Rattus norvegicus

18 known processes

Angptl4

angiopoietin-like 4

Angptl4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxoacid metabolic process GO:0043436 290 0.191
carboxylic acid metabolic process GO:0019752 289 0.186
cellular lipid metabolic process GO:0044255 208 0.182
lipid metabolic process GO:0006629 283 0.179
single organism reproductive process GO:0044702 297 0.158
Rat
cellular lipid catabolic process GO:0044242 37 0.127
macromolecular complex subunit organization GO:0043933 339 0.119
reproductive process GO:0022414 372 0.119
Rat
organic acid transport GO:0015849 116 0.114
cellular component assembly GO:0022607 360 0.111
monocarboxylic acid metabolic process GO:0032787 152 0.109
coenzyme metabolic process GO:0006732 86 0.108
developmental process involved in reproduction GO:0003006 159 0.106
Rat
cardiovascular system development GO:0072358 134 0.103
Rat
organic acid metabolic process GO:0006082 292 0.103
protein complex assembly GO:0006461 263 0.101
organic anion transport GO:0015711 132 0.095
response to extracellular stimulus GO:0009991 380 0.093
organic substance catabolic process GO:1901575 316 0.091
regulation of phosphorus metabolic process GO:0051174 349 0.090
regulation of programmed cell death GO:0043067 341 0.089
Human Mouse
positive regulation of phosphorus metabolic process GO:0010562 262 0.089
positive regulation of lipid catabolic process GO:0050996 4 0.089
positive regulation of response to stimulus GO:0048584 285 0.083
protein complex biogenesis GO:0070271 263 0.083
protein oligomerization GO:0051259 191 0.081
single organism catabolic process GO:0044712 283 0.080
protein homooligomerization GO:0051260 91 0.075
cellular component biogenesis GO:0044085 368 0.074
reproduction GO:0000003 245 0.073
Rat
regulation of phosphate metabolic process GO:0019220 349 0.073
cellular response to lipid GO:0071396 201 0.072
macromolecular complex assembly GO:0065003 273 0.072
small molecule catabolic process GO:0044282 59 0.067
carbohydrate metabolic process GO:0005975 130 0.066
cellular catabolic process GO:0044248 295 0.064
single organism biosynthetic process GO:0044711 342 0.064
cellular response to oxygen containing compound GO:1901701 386 0.063
regulation of multicellular organismal development GO:2000026 376 0.063
Rat
transcription dna templated GO:0006351 377 0.063
protein complex subunit organization GO:0071822 302 0.062
single organism carbohydrate metabolic process GO:0044723 118 0.062
organophosphate metabolic process GO:0019637 370 0.060
carboxylic acid catabolic process GO:0046395 49 0.060
regulation of hydrolase activity GO:0051336 143 0.060
Human Mouse
anatomical structure morphogenesis GO:0009653 298 0.059
Rat
cellular ketone metabolic process GO:0042180 51 0.058
negative regulation of metabolic process GO:0009892 331 0.058
Human Mouse
response to inorganic substance GO:0010035 377 0.058
multicellular organism reproduction GO:0032504 233 0.058
Rat
urogenital system development GO:0001655 78 0.056
Rat
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.056
carboxylic acid transport GO:0046942 115 0.055
regulation of cell differentiation GO:0045595 320 0.055
multi organism reproductive process GO:0044703 262 0.055
Rat
nitrogen compound transport GO:0071705 229 0.055
positive regulation of cell differentiation GO:0045597 217 0.054
nucleic acid templated transcription GO:0097659 379 0.053
regulation of signal transduction GO:0009966 318 0.053
regulation of nervous system development GO:0051960 264 0.052
regulation of molecular function GO:0065009 398 0.051
Human Mouse
fatty acid metabolic process GO:0006631 99 0.051
lipid biosynthetic process GO:0008610 128 0.051
reproductive structure development GO:0048608 128 0.050
neuron differentiation GO:0030182 368 0.050
circulatory system development GO:0072359 134 0.050
Rat
intracellular signal transduction GO:0035556 314 0.049
regulation of transcription dna templated GO:0006355 374 0.049
locomotion GO:0040011 237 0.049
regulation of apoptotic process GO:0042981 335 0.048
Human Mouse
catabolic process GO:0009056 351 0.047
apoptotic process GO:0006915 381 0.047
Human Mouse
regulation of catalytic activity GO:0050790 304 0.046
Human Mouse
rna metabolic process GO:0016070 406 0.046
positive regulation of nervous system development GO:0051962 178 0.045
development of primary sexual characteristics GO:0045137 107 0.045
regulation of lipid metabolic process GO:0019216 68 0.044
chemical homeostasis GO:0048878 292 0.044
Mouse
cofactor metabolic process GO:0051186 95 0.044
reproductive system development GO:0061458 128 0.043
sex differentiation GO:0007548 113 0.042
response to fatty acid GO:0070542 65 0.042
regulation of rna biosynthetic process GO:2001141 381 0.042
positive regulation of multicellular organismal process GO:0051240 387 0.042
Rat
regulation of anatomical structure morphogenesis GO:0022603 141 0.042
Rat
sulfur compound metabolic process GO:0006790 70 0.041
positive regulation of cellular component organization GO:0051130 200 0.041
regulation of cellular ketone metabolic process GO:0010565 27 0.041
nucleotide metabolic process GO:0009117 279 0.040
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.040
cell cell signaling GO:0007267 335 0.039
negative regulation of macromolecule metabolic process GO:0010605 260 0.039
regulation of cell development GO:0060284 263 0.039
hexose metabolic process GO:0019318 58 0.038
positive regulation of hydrolase activity GO:0051345 86 0.038
regulation of cell migration GO:0030334 128 0.038
homeostatic process GO:0042592 331 0.038
Mouse
growth GO:0040007 165 0.037
long chain fatty acid metabolic process GO:0001676 32 0.037
response to acid chemical GO:0001101 222 0.037
negative regulation of cellular metabolic process GO:0031324 281 0.037
anion transport GO:0006820 178 0.037
regulation of protein metabolic process GO:0051246 289 0.036
cell migration GO:0016477 197 0.036
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.036
localization of cell GO:0051674 202 0.036
monocarboxylic acid transport GO:0015718 52 0.036
cation transport GO:0006812 382 0.035
response to biotic stimulus GO:0009607 226 0.035
nucleobase containing small molecule metabolic process GO:0055086 316 0.035
secretion GO:0046903 307 0.035
response to decreased oxygen levels GO:0036293 237 0.035
female gonad development GO:0008585 53 0.035
regulation of cellular protein metabolic process GO:0032268 267 0.035
glycerolipid metabolic process GO:0046486 67 0.034
gonad development GO:0008406 104 0.034
central nervous system development GO:0007417 311 0.034
lipid catabolic process GO:0016042 46 0.033
carbohydrate derivative metabolic process GO:1901135 346 0.033
programmed cell death GO:0012501 392 0.033
Human Mouse
signal release GO:0023061 145 0.033
purine containing compound metabolic process GO:0072521 253 0.032
acetate ester biosynthetic process GO:1900620 2 0.032
behavior GO:0007610 205 0.032
multicellular organismal reproductive process GO:0048609 233 0.032
Rat
response to oxygen levels GO:0070482 265 0.032
cell motility GO:0048870 202 0.032
regulation of cell proliferation GO:0042127 359 0.031
organic acid catabolic process GO:0016054 49 0.031
regulation of protein modification process GO:0031399 194 0.031
regulation of cellular localization GO:0060341 263 0.031
secretion by cell GO:0032940 248 0.031
regulation of cell projection organization GO:0031344 175 0.030
positive regulation of cell development GO:0010720 176 0.030
positive regulation of protein metabolic process GO:0051247 178 0.030
response to peptide hormone GO:0043434 278 0.030
rhythmic process GO:0048511 156 0.030
negative regulation of cell death GO:0060548 229 0.030
Human Mouse
regulation of neurogenesis GO:0050767 247 0.030
positive regulation of catalytic activity GO:0043085 184 0.030
regulation of cellular amino acid metabolic process GO:0006521 2 0.030
cellular response to hormone stimulus GO:0032870 247 0.029
response to peptide GO:1901652 292 0.029
kidney development GO:0001822 67 0.029
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.029
neuron projection development GO:0031175 273 0.029
positive regulation of phosphate metabolic process GO:0045937 262 0.029
response to nutrient levels GO:0031667 370 0.028
response to nutrient GO:0007584 248 0.028
response to ethanol GO:0045471 162 0.028
regulation of locomotion GO:0040012 148 0.028
positive regulation of programmed cell death GO:0043068 157 0.028
nucleoside phosphate metabolic process GO:0006753 283 0.028
peptide secretion GO:0002790 86 0.028
cellular component movement GO:0006928 248 0.027
regulation of rna metabolic process GO:0051252 391 0.027
cellular amine metabolic process GO:0044106 38 0.027
amide transport GO:0042886 105 0.027
negative regulation of cell differentiation GO:0045596 99 0.027
regulation of protein phosphorylation GO:0001932 183 0.026
head development GO:0060322 247 0.026
tissue development GO:0009888 252 0.026
positive regulation of cellular component movement GO:0051272 102 0.026
negative regulation of response to stimulus GO:0048585 155 0.026
protein phosphorylation GO:0006468 345 0.025
regulation of catabolic process GO:0009894 113 0.025
regulation of response to stress GO:0080134 126 0.025
negative regulation of cellular biosynthetic process GO:0031327 161 0.025
cell projection organization GO:0030030 302 0.025
purine nucleotide metabolic process GO:0006163 229 0.025
cellular response to acid chemical GO:0071229 75 0.025
positive regulation of locomotion GO:0040017 102 0.025
positive regulation of signal transduction GO:0009967 175 0.025
defense response GO:0006952 194 0.025
small molecule biosynthetic process GO:0044283 124 0.025
reactive oxygen species metabolic process GO:0072593 37 0.024
positive regulation of cell motility GO:2000147 97 0.024
acylglycerol metabolic process GO:0006639 21 0.024
response to radiation GO:0009314 137 0.024
Rat
intracellular transport GO:0046907 185 0.024
response to cytokine GO:0034097 215 0.024
neuron development GO:0048666 286 0.024
positive regulation of molecular function GO:0044093 230 0.023
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.023
ribonucleotide metabolic process GO:0009259 231 0.023
response to hypoxia GO:0001666 231 0.023
positive regulation of intracellular signal transduction GO:1902533 138 0.023
positive regulation of cellular catabolic process GO:0031331 71 0.023
regulation of neuron differentiation GO:0045664 208 0.023
negative regulation of developmental process GO:0051093 125 0.023
enzyme linked receptor protein signaling pathway GO:0007167 116 0.022
regulation of cellular component organization GO:0051128 368 0.022
positive regulation of developmental process GO:0051094 283 0.022
Rat
single organism behavior GO:0044708 130 0.022
positive regulation of rna biosynthetic process GO:1902680 197 0.022
lipid localization GO:0010876 62 0.022
biological adhesion GO:0022610 110 0.022
ribonucleoside metabolic process GO:0009119 174 0.022
positive regulation of fatty acid beta oxidation GO:0032000 4 0.022
regulation of fatty acid metabolic process GO:0019217 18 0.021
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
positive regulation of cell communication GO:0010647 271 0.021
cellular response to endogenous stimulus GO:0071495 377 0.021
positive regulation of cell death GO:0010942 184 0.021
positive regulation of neuron projection development GO:0010976 99 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
response to estrogen GO:0043627 232 0.020
cellular response to organonitrogen compound GO:0071417 197 0.020
sexual reproduction GO:0019953 148 0.020
Rat
cell adhesion GO:0007155 110 0.020
learning or memory GO:0007611 90 0.020
response to other organism GO:0051707 220 0.020
cellular response to biotic stimulus GO:0071216 59 0.020
response to carbohydrate GO:0009743 183 0.020
Rat
single organism intracellular transport GO:1902582 166 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
response to metal ion GO:0010038 253 0.019
heart morphogenesis GO:0003007 3 0.019
response to wounding GO:0009611 254 0.019
positive regulation of apoptotic process GO:0043065 154 0.019
regulation of cellular component movement GO:0051270 150 0.019
positive regulation of gene expression GO:0010628 244 0.019
organ regeneration GO:0031100 101 0.019
Rat
female sex differentiation GO:0046660 59 0.019
fatty acid beta oxidation GO:0006635 22 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
positive regulation of neurogenesis GO:0050769 165 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
Human Mouse
regulation of response to external stimulus GO:0032101 106 0.018
epithelial cell differentiation GO:0030855 71 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
amine metabolic process GO:0009308 38 0.018
organelle organization GO:0006996 266 0.018
epithelium development GO:0060429 96 0.018
regulation of cellular catabolic process GO:0031329 101 0.018
positive regulation of catabolic process GO:0009896 78 0.018
heterocycle catabolic process GO:0046700 167 0.018
rna biosynthetic process GO:0032774 380 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.018
peptide transport GO:0015833 97 0.018
brain development GO:0007420 247 0.018
cellular response to molecule of bacterial origin GO:0071219 56 0.018
response to external biotic stimulus GO:0043207 221 0.018
cellular component morphogenesis GO:0032989 155 0.017
positive regulation of cell proliferation GO:0008284 249 0.017
axis specification GO:0009798 4 0.017
negative regulation of biosynthetic process GO:0009890 168 0.017
inflammatory response GO:0006954 150 0.017
triglyceride metabolic process GO:0006641 21 0.017
organonitrogen compound biosynthetic process GO:1901566 167 0.017
positive regulation of signaling GO:0023056 270 0.017
response to monosaccharide GO:0034284 159 0.017
Rat
hepaticobiliary system development GO:0061008 90 0.017
glucose metabolic process GO:0006006 52 0.017
ovulation cycle process GO:0022602 50 0.017
peptidyl tyrosine modification GO:0018212 72 0.017
vasculature development GO:0001944 70 0.017
Rat
gland development GO:0048732 155 0.016
regulation of gtpase activity GO:0043087 57 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
fatty acid catabolic process GO:0009062 26 0.016
oxidation reduction process GO:0055114 304 0.016
positive regulation of neuron differentiation GO:0045666 126 0.016
positive regulation of cellular protein metabolic process GO:0032270 167 0.016
negative regulation of cellular component organization GO:0051129 83 0.016
regulation of phosphorylation GO:0042325 248 0.016
gamete generation GO:0007276 124 0.016
Rat
alcohol metabolic process GO:0006066 77 0.016
blood circulation GO:0008015 183 0.016
proteolysis GO:0006508 175 0.016
purine ribonucleoside metabolic process GO:0046128 168 0.016
neurological system process GO:0050877 219 0.016
metal ion homeostasis GO:0055065 186 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
regulation of immune system process GO:0002682 123 0.016
antral ovarian follicle growth GO:0001547 3 0.016
negative regulation of cell communication GO:0010648 158 0.016
cellular homeostasis GO:0019725 252 0.016
positive regulation of rna metabolic process GO:0051254 203 0.015
spermatogenesis GO:0007283 99 0.015
response to lipopolysaccharide GO:0032496 191 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
tube development GO:0035295 89 0.015
gliogenesis GO:0042063 93 0.015
regulation of neuron projection development GO:0010975 161 0.015
cellular chemical homeostasis GO:0055082 247 0.015
regulation of peptide transport GO:0090087 87 0.015
regulation of hormone levels GO:0010817 187 0.015
gastrulation GO:0007369 2 0.015
ras protein signal transduction GO:0007265 29 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
male gonad development GO:0008584 59 0.015
negative regulation of multicellular organismal process GO:0051241 203 0.015
negative regulation of signaling GO:0023057 157 0.015
blood vessel development GO:0001568 69 0.015
Rat
multicellular organism growth GO:0035264 1 0.015
peptide hormone secretion GO:0030072 84 0.015
regeneration GO:0031099 163 0.015
Rat
small gtpase mediated signal transduction GO:0007264 36 0.015
positive regulation of transport GO:0051050 245 0.014
positive regulation of cell migration GO:0030335 96 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
regulation of reactive oxygen species metabolic process GO:2000377 26 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
regulation of response to wounding GO:1903034 69 0.014
regulation of secretion GO:0051046 224 0.014
glycosyl compound catabolic process GO:1901658 126 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
cognition GO:0050890 92 0.014
organic acid biosynthetic process GO:0016053 83 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
t cell chemotaxis GO:0010818 2 0.014
regulation of purine nucleotide metabolic process GO:1900542 115 0.014
response to glucocorticoid GO:0051384 223 0.014
cellular response to glucocorticoid stimulus GO:0071385 68 0.014
necroptotic process GO:0070266 2 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
male gamete generation GO:0048232 99 0.014
peptidyl amino acid modification GO:0018193 126 0.013
cellular response to steroid hormone stimulus GO:0071383 93 0.013
negative regulation of neuron differentiation GO:0045665 62 0.013
cellular response to cytokine stimulus GO:0071345 127 0.013
renal system development GO:0072001 67 0.013
Rat
response to insulin GO:0032868 133 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
organophosphate catabolic process GO:0046434 148 0.013
protein localization GO:0008104 191 0.013
muscle cell proliferation GO:0033002 84 0.013
negative regulation of transcription dna templated GO:0045892 116 0.013
steroid metabolic process GO:0008202 73 0.013
cytokine production GO:0001816 61 0.013
cellular response to external stimulus GO:0071496 118 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
purine nucleoside metabolic process GO:0042278 169 0.013
peptidyl tyrosine phosphorylation GO:0018108 72 0.013
cation transmembrane transport GO:0098655 263 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
positive regulation of protein modification process GO:0031401 142 0.013
response to growth factor GO:0070848 189 0.013
Rat
lung development GO:0030324 43 0.013
ion transmembrane transport GO:0034220 365 0.012
lipid transport GO:0006869 61 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
response to purine containing compound GO:0014074 126 0.012
cellular response to lipopolysaccharide GO:0071222 55 0.012
purine ribonucleotide catabolic process GO:0009154 136 0.012
developmental growth GO:0048589 100 0.012
hormone transport GO:0009914 121 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
response to corticosteroid GO:0031960 235 0.012
regulation of defense response GO:0031347 68 0.012
regulation of secretion by cell GO:1903530 208 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
regulation of mapk cascade GO:0043408 116 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.012
response to interleukin 13 GO:0035962 3 0.012
negative regulation of gene expression GO:0010629 199 0.012
cytokine biosynthetic process GO:0042089 3 0.012
limb morphogenesis GO:0035108 4 0.012
organic hydroxy compound metabolic process GO:1901615 115 0.012
positive regulation of biosynthetic process GO:0009891 319 0.012
purine containing compound catabolic process GO:0072523 138 0.012
female pregnancy GO:0007565 122 0.012
Rat
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
regulation of endothelial cell apoptotic process GO:2000351 3 0.012
Mouse
immune effector process GO:0002252 53 0.012
immune system process GO:0002376 204 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
leukocyte activation GO:0045321 76 0.012
cellular response to stress GO:0033554 269 0.012
negative regulation of transport GO:0051051 136 0.012
carbohydrate derivative catabolic process GO:1901136 147 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
multicellular organismal signaling GO:0035637 44 0.011
ovarian follicle development GO:0001541 31 0.011
t cell migration GO:0072678 2 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
organ morphogenesis GO:0009887 75 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
response to ketone GO:1901654 182 0.011
cellular amino acid metabolic process GO:0006520 107 0.011
response to bacterium GO:0009617 200 0.011
neurotransmitter biosynthetic process GO:0042136 2 0.011
transcription from rna polymerase ii promoter GO:0006366 252 0.011
salivary gland morphogenesis GO:0007435 1 0.011
regulation of peptide hormone secretion GO:0090276 80 0.011
salivary gland development GO:0007431 3 0.011
carboxylic acid biosynthetic process GO:0046394 83 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
regulation of system process GO:0044057 208 0.011
epithelial cell proliferation GO:0050673 54 0.011
activation of cysteine type endopeptidase activity GO:0097202 4 0.011
response to amino acid GO:0043200 75 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
very long chain fatty acid metabolic process GO:0000038 3 0.010
endomembrane system organization GO:0010256 48 0.010
insulin secretion GO:0030073 69 0.010
purine nucleoside triphosphate catabolic process GO:0009146 122 0.010
negative regulation of response to external stimulus GO:0032102 37 0.010
regulation of immunoglobulin production GO:0002637 4 0.010
b cell mediated immunity GO:0019724 4 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
memory GO:0007613 54 0.010
lipid storage GO:0019915 1 0.010
response to temperature stimulus GO:0009266 94 0.010
divalent inorganic cation homeostasis GO:0072507 165 0.010
cellular response to corticosteroid stimulus GO:0071384 69 0.010
cellular carbohydrate metabolic process GO:0044262 72 0.010
ovulation cycle GO:0042698 67 0.010
cell morphogenesis GO:0000902 142 0.010
regulation of peptide secretion GO:0002791 82 0.010
response to estradiol GO:0032355 164 0.010
development of primary male sexual characteristics GO:0046546 59 0.010
g protein coupled receptor signaling pathway GO:0007186 242 0.010

Angptl4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.035
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.035
eye and adnexa disease DOID:1492 0 0.013
retinal disease DOID:5679 0 0.012
eye disease DOID:5614 0 0.012