Rattus norvegicus

19 known processes

Hpgd

hydroxyprostaglandin dehydrogenase 15 (NAD)

Hpgd biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxoacid metabolic process GO:0043436 290 0.138
Human
response to corticosteroid GO:0031960 235 0.128
regulation of cellular component organization GO:0051128 368 0.120
cation transport GO:0006812 382 0.115
response to metal ion GO:0010038 253 0.113
cell cell signaling GO:0007267 335 0.093
cellular response to hormone stimulus GO:0032870 247 0.093
organic acid metabolic process GO:0006082 292 0.091
Human
cellular response to oxygen containing compound GO:1901701 386 0.091
response to peptide hormone GO:0043434 278 0.087
cellular response to endogenous stimulus GO:0071495 377 0.083
Human
single organism biosynthetic process GO:0044711 342 0.082
aging GO:0007568 241 0.076
reproductive process GO:0022414 372 0.074
Human
carboxylic acid metabolic process GO:0019752 289 0.073
Human
secretion GO:0046903 307 0.072
metal ion transport GO:0030001 289 0.072
response to nutrient levels GO:0031667 370 0.068
cation transmembrane transport GO:0098655 263 0.067
response to extracellular stimulus GO:0009991 380 0.066
response to inorganic substance GO:0010035 377 0.065
organophosphate metabolic process GO:0019637 370 0.065
lipid metabolic process GO:0006629 283 0.061
Human Fly
homeostatic process GO:0042592 331 0.060
single organism catabolic process GO:0044712 283 0.060
Fly
regulation of cell proliferation GO:0042127 359 0.059
cellular homeostasis GO:0019725 252 0.058
catabolic process GO:0009056 351 0.054
Fly
positive regulation of multicellular organismal process GO:0051240 387 0.054
apoptotic process GO:0006915 381 0.054
multi organism reproductive process GO:0044703 262 0.053
Human
cellular response to peptide GO:1901653 133 0.053
regulation of molecular function GO:0065009 398 0.052
organic substance catabolic process GO:1901575 316 0.051
Fly
nucleobase containing small molecule metabolic process GO:0055086 316 0.050
response to acid chemical GO:0001101 222 0.050
response to insulin GO:0032868 133 0.049
intracellular signal transduction GO:0035556 314 0.049
regulation of synaptic transmission GO:0050804 141 0.049
cellular response to peptide hormone stimulus GO:0071375 120 0.048
monocarboxylic acid metabolic process GO:0032787 152 0.046
Human
regulation of ion transport GO:0043269 245 0.046
reproduction GO:0000003 245 0.045
multi multicellular organism process GO:0044706 138 0.044
Human
rna biosynthetic process GO:0032774 380 0.044
response to cytokine GO:0034097 215 0.044
cellular response to organonitrogen compound GO:0071417 197 0.044
negative regulation of cellular metabolic process GO:0031324 281 0.043
response to glucocorticoid GO:0051384 223 0.043
chemical homeostasis GO:0048878 292 0.043
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.042
cellular response to stress GO:0033554 269 0.042
cellular ketone metabolic process GO:0042180 51 0.042
regulation of multicellular organismal development GO:2000026 376 0.042
nucleotide metabolic process GO:0009117 279 0.041
regulation of metal ion transport GO:0010959 118 0.041
purine nucleotide metabolic process GO:0006163 229 0.041
heterocycle catabolic process GO:0046700 167 0.040
blood circulation GO:0008015 183 0.040
cell projection organization GO:0030030 302 0.039
Fly
response to monosaccharide GO:0034284 159 0.039
regulation of catalytic activity GO:0050790 304 0.038
anatomical structure morphogenesis GO:0009653 298 0.038
Mouse Fly
regulation of secretion by cell GO:1903530 208 0.038
regulation of phosphate metabolic process GO:0019220 349 0.038
negative regulation of metabolic process GO:0009892 331 0.038
multicellular organism reproduction GO:0032504 233 0.038
cellular chemical homeostasis GO:0055082 247 0.038
positive regulation of cellular component organization GO:0051130 200 0.037
response to peptide GO:1901652 292 0.037
regulation of cellular ketone metabolic process GO:0010565 27 0.037
protein phosphorylation GO:0006468 345 0.036
programmed cell death GO:0012501 392 0.036
monovalent inorganic cation transport GO:0015672 172 0.036
vascular process in circulatory system GO:0003018 96 0.036
response to nutrient GO:0007584 248 0.036
carbohydrate derivative metabolic process GO:1901135 346 0.035
regulation of blood pressure GO:0008217 83 0.035
regulation of phosphorylation GO:0042325 248 0.035
response to oxygen levels GO:0070482 265 0.035
cation homeostasis GO:0055080 195 0.035
aromatic compound catabolic process GO:0019439 168 0.034
cellular catabolic process GO:0044248 295 0.034
central nervous system development GO:0007417 311 0.034
cellular amino acid metabolic process GO:0006520 107 0.034
amine metabolic process GO:0009308 38 0.034
response to ketone GO:1901654 182 0.034
nucleoside phosphate metabolic process GO:0006753 283 0.034
ion transmembrane transport GO:0034220 365 0.034
response to hypoxia GO:0001666 231 0.033
regulation of rna metabolic process GO:0051252 391 0.033
carbohydrate metabolic process GO:0005975 130 0.032
cellular component biogenesis GO:0044085 368 0.032
cellular cation homeostasis GO:0030003 180 0.032
cellular response to insulin stimulus GO:0032869 81 0.032
nucleic acid templated transcription GO:0097659 379 0.031
single organism carbohydrate metabolic process GO:0044723 118 0.031
organelle organization GO:0006996 266 0.031
sexual reproduction GO:0019953 148 0.031
cellular response to nitrogen compound GO:1901699 210 0.031
regulation of phosphorus metabolic process GO:0051174 349 0.031
cellular response to organic cyclic compound GO:0071407 202 0.031
response to decreased oxygen levels GO:0036293 237 0.031
multicellular organismal reproductive process GO:0048609 233 0.030
tissue development GO:0009888 252 0.030
response to estrogen GO:0043627 232 0.030
ribonucleotide metabolic process GO:0009259 231 0.030
regulation of blood circulation GO:1903522 110 0.030
response to radiation GO:0009314 137 0.030
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.030
gamete generation GO:0007276 124 0.029
purine ribonucleotide metabolic process GO:0009150 227 0.029
single organism reproductive process GO:0044702 297 0.029
ribose phosphate metabolic process GO:0019693 235 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.029
regulation of anatomical structure size GO:0090066 135 0.029
positive regulation of developmental process GO:0051094 283 0.029
muscle system process GO:0003012 115 0.029
response to oxidative stress GO:0006979 186 0.029
rna metabolic process GO:0016070 406 0.028
response to purine containing compound GO:0014074 126 0.028
transmembrane transport GO:0055085 412 0.028
purine ribonucleoside metabolic process GO:0046128 168 0.028
ribonucleotide catabolic process GO:0009261 136 0.027
rhythmic process GO:0048511 156 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
neuron projection development GO:0031175 273 0.027
Fly
negative regulation of macromolecule metabolic process GO:0010605 260 0.027
small molecule catabolic process GO:0044282 59 0.026
Fly
inorganic cation transmembrane transport GO:0098662 202 0.026
positive regulation of phosphorus metabolic process GO:0010562 262 0.026
synaptic transmission GO:0007268 235 0.026
muscle contraction GO:0006936 88 0.026
purine containing compound metabolic process GO:0072521 253 0.026
cellular response to lipid GO:0071396 201 0.026
regulation of transcription dna templated GO:0006355 374 0.026
response to growth factor GO:0070848 189 0.025
Human
organic anion transport GO:0015711 132 0.025
regulation of signal transduction GO:0009966 318 0.025
regulation of protein modification process GO:0031399 194 0.025
localization of cell GO:0051674 202 0.025
organonitrogen compound catabolic process GO:1901565 179 0.024
regulation of nucleic acid templated transcription GO:1903506 380 0.024
nucleoside phosphate catabolic process GO:1901292 140 0.024
nucleobase containing compound catabolic process GO:0034655 152 0.024
head development GO:0060322 247 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.024
anion transport GO:0006820 178 0.024
fatty acid metabolic process GO:0006631 99 0.024
Human
response to alkaloid GO:0043279 132 0.024
cellular component movement GO:0006928 248 0.024
locomotion GO:0040011 237 0.024
purine nucleoside triphosphate metabolic process GO:0009144 141 0.023
regulation of cell projection organization GO:0031344 175 0.023
cellular nitrogen compound catabolic process GO:0044270 163 0.023
negative regulation of apoptotic process GO:0043066 181 0.023
ion homeostasis GO:0050801 212 0.023
organophosphate catabolic process GO:0046434 148 0.023
cellular ion homeostasis GO:0006873 184 0.023
regulation of apoptotic process GO:0042981 335 0.023
secretion by cell GO:0032940 248 0.022
negative regulation of cellular protein metabolic process GO:0032269 106 0.022
divalent metal ion transport GO:0070838 132 0.022
circulatory system process GO:0003013 183 0.022
cellular amine metabolic process GO:0044106 38 0.022
organic acid transport GO:0015849 116 0.022
response to organophosphorus GO:0046683 102 0.022
proteolysis GO:0006508 175 0.022
intracellular transport GO:0046907 185 0.022
growth GO:0040007 165 0.022
carboxylic acid transport GO:0046942 115 0.022
cellular response to abiotic stimulus GO:0071214 85 0.022
cell growth GO:0016049 104 0.021
regulation of programmed cell death GO:0043067 341 0.021
purine nucleoside metabolic process GO:0042278 169 0.021
organonitrogen compound biosynthetic process GO:1901566 167 0.021
response to hexose GO:0009746 144 0.021
response to camp GO:0051591 91 0.021
response to glucose GO:0009749 136 0.021
cell motility GO:0048870 202 0.021
cellular component assembly GO:0022607 360 0.021
regulation of nucleotide metabolic process GO:0006140 117 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.020
small molecule biosynthetic process GO:0044283 124 0.020
purine ribonucleotide catabolic process GO:0009154 136 0.020
regulation of purine nucleotide metabolic process GO:1900542 115 0.020
small gtpase mediated signal transduction GO:0007264 36 0.020
regulation of locomotion GO:0040012 148 0.020
regulation of cell differentiation GO:0045595 320 0.020
purine nucleotide catabolic process GO:0006195 136 0.020
transcription dna templated GO:0006351 377 0.020
transcription from rna polymerase ii promoter GO:0006366 252 0.020
biological adhesion GO:0022610 110 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
cardiovascular system development GO:0072358 134 0.020
Mouse
carbohydrate derivative catabolic process GO:1901136 147 0.020
nucleoside metabolic process GO:0009116 179 0.020
nucleotide catabolic process GO:0009166 139 0.020
regulation of cellular localization GO:0060341 263 0.019
regulation of intracellular signal transduction GO:1902531 218 0.019
circulatory system development GO:0072359 134 0.019
Mouse
response to ethanol GO:0045471 162 0.019
Fly
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
ribonucleoside metabolic process GO:0009119 174 0.019
regulation of cell growth GO:0001558 85 0.019
brain development GO:0007420 247 0.019
nucleoside triphosphate metabolic process GO:0009141 144 0.019
cellular response to external stimulus GO:0071496 118 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
ribonucleoside triphosphate metabolic process GO:0009199 141 0.019
positive regulation of cell death GO:0010942 184 0.019
calcium ion transport GO:0006816 131 0.019
positive regulation of cell proliferation GO:0008284 249 0.019
calcium ion homeostasis GO:0055074 162 0.019
positive regulation of molecular function GO:0044093 230 0.019
response to biotic stimulus GO:0009607 226 0.019
negative regulation of multicellular organismal process GO:0051241 203 0.019
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.018
single organism intracellular transport GO:1902582 166 0.018
regulation of hormone levels GO:0010817 187 0.018
Fly
regulation of hydrolase activity GO:0051336 143 0.018
regulation of tube size GO:0035150 89 0.018
regulation of nervous system development GO:0051960 264 0.018
organic acid biosynthetic process GO:0016053 83 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.018
positive regulation of response to stimulus GO:0048584 285 0.018
positive regulation of secretion by cell GO:1903532 128 0.017
cellular calcium ion homeostasis GO:0006874 160 0.017
protein targeting GO:0006605 61 0.017
glycosyl compound metabolic process GO:1901657 182 0.017
regulation of secretion GO:0051046 224 0.017
response to transition metal nanoparticle GO:1990267 122 0.017
purine nucleoside catabolic process GO:0006152 124 0.017
single organism organelle organization GO:1902589 180 0.017
developmental process involved in reproduction GO:0003006 159 0.017
divalent inorganic cation transport GO:0072511 134 0.017
response to carbohydrate GO:0009743 183 0.017
negative regulation of transport GO:0051051 136 0.017
regeneration GO:0031099 163 0.017
neuron differentiation GO:0030182 368 0.017
Fly
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.017
negative regulation of signaling GO:0023057 157 0.017
regulation of system process GO:0044057 208 0.016
nitrogen compound transport GO:0071705 229 0.016
purine containing compound catabolic process GO:0072523 138 0.016
g protein coupled receptor signaling pathway GO:0007186 242 0.016
response to vitamin GO:0033273 131 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
negative regulation of protein metabolic process GO:0051248 114 0.016
metal ion homeostasis GO:0055065 186 0.016
potassium ion transport GO:0006813 97 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
organophosphate biosynthetic process GO:0090407 143 0.016
protein complex biogenesis GO:0070271 263 0.016
purine ribonucleoside catabolic process GO:0046130 124 0.016
macromolecule localization GO:0033036 252 0.016
negative regulation of molecular function GO:0044092 133 0.015
ras protein signal transduction GO:0007265 29 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
Human
regulation of rna biosynthetic process GO:2001141 381 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.015
single organism behavior GO:0044708 130 0.015
Fly
cellular response to alcohol GO:0097306 87 0.015
regulation of neuron projection development GO:0010975 161 0.015
hormone transport GO:0009914 121 0.015
mapk cascade GO:0000165 140 0.015
glucose homeostasis GO:0042593 75 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
regulation of catabolic process GO:0009894 113 0.015
regulation of cell development GO:0060284 263 0.015
nucleoside triphosphate catabolic process GO:0009143 123 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
ribonucleoside triphosphate catabolic process GO:0009203 122 0.015
cell migration GO:0016477 197 0.015
divalent inorganic cation homeostasis GO:0072507 165 0.015
nucleoside catabolic process GO:0009164 126 0.015
liver development GO:0001889 90 0.015
positive regulation of protein phosphorylation GO:0001934 135 0.014
purine nucleoside triphosphate catabolic process GO:0009146 122 0.014
reactive oxygen species metabolic process GO:0072593 37 0.014
glycosyl compound catabolic process GO:1901658 126 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
calcium ion transmembrane transport GO:0070588 70 0.014
negative regulation of gene expression GO:0010629 199 0.014
heart contraction GO:0060047 57 0.014
negative regulation of phosphorus metabolic process GO:0010563 80 0.014
negative regulation of cell death GO:0060548 229 0.014
heart process GO:0003015 57 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
sulfur amino acid metabolic process GO:0000096 9 0.014
lipid storage GO:0019915 1 0.014
positive regulation of nucleoside metabolic process GO:0045979 55 0.014
neuron development GO:0048666 286 0.014
Fly
positive regulation of cell development GO:0010720 176 0.014
protein oligomerization GO:0051259 191 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
circadian rhythm GO:0007623 88 0.014
cellular metal ion homeostasis GO:0006875 172 0.014
response to wounding GO:0009611 254 0.014
response to temperature stimulus GO:0009266 94 0.014
glial cell differentiation GO:0010001 65 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
cellular lipid metabolic process GO:0044255 208 0.013
Human Fly
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
dna metabolic process GO:0006259 96 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
cardiac muscle contraction GO:0060048 27 0.013
regulation of nucleotide catabolic process GO:0030811 65 0.013
regulation of mapk cascade GO:0043408 116 0.013
monocarboxylic acid biosynthetic process GO:0072330 48 0.013
negative regulation of phosphate metabolic process GO:0045936 80 0.013
establishment of protein localization GO:0045184 141 0.013
multicellular organism growth GO:0035264 1 0.013
regulation of purine nucleotide catabolic process GO:0033121 65 0.013
cell cycle GO:0007049 101 0.013
Human
response to starvation GO:0042594 59 0.013
alpha amino acid metabolic process GO:1901605 71 0.013
action potential GO:0001508 54 0.013
heart morphogenesis GO:0003007 3 0.013
cellular response to corticosteroid stimulus GO:0071384 69 0.013
forebrain development GO:0030900 98 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
lipid biosynthetic process GO:0008610 128 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
carbohydrate homeostasis GO:0033500 75 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
monosaccharide metabolic process GO:0005996 61 0.012
positive regulation of ion transport GO:0043270 94 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
organ morphogenesis GO:0009887 75 0.012
regulation of neurogenesis GO:0050767 247 0.012
positive regulation of biosynthetic process GO:0009891 319 0.012
positive regulation of transport GO:0051050 245 0.012
response to amino acid GO:0043200 75 0.012
positive regulation of gene expression GO:0010628 244 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
cell adhesion GO:0007155 110 0.012
regulation of transmembrane transport GO:0034762 122 0.012
maintenance of location GO:0051235 17 0.012
macromolecular complex assembly GO:0065003 273 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
regulation of lipid metabolic process GO:0019216 68 0.012
developmental growth GO:0048589 100 0.012
regulation of protein metabolic process GO:0051246 289 0.012
cellular response to acid chemical GO:0071229 75 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.012
lipid oxidation GO:0034440 30 0.012
response to zinc ion GO:0010043 39 0.012
dephosphorylation GO:0016311 98 0.012
female pregnancy GO:0007565 122 0.012
Human
response to reactive oxygen species GO:0000302 120 0.012
lipid modification GO:0030258 52 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.012
wound healing GO:0042060 122 0.012
chromosome segregation GO:0007059 2 0.011
fatty acid oxidation GO:0019395 29 0.011
positive regulation of protein modification process GO:0031401 142 0.011
positive regulation of cell communication GO:0010647 271 0.011
salivary gland development GO:0007431 3 0.011
neurological system process GO:0050877 219 0.011
regulation of nucleoside metabolic process GO:0009118 66 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
response to estradiol GO:0032355 164 0.011
carboxylic acid catabolic process GO:0046395 49 0.011
regulation of body fluid levels GO:0050878 90 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
regulation of nitric oxide synthase activity GO:0050999 8 0.011
male gamete generation GO:0048232 99 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
insulin like growth factor receptor signaling pathway GO:0048009 3 0.011
regulation of smooth muscle cell proliferation GO:0048660 75 0.011
acid secretion GO:0046717 48 0.011
multicellular organismal homeostasis GO:0048871 49 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
axis specification GO:0009798 4 0.011
cellular amide metabolic process GO:0043603 44 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
regulation of calcium ion transport GO:0051924 77 0.011
blood vessel morphogenesis GO:0048514 58 0.011
Mouse
regulation of neuron differentiation GO:0045664 208 0.011
epithelium development GO:0060429 96 0.011
protein complex subunit organization GO:0071822 302 0.011
camp metabolic process GO:0046058 63 0.011
cyclic nucleotide metabolic process GO:0009187 80 0.010
regulation of membrane potential GO:0042391 110 0.010
regulation of cell migration GO:0030334 128 0.010
positive regulation of cellular catabolic process GO:0031331 71 0.010
organic hydroxy compound transport GO:0015850 77 0.010
regulation of response to external stimulus GO:0032101 106 0.010
positive regulation of rna metabolic process GO:0051254 203 0.010
regulation of peptide secretion GO:0002791 82 0.010
telencephalon development GO:0021537 62 0.010
positive regulation of neuron projection development GO:0010976 99 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.010
cellular response to nutrient levels GO:0031669 60 0.010
pallium development GO:0021543 42 0.010
regulation of canonical wnt signaling pathway GO:0060828 4 0.010
coenzyme metabolic process GO:0006732 86 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
reproductive system development GO:0061458 128 0.010
cellular response to cytokine stimulus GO:0071345 127 0.010
regulation of transporter activity GO:0032409 50 0.010
regulation of reactive oxygen species metabolic process GO:2000377 26 0.010
regulation of ion transmembrane transport GO:0034765 121 0.010
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
positive regulation of catabolic process GO:0009896 78 0.010
protein transport GO:0015031 132 0.010
positive regulation of nervous system development GO:0051962 178 0.010
protein maturation GO:0051604 68 0.010
protein localization GO:0008104 191 0.010
eye morphogenesis GO:0048592 4 0.010
positive regulation of nucleotide catabolic process GO:0030813 53 0.010
inorganic ion transmembrane transport GO:0098660 229 0.010

Hpgd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
nervous system disease DOID:863 0 0.019
disease of metabolism DOID:0014667 0 0.017
central nervous system disease DOID:331 0 0.013
inherited metabolic disorder DOID:655 0 0.011