Rattus norvegicus

0 known processes

Heph

hephaestin

Heph biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 292 0.093
single organism biosynthetic process GO:0044711 342 0.090
lipid metabolic process GO:0006629 283 0.084
biological adhesion GO:0022610 110 0.082
positive regulation of multicellular organismal process GO:0051240 387 0.077
carboxylic acid metabolic process GO:0019752 289 0.065
cellular lipid metabolic process GO:0044255 208 0.065
organophosphate metabolic process GO:0019637 370 0.065
regulation of molecular function GO:0065009 398 0.064
positive regulation of signaling GO:0023056 270 0.063
organonitrogen compound biosynthetic process GO:1901566 167 0.063
oxoacid metabolic process GO:0043436 290 0.062
apoptotic process GO:0006915 381 0.061
catabolic process GO:0009056 351 0.060
organ regeneration GO:0031100 101 0.060
regulation of catalytic activity GO:0050790 304 0.058
cellular amino acid metabolic process GO:0006520 107 0.057
positive regulation of cell communication GO:0010647 271 0.055
regulation of phosphorylation GO:0042325 248 0.052
intracellular signal transduction GO:0035556 314 0.050
g protein coupled receptor signaling pathway GO:0007186 242 0.050
positive regulation of developmental process GO:0051094 283 0.048
response to decreased oxygen levels GO:0036293 237 0.047
cation transport GO:0006812 382 0.046
Human
nucleobase containing small molecule metabolic process GO:0055086 316 0.046
positive regulation of biosynthetic process GO:0009891 319 0.045
transmembrane transport GO:0055085 412 0.045
single organism catabolic process GO:0044712 283 0.045
protein autophosphorylation GO:0046777 66 0.044
protein complex subunit organization GO:0071822 302 0.042
cellular component assembly GO:0022607 360 0.042
response to oxygen levels GO:0070482 265 0.042
regulation of phosphorus metabolic process GO:0051174 349 0.041
regulation of secretion GO:0051046 224 0.041
macromolecular complex subunit organization GO:0043933 339 0.040
regulation of cell proliferation GO:0042127 359 0.040
positive regulation of response to stimulus GO:0048584 285 0.040
regulation of signal transduction GO:0009966 318 0.039
positive regulation of transport GO:0051050 245 0.037
regulation of metal ion transport GO:0010959 118 0.037
regulation of phosphate metabolic process GO:0019220 349 0.037
programmed cell death GO:0012501 392 0.036
proteolysis GO:0006508 175 0.035
Rat
regulation of cellular amine metabolic process GO:0033238 8 0.035
positive regulation of cell proliferation GO:0008284 249 0.035
organic substance catabolic process GO:1901575 316 0.035
regulation of system process GO:0044057 208 0.035
regulation of multicellular organismal development GO:2000026 376 0.034
amine metabolic process GO:0009308 38 0.033
response to nutrient GO:0007584 248 0.033
Rat
cellular response to stress GO:0033554 269 0.032
response to inorganic substance GO:0010035 377 0.032
Rat
response to hypoxia GO:0001666 231 0.031
regulation of ion transport GO:0043269 245 0.031
regulation of cell differentiation GO:0045595 320 0.031
monovalent inorganic cation transport GO:0015672 172 0.030
response to peptide GO:1901652 292 0.029
cellular ketone metabolic process GO:0042180 51 0.029
regulation of immune system process GO:0002682 123 0.029
comma shaped body morphogenesis GO:0072049 2 0.029
homeostatic process GO:0042592 331 0.028
positive regulation of phosphorus metabolic process GO:0010562 262 0.028
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.028
negative regulation of programmed cell death GO:0043069 183 0.028
secretion by cell GO:0032940 248 0.028
chemical homeostasis GO:0048878 292 0.028
protein complex assembly GO:0006461 263 0.028
nucleoside phosphate metabolic process GO:0006753 283 0.028
oxidation reduction process GO:0055114 304 0.027
Human
cytoskeleton organization GO:0007010 111 0.027
regulation of secretion by cell GO:1903530 208 0.026
carbohydrate metabolic process GO:0005975 130 0.026
response to acid chemical GO:0001101 222 0.026
protein complex biogenesis GO:0070271 263 0.026
response to nutrient levels GO:0031667 370 0.026
Rat
positive regulation of cellular amine metabolic process GO:0033240 3 0.026
response to oxidative stress GO:0006979 186 0.026
positive regulation of cell differentiation GO:0045597 217 0.026
positive regulation of phosphate metabolic process GO:0045937 262 0.025
monocarboxylic acid metabolic process GO:0032787 152 0.025
metanephric s shaped body morphogenesis GO:0072284 2 0.025
purine containing compound metabolic process GO:0072521 253 0.025
response to metal ion GO:0010038 253 0.025
Rat
nitrogen compound transport GO:0071705 229 0.025
cellular component movement GO:0006928 248 0.025
immune response GO:0006955 104 0.025
response to toxic substance GO:0009636 133 0.025
central nervous system development GO:0007417 311 0.025
defense response GO:0006952 194 0.024
multicellular organism reproduction GO:0032504 233 0.024
positive regulation of signal transduction GO:0009967 175 0.024
metal ion transport GO:0030001 289 0.024
Human
cellular response to endogenous stimulus GO:0071495 377 0.024
cellular homeostasis GO:0019725 252 0.024
protein phosphorylation GO:0006468 345 0.024
regulation of membrane potential GO:0042391 110 0.023
growth GO:0040007 165 0.023
response to estrogen GO:0043627 232 0.023
cellular amine metabolic process GO:0044106 38 0.023
peptidyl tyrosine modification GO:0018212 72 0.023
response to insulin GO:0032868 133 0.023
regulation of cell development GO:0060284 263 0.023
regulation of apoptotic process GO:0042981 335 0.023
response to ketone GO:1901654 182 0.023
regulation of cellular component movement GO:0051270 150 0.022
organelle organization GO:0006996 266 0.022
negative regulation of apoptotic process GO:0043066 181 0.022
regeneration GO:0031099 163 0.022
neuron development GO:0048666 286 0.022
cation homeostasis GO:0055080 195 0.022
macromolecular complex assembly GO:0065003 273 0.022
rhythmic process GO:0048511 156 0.022
cellular catabolic process GO:0044248 295 0.022
endocytosis GO:0006897 84 0.022
actin cytoskeleton organization GO:0030036 73 0.022
regulation of neurogenesis GO:0050767 247 0.022
nucleotide metabolic process GO:0009117 279 0.022
secretion GO:0046903 307 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.021
synaptic transmission GO:0007268 235 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.021
cell cell signaling GO:0007267 335 0.021
cellular response to oxygen containing compound GO:1901701 386 0.021
cell projection organization GO:0030030 302 0.021
single organism organelle organization GO:1902589 180 0.021
actin filament based process GO:0030029 86 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
vesicle mediated transport GO:0016192 181 0.020
regulation of programmed cell death GO:0043067 341 0.020
cellular ion homeostasis GO:0006873 184 0.020
lymphoid progenitor cell differentiation GO:0002320 2 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
regulation of protein modification process GO:0031399 194 0.019
immune system process GO:0002376 204 0.019
circadian rhythm GO:0007623 88 0.019
positive regulation of molecular function GO:0044093 230 0.019
response to growth factor GO:0070848 189 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
regulation of hormone levels GO:0010817 187 0.019
cellular response to lipid GO:0071396 201 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
head development GO:0060322 247 0.018
carbohydrate derivative metabolic process GO:1901135 346 0.018
regulation of mapk cascade GO:0043408 116 0.018
action potential GO:0001508 54 0.018
inorganic ion transmembrane transport GO:0098660 229 0.018
positive regulation of erk1 and erk2 cascade GO:0070374 29 0.018
multi organism reproductive process GO:0044703 262 0.018
positive regulation of protein tyrosine kinase activity GO:0061098 2 0.018
cellular component biogenesis GO:0044085 368 0.017
reproduction GO:0000003 245 0.017
neuron differentiation GO:0030182 368 0.017
regulation of cellular protein metabolic process GO:0032268 267 0.017
cation transmembrane transport GO:0098655 263 0.017
regulation of kinase activity GO:0043549 117 0.017
macromolecule localization GO:0033036 252 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
carbohydrate derivative biosynthetic process GO:1901137 124 0.017
cellular metal ion homeostasis GO:0006875 172 0.017
negative regulation of cell death GO:0060548 229 0.017
reproductive process GO:0022414 372 0.017
tissue development GO:0009888 252 0.017
peptidyl amino acid modification GO:0018193 126 0.017
calcium ion homeostasis GO:0055074 162 0.017
blood circulation GO:0008015 183 0.017
response to peptide hormone GO:0043434 278 0.017
regulation of protein phosphorylation GO:0001932 183 0.016
positive regulation of protein phosphorylation GO:0001934 135 0.016
neurological system process GO:0050877 219 0.016
regulation of nervous system development GO:0051960 264 0.016
cellular cation homeostasis GO:0030003 180 0.016
response to monosaccharide GO:0034284 159 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
cardiovascular system development GO:0072358 134 0.016
potassium ion transport GO:0006813 97 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
positive regulation of protein modification process GO:0031401 142 0.015
single organism reproductive process GO:0044702 297 0.015
developmental growth GO:0048589 100 0.015
positive regulation of apoptotic process GO:0043065 154 0.015
negative regulation of developmental process GO:0051093 125 0.015
cytokine production GO:0001816 61 0.015
ion homeostasis GO:0050801 212 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
response to carbohydrate GO:0009743 183 0.015
locomotion GO:0040011 237 0.015
regulation of transferase activity GO:0051338 123 0.015
response to ethanol GO:0045471 162 0.015
positive regulation of secretion by cell GO:1903532 128 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
vasculogenesis GO:0001570 3 0.015
cellular chemical homeostasis GO:0055082 247 0.015
regulation of protein metabolic process GO:0051246 289 0.015
response to extracellular stimulus GO:0009991 380 0.015
Rat
positive regulation of endothelial cell migration GO:0010595 4 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
cell adhesion GO:0007155 110 0.015
nucleic acid templated transcription GO:0097659 379 0.014
regulation of response to external stimulus GO:0032101 106 0.014
regulation of cellular amino acid metabolic process GO:0006521 2 0.014
localization of cell GO:0051674 202 0.014
cellular response to hormone stimulus GO:0032870 247 0.014
positive regulation of nervous system development GO:0051962 178 0.014
response to alkaloid GO:0043279 132 0.014
cellular amide metabolic process GO:0043603 44 0.014
cytokine biosynthetic process GO:0042089 3 0.014
regulation of cellular component organization GO:0051128 368 0.014
regulation of response to stress GO:0080134 126 0.014
phospholipid metabolic process GO:0006644 61 0.014
protein oligomerization GO:0051259 191 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
sensory organ development GO:0007423 74 0.014
behavior GO:0007610 205 0.014
cellular response to abiotic stimulus GO:0071214 85 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
positive regulation of cell death GO:0010942 184 0.014
regulation of neuron projection development GO:0010975 161 0.014
cellular response to acid chemical GO:0071229 75 0.013
spindle organization GO:0007051 2 0.013
regulation of rna biosynthetic process GO:2001141 381 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
sensory perception GO:0007600 101 0.013
regulation of transcription dna templated GO:0006355 374 0.013
regulation of anatomical structure size GO:0090066 135 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
rho protein signal transduction GO:0007266 11 0.013
regulation of catabolic process GO:0009894 113 0.013
positive regulation of cellular component biogenesis GO:0044089 55 0.013
regulation of locomotion GO:0040012 148 0.013
metal ion homeostasis GO:0055065 186 0.013
amide transport GO:0042886 105 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.013
negative regulation of cell communication GO:0010648 158 0.013
organic hydroxy compound metabolic process GO:1901615 115 0.013
small molecule catabolic process GO:0044282 59 0.013
positive regulation of secretion GO:0051047 140 0.012
protein localization GO:0008104 191 0.012
cellular hormone metabolic process GO:0034754 49 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
negative regulation of transport GO:0051051 136 0.012
positive regulation of cell development GO:0010720 176 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
negative regulation of cellular metabolic process GO:0031324 281 0.012
ribose phosphate metabolic process GO:0019693 235 0.012
metanephric mesenchymal cell migration GO:0035789 2 0.012
response to glucose GO:0009749 136 0.012
regulation of erk1 and erk2 cascade GO:0070372 41 0.012
regulation of muscle system process GO:0090257 79 0.012
regulation of rna metabolic process GO:0051252 391 0.012
regulation of growth GO:0040008 105 0.012
single organism carbohydrate metabolic process GO:0044723 118 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.012
positive regulation of immune response GO:0050778 42 0.012
anatomical structure morphogenesis GO:0009653 298 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
spermatogenesis GO:0007283 99 0.012
ion transmembrane transport GO:0034220 365 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
positive regulation of immune system process GO:0002684 90 0.012
regulation of cytokine production GO:0001817 56 0.011
adult locomotory behavior GO:0008344 4 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
maintenance of location GO:0051235 17 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
protein heterooligomerization GO:0051291 89 0.011
response to wounding GO:0009611 254 0.011
Rat
regulation of cell projection organization GO:0031344 175 0.011
fatty acid metabolic process GO:0006631 99 0.011
innate immune response GO:0045087 35 0.011
sensory perception of pain GO:0019233 73 0.011
positive regulation of transferase activity GO:0051347 81 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
intracellular transport GO:0046907 185 0.011
divalent inorganic cation transport GO:0072511 134 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
regulation of blood circulation GO:1903522 110 0.011
protein maturation GO:0051604 68 0.011
sex differentiation GO:0007548 113 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
response to glucocorticoid GO:0051384 223 0.011
eye development GO:0001654 50 0.011
erk1 and erk2 cascade GO:0070371 48 0.011
positive regulation of cytokine production GO:0001819 42 0.011
purine containing compound catabolic process GO:0072523 138 0.011
coronary vasculature morphogenesis GO:0060977 3 0.011
muscle system process GO:0003012 115 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
regulation of neuron differentiation GO:0045664 208 0.011
hormone metabolic process GO:0042445 69 0.011
hematopoietic progenitor cell differentiation GO:0002244 2 0.011
protein processing GO:0016485 68 0.011
response to corticosteroid GO:0031960 235 0.011
positive regulation of ion transport GO:0043270 94 0.010
small molecule biosynthetic process GO:0044283 124 0.010
cellular potassium ion transport GO:0071804 72 0.010
transcription dna templated GO:0006351 377 0.010
synaptic growth at neuromuscular junction GO:0051124 1 0.010
circulatory system process GO:0003013 183 0.010
regulation of blood vessel size GO:0050880 89 0.010
synapse organization GO:0050808 46 0.010
positive regulation of transcription dna templated GO:0045893 197 0.010
nucleoside metabolic process GO:0009116 179 0.010
regulation of body fluid levels GO:0050878 90 0.010
Rat
ras protein signal transduction GO:0007265 29 0.010
brain development GO:0007420 247 0.010
rna biosynthetic process GO:0032774 380 0.010
ribonucleoside metabolic process GO:0009119 174 0.010
male gamete generation GO:0048232 99 0.010

Heph disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
sensory system disease DOID:0050155 0 0.023
retinal disease DOID:5679 0 0.011
retinal degeneration DOID:8466 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011