Rattus norvegicus

0 known processes

Cldn6

claudin 6

Cldn6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response GO:0006952 194 0.099
regulation of cell proliferation GO:0042127 359 0.096
apoptotic process GO:0006915 381 0.095
homeostatic process GO:0042592 331 0.093
chemical homeostasis GO:0048878 292 0.093
positive regulation of programmed cell death GO:0043068 157 0.090
cellular ion homeostasis GO:0006873 184 0.088
metal ion homeostasis GO:0055065 186 0.088
cation transport GO:0006812 382 0.083
response to external biotic stimulus GO:0043207 221 0.071
regulation of catalytic activity GO:0050790 304 0.071
ion homeostasis GO:0050801 212 0.070
regulation of rna biosynthetic process GO:2001141 381 0.068
circulatory system process GO:0003013 183 0.065
muscle system process GO:0003012 115 0.065
negative regulation of immune system process GO:0002683 39 0.059
positive regulation of cell death GO:0010942 184 0.058
response to inorganic substance GO:0010035 377 0.058
nucleobase containing small molecule metabolic process GO:0055086 316 0.057
nucleic acid templated transcription GO:0097659 379 0.055
positive regulation of response to stimulus GO:0048584 285 0.055
response to nutrient levels GO:0031667 370 0.053
cytosolic calcium ion homeostasis GO:0051480 140 0.053
cellular cation homeostasis GO:0030003 180 0.053
regulation of programmed cell death GO:0043067 341 0.053
neuron differentiation GO:0030182 368 0.052
rna metabolic process GO:0016070 406 0.051
vascular process in circulatory system GO:0003018 96 0.051
regulation of system process GO:0044057 208 0.051
positive regulation of nucleic acid templated transcription GO:1903508 197 0.050
positive regulation of biosynthetic process GO:0009891 319 0.049
cellular chemical homeostasis GO:0055082 247 0.048
positive regulation of cellular component organization GO:0051130 200 0.048
positive regulation of multicellular organismal process GO:0051240 387 0.047
regulation of apoptotic process GO:0042981 335 0.046
response to wounding GO:0009611 254 0.046
programmed cell death GO:0012501 392 0.046
immune response GO:0006955 104 0.045
regulation of nucleic acid templated transcription GO:1903506 380 0.045
response to estrogen GO:0043627 232 0.045
blood circulation GO:0008015 183 0.045
locomotion GO:0040011 237 0.045
cellular component biogenesis GO:0044085 368 0.045
metal ion transport GO:0030001 289 0.044
rna biosynthetic process GO:0032774 380 0.044
transcription dna templated GO:0006351 377 0.043
response to growth factor GO:0070848 189 0.043
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.043
gland development GO:0048732 155 0.043
cellular calcium ion homeostasis GO:0006874 160 0.043
positive regulation of cell communication GO:0010647 271 0.043
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.042
cell projection organization GO:0030030 302 0.042
nitrogen compound transport GO:0071705 229 0.042
cellular divalent inorganic cation homeostasis GO:0072503 162 0.042
response to oxidative stress GO:0006979 186 0.042
intracellular signal transduction GO:0035556 314 0.041
response to molecule of bacterial origin GO:0002237 194 0.041
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.041
regulation of cellular localization GO:0060341 263 0.041
regulation of molecular function GO:0065009 398 0.040
cellular component assembly GO:0022607 360 0.040
positive regulation of neurogenesis GO:0050769 165 0.040
regulation of cell differentiation GO:0045595 320 0.040
central nervous system development GO:0007417 311 0.039
cation homeostasis GO:0055080 195 0.039
regulation of rna metabolic process GO:0051252 391 0.039
regulation of cell motility GO:2000145 131 0.039
response to other organism GO:0051707 220 0.038
brain development GO:0007420 247 0.038
cellular homeostasis GO:0019725 252 0.038
positive regulation of apoptotic process GO:0043065 154 0.037
positive regulation of rna biosynthetic process GO:1902680 197 0.037
secretion GO:0046903 307 0.037
regulation of blood circulation GO:1903522 110 0.036
female pregnancy GO:0007565 122 0.036
Rat
regulation of nervous system development GO:0051960 264 0.036
response to estradiol GO:0032355 164 0.036
regulation of protein metabolic process GO:0051246 289 0.036
negative regulation of cell proliferation GO:0008285 119 0.036
response to lipopolysaccharide GO:0032496 191 0.035
response to hypoxia GO:0001666 231 0.035
positive regulation of signaling GO:0023056 270 0.035
heart process GO:0003015 57 0.035
negative regulation of cellular metabolic process GO:0031324 281 0.035
cellular response to organic cyclic compound GO:0071407 202 0.034
cellular response to oxygen containing compound GO:1901701 386 0.034
positive regulation of nervous system development GO:0051962 178 0.034
cellular response to growth factor stimulus GO:0071363 162 0.034
cellular component movement GO:0006928 248 0.034
negative regulation of metabolic process GO:0009892 331 0.034
positive regulation of cellular biosynthetic process GO:0031328 295 0.034
response to bacterium GO:0009617 200 0.033
positive regulation of developmental process GO:0051094 283 0.033
regulation of synaptic transmission GO:0050804 141 0.033
regulation of anatomical structure morphogenesis GO:0022603 141 0.033
regulation of protein modification process GO:0031399 194 0.033
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.033
calcium ion homeostasis GO:0055074 162 0.033
action potential GO:0001508 54 0.032
regulation of transcription dna templated GO:0006355 374 0.032
response to extracellular stimulus GO:0009991 380 0.031
tissue development GO:0009888 252 0.031
synaptic transmission GO:0007268 235 0.031
regulation of phosphate metabolic process GO:0019220 349 0.030
neurological system process GO:0050877 219 0.030
divalent inorganic cation homeostasis GO:0072507 165 0.030
nucleotide metabolic process GO:0009117 279 0.030
catabolic process GO:0009056 351 0.030
regulation of immune system process GO:0002682 123 0.030
proteolysis GO:0006508 175 0.030
regulation of cell development GO:0060284 263 0.030
purine nucleotide metabolic process GO:0006163 229 0.030
carboxylic acid metabolic process GO:0019752 289 0.029
macromolecular complex subunit organization GO:0043933 339 0.029
positive regulation of gene expression GO:0010628 244 0.029
purine ribonucleotide metabolic process GO:0009150 227 0.029
cellular response to stress GO:0033554 269 0.029
regulation of membrane potential GO:0042391 110 0.029
signal transduction by phosphorylation GO:0023014 144 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.028
response to oxygen levels GO:0070482 265 0.028
positive regulation of transcription dna templated GO:0045893 197 0.028
positive regulation of catalytic activity GO:0043085 184 0.028
response to reactive oxygen species GO:0000302 120 0.028
cellular metal ion homeostasis GO:0006875 172 0.028
positive regulation of rna metabolic process GO:0051254 203 0.027
organic acid metabolic process GO:0006082 292 0.027
phasic smooth muscle contraction GO:0014821 3 0.027
cell migration GO:0016477 197 0.027
positive regulation of cell development GO:0010720 176 0.027
calcium ion transport GO:0006816 131 0.027
response to decreased oxygen levels GO:0036293 237 0.027
response to toxic substance GO:0009636 133 0.026
sensory perception GO:0007600 101 0.026
aging GO:0007568 241 0.026
regulation of ion transport GO:0043269 245 0.025
response to mechanical stimulus GO:0009612 134 0.025
cell morphogenesis involved in differentiation GO:0000904 119 0.025
regulation of cell migration GO:0030334 128 0.025
regulation of neuron differentiation GO:0045664 208 0.025
protein phosphorylation GO:0006468 345 0.024
carbohydrate derivative metabolic process GO:1901135 346 0.024
lipid metabolic process GO:0006629 283 0.024
neuron projection development GO:0031175 273 0.024
regulation of mapk cascade GO:0043408 116 0.024
signal release GO:0023061 145 0.024
multi organism reproductive process GO:0044703 262 0.024
Rat
response to ketone GO:1901654 182 0.024
Rat
cellular catabolic process GO:0044248 295 0.024
purine containing compound metabolic process GO:0072521 253 0.024
anterior posterior pattern specification GO:0009952 1 0.024
cell motility GO:0048870 202 0.024
localization of cell GO:0051674 202 0.024
negative regulation of biosynthetic process GO:0009890 168 0.024
nucleoside phosphate metabolic process GO:0006753 283 0.023
cell cell signaling GO:0007267 335 0.023
muscle contraction GO:0006936 88 0.023
negative regulation of macromolecule metabolic process GO:0010605 260 0.023
organic substance catabolic process GO:1901575 316 0.023
organophosphate metabolic process GO:0019637 370 0.023
single organism intracellular transport GO:1902582 166 0.023
single organism organelle organization GO:1902589 180 0.023
inorganic ion transmembrane transport GO:0098660 229 0.022
positive regulation of transport GO:0051050 245 0.022
divalent metal ion transport GO:0070838 132 0.022
regulation of secretion GO:0051046 224 0.022
biological adhesion GO:0022610 110 0.022
cellular amino acid metabolic process GO:0006520 107 0.022
secretion by cell GO:0032940 248 0.022
response to peptide GO:1901652 292 0.022
positive regulation of cell proliferation GO:0008284 249 0.022
immune system process GO:0002376 204 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
reproductive process GO:0022414 372 0.021
Rat
ribose phosphate metabolic process GO:0019693 235 0.021
ribonucleotide metabolic process GO:0009259 231 0.021
cardiovascular system development GO:0072358 134 0.021
response to monosaccharide GO:0034284 159 0.021
cellular component morphogenesis GO:0032989 155 0.021
positive regulation of phosphorus metabolic process GO:0010562 262 0.021
regulation of locomotion GO:0040012 148 0.021
regulation of blood pressure GO:0008217 83 0.020
cellular amine metabolic process GO:0044106 38 0.020
circulatory system development GO:0072359 134 0.020
positive regulation of molecular function GO:0044093 230 0.020
neuron development GO:0048666 286 0.020
cellular response to cytokine stimulus GO:0071345 127 0.020
protein complex subunit organization GO:0071822 302 0.020
hormone secretion GO:0046879 115 0.020
carbohydrate derivative catabolic process GO:1901136 147 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
positive regulation of cell differentiation GO:0045597 217 0.020
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.019
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.019
regulation of defense response GO:0031347 68 0.019
multicellular organismal signaling GO:0035637 44 0.019
regulation of phosphorus metabolic process GO:0051174 349 0.019
heart morphogenesis GO:0003007 3 0.019
purine ribonucleoside metabolic process GO:0046128 168 0.018
multicellular organism growth GO:0035264 1 0.018
cell projection morphogenesis GO:0048858 123 0.018
nucleoside phosphate catabolic process GO:1901292 140 0.018
regulation of hormone secretion GO:0046883 106 0.018
head development GO:0060322 247 0.018
regulation of synaptic plasticity GO:0048167 70 0.018
cellular response to steroid hormone stimulus GO:0071383 93 0.018
regulation of response to stress GO:0080134 126 0.018
single organism reproductive process GO:0044702 297 0.018
epithelium development GO:0060429 96 0.018
regulation of signal transduction GO:0009966 318 0.018
behavior GO:0007610 205 0.018
amine metabolic process GO:0009308 38 0.018
negative regulation of cell death GO:0060548 229 0.018
muscle cell proliferation GO:0033002 84 0.017
negative regulation of cell communication GO:0010648 158 0.017
cell morphogenesis GO:0000902 142 0.017
negative regulation of secretion by cell GO:1903531 72 0.017
negative regulation of transport GO:0051051 136 0.017
urogenital system development GO:0001655 78 0.017
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.017
regeneration GO:0031099 163 0.017
cell adhesion GO:0007155 110 0.017
gliogenesis GO:0042063 93 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
regulation of smooth muscle cell proliferation GO:0048660 75 0.017
positive regulation of phosphate metabolic process GO:0045937 262 0.017
single organism biosynthetic process GO:0044711 342 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
response to metal ion GO:0010038 253 0.016
neuron death GO:0070997 127 0.016
regulation of blood vessel size GO:0050880 89 0.016
positive regulation of signal transduction GO:0009967 175 0.016
response to glucocorticoid GO:0051384 223 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
intracellular transport GO:0046907 185 0.016
response to glucose GO:0009749 136 0.016
cellular ketone metabolic process GO:0042180 51 0.016
neuron projection morphogenesis GO:0048812 122 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
purine containing compound catabolic process GO:0072523 138 0.016
cellular protein localization GO:0034613 122 0.016
cofactor metabolic process GO:0051186 95 0.016
regulation of behavior GO:0050795 61 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
regulation of muscle system process GO:0090257 79 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
wound healing GO:0042060 122 0.015
response to carbohydrate GO:0009743 183 0.015
cellular response to organonitrogen compound GO:0071417 197 0.015
organic hydroxy compound transport GO:0015850 77 0.015
bmp signaling pathway GO:0030509 4 0.015
cellular response to external stimulus GO:0071496 118 0.015
cellular macromolecule localization GO:0070727 122 0.015
blood vessel development GO:0001568 69 0.015
camera type eye development GO:0043010 48 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
response to peptide hormone GO:0043434 278 0.015
regulation of cellular protein metabolic process GO:0032268 267 0.015
regulation of multicellular organismal development GO:2000026 376 0.015
cell part morphogenesis GO:0032990 123 0.015
single organism catabolic process GO:0044712 283 0.015
rhythmic process GO:0048511 156 0.015
Rat
cytoplasmic transport GO:0016482 115 0.015
macromolecular complex assembly GO:0065003 273 0.015
reactive nitrogen species metabolic process GO:2001057 1 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
negative regulation of cellular biosynthetic process GO:0031327 161 0.015
nucleoside metabolic process GO:0009116 179 0.015
ribonucleoside triphosphate catabolic process GO:0009203 122 0.015
positive regulation of neuron projection development GO:0010976 99 0.014
negative regulation of gene expression GO:0010629 199 0.014
cellular response to abiotic stimulus GO:0071214 85 0.014
circadian rhythm GO:0007623 88 0.014
Rat
single organism behavior GO:0044708 130 0.014
regulation of establishment of planar polarity GO:0090175 2 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
regulation of anatomical structure size GO:0090066 135 0.014
response to purine containing compound GO:0014074 126 0.014
sterol homeostasis GO:0055092 3 0.014
regulation of peptide secretion GO:0002791 82 0.014
response to corticosteroid GO:0031960 235 0.014
response to biotic stimulus GO:0009607 226 0.014
positive regulation of protein modification process GO:0031401 142 0.014
cellular lipid metabolic process GO:0044255 208 0.014
response to vitamin GO:0033273 131 0.014
regulation of neurogenesis GO:0050767 247 0.014
macromolecule localization GO:0033036 252 0.014
growth GO:0040007 165 0.014
regulation of neuron projection development GO:0010975 161 0.013
purine nucleoside metabolic process GO:0042278 169 0.013
organelle organization GO:0006996 266 0.013
establishment of protein localization GO:0045184 141 0.013
establishment of tissue polarity GO:0007164 2 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
organ regeneration GO:0031100 101 0.013
cell type specific apoptotic process GO:0097285 134 0.013
regulation of canonical wnt signaling pathway GO:0060828 4 0.013
regulation of calcium ion transport GO:0051924 77 0.013
organic hydroxy compound metabolic process GO:1901615 115 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
gastrulation GO:0007369 2 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
protein targeting GO:0006605 61 0.013
amide transport GO:0042886 105 0.013
response to cytokine GO:0034097 215 0.013
multi multicellular organism process GO:0044706 138 0.013
Rat
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
transmembrane transport GO:0055085 412 0.013
striated muscle tissue development GO:0014706 58 0.013
hematopoietic progenitor cell differentiation GO:0002244 2 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
ras protein signal transduction GO:0007265 29 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
response to interleukin 1 GO:0070555 55 0.012
cellular response to corticosteroid stimulus GO:0071384 69 0.012
vasoconstriction GO:0042310 54 0.012
anatomical structure morphogenesis GO:0009653 298 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
metanephric tubule morphogenesis GO:0072173 2 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
regulation of phosphorylation GO:0042325 248 0.012
nucleoside phosphate biosynthetic process GO:1901293 102 0.012
response to nutrient GO:0007584 248 0.012
protein localization GO:0008104 191 0.012
positive regulation of ion transport GO:0043270 94 0.012
protein complex biogenesis GO:0070271 263 0.012
ion transmembrane transport GO:0034220 365 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
transmission of nerve impulse GO:0019226 42 0.012
sulfur compound metabolic process GO:0006790 70 0.012
regulation of response to wounding GO:1903034 69 0.012
muscle structure development GO:0061061 87 0.012
positive regulation of cell migration GO:0030335 96 0.012
liver development GO:0001889 90 0.012
multicellular organism reproduction GO:0032504 233 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
regulation of cell projection organization GO:0031344 175 0.012
regulation of bmp signaling pathway GO:0030510 2 0.012
regulation of hormone levels GO:0010817 187 0.012
divalent inorganic cation transport GO:0072511 134 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
purine nucleotide biosynthetic process GO:0006164 83 0.012
intracellular protein transport GO:0006886 79 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
renal system development GO:0072001 67 0.012
regulation of metal ion transport GO:0010959 118 0.012
kidney development GO:0001822 67 0.011
comma shaped body morphogenesis GO:0072049 2 0.011
blood vessel morphogenesis GO:0048514 58 0.011
hepaticobiliary system development GO:0061008 90 0.011
reproduction GO:0000003 245 0.011
cellular response to glucocorticoid stimulus GO:0071385 68 0.011
ensheathment of neurons GO:0007272 40 0.011
positive regulation of fibroblast proliferation GO:0048146 15 0.011
positive regulation of blood circulation GO:1903524 65 0.011
negative regulation of programmed cell death GO:0043069 183 0.011
regulation of circadian sleep wake cycle sleep GO:0045187 18 0.011
response to acid chemical GO:0001101 222 0.011
hair cell differentiation GO:0035315 2 0.011
metanephric tubule development GO:0072170 4 0.011
negative regulation of molecular function GO:0044092 133 0.011
stress activated protein kinase signaling cascade GO:0031098 37 0.011
negative regulation of signaling GO:0023057 157 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.011
regulation of hydrolase activity GO:0051336 143 0.011
gamete generation GO:0007276 124 0.011
non canonical wnt signaling pathway GO:0035567 3 0.011
regulation of epithelial cell proliferation GO:0050678 49 0.011
regulation of mononuclear cell proliferation GO:0032944 26 0.011
regulation of stem cell differentiation GO:2000736 2 0.011
brain renin angiotensin system GO:0002035 3 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
aromatic compound catabolic process GO:0019439 168 0.011
regulation of g0 to g1 transition GO:0070316 3 0.011
regulation of heart contraction GO:0008016 48 0.011
salivary gland morphogenesis GO:0007435 1 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
heart contraction GO:0060047 57 0.010
regulation of intracellular transport GO:0032386 65 0.010
t cell activation GO:0042110 29 0.010
nucleoside monophosphate metabolic process GO:0009123 93 0.010
negative regulation of innate immune response GO:0045824 4 0.010
positive regulation of secretion by cell GO:1903532 128 0.010
protein oligomerization GO:0051259 191 0.010
s shaped body morphogenesis GO:0072050 2 0.010
regulation of body fluid levels GO:0050878 90 0.010
organonitrogen compound catabolic process GO:1901565 179 0.010
negative regulation of secretion GO:0051048 82 0.010
reactive oxygen species metabolic process GO:0072593 37 0.010
dendrite development GO:0016358 72 0.010
organonitrogen compound biosynthetic process GO:1901566 167 0.010
cyclic nucleotide metabolic process GO:0009187 80 0.010
regulation of leukocyte proliferation GO:0070663 26 0.010
myelination GO:0042552 39 0.010
positive regulation of hormone secretion GO:0046887 65 0.010
response to dexamethasone GO:0071548 49 0.010
rna localization GO:0006403 4 0.010
tube development GO:0035295 89 0.010

Cldn6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.024
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
retinal disease DOID:5679 0 0.022
eye and adnexa disease DOID:1492 0 0.022
eye disease DOID:5614 0 0.022
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011