Rattus norvegicus

0 known processes

Smtn

smoothelin

Smtn biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of developmental process GO:0051094 283 0.098
regulation of rna metabolic process GO:0051252 391 0.075
tissue development GO:0009888 252 0.073
positive regulation of biosynthetic process GO:0009891 319 0.066
rna biosynthetic process GO:0032774 380 0.064
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.063
regulation of signal transduction GO:0009966 318 0.062
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.061
chemical homeostasis GO:0048878 292 0.061
intracellular signal transduction GO:0035556 314 0.060
nucleic acid templated transcription GO:0097659 379 0.057
macromolecular complex subunit organization GO:0043933 339 0.055
positive regulation of gene expression GO:0010628 244 0.054
reproductive process GO:0022414 372 0.054
cytoskeleton organization GO:0007010 111 0.054
single organism organelle organization GO:1902589 180 0.053
regulation of nucleic acid templated transcription GO:1903506 380 0.053
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.052
protein complex subunit organization GO:0071822 302 0.052
organelle organization GO:0006996 266 0.052
regulation of nervous system development GO:0051960 264 0.052
regulation of transcription dna templated GO:0006355 374 0.051
regulation of phosphorus metabolic process GO:0051174 349 0.051
cellular divalent inorganic cation homeostasis GO:0072503 162 0.050
circulatory system development GO:0072359 134 0.050
cellular response to oxygen containing compound GO:1901701 386 0.050
cell cell signaling GO:0007267 335 0.050
cellular component biogenesis GO:0044085 368 0.049
regulation of multicellular organismal development GO:2000026 376 0.049
negative regulation of multicellular organismal process GO:0051241 203 0.048
cellular homeostasis GO:0019725 252 0.047
transcription dna templated GO:0006351 377 0.046
single organism catabolic process GO:0044712 283 0.045
regulation of proteasomal protein catabolic process GO:0061136 4 0.045
carbohydrate derivative metabolic process GO:1901135 346 0.043
positive regulation of rna metabolic process GO:0051254 203 0.043
cellular component assembly GO:0022607 360 0.043
rna metabolic process GO:0016070 406 0.042
cellular catabolic process GO:0044248 295 0.041
negative regulation of metabolic process GO:0009892 331 0.041
neurological system process GO:0050877 219 0.041
regulation of cell differentiation GO:0045595 320 0.040
positive regulation of multicellular organismal process GO:0051240 387 0.040
regulation of cellular component organization GO:0051128 368 0.040
anatomical structure morphogenesis GO:0009653 298 0.040
regulation of neurogenesis GO:0050767 247 0.040
regulation of rna biosynthetic process GO:2001141 381 0.039
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.039
positive regulation of rna biosynthetic process GO:1902680 197 0.039
cellular response to organic cyclic compound GO:0071407 202 0.039
anterior posterior pattern specification GO:0009952 1 0.038
negative regulation of cellular metabolic process GO:0031324 281 0.038
regulation of cell development GO:0060284 263 0.038
positive regulation of cell proliferation GO:0008284 249 0.038
positive regulation of transcription dna templated GO:0045893 197 0.036
regulation of cellular amino acid metabolic process GO:0006521 2 0.036
catabolic process GO:0009056 351 0.036
nucleotide metabolic process GO:0009117 279 0.035
synaptic transmission GO:0007268 235 0.035
tube formation GO:0035148 3 0.034
positive regulation of nervous system development GO:0051962 178 0.034
head development GO:0060322 247 0.034
regulation of cell proliferation GO:0042127 359 0.034
brain development GO:0007420 247 0.034
positive regulation of cellular biosynthetic process GO:0031328 295 0.034
homeostatic process GO:0042592 331 0.033
regulation of intracellular signal transduction GO:1902531 218 0.033
cellular response to hormone stimulus GO:0032870 247 0.033
cellular chemical homeostasis GO:0055082 247 0.033
purine nucleotide metabolic process GO:0006163 229 0.032
organic substance catabolic process GO:1901575 316 0.032
response to extracellular stimulus GO:0009991 380 0.032
cytosolic calcium ion homeostasis GO:0051480 140 0.032
cardiovascular system development GO:0072358 134 0.032
purine containing compound metabolic process GO:0072521 253 0.032
regulation of anatomical structure morphogenesis GO:0022603 141 0.032
central nervous system development GO:0007417 311 0.032
regulation of phosphate metabolic process GO:0019220 349 0.031
regulation of apoptotic process GO:0042981 335 0.031
response to oxygen levels GO:0070482 265 0.031
cellular calcium ion homeostasis GO:0006874 160 0.031
cellular response to endogenous stimulus GO:0071495 377 0.031
cellular amine metabolic process GO:0044106 38 0.030
ribose phosphate metabolic process GO:0019693 235 0.030
ribonucleotide metabolic process GO:0009259 231 0.030
response to estrogen GO:0043627 232 0.030
nucleoside phosphate metabolic process GO:0006753 283 0.030
cellular response to stress GO:0033554 269 0.029
negative regulation of apoptotic process GO:0043066 181 0.029
positive regulation of cell differentiation GO:0045597 217 0.029
proteolysis GO:0006508 175 0.029
multi organism reproductive process GO:0044703 262 0.029
positive regulation of nucleic acid templated transcription GO:1903508 197 0.029
carboxylic acid metabolic process GO:0019752 289 0.028
cellular component movement GO:0006928 248 0.028
negative regulation of cell communication GO:0010648 158 0.028
programmed cell death GO:0012501 392 0.028
positive regulation of molecular function GO:0044093 230 0.028
ion transmembrane transport GO:0034220 365 0.028
metal ion homeostasis GO:0055065 186 0.028
neuron projection development GO:0031175 273 0.028
protein complex assembly GO:0006461 263 0.028
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.028
response to nutrient levels GO:0031667 370 0.027
regulation of cellular amine metabolic process GO:0033238 8 0.027
ion homeostasis GO:0050801 212 0.027
cellular amino acid metabolic process GO:0006520 107 0.027
ribonucleoside metabolic process GO:0009119 174 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.027
cell cycle GO:0007049 101 0.027
positive regulation of cell development GO:0010720 176 0.027
negative regulation of signaling GO:0023057 157 0.027
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.026
nucleobase containing small molecule metabolic process GO:0055086 316 0.026
protein phosphorylation GO:0006468 345 0.026
cellular nitrogen compound catabolic process GO:0044270 163 0.026
heterocycle catabolic process GO:0046700 167 0.026
regulation of canonical wnt signaling pathway GO:0060828 4 0.026
regulation of programmed cell death GO:0043067 341 0.026
cell adhesion GO:0007155 110 0.026
muscle system process GO:0003012 115 0.026
cell projection organization GO:0030030 302 0.026
sensory organ development GO:0007423 74 0.026
single organism reproductive process GO:0044702 297 0.026
regulation of catalytic activity GO:0050790 304 0.026
multicellular organism reproduction GO:0032504 233 0.025
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.025
carbohydrate derivative catabolic process GO:1901136 147 0.025
negative regulation of rna metabolic process GO:0051253 123 0.025
macromolecular complex assembly GO:0065003 273 0.025
purine ribonucleotide metabolic process GO:0009150 227 0.025
muscle structure development GO:0061061 87 0.025
amine metabolic process GO:0009308 38 0.025
regulation of synaptic transmission GO:0050804 141 0.025
metal ion transport GO:0030001 289 0.025
negative regulation of programmed cell death GO:0043069 183 0.024
cellular metal ion homeostasis GO:0006875 172 0.024
organic acid metabolic process GO:0006082 292 0.024
regulation of protein metabolic process GO:0051246 289 0.024
negative regulation of gene expression GO:0010629 199 0.024
protein oligomerization GO:0051259 191 0.024
negative regulation of nucleic acid templated transcription GO:1903507 117 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.024
cellular ion homeostasis GO:0006873 184 0.023
calcium ion homeostasis GO:0055074 162 0.023
organ morphogenesis GO:0009887 75 0.023
neuron differentiation GO:0030182 368 0.023
nucleoside catabolic process GO:0009164 126 0.023
negative regulation of signal transduction GO:0009968 83 0.023
embryonic appendage morphogenesis GO:0035113 4 0.023
gastrulation GO:0007369 2 0.023
protein complex biogenesis GO:0070271 263 0.023
response to ketone GO:1901654 182 0.022
apoptotic process GO:0006915 381 0.022
blood circulation GO:0008015 183 0.022
positive regulation of cell communication GO:0010647 271 0.022
nucleoside metabolic process GO:0009116 179 0.022
cation homeostasis GO:0055080 195 0.022
divalent inorganic cation homeostasis GO:0072507 165 0.022
cell migration GO:0016477 197 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
reproduction GO:0000003 245 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.022
regulation of cell cycle GO:0051726 73 0.022
response to hypoxia GO:0001666 231 0.022
cardiac chamber development GO:0003205 1 0.021
macromolecule localization GO:0033036 252 0.021
oxoacid metabolic process GO:0043436 290 0.021
purine ribonucleoside metabolic process GO:0046128 168 0.021
cellular ketone metabolic process GO:0042180 51 0.021
purine nucleoside metabolic process GO:0042278 169 0.021
g protein coupled receptor signaling pathway GO:0007186 242 0.021
cellular cation homeostasis GO:0030003 180 0.021
secretion by cell GO:0032940 248 0.021
regulation of molecular function GO:0065009 398 0.021
negative regulation of biosynthetic process GO:0009890 168 0.021
regulation of nucleotide metabolic process GO:0006140 117 0.021
positive regulation of neurogenesis GO:0050769 165 0.020
small gtpase mediated signal transduction GO:0007264 36 0.020
appendage morphogenesis GO:0035107 4 0.020
negative regulation of developmental process GO:0051093 125 0.020
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
response to wounding GO:0009611 254 0.020
regulation of cell projection organization GO:0031344 175 0.020
cation transport GO:0006812 382 0.020
secretion GO:0046903 307 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.019
ras protein signal transduction GO:0007265 29 0.019
circulatory system process GO:0003013 183 0.019
transmembrane transport GO:0055085 412 0.019
regulation of neuron differentiation GO:0045664 208 0.019
organophosphate metabolic process GO:0019637 370 0.019
purine nucleoside triphosphate metabolic process GO:0009144 141 0.019
cellular response to nitrogen compound GO:1901699 210 0.019
response to peptide hormone GO:0043434 278 0.019
axis specification GO:0009798 4 0.018
cellular response to growth factor stimulus GO:0071363 162 0.018
divalent metal ion transport GO:0070838 132 0.018
ribonucleoside triphosphate catabolic process GO:0009203 122 0.018
purine ribonucleoside catabolic process GO:0046130 124 0.018
nucleoside triphosphate catabolic process GO:0009143 123 0.018
regulation of system process GO:0044057 208 0.018
anatomical structure formation involved in morphogenesis GO:0048646 83 0.018
bmp signaling pathway GO:0030509 4 0.018
response to decreased oxygen levels GO:0036293 237 0.018
muscle contraction GO:0006936 88 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
positive regulation of ion transport GO:0043270 94 0.018
protein heterooligomerization GO:0051291 89 0.018
negative regulation of cell death GO:0060548 229 0.018
regulation of cell morphogenesis GO:0022604 77 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.018
regulation of cell motility GO:2000145 131 0.018
synaptic growth at neuromuscular junction GO:0051124 1 0.017
purine nucleoside catabolic process GO:0006152 124 0.017
skeletal system development GO:0001501 41 0.017
regulation of purine nucleotide metabolic process GO:1900542 115 0.017
mechanoreceptor differentiation GO:0042490 2 0.017
positive regulation of transport GO:0051050 245 0.017
sensory perception GO:0007600 101 0.017
aging GO:0007568 241 0.017
positive regulation of synaptic transmission GO:0050806 62 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
gamete generation GO:0007276 124 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
response to temperature stimulus GO:0009266 94 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
single organism biosynthetic process GO:0044711 342 0.017
negative regulation of response to stimulus GO:0048585 155 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
regulation of phosphorylation GO:0042325 248 0.017
protein localization GO:0008104 191 0.016
developmental process involved in reproduction GO:0003006 159 0.016
regulation of ion transport GO:0043269 245 0.016
inorganic cation transmembrane transport GO:0098662 202 0.016
morphogenesis of embryonic epithelium GO:0016331 3 0.016
limb morphogenesis GO:0035108 4 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
response to growth factor GO:0070848 189 0.016
organophosphate catabolic process GO:0046434 148 0.016
establishment of protein localization GO:0045184 141 0.016
response to peptide GO:1901652 292 0.016
response to corticosteroid GO:0031960 235 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
actin filament based process GO:0030029 86 0.016
blood vessel development GO:0001568 69 0.016
monovalent inorganic cation transport GO:0015672 172 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
response to nutrient GO:0007584 248 0.016
neuron development GO:0048666 286 0.015
regulation of neuron projection development GO:0010975 161 0.015
heart morphogenesis GO:0003007 3 0.015
actin cytoskeleton organization GO:0030036 73 0.015
glycosyl compound catabolic process GO:1901658 126 0.015
cell cycle process GO:0022402 57 0.015
cellular macromolecule localization GO:0070727 122 0.015
regulation of fat cell differentiation GO:0045598 3 0.015
cellular response to peptide hormone stimulus GO:0071375 120 0.015
regulation of cellular catabolic process GO:0031329 101 0.015
cell morphogenesis GO:0000902 142 0.015
response to inorganic substance GO:0010035 377 0.015
cellular response to abiotic stimulus GO:0071214 85 0.015
reproductive structure development GO:0048608 128 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
vasculature development GO:0001944 70 0.015
response to external biotic stimulus GO:0043207 221 0.015
regulation of g0 to g1 transition GO:0070316 3 0.015
cellular component morphogenesis GO:0032989 155 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
tube development GO:0035295 89 0.014
negative regulation of transcription dna templated GO:0045892 116 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
regulation of response to external stimulus GO:0032101 106 0.014
regulation of cellular localization GO:0060341 263 0.014
neuron neuron synaptic transmission GO:0007270 60 0.014
purine ribonucleotide catabolic process GO:0009154 136 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
response to hexose GO:0009746 144 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
nucleotide catabolic process GO:0009166 139 0.014
regulation of protein modification process GO:0031399 194 0.014
response to vitamin GO:0033273 131 0.014
carbohydrate metabolic process GO:0005975 130 0.014
ribonucleotide catabolic process GO:0009261 136 0.014
cellular response to alcohol GO:0097306 87 0.014
cardiac ventricle development GO:0003231 1 0.014
calcium ion transport GO:0006816 131 0.014
aromatic compound catabolic process GO:0019439 168 0.014
cellular response to external stimulus GO:0071496 118 0.014
response to glucose GO:0009749 136 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
cellular response to peptide GO:1901653 133 0.013
response to glucocorticoid GO:0051384 223 0.013
positive regulation of cell projection organization GO:0031346 111 0.013
multi multicellular organism process GO:0044706 138 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
positive regulation of phosphate metabolic process GO:0045937 262 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
blood vessel morphogenesis GO:0048514 58 0.013
guanosine containing compound metabolic process GO:1901068 74 0.013
response to carbohydrate GO:0009743 183 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
regulation of cell migration GO:0030334 128 0.013
divalent inorganic cation transport GO:0072511 134 0.013
rhythmic process GO:0048511 156 0.013
cell cycle checkpoint GO:0000075 2 0.013
digestive system development GO:0055123 41 0.013
defense response GO:0006952 194 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
inorganic ion transmembrane transport GO:0098660 229 0.013
response to acid chemical GO:0001101 222 0.013
angiogenesis GO:0001525 53 0.013
anion transport GO:0006820 178 0.013
single organism cellular localization GO:1902580 102 0.013
embryo development GO:0009790 49 0.013
spindle organization GO:0007051 2 0.013
negative regulation of transport GO:0051051 136 0.013
regulation of membrane potential GO:0042391 110 0.013
cyclic nucleotide metabolic process GO:0009187 80 0.013
cellular protein localization GO:0034613 122 0.013
localization of cell GO:0051674 202 0.013
locomotion GO:0040011 237 0.013
ossification GO:0001503 70 0.013
positive regulation of neuron projection development GO:0010976 99 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
cation transmembrane transport GO:0098655 263 0.012
sexual reproduction GO:0019953 148 0.012
vascular process in circulatory system GO:0003018 96 0.012
negative regulation of phosphate metabolic process GO:0045936 80 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
embryonic pattern specification GO:0009880 1 0.012
muscle tissue morphogenesis GO:0060415 1 0.012
regulation of hydrolase activity GO:0051336 143 0.012
single organism carbohydrate metabolic process GO:0044723 118 0.012
response to mechanical stimulus GO:0009612 134 0.012
formation of primary germ layer GO:0001704 1 0.012
regulation of metal ion transport GO:0010959 118 0.012
regulation of muscle system process GO:0090257 79 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
eye morphogenesis GO:0048592 4 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
epithelium development GO:0060429 96 0.012
cytoplasmic transport GO:0016482 115 0.012
action potential GO:0001508 54 0.012
mesoderm development GO:0007498 2 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
response to ethanol GO:0045471 162 0.011
cellular response to cytokine stimulus GO:0071345 127 0.011
regulation of ossification GO:0030278 32 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
regulation of transferase activity GO:0051338 123 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
response to activity GO:0014823 73 0.011
vasculogenesis GO:0001570 3 0.011
mitotic cell cycle GO:0000278 49 0.011
regulation of cellular component movement GO:0051270 150 0.011
response to oxidative stress GO:0006979 186 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
heart contraction GO:0060047 57 0.011
reproductive system development GO:0061458 128 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
embryonic axis specification GO:0000578 1 0.011
positive regulation of endothelial cell migration GO:0010595 4 0.011
connective tissue development GO:0061448 33 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
potassium ion transport GO:0006813 97 0.011
response to heat GO:0009408 60 0.011
purine containing compound catabolic process GO:0072523 138 0.011
memory GO:0007613 54 0.011
regulation of secretion GO:0051046 224 0.011
response to lipopolysaccharide GO:0032496 191 0.011
inner ear receptor cell differentiation GO:0060113 2 0.011
multicellular organismal signaling GO:0035637 44 0.011
regulation of kinase activity GO:0043549 117 0.010
oxidation reduction process GO:0055114 304 0.010
negative regulation of phosphorus metabolic process GO:0010563 80 0.010
cellular response to nutrient levels GO:0031669 60 0.010
negative regulation of cell development GO:0010721 82 0.010
rho protein signal transduction GO:0007266 11 0.010
neuronal action potential GO:0019228 35 0.010
signal transduction by phosphorylation GO:0023014 144 0.010
camera type eye development GO:0043010 48 0.010
dephosphorylation GO:0016311 98 0.010
muscle cell differentiation GO:0042692 52 0.010
actin filament organization GO:0007015 42 0.010
purine nucleoside triphosphate catabolic process GO:0009146 122 0.010
neuron death GO:0070997 127 0.010
regulation of catabolic process GO:0009894 113 0.010
response to bacterium GO:0009617 200 0.010
cellular response to extracellular stimulus GO:0031668 73 0.010
positive regulation of phosphorylation GO:0042327 177 0.010
myoblast fusion GO:0007520 2 0.010

Smtn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
musculoskeletal system disease DOID:17 0 0.043
nervous system disease DOID:863 0 0.024
connective tissue disease DOID:65 0 0.023
muscular disease DOID:0080000 0 0.020
muscle tissue disease DOID:66 0 0.020
bone disease DOID:0080001 0 0.016
cardiovascular system disease DOID:1287 0 0.015
bone development disease DOID:0080006 0 0.015
myopathy DOID:423 0 0.013
muscular dystrophy DOID:9884 0 0.013
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.010