Rattus norvegicus

70 known processes

Kcnma1

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

(Aliases: Slo,Kcnma,KCNMA1b,KCNMA1c)

Kcnma1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
intracellular signal transduction GO:0035556 314 0.171
positive regulation of response to stimulus GO:0048584 285 0.165
regulation of signal transduction GO:0009966 318 0.154
regulation of molecular function GO:0065009 398 0.154
positive regulation of multicellular organismal process GO:0051240 387 0.133
oxoacid metabolic process GO:0043436 290 0.117
macromolecular complex subunit organization GO:0043933 339 0.116
response to monosaccharide GO:0034284 159 0.100
regulation of phosphate metabolic process GO:0019220 349 0.099
response to external biotic stimulus GO:0043207 221 0.096
cell cell signaling GO:0007267 335 0.093
Mouse
protein complex assembly GO:0006461 263 0.091
positive regulation of gene expression GO:0010628 244 0.089
apoptotic process GO:0006915 381 0.088
Human
response to growth factor GO:0070848 189 0.084
protein complex biogenesis GO:0070271 263 0.084
neuron development GO:0048666 286 0.082
axon development GO:0061564 96 0.081
carboxylic acid metabolic process GO:0019752 289 0.077
positive regulation of signal transduction GO:0009967 175 0.076
protein phosphorylation GO:0006468 345 0.076
homeostatic process GO:0042592 331 0.070
Human Mouse
metal ion transport GO:0030001 289 0.069
regulation of phosphorus metabolic process GO:0051174 349 0.068
anatomical structure morphogenesis GO:0009653 298 0.066
response to carbohydrate GO:0009743 183 0.066
carbohydrate derivative metabolic process GO:1901135 346 0.065
regulation of catalytic activity GO:0050790 304 0.064
response to hexose GO:0009746 144 0.063
cell migration GO:0016477 197 0.062
inorganic ion transmembrane transport GO:0098660 229 0.061
positive regulation of biosynthetic process GO:0009891 319 0.061
catabolic process GO:0009056 351 0.059
regulation of response to stress GO:0080134 126 0.059
multicellular organism reproduction GO:0032504 233 0.058
cellular response to stress GO:0033554 269 0.058
cellular component biogenesis GO:0044085 368 0.057
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.057
rna biosynthetic process GO:0032774 380 0.057
cellular catabolic process GO:0044248 295 0.056
anterior posterior pattern specification GO:0009952 1 0.055
regulation of protein metabolic process GO:0051246 289 0.055
cardiovascular system development GO:0072358 134 0.055
positive regulation of phosphorus metabolic process GO:0010562 262 0.054
response to oxygen levels GO:0070482 265 0.053
response to lipopolysaccharide GO:0032496 191 0.053
response to inorganic substance GO:0010035 377 0.053
cardiac conduction GO:0061337 2 0.052
protein complex subunit organization GO:0071822 302 0.051
negative regulation of metabolic process GO:0009892 331 0.051
macromolecular complex assembly GO:0065003 273 0.051
cell type specific apoptotic process GO:0097285 134 0.051
regulation of ion transport GO:0043269 245 0.051
Human Mouse
neuron differentiation GO:0030182 368 0.049
Mouse
positive regulation of molecular function GO:0044093 230 0.049
regulation of intracellular signal transduction GO:1902531 218 0.049
purine containing compound metabolic process GO:0072521 253 0.047
cellular response to organonitrogen compound GO:0071417 197 0.046
positive regulation of cellular biosynthetic process GO:0031328 295 0.046
positive regulation of phosphate metabolic process GO:0045937 262 0.045
response to estrogen GO:0043627 232 0.045
reproduction GO:0000003 245 0.044
peptidyl amino acid modification GO:0018193 126 0.044
reproductive process GO:0022414 372 0.044
response to bacterium GO:0009617 200 0.044
cell communication involved in cardiac conduction GO:0086065 2 0.044
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.042
positive regulation of transport GO:0051050 245 0.042
nucleobase containing small molecule metabolic process GO:0055086 316 0.041
neuron projection morphogenesis GO:0048812 122 0.041
response to biotic stimulus GO:0009607 226 0.041
response to cytokine GO:0034097 215 0.040
positive regulation of cell communication GO:0010647 271 0.040
single organism reproductive process GO:0044702 297 0.039
positive regulation of rna metabolic process GO:0051254 203 0.039
regulation of hormone levels GO:0010817 187 0.039
Mouse
regulation of rna metabolic process GO:0051252 391 0.038
cellular response to endogenous stimulus GO:0071495 377 0.038
cellular response to hormone stimulus GO:0032870 247 0.037
programmed cell death GO:0012501 392 0.037
Human
nitrogen compound transport GO:0071705 229 0.037
regulation of cellular protein metabolic process GO:0032268 267 0.037
circulatory system development GO:0072359 134 0.037
organophosphate metabolic process GO:0019637 370 0.037
negative regulation of cellular metabolic process GO:0031324 281 0.036
purine ribonucleotide metabolic process GO:0009150 227 0.036
lipid metabolic process GO:0006629 283 0.036
Mouse
negative regulation of gene expression GO:0010629 199 0.036
vesicle mediated transport GO:0016192 181 0.035
response to other organism GO:0051707 220 0.035
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.035
cellular component assembly GO:0022607 360 0.034
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.034
regulation of cellular amino acid metabolic process GO:0006521 2 0.034
cell cycle process GO:0022402 57 0.034
muscle contraction GO:0006936 88 0.033
Human Mouse
response to nutrient levels GO:0031667 370 0.033
synaptic transmission GO:0007268 235 0.033
Mouse
cellular amino acid metabolic process GO:0006520 107 0.032
nucleic acid templated transcription GO:0097659 379 0.032
nucleotide catabolic process GO:0009166 139 0.031
protein heterooligomerization GO:0051291 89 0.031
secretion by cell GO:0032940 248 0.031
establishment of protein localization GO:0045184 141 0.031
organic substance catabolic process GO:1901575 316 0.031
regulation of nucleic acid templated transcription GO:1903506 380 0.031
response to glucose GO:0009749 136 0.031
regulation of cellular localization GO:0060341 263 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
regeneration GO:0031099 163 0.030
response to oxidative stress GO:0006979 186 0.030
organic acid metabolic process GO:0006082 292 0.030
positive regulation of developmental process GO:0051094 283 0.030
protein homooligomerization GO:0051260 91 0.029
cell cycle GO:0007049 101 0.029
organ morphogenesis GO:0009887 75 0.029
response to anoxia GO:0034059 4 0.029
regulation of anatomical structure morphogenesis GO:0022603 141 0.028
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.028
single organism catabolic process GO:0044712 283 0.028
positive regulation of protein metabolic process GO:0051247 178 0.028
regulation of protein transport GO:0051223 68 0.028
secretion GO:0046903 307 0.028
Mouse
cation transport GO:0006812 382 0.027
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 3 0.027
response to molecule of bacterial origin GO:0002237 194 0.027
developmental process involved in reproduction GO:0003006 159 0.027
protein oligomerization GO:0051259 191 0.027
rna metabolic process GO:0016070 406 0.027
chemical homeostasis GO:0048878 292 0.027
Human
heart morphogenesis GO:0003007 3 0.026
positive regulation of cell proliferation GO:0008284 249 0.026
detection of visible light GO:0009584 3 0.026
neuromuscular synaptic transmission GO:0007274 2 0.026
protein transport GO:0015031 132 0.026
nucleotide metabolic process GO:0009117 279 0.026
response to decreased oxygen levels GO:0036293 237 0.026
chemotaxis GO:0006935 66 0.026
cell projection morphogenesis GO:0048858 123 0.025
axonogenesis GO:0007409 71 0.025
regulation of multicellular organismal development GO:2000026 376 0.025
regulation of cell differentiation GO:0045595 320 0.025
glycosyl compound catabolic process GO:1901658 126 0.025
single organism organelle organization GO:1902589 180 0.025
regulation of phosphorylation GO:0042325 248 0.025
glycosyl compound metabolic process GO:1901657 182 0.025
positive regulation of cell death GO:0010942 184 0.025
Human
positive regulation of signaling GO:0023056 270 0.025
positive regulation of apoptotic process GO:0043065 154 0.024
Human
positive regulation of cellular component organization GO:0051130 200 0.024
macromolecule localization GO:0033036 252 0.024
purine nucleotide metabolic process GO:0006163 229 0.024
ribonucleotide catabolic process GO:0009261 136 0.024
regulation of apoptotic process GO:0042981 335 0.024
Human
jnk cascade GO:0007254 28 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.024
Mouse
multicellular organismal homeostasis GO:0048871 49 0.024
positive regulation of nucleic acid templated transcription GO:1903508 197 0.023
cellular macromolecule localization GO:0070727 122 0.023
hormone metabolic process GO:0042445 69 0.023
Mouse
protein localization GO:0008104 191 0.023
calcium ion transmembrane transport GO:0070588 70 0.023
regulation of cell development GO:0060284 263 0.023
response to insulin GO:0032868 133 0.023
nucleoside metabolic process GO:0009116 179 0.023
ribonucleoside metabolic process GO:0009119 174 0.023
organelle organization GO:0006996 266 0.023
development of primary female sexual characteristics GO:0046545 56 0.022
endoplasmic reticulum to cytosol transport GO:1903513 4 0.022
microtubule polymerization or depolymerization GO:0031109 13 0.022
positive regulation of nervous system development GO:0051962 178 0.022
purine containing compound catabolic process GO:0072523 138 0.022
cellular response to nitrogen compound GO:1901699 210 0.022
purine ribonucleoside metabolic process GO:0046128 168 0.022
transcription dna templated GO:0006351 377 0.022
coronary vasculature morphogenesis GO:0060977 3 0.022
positive regulation of cell differentiation GO:0045597 217 0.021
enzyme linked receptor protein signaling pathway GO:0007167 116 0.021
organonitrogen compound biosynthetic process GO:1901566 167 0.021
cell morphogenesis involved in differentiation GO:0000904 119 0.021
gonad development GO:0008406 104 0.021
inorganic cation transmembrane transport GO:0098662 202 0.021
cellular homeostasis GO:0019725 252 0.021
Human Mouse
negative regulation of biosynthetic process GO:0009890 168 0.021
neuron projection development GO:0031175 273 0.021
response to extracellular stimulus GO:0009991 380 0.021
cell growth GO:0016049 104 0.021
positive regulation of phosphorylation GO:0042327 177 0.021
ribose phosphate metabolic process GO:0019693 235 0.020
cellular response to oxidative stress GO:0034599 76 0.020
cellular response to growth factor stimulus GO:0071363 162 0.020
signal transduction by phosphorylation GO:0023014 144 0.020
nucleobase containing compound catabolic process GO:0034655 152 0.020
protein tetramerization GO:0051262 38 0.020
regulation of protein phosphorylation GO:0001932 183 0.020
calcium ion homeostasis GO:0055074 162 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
cell part morphogenesis GO:0032990 123 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
protein autophosphorylation GO:0046777 66 0.020
muscle cell proliferation GO:0033002 84 0.020
nucleoside phosphate catabolic process GO:1901292 140 0.020
sarcoplasmic reticulum calcium ion transport GO:0070296 8 0.019
cellular response to insulin stimulus GO:0032869 81 0.019
regulation of cellular component biogenesis GO:0044087 86 0.019
locomotion GO:0040011 237 0.019
cell morphogenesis GO:0000902 142 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.019
cellular component movement GO:0006928 248 0.019
cellular protein complex assembly GO:0043623 44 0.019
cell cell signaling involved in cell fate commitment GO:0045168 2 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.019
purine nucleotide catabolic process GO:0006195 136 0.019
tube development GO:0035295 89 0.019
axon guidance GO:0007411 24 0.019
tissue development GO:0009888 252 0.019
Mouse
regulation of programmed cell death GO:0043067 341 0.019
Human
multicellular organismal reproductive process GO:0048609 233 0.018
metal ion homeostasis GO:0055065 186 0.018
Human
protein processing GO:0016485 68 0.018
ion transmembrane transport GO:0034220 365 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
response to wounding GO:0009611 254 0.018
organophosphate catabolic process GO:0046434 148 0.018
peptide secretion GO:0002790 86 0.018
cellular amine metabolic process GO:0044106 38 0.018
regulation of fat cell proliferation GO:0070344 1 0.018
neuronal action potential GO:0019228 35 0.018
Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.018
circulatory system process GO:0003013 183 0.018
ribonucleoside catabolic process GO:0042454 126 0.018
ion homeostasis GO:0050801 212 0.017
Human
response to hypoxia GO:0001666 231 0.017
epithelial cell proliferation GO:0050673 54 0.017
response to nutrient GO:0007584 248 0.017
intracellular protein transport GO:0006886 79 0.017
regulation of catabolic process GO:0009894 113 0.017
cellular macromolecular complex assembly GO:0034622 58 0.017
cellular response to peptide hormone stimulus GO:0071375 120 0.017
cellular nitrogen compound catabolic process GO:0044270 163 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
nucleoside triphosphate catabolic process GO:0009143 123 0.017
cell projection organization GO:0030030 302 0.017
epithelium development GO:0060429 96 0.017
Mouse
multicellular organism growth GO:0035264 1 0.017
heterocycle catabolic process GO:0046700 167 0.017
negative regulation of cellular protein metabolic process GO:0032269 106 0.017
reproductive structure development GO:0048608 128 0.017
cellular response to peptide GO:1901653 133 0.017
positive regulation of cell development GO:0010720 176 0.016
sex differentiation GO:0007548 113 0.016
regulation of cellular component organization GO:0051128 368 0.016
development of primary sexual characteristics GO:0045137 107 0.016
regulation of cell morphogenesis GO:0022604 77 0.016
negative regulation of response to stimulus GO:0048585 155 0.016
cellular response to reactive oxygen species GO:0034614 55 0.016
regulation of cellular catabolic process GO:0031329 101 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.016
adult locomotory behavior GO:0008344 4 0.016
Mouse
female gonad development GO:0008585 53 0.016
regulation of protein kinase activity GO:0045859 105 0.016
transmembrane transport GO:0055085 412 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.016
smooth muscle cell proliferation GO:0048659 77 0.016
carbohydrate derivative catabolic process GO:1901136 147 0.015
nucleoside catabolic process GO:0009164 126 0.015
localization of cell GO:0051674 202 0.015
regulation of protein serine threonine kinase activity GO:0071900 64 0.015
cellular cation homeostasis GO:0030003 180 0.015
Human
purine ribonucleoside catabolic process GO:0046130 124 0.015
positive regulation of cell motility GO:2000147 97 0.015
single organism biosynthetic process GO:0044711 342 0.015
response to ketone GO:1901654 182 0.015
regulation of microtubule cytoskeleton organization GO:0070507 14 0.015
cellular response to oxygen containing compound GO:1901701 386 0.015
muscle tissue development GO:0060537 58 0.015
sequestering of calcium ion GO:0051208 8 0.015
positive regulation of brown fat cell proliferation GO:0070349 1 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
heart development GO:0007507 72 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
cytokinetic process GO:0032506 1 0.015
cellular component morphogenesis GO:0032989 155 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
transcription from rna polymerase ii promoter GO:0006366 252 0.015
aging GO:0007568 241 0.014
regulation of hydrolase activity GO:0051336 143 0.014
regulation of smooth muscle cell proliferation GO:0048660 75 0.014
negative regulation of molecular function GO:0044092 133 0.014
cation homeostasis GO:0055080 195 0.014
Human
neurological system process GO:0050877 219 0.014
Mouse
cell motility GO:0048870 202 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
positive regulation of kinase activity GO:0033674 77 0.014
positive regulation of fat cell proliferation GO:0070346 1 0.014
amine metabolic process GO:0009308 38 0.014
growth GO:0040007 165 0.014
monocarboxylic acid metabolic process GO:0032787 152 0.014
regulation of cell proliferation GO:0042127 359 0.014
cellular lipid metabolic process GO:0044255 208 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
developmental growth GO:0048589 100 0.014
sensory perception GO:0007600 101 0.014
Mouse
regulation of homeostatic process GO:0032844 101 0.014
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 4 0.014
regulation of rna biosynthetic process GO:2001141 381 0.014
response to toxic substance GO:0009636 133 0.014
cellular metal ion homeostasis GO:0006875 172 0.013
Human
respiratory system development GO:0060541 45 0.013
regulation of secretion GO:0051046 224 0.013
regulation of developmental growth GO:0048638 45 0.013
ribonucleoside triphosphate catabolic process GO:0009203 122 0.013
regulation of organ formation GO:0003156 2 0.013
neural crest cell development GO:0014032 2 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
negative regulation of rna biosynthetic process GO:1902679 118 0.013
striated muscle contraction GO:0006941 44 0.013
ovulation cycle GO:0042698 67 0.013
response to light stimulus GO:0009416 52 0.013
multi organism reproductive process GO:0044703 262 0.013
morphogenesis of embryonic epithelium GO:0016331 3 0.013
cellular ketone metabolic process GO:0042180 51 0.013
Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
fat cell proliferation GO:0070341 2 0.013
regulation of peptidase activity GO:0052547 55 0.012
mapk cascade GO:0000165 140 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
neuron projection guidance GO:0097485 24 0.012
dendrite development GO:0016358 72 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
salivary gland development GO:0007431 3 0.012
positive regulation of cardiac muscle cell proliferation GO:0060045 4 0.012
muscle structure development GO:0061061 87 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
positive regulation of protein kinase activity GO:0045860 73 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
Human
regulation of peptide transport GO:0090087 87 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
ras protein signal transduction GO:0007265 29 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
regulation of small gtpase mediated signal transduction GO:0051056 48 0.012
cellular ion homeostasis GO:0006873 184 0.012
Human
regulation of corticotropin secretion GO:0051459 7 0.012
brain development GO:0007420 247 0.012
regulation of cellular amine metabolic process GO:0033238 8 0.012
male gamete generation GO:0048232 99 0.012
sodium ion transmembrane transport GO:0035725 67 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
regulation of transcription dna templated GO:0006355 374 0.012
negative regulation of rna metabolic process GO:0051253 123 0.012
response to peptide GO:1901652 292 0.012
transmission of nerve impulse GO:0019226 42 0.012
Mouse
gamete generation GO:0007276 124 0.011
response to hydrogen peroxide GO:0042542 89 0.011
regulation of axon extension GO:0030516 24 0.011
regulation of kinase activity GO:0043549 117 0.011
reproductive system development GO:0061458 128 0.011
gtp catabolic process GO:0006184 71 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
regulation of nucleotide catabolic process GO:0030811 65 0.011
regulation of membrane potential GO:0042391 110 0.011
Human Mouse
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.011
mesoderm formation GO:0001707 1 0.011
protein maturation GO:0051604 68 0.011
mesoderm development GO:0007498 2 0.011
oxidation reduction process GO:0055114 304 0.011
regulation of cell migration GO:0030334 128 0.011
motor neuron axon guidance GO:0008045 1 0.011
regulation of cell growth GO:0001558 85 0.011
second messenger mediated signaling GO:0019932 51 0.011
female sex differentiation GO:0046660 59 0.011
negative regulation of cell communication GO:0010648 158 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
regulation of protein modification process GO:0031399 194 0.011
eye morphogenesis GO:0048592 4 0.011
cardiac muscle contraction GO:0060048 27 0.011
organ induction GO:0001759 1 0.011
cardiac ventricle development GO:0003231 1 0.011
cytoplasmic transport GO:0016482 115 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
regulation of proteolysis GO:0030162 66 0.010
positive regulation of synaptic vesicle exocytosis GO:2000302 3 0.010
anatomical structure homeostasis GO:0060249 29 0.010
single organism intracellular transport GO:1902582 166 0.010
regulation of protein complex assembly GO:0043254 33 0.010
regulation of cellular component size GO:0032535 51 0.010
lipid modification GO:0030258 52 0.010
negative regulation of transcription dna templated GO:0045892 116 0.010
sequestering of metal ion GO:0051238 9 0.010
gtp metabolic process GO:0046039 72 0.010
negative regulation of microtubule depolymerization GO:0007026 3 0.010
calcium ion import GO:0070509 22 0.010
negative regulation of innate immune response GO:0045824 4 0.010
intracellular transport GO:0046907 185 0.010
single organism cellular localization GO:1902580 102 0.010

Kcnma1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.047
disease of anatomical entity DOID:7 0 0.047
eye and adnexa disease DOID:1492 0 0.047
nervous system disease DOID:863 0 0.047
eye disease DOID:5614 0 0.047
retinal disease DOID:5679 0 0.028
retinal degeneration DOID:8466 0 0.016
substance dependence DOID:9973 0 0.013
substance related disorder DOID:303 0 0.013
disease of mental health DOID:150 0 0.013
disease of metabolism DOID:0014667 0 0.011
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010