Rattus norvegicus

14 known processes

Evc

Ellis van Creveld syndrome homolog (human)

Evc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna metabolic process GO:0016070 406 0.123
regulation of rna biosynthetic process GO:2001141 381 0.116
transcription from rna polymerase ii promoter GO:0006366 252 0.099
cellular component biogenesis GO:0044085 368 0.097
transcription dna templated GO:0006351 377 0.096
regulation of rna metabolic process GO:0051252 391 0.091
nucleic acid templated transcription GO:0097659 379 0.090
positive regulation of biosynthetic process GO:0009891 319 0.083
programmed cell death GO:0012501 392 0.081
rna biosynthetic process GO:0032774 380 0.074
regulation of transcription dna templated GO:0006355 374 0.073
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.072
apoptotic process GO:0006915 381 0.070
regulation of phosphate metabolic process GO:0019220 349 0.066
regulation of nucleic acid templated transcription GO:1903506 380 0.062
positive regulation of cellular biosynthetic process GO:0031328 295 0.061
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.059
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.058
regulation of phosphorus metabolic process GO:0051174 349 0.058
intracellular signal transduction GO:0035556 314 0.057
regulation of mapk cascade GO:0043408 116 0.056
protein complex subunit organization GO:0071822 302 0.056
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.053
carboxylic acid metabolic process GO:0019752 289 0.052
macromolecular complex subunit organization GO:0043933 339 0.051
single organism catabolic process GO:0044712 283 0.048
regulation of molecular function GO:0065009 398 0.048
reproductive process GO:0022414 372 0.048
regulation of phosphorylation GO:0042325 248 0.048
positive regulation of rna metabolic process GO:0051254 203 0.046
regulation of apoptotic process GO:0042981 335 0.046
organic acid metabolic process GO:0006082 292 0.044
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.044
negative regulation of biosynthetic process GO:0009890 168 0.044
single organism reproductive process GO:0044702 297 0.044
positive regulation of phosphate metabolic process GO:0045937 262 0.043
positive regulation of phosphorus metabolic process GO:0010562 262 0.042
positive regulation of transcription dna templated GO:0045893 197 0.041
positive regulation of nucleic acid templated transcription GO:1903508 197 0.041
negative regulation of macromolecule metabolic process GO:0010605 260 0.041
cellular component assembly GO:0022607 360 0.041
organophosphate metabolic process GO:0019637 370 0.041
catabolic process GO:0009056 351 0.041
macromolecular complex assembly GO:0065003 273 0.040
regulation of programmed cell death GO:0043067 341 0.039
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.039
cellular response to oxygen containing compound GO:1901701 386 0.038
intracellular transport GO:0046907 185 0.038
protein complex assembly GO:0006461 263 0.038
regulation of signal transduction GO:0009966 318 0.038
tissue development GO:0009888 252 0.038
positive regulation of apoptotic process GO:0043065 154 0.037
response to acid chemical GO:0001101 222 0.037
positive regulation of gene expression GO:0010628 244 0.037
carbohydrate derivative metabolic process GO:1901135 346 0.037
protein phosphorylation GO:0006468 345 0.037
positive regulation of rna biosynthetic process GO:1902680 197 0.036
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.036
response to peptide GO:1901652 292 0.036
non canonical wnt signaling pathway GO:0035567 3 0.036
nucleoside phosphate metabolic process GO:0006753 283 0.036
negative regulation of cellular biosynthetic process GO:0031327 161 0.035
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.035
single organism biosynthetic process GO:0044711 342 0.034
ribose phosphate metabolic process GO:0019693 235 0.034
cellular ketone metabolic process GO:0042180 51 0.033
nucleobase containing small molecule metabolic process GO:0055086 316 0.033
oxoacid metabolic process GO:0043436 290 0.033
cellular amino acid metabolic process GO:0006520 107 0.033
nucleotide metabolic process GO:0009117 279 0.033
ribonucleotide metabolic process GO:0009259 231 0.032
positive regulation of cell death GO:0010942 184 0.032
positive regulation of mapk cascade GO:0043410 92 0.032
purine nucleotide metabolic process GO:0006163 229 0.032
regulation of intracellular signal transduction GO:1902531 218 0.032
neuron differentiation GO:0030182 368 0.032
chemical homeostasis GO:0048878 292 0.031
purine ribonucleotide metabolic process GO:0009150 227 0.031
organic substance catabolic process GO:1901575 316 0.031
g protein coupled receptor signaling pathway GO:0007186 242 0.031
multi organism reproductive process GO:0044703 262 0.031
positive regulation of cell proliferation GO:0008284 249 0.030
regulation of cellular component organization GO:0051128 368 0.030
protein complex biogenesis GO:0070271 263 0.030
response to inorganic substance GO:0010035 377 0.030
amine metabolic process GO:0009308 38 0.030
negative regulation of nucleic acid templated transcription GO:1903507 117 0.030
reproduction GO:0000003 245 0.030
cellular response to hormone stimulus GO:0032870 247 0.030
regulation of cellular amine metabolic process GO:0033238 8 0.030
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.030
regulation of multicellular organismal development GO:2000026 376 0.029
mapk cascade GO:0000165 140 0.029
regulation of cellular localization GO:0060341 263 0.029
cellular catabolic process GO:0044248 295 0.029
regulation of cellular ketone metabolic process GO:0010565 27 0.029
protein oligomerization GO:0051259 191 0.029
negative regulation of rna metabolic process GO:0051253 123 0.028
carboxylic acid biosynthetic process GO:0046394 83 0.028
negative regulation of gene expression GO:0010629 199 0.028
regulation of protein metabolic process GO:0051246 289 0.028
anatomical structure morphogenesis GO:0009653 298 0.028
regulation of cell differentiation GO:0045595 320 0.028
divalent inorganic cation homeostasis GO:0072507 165 0.027
negative regulation of metabolic process GO:0009892 331 0.027
positive regulation of cell communication GO:0010647 271 0.027
cellular response to stress GO:0033554 269 0.027
neurological system process GO:0050877 219 0.027
positive regulation of response to stimulus GO:0048584 285 0.026
central nervous system development GO:0007417 311 0.026
positive regulation of signal transduction GO:0009967 175 0.026
cellular response to nitrogen compound GO:1901699 210 0.026
regulation of cell proliferation GO:0042127 359 0.026
metal ion homeostasis GO:0055065 186 0.026
response to peptide hormone GO:0043434 278 0.026
purine containing compound metabolic process GO:0072521 253 0.026
cyclic nucleotide metabolic process GO:0009187 80 0.025
negative regulation of transcription dna templated GO:0045892 116 0.025
establishment of protein localization GO:0045184 141 0.025
organic cyclic compound catabolic process GO:1901361 175 0.025
cellular protein localization GO:0034613 122 0.025
establishment of tissue polarity GO:0007164 2 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.024
ras protein signal transduction GO:0007265 29 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
gland development GO:0048732 155 0.024
cellular amine metabolic process GO:0044106 38 0.024
transmembrane transport GO:0055085 412 0.024
cell cell signaling GO:0007267 335 0.024
regulation of cellular amino acid metabolic process GO:0006521 2 0.024
negative regulation of rna biosynthetic process GO:1902679 118 0.023
regulation of neuron differentiation GO:0045664 208 0.023
regulation of catalytic activity GO:0050790 304 0.023
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.023
heterocycle catabolic process GO:0046700 167 0.023
inflammatory response GO:0006954 150 0.023
protein homooligomerization GO:0051260 91 0.023
positive regulation of molecular function GO:0044093 230 0.023
homeostatic process GO:0042592 331 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
positive regulation of phosphorylation GO:0042327 177 0.023
carbohydrate derivative biosynthetic process GO:1901137 124 0.023
positive regulation of programmed cell death GO:0043068 157 0.022
positive regulation of protein phosphorylation GO:0001934 135 0.022
positive regulation of signaling GO:0023056 270 0.022
cellular component movement GO:0006928 248 0.022
cell adhesion GO:0007155 110 0.022
organophosphate catabolic process GO:0046434 148 0.022
positive regulation of protein modification process GO:0031401 142 0.022
cellular lipid metabolic process GO:0044255 208 0.021
positive regulation of cellular component organization GO:0051130 200 0.021
calcium ion homeostasis GO:0055074 162 0.021
cellular homeostasis GO:0019725 252 0.021
cation transport GO:0006812 382 0.021
positive regulation of protein metabolic process GO:0051247 178 0.021
ribose phosphate biosynthetic process GO:0046390 87 0.021
regulation of response to stress GO:0080134 126 0.021
regulation of cell development GO:0060284 263 0.021
oxidation reduction process GO:0055114 304 0.021
cellular response to lipid GO:0071396 201 0.021
macromolecule localization GO:0033036 252 0.021
negative regulation of cellular metabolic process GO:0031324 281 0.020
regulation of nervous system development GO:0051960 264 0.020
cellular chemical homeostasis GO:0055082 247 0.020
multicellular organism reproduction GO:0032504 233 0.020
ribonucleotide biosynthetic process GO:0009260 85 0.020
regulation of membrane potential GO:0042391 110 0.020
organophosphate biosynthetic process GO:0090407 143 0.020
regulation of system process GO:0044057 208 0.020
regulation of neurogenesis GO:0050767 247 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
protein localization GO:0008104 191 0.020
gastrulation GO:0007369 2 0.020
aromatic compound catabolic process GO:0019439 168 0.020
cation homeostasis GO:0055080 195 0.020
multicellular organismal reproductive process GO:0048609 233 0.019
positive regulation of multicellular organismal process GO:0051240 387 0.019
response to nutrient levels GO:0031667 370 0.019
response to carbohydrate GO:0009743 183 0.019
response to glucose GO:0009749 136 0.019
response to oxygen levels GO:0070482 265 0.019
cation transmembrane transport GO:0098655 263 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
wound healing GO:0042060 122 0.019
neuron development GO:0048666 286 0.018
response to nutrient GO:0007584 248 0.018
single organism intracellular transport GO:1902582 166 0.018
regulation of establishment of planar polarity GO:0090175 2 0.018
anatomical structure formation involved in morphogenesis GO:0048646 83 0.018
cytosolic calcium ion homeostasis GO:0051480 140 0.018
synaptic transmission GO:0007268 235 0.018
positive regulation of developmental process GO:0051094 283 0.018
regulation of purine nucleotide metabolic process GO:1900542 115 0.018
response to radiation GO:0009314 137 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
neuron projection development GO:0031175 273 0.018
regulation of body fluid levels GO:0050878 90 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
response to hexose GO:0009746 144 0.018
regeneration GO:0031099 163 0.017
purine nucleoside catabolic process GO:0006152 124 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
response to wounding GO:0009611 254 0.017
embryonic skeletal system development GO:0048706 3 0.017
cell migration GO:0016477 197 0.017
cellular divalent inorganic cation homeostasis GO:0072503 162 0.017
cellular response to organonitrogen compound GO:0071417 197 0.017
organelle organization GO:0006996 266 0.017
positive regulation of protein kinase activity GO:0045860 73 0.017
positive regulation of intracellular signal transduction GO:1902533 138 0.017
signal transduction by phosphorylation GO:0023014 144 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.017
female pregnancy GO:0007565 122 0.017
regulation of protein modification process GO:0031399 194 0.017
regulation of kinase activity GO:0043549 117 0.017
ion transmembrane transport GO:0034220 365 0.017
sensory perception GO:0007600 101 0.016
limb morphogenesis GO:0035108 4 0.016
forebrain development GO:0030900 98 0.016
response to extracellular stimulus GO:0009991 380 0.016
carbohydrate metabolic process GO:0005975 130 0.016
cellular response to peptide GO:1901653 133 0.016
positive regulation of kinase activity GO:0033674 77 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
anion transport GO:0006820 178 0.016
regulation of nucleotide metabolic process GO:0006140 117 0.016
cellular response to endogenous stimulus GO:0071495 377 0.016
purine containing compound biosynthetic process GO:0072522 85 0.016
purine ribonucleotide biosynthetic process GO:0009152 81 0.016
nucleoside phosphate biosynthetic process GO:1901293 102 0.016
lipid metabolic process GO:0006629 283 0.016
organic anion transport GO:0015711 132 0.016
response to corticosteroid GO:0031960 235 0.016
cellular macromolecule localization GO:0070727 122 0.016
response to growth factor GO:0070848 189 0.016
ion homeostasis GO:0050801 212 0.016
cell projection organization GO:0030030 302 0.016
brain development GO:0007420 247 0.015
single organism carbohydrate metabolic process GO:0044723 118 0.015
biological adhesion GO:0022610 110 0.015
head development GO:0060322 247 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
purine ribonucleoside catabolic process GO:0046130 124 0.015
nucleotide catabolic process GO:0009166 139 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
secretion by cell GO:0032940 248 0.015
ribonucleoside triphosphate catabolic process GO:0009203 122 0.015
response to estrogen GO:0043627 232 0.015
actin filament based process GO:0030029 86 0.015
cellular cation homeostasis GO:0030003 180 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
positive regulation of transport GO:0051050 245 0.015
nucleoside phosphate catabolic process GO:1901292 140 0.015
regulation of hormone levels GO:0010817 187 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
regulation of catabolic process GO:0009894 113 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
appendage morphogenesis GO:0035107 4 0.015
response to ketone GO:1901654 182 0.014
peptidyl amino acid modification GO:0018193 126 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
vesicle mediated transport GO:0016192 181 0.014
cyclic purine nucleotide metabolic process GO:0052652 62 0.014
nucleoside triphosphate catabolic process GO:0009143 123 0.014
positive regulation of cell development GO:0010720 176 0.014
purine nucleoside triphosphate catabolic process GO:0009146 122 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
proteolysis GO:0006508 175 0.014
purine nucleoside triphosphate metabolic process GO:0009144 141 0.014
single organism cellular localization GO:1902580 102 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.014
chromosome segregation GO:0007059 2 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
circulatory system development GO:0072359 134 0.014
ossification GO:0001503 70 0.014
epithelium development GO:0060429 96 0.014
response to glucocorticoid GO:0051384 223 0.014
cellular nitrogen compound catabolic process GO:0044270 163 0.014
mesoderm development GO:0007498 2 0.014
liver development GO:0001889 90 0.014
ribonucleoside catabolic process GO:0042454 126 0.014
developmental growth GO:0048589 100 0.014
response to organophosphorus GO:0046683 102 0.014
negative regulation of transport GO:0051051 136 0.014
regulation of protein localization GO:0032880 81 0.014
anterior posterior pattern specification GO:0009952 1 0.014
response to estradiol GO:0032355 164 0.014
carbohydrate derivative catabolic process GO:1901136 147 0.014
muscle cell proliferation GO:0033002 84 0.014
purine nucleotide biosynthetic process GO:0006164 83 0.013
regulation of neuron projection development GO:0010975 161 0.013
cell type specific apoptotic process GO:0097285 134 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
regulation of transferase activity GO:0051338 123 0.013
muscle structure development GO:0061061 87 0.013
heart morphogenesis GO:0003007 3 0.013
sexual reproduction GO:0019953 148 0.013
developmental process involved in reproduction GO:0003006 159 0.013
single organism organelle organization GO:1902589 180 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
multicellular organism growth GO:0035264 1 0.013
negative regulation of programmed cell death GO:0043069 183 0.013
regulation of response to external stimulus GO:0032101 106 0.013
purine nucleotide catabolic process GO:0006195 136 0.013
organic acid transport GO:0015849 116 0.013
positive regulation of transferase activity GO:0051347 81 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
axis specification GO:0009798 4 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
protein homotrimerization GO:0070207 15 0.013
response to monosaccharide GO:0034284 159 0.013
positive regulation of nervous system development GO:0051962 178 0.013
gamete generation GO:0007276 124 0.013
regulation of synaptic transmission GO:0050804 141 0.013
cyclic nucleotide biosynthetic process GO:0009190 63 0.013
regulation of metal ion transport GO:0010959 118 0.013
regulation of secretion GO:0051046 224 0.013
response to alkaloid GO:0043279 132 0.013
nucleoside metabolic process GO:0009116 179 0.013
regulation of cell adhesion GO:0030155 52 0.013
regulation of protein kinase activity GO:0045859 105 0.013
camp biosynthetic process GO:0006171 47 0.013
positive regulation of cell projection organization GO:0031346 111 0.013
response to vitamin GO:0033273 131 0.012
regulation of protein transport GO:0051223 68 0.012
response to decreased oxygen levels GO:0036293 237 0.012
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.012
intracellular protein transport GO:0006886 79 0.012
negative regulation of signaling GO:0023057 157 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
small molecule biosynthetic process GO:0044283 124 0.012
cellular component morphogenesis GO:0032989 155 0.012
regulation of cytoskeleton organization GO:0051493 49 0.012
epithelial cell differentiation GO:0030855 71 0.012
regulation of cellular response to stress GO:0080135 49 0.012
protein transport GO:0015031 132 0.012
olfactory behavior GO:0042048 2 0.012
regulation of stem cell differentiation GO:2000736 2 0.012
lipid storage GO:0019915 1 0.012
response to increased oxygen levels GO:0036296 45 0.012
localization of cell GO:0051674 202 0.012
regulation of cellular catabolic process GO:0031329 101 0.012
response to retinoic acid GO:0032526 63 0.012
organic acid biosynthetic process GO:0016053 83 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
regulation of anatomical structure size GO:0090066 135 0.012
inorganic cation transmembrane transport GO:0098662 202 0.012
maintenance of location GO:0051235 17 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
response to ethanol GO:0045471 162 0.012
positive regulation of cellular catabolic process GO:0031331 71 0.012
peptide transport GO:0015833 97 0.012
defense response GO:0006952 194 0.012
aging GO:0007568 241 0.012
cellular ion homeostasis GO:0006873 184 0.012
negative regulation of cell communication GO:0010648 158 0.012
regulation of secretion by cell GO:1903530 208 0.012
response to purine containing compound GO:0014074 126 0.012
linoleic acid metabolic process GO:0043651 4 0.012
cytoplasmic transport GO:0016482 115 0.011
glucose homeostasis GO:0042593 75 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
regulation of cell projection organization GO:0031344 175 0.011
locomotion GO:0040011 237 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
establishment of planar polarity GO:0001736 1 0.011
immune system process GO:0002376 204 0.011
tube development GO:0035295 89 0.011
positive regulation of cellular component biogenesis GO:0044089 55 0.011
eye morphogenesis GO:0048592 4 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
cytoskeleton organization GO:0007010 111 0.011
nucleoside catabolic process GO:0009164 126 0.011
regulation of growth GO:0040008 105 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
blood circulation GO:0008015 183 0.011
pallium development GO:0021543 42 0.011
regulation of blood circulation GO:1903522 110 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
negative regulation of molecular function GO:0044092 133 0.011
cell motility GO:0048870 202 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
carboxylic acid transport GO:0046942 115 0.011
embryonic appendage morphogenesis GO:0035113 4 0.011
regulation of anatomical structure morphogenesis GO:0022603 141 0.011
response to hypoxia GO:0001666 231 0.011
response to reactive oxygen species GO:0000302 120 0.011
positive regulation of secretion GO:0051047 140 0.011
cell fate determination GO:0001709 2 0.011
cardiovascular system development GO:0072358 134 0.011
response to temperature stimulus GO:0009266 94 0.011
rho protein signal transduction GO:0007266 11 0.011
spermatogenesis GO:0007283 99 0.011
cellular carbohydrate metabolic process GO:0044262 72 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
carbohydrate homeostasis GO:0033500 75 0.011
stress activated protein kinase signaling cascade GO:0031098 37 0.011
morphogenesis of a polarized epithelium GO:0001738 1 0.011
response to mechanical stimulus GO:0009612 134 0.011
chemosensory behavior GO:0007635 2 0.011
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.010
negative regulation of developmental process GO:0051093 125 0.010
secretion GO:0046903 307 0.010
multi multicellular organism process GO:0044706 138 0.010
cellular response to alcohol GO:0097306 87 0.010
circulatory system process GO:0003013 183 0.010
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.010
amide transport GO:0042886 105 0.010
inorganic ion transmembrane transport GO:0098660 229 0.010
regulation of establishment of protein localization GO:0070201 69 0.010
organ regeneration GO:0031100 101 0.010
enzyme linked receptor protein signaling pathway GO:0007167 116 0.010
male gamete generation GO:0048232 99 0.010
smooth muscle cell proliferation GO:0048659 77 0.010
positive regulation of catabolic process GO:0009896 78 0.010
jnk cascade GO:0007254 28 0.010
behavior GO:0007610 205 0.010
positive regulation of secretion by cell GO:1903532 128 0.010
muscle tissue development GO:0060537 58 0.010
regulation of cellular protein metabolic process GO:0032268 267 0.010
cellular response to organic cyclic compound GO:0071407 202 0.010
regulation of fat cell differentiation GO:0045598 3 0.010

Evc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
nervous system disease DOID:863 0 0.034
musculoskeletal system disease DOID:17 0 0.023
sensory system disease DOID:0050155 0 0.018
bone disease DOID:0080001 0 0.017
connective tissue disease DOID:65 0 0.017
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.011
muscular disease DOID:0080000 0 0.010
muscle tissue disease DOID:66 0 0.010