035150 89 0.017
negative regulation of metabolic process GO:0009892 331 0.017
cellular carbohydrate metabolic process GO:0044262 72 0.017
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.017
response to growth factor GO:0070848 189 0.017
negative regulation of molecular function GO:0044092 133 0.017
response to retinoic acid GO:0032526 63 0.017
response to vitamin GO:0033273 131 0.017
cellular response to organonitrogen compound GO:0071417 197 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
cardiac conduction GO:0061337 2 0.017
metal ion homeostasis GO:0055065 186 0.017
reproduction GO:0000003 245 0.016
organophosphate biosynthetic process GO:0090407 143 0.016
response to nutrient levels GO:0031667 370 0.016
glycosyl compound catabolic process GO:1901658 126 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
purine ribonucleotide catabolic process GO:0009154 136 0.016
response to cytokine GO:0034097 215 0.016
negative regulation of developmental process GO:0051093 125 0.016
regulation of cell proliferation GO:0042127 359 0.016
transcription dna templated GO:0006351 377 0.016
chemotaxis GO:0006935 66 0.016
cognition GO:0050890 92 0.016
single organism cellular localization GO:1902580 102 0.016
single organism behavior GO:0044708 130 0.016
negative regulation of cell death GO:0060548 229 0.016
spermatogenesis GO:0007283 99 0.016
vesicle mediated transport GO:0016192 181 0.016
positive regulation of developmental process GO:0051094 283 0.016
response to carbohydrate GO:0009743 183 0.016
response to peptide GO:1901652 292 0.016
negative regulation of cell communication GO:0010648 158 0.016
response to high density lipoprotein particle GO:0055099 2 0.016
ensheathment of neurons GO:0007272 40 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
gliogenesis GO:0042063 93 0.016
development of primary sexual characteristics GO:0045137 107 0.015
actin filament based process GO:0030029 86 0.015
neuron projection morphogenesis GO:0048812 122 0.015
cellular component maintenance GO:0043954 4 0.015
cell migration GO:0016477 197 0.015
negative regulation of cell development GO:0010721 82 0.015
cellular response to extracellular stimulus GO:0031668 73 0.015
positive regulation of cell death GO:0010942 184 0.015
amine metabolic process GO:0009308 38 0.015
positive regulation of nervous system development GO:0051962 178 0.015
nucleoside triphosphate catabolic process GO:0009143 123 0.015
regulation of transferase activity GO:0051338 123 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
positive regulation of biosynthetic process GO:0009891 319 0.015
regulation of blood circulation GO:1903522 110 0.015
response to glucocorticoid GO:0051384 223 0.015
positive regulation of ion transport GO:0043270 94 0.015
cell growth GO:0016049 104 0.015
negative regulation of cell proliferation GO:0008285 119 0.015
ribonucleoside triphosphate metabolic process GO:0009199 141 0.015
regulation of synaptic plasticity GO:0048167 70 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
axon ensheathment GO:0008366 40 0.014
nucleoside triphosphate metabolic process GO:0009141 144 0.014
cellular amine metabolic process GO:0044106 38 0.014
cellular cation homeostasis GO:0030003 180 0.014
regulation of nucleic acid templated transcription GO:1903506 380 0.014
positive regulation of cell communication GO:0010647 271 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
negative regulation of nervous system development GO:0051961 79 0.014
regulation of cell morphogenesis GO:0022604 77 0.014
gonad development GO:0008406 104 0.014
regulation of cytokine biosynthetic process GO:0042035 3 0.014
nucleotide catabolic process GO:0009166 139 0.014
positive regulation of multicellular organismal process GO:0051240 387 0.014
purine ribonucleoside catabolic process GO:0046130 124 0.014
neuronal action potential GO:0019228 35 0.014
positive regulation of growth GO:0045927 55 0.014
reactive oxygen species metabolic process GO:0072593 37 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
negative regulation of phosphate metabolic process GO:0045936 80 0.014
erk1 and erk2 cascade GO:0070371 48 0.014
cell cycle GO:0007049 101 0.014
regulation of growth GO:0040008 105 0.014
response to nutrient GO:0007584 248 0.014
response to reactive oxygen species GO:0000302 120 0.013
response to hypoxia GO:0001666 231 0.013
rhythmic process GO:0048511 156 0.013
response to ionizing radiation GO:0010212 59 0.013
negative regulation of gene expression GO:0010629 199 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
cofactor metabolic process GO:0051186 95 0.013
regeneration GO:0031099 163 0.013
peptidyl tyrosine phosphorylation GO:0018108 72 0.013
regulation of anatomical structure size GO:0090066 135 0.013
lipid metabolic process GO:0006629 283 0.013
regulation of cellular localization GO:0060341 263 0.013
male gamete generation GO:0048232 99 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
response to external biotic stimulus GO:0043207 221 0.013
olfactory behavior GO:0042048 2 0.013
cellular response to acid chemical GO:0071229 75 0.013
regulation of dendrite development GO:0050773 59 0.013
calcium ion homeostasis GO:0055074 162 0.013
cellular amide metabolic process GO:0043603 44 0.013
rho protein signal transduction GO:0007266 11 0.013
regulation of angiogenesis GO:0045765 39 0.013
protein localization to membrane GO:0072657 36 0.013
ion homeostasis GO:0050801 212 0.013
organic acid metabolic process GO:0006082 292 0.013
cellular response to biotic stimulus GO:0071216 59 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
nucleoside monophosphate metabolic process GO:0009123 93 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
response to axon injury GO:0048678 59 0.013
protein maturation GO:0051604 68 0.012
fertilization GO:0009566 3 0.012
positive regulation of cellular biosynthetic process GO:0031328 295 0.012
circulatory system development GO:0072359 134 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
response to progesterone GO:0032570 48 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
positive regulation of signal transduction GO:0009967 175 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
response to tumor necrosis factor GO:0034612 56 0.012
kidney development GO:0001822 67 0.012
multicellular organismal signaling GO:0035637 44 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
transmission of nerve impulse GO:0019226 42 0.012
rna metabolic process GO:0016070 406 0.012
response to peptide hormone GO:0043434 278 0.012
sex differentiation GO:0007548 113 0.012
positive regulation of erk1 and erk2 cascade GO:0070374 29 0.012
regulation of small gtpase mediated signal transduction GO:0051056 48 0.012
positive regulation of nucleic acid templated transcription GO:1903508 197 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
response to corticosteroid GO:0031960 235 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
muscle system process GO:0003012 115 0.012
t cell extravasation GO:0072683 1 0.012
cd8 positive alpha beta t cell extravasation GO:0035697 0 0.012
regulation of metal ion transport GO:0010959 118 0.012
cardiac muscle contraction GO:0060048 27 0.012
actin cytoskeleton organization GO:0030036 73 0.012
transmembrane transport GO:0055085 412 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
negative regulation of cellular component organization GO:0051129 83 0.012
male sex differentiation GO:0046661 64 0.012
response to insulin GO:0032868 133 0.011
positive regulation of transferase activity GO:0051347 81 0.011
regulation of map kinase activity GO:0043405 53 0.011
muscle cell proliferation GO:0033002 84 0.011
regulation of secretion by cell GO:1903530 208 0.011
circadian rhythm GO:0007623 88 0.011
lipid localization GO:0010876 62 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
cation homeostasis GO:0055080 195 0.011
regulation of actin filament based process GO:0032970 42 0.011
regulation of kinase activity GO:0043549 117 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
cell adhesion GO:0007155 110 0.011
regulation of cell activation GO:0050865 50 0.011
peptidyl tyrosine modification GO:0018212 72 0.011
cellular response to nutrient levels GO:0031669 60 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.011
cellular macromolecular complex assembly GO:0034622 58 0.011
cellular response to organic cyclic compound GO:0071407 202 0.011
regulation of hydrolase activity GO:0051336 143 0.011
chemosensory behavior GO:0007635 2 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
organic hydroxy compound transport GO:0015850 77 0.011
regulation of ion transport GO:0043269 245 0.011
positive regulation of cellular component biogenesis GO:0044089 55 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
ribonucleoside monophosphate catabolic process GO:0009158 55 0.011
protein processing GO:0016485 68 0.011
regulation of response to wounding GO:1903034 69 0.011
cellular response to external stimulus GO:0071496 118 0.011
aromatic compound catabolic process GO:0019439 168 0.011
regulation of rna metabolic process GO:0051252 391 0.011
negative regulation of signaling GO:0023057 157 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
defense response to gram negative bacterium GO:0050829 3 0.010
regulation of programmed cell death GO:0043067 341 0.010
meiotic cell cycle process GO:1903046 3 0.010
growth GO:0040007 165 0.010
negative regulation of programmed cell death GO:0043069 183 0.010
monocarboxylic acid transport GO:0015718 52 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010
multi multicellular organism process GO:0044706 138 0.010
positive regulation of blood circulation GO:1903524 65 0.010
regulation of erk1 and erk2 cascade GO:0070372 41 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
sensory perception of pain GO:0019233 73 0.010
response to light stimulus GO:0009416 52 0.010
axis specification GO:0009798 4 0.010
ribonucleotide catabolic process GO:0009261 136 0.010
regulation of rna biosynthetic process GO:2001141 381 0.010
purine nucleotide biosynthetic process GO:0006164 83 0.010
lipid storage GO:0019915 1 0.010

Cldn4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
nervous system disease DOID:863 0 0.020
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015