Rattus norvegicus

0 known processes

Kng2

kininogen 2

(Aliases: KINKG,Kng1,KINKH,Kngk)

Kng2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
mapk cascade GO:0000165 140 0.152
intracellular signal transduction GO:0035556 314 0.136
signal transduction by phosphorylation GO:0023014 144 0.133
regulation of molecular function GO:0065009 398 0.129
response to acid chemical GO:0001101 222 0.115
gland development GO:0048732 155 0.108
protein maturation GO:0051604 68 0.107
negative regulation of gene expression GO:0010629 199 0.102
organ regeneration GO:0031100 101 0.097
negative regulation of macromolecule metabolic process GO:0010605 260 0.094
response to peptide GO:1901652 292 0.092
regulation of protein metabolic process GO:0051246 289 0.090
regulation of cell proliferation GO:0042127 359 0.087
cellular response to peptide hormone stimulus GO:0071375 120 0.085
carboxylic acid metabolic process GO:0019752 289 0.084
response to molecule of bacterial origin GO:0002237 194 0.082
organic acid metabolic process GO:0006082 292 0.082
single organism reproductive process GO:0044702 297 0.081
organic hydroxy compound metabolic process GO:1901615 115 0.079
single organism biosynthetic process GO:0044711 342 0.077
lipid metabolic process GO:0006629 283 0.077
protein processing GO:0016485 68 0.074
apoptotic process GO:0006915 381 0.074
macromolecule localization GO:0033036 252 0.073
liver development GO:0001889 90 0.071
response to lipopolysaccharide GO:0032496 191 0.070
negative regulation of metabolic process GO:0009892 331 0.066
regeneration GO:0031099 163 0.065
response to extracellular stimulus GO:0009991 380 0.062
blood vessel development GO:0001568 69 0.060
negative regulation of cellular protein metabolic process GO:0032269 106 0.057
response to ketone GO:1901654 182 0.057
cellular lipid metabolic process GO:0044255 208 0.056
positive regulation of response to stimulus GO:0048584 285 0.055
negative regulation of protein metabolic process GO:0051248 114 0.055
regulation of catalytic activity GO:0050790 304 0.055
chlorinated hydrocarbon metabolic process GO:0042196 4 0.054
positive regulation of signal transduction GO:0009967 175 0.054
regulation of peptidase activity GO:0052547 55 0.053
cellular response to oxygen containing compound GO:1901701 386 0.053
regulation of programmed cell death GO:0043067 341 0.051
positive regulation of signaling GO:0023056 270 0.051
positive regulation of multicellular organismal process GO:0051240 387 0.051
regulation of apoptotic process GO:0042981 335 0.051
regulation of mapk cascade GO:0043408 116 0.051
cellular amino acid metabolic process GO:0006520 107 0.050
response to nutrient GO:0007584 248 0.049
reproductive process GO:0022414 372 0.047
alcohol metabolic process GO:0006066 77 0.047
regulation of cellular protein metabolic process GO:0032268 267 0.047
organic acid biosynthetic process GO:0016053 83 0.046
carboxylic acid biosynthetic process GO:0046394 83 0.046
extracellular matrix constituent secretion GO:0070278 4 0.046
icosanoid metabolic process GO:0006690 38 0.046
cation transport GO:0006812 382 0.045
wound healing GO:0042060 122 0.045
positive regulation of cell communication GO:0010647 271 0.044
positive regulation of molecular function GO:0044093 230 0.044
reproduction GO:0000003 245 0.044
hormone metabolic process GO:0042445 69 0.043
regulation of phosphorus metabolic process GO:0051174 349 0.042
macromolecular complex assembly GO:0065003 273 0.042
blood vessel morphogenesis GO:0048514 58 0.041
negative regulation of molecular function GO:0044092 133 0.041
cellular hormone metabolic process GO:0034754 49 0.041
programmed cell death GO:0012501 392 0.040
rhythmic process GO:0048511 156 0.040
lipid biosynthetic process GO:0008610 128 0.040
regulation of epithelial cell proliferation GO:0050678 49 0.039
positive regulation of extracellular matrix constituent secretion GO:0003331 2 0.038
circulatory system development GO:0072359 134 0.038
amine metabolic process GO:0009308 38 0.038
steroid metabolic process GO:0008202 73 0.038
response to corticosteroid GO:0031960 235 0.038
multi organism reproductive process GO:0044703 262 0.038
positive regulation of catalytic activity GO:0043085 184 0.038
inflammatory response GO:0006954 150 0.038
oxoacid metabolic process GO:0043436 290 0.038
positive regulation of phosphate metabolic process GO:0045937 262 0.038
regulation of signal transduction GO:0009966 318 0.037
cellular chemical homeostasis GO:0055082 247 0.036
innate immune response GO:0045087 35 0.036
regulation of phosphorylation GO:0042325 248 0.036
regulation of protein maturation GO:1903317 50 0.036
response to nutrient levels GO:0031667 370 0.036
lipid transport GO:0006869 61 0.036
hepaticobiliary system development GO:0061008 90 0.035
epithelial cell proliferation GO:0050673 54 0.034
multi multicellular organism process GO:0044706 138 0.034
regulation of intracellular signal transduction GO:1902531 218 0.034
response to inorganic substance GO:0010035 377 0.034
regulation of protein processing GO:0070613 50 0.034
vasculature development GO:0001944 70 0.034
defense response GO:0006952 194 0.034
negative regulation of cellular metabolic process GO:0031324 281 0.034
regulation of serine type peptidase activity GO:1902571 1 0.034
regulation of hydrolase activity GO:0051336 143 0.034
negative regulation of protein maturation GO:1903318 47 0.033
monocarboxylic acid metabolic process GO:0032787 152 0.033
negative regulation of epithelial cell proliferation GO:0050680 16 0.032
negative regulation of peptidase activity GO:0010466 38 0.032
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.031
protein complex assembly GO:0006461 263 0.031
regulation of phosphate metabolic process GO:0019220 349 0.031
cellular response to cytokine stimulus GO:0071345 127 0.030
unsaturated fatty acid metabolic process GO:0033559 39 0.030
inorganic ion transmembrane transport GO:0098660 229 0.030
positive regulation of cell proliferation GO:0008284 249 0.030
multicellular organism reproduction GO:0032504 233 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.030
positive regulation of developmental process GO:0051094 283 0.030
positive regulation of mapk cascade GO:0043410 92 0.030
cellular response to ketone GO:1901655 51 0.029
naphthalene containing compound metabolic process GO:0090420 2 0.029
negative regulation of cell communication GO:0010648 158 0.029
negative regulation of serine type endopeptidase activity GO:1900004 1 0.029
cellular response to endogenous stimulus GO:0071495 377 0.029
cofactor metabolic process GO:0051186 95 0.028
small molecule biosynthetic process GO:0044283 124 0.028
response to glucocorticoid GO:0051384 223 0.028
negative regulation of endopeptidase activity GO:0010951 36 0.028
anion transport GO:0006820 178 0.027
small molecule catabolic process GO:0044282 59 0.027
cellular ketone metabolic process GO:0042180 51 0.027
regulation of acute inflammatory response GO:0002673 23 0.027
positive regulation of cellular biosynthetic process GO:0031328 295 0.027
negative regulation of proteolysis GO:0045861 41 0.027
negative regulation of signal transduction GO:0009968 83 0.026
vascular process in circulatory system GO:0003018 96 0.026
response to metal ion GO:0010038 253 0.026
response to heat GO:0009408 60 0.026
protein complex biogenesis GO:0070271 263 0.026
response to external biotic stimulus GO:0043207 221 0.026
rna metabolic process GO:0016070 406 0.026
locomotion GO:0040011 237 0.026
cardiovascular system development GO:0072358 134 0.026
renal sodium excretion GO:0035812 20 0.025
regulation of proteolysis GO:0030162 66 0.025
naphthalene metabolic process GO:0018931 2 0.025
positive regulation of immune system process GO:0002684 90 0.025
negative regulation of transport GO:0051051 136 0.025
ion transmembrane transport GO:0034220 365 0.024
negative regulation of protein processing GO:0010955 47 0.024
positive regulation of secretion GO:0051047 140 0.024
regulation of rna biosynthetic process GO:2001141 381 0.024
gonad development GO:0008406 104 0.024
head development GO:0060322 247 0.024
cellular amine metabolic process GO:0044106 38 0.024
positive regulation of neuron projection development GO:0010976 99 0.024
regulation of serine type endopeptidase activity GO:1900003 1 0.023
female pregnancy GO:0007565 122 0.023
cellular component biogenesis GO:0044085 368 0.023
transmembrane transport GO:0055085 412 0.023
regulation of extracellular matrix constituent secretion GO:0003330 2 0.023
regulation of transcription dna templated GO:0006355 374 0.023
proteolysis GO:0006508 175 0.023
regulation of blood vessel size GO:0050880 89 0.023
feeding behavior GO:0007631 53 0.023
macromolecular complex subunit organization GO:0043933 339 0.022
regulation of body fluid levels GO:0050878 90 0.022
secretion by cell GO:0032940 248 0.022
response to oxygen levels GO:0070482 265 0.022
protein phosphorylation GO:0006468 345 0.022
immune system process GO:0002376 204 0.022
regulation of locomotion GO:0040012 148 0.022
negative regulation of endothelial cell proliferation GO:0001937 5 0.022
nuclear transport GO:0051169 49 0.022
carboxylic acid transport GO:0046942 115 0.022
response to estradiol GO:0032355 164 0.021
cellular component assembly GO:0022607 360 0.021
cellular response to acid chemical GO:0071229 75 0.021
acute phase response GO:0006953 20 0.021
regulation of protein modification process GO:0031399 194 0.021
regulation of ion transport GO:0043269 245 0.021
response to oxidative stress GO:0006979 186 0.020
response to insulin GO:0032868 133 0.020
growth GO:0040007 165 0.020
positive regulation of secretion by cell GO:1903532 128 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
positive regulation of neuron differentiation GO:0045666 126 0.020
response to peptide hormone GO:0043434 278 0.020
nucleocytoplasmic transport GO:0006913 48 0.020
protein homooligomerization GO:0051260 91 0.020
phenylpropanoid catabolic process GO:0046271 3 0.020
regulation of nucleic acid templated transcription GO:1903506 380 0.020
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.019
coagulation GO:0050817 28 0.019
regulation of protein phosphorylation GO:0001932 183 0.019
response to other organism GO:0051707 220 0.019
reactive nitrogen species metabolic process GO:2001057 1 0.019
central nervous system development GO:0007417 311 0.019
cellular response to interferon gamma GO:0071346 14 0.019
terpenoid metabolic process GO:0006721 37 0.019
nucleic acid templated transcription GO:0097659 379 0.019
transmission of nerve impulse GO:0019226 42 0.019
organic substance catabolic process GO:1901575 316 0.019
cellular response to steroid hormone stimulus GO:0071383 93 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
lipid localization GO:0010876 62 0.018
response to reactive oxygen species GO:0000302 120 0.018
negative regulation of catalytic activity GO:0043086 103 0.018
negative regulation of apoptotic process GO:0043066 181 0.018
regulation of lipid metabolic process GO:0019216 68 0.018
regulation of map kinase activity GO:0043405 53 0.018
metal ion transport GO:0030001 289 0.018
angiotensin mediated drinking behavior GO:0003051 2 0.018
positive regulation of gene expression GO:0010628 244 0.018
angiogenesis GO:0001525 53 0.018
sexual reproduction GO:0019953 148 0.018
stress activated protein kinase signaling cascade GO:0031098 37 0.018
positive regulation of blood coagulation GO:0030194 4 0.018
endothelial cell proliferation GO:0001935 20 0.017
chemical homeostasis GO:0048878 292 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.017
fatty acid derivative metabolic process GO:1901568 38 0.017
response to vitamin b6 GO:0034516 1 0.017
anterior posterior pattern specification GO:0009952 1 0.017
negative regulation of phosphorus metabolic process GO:0010563 80 0.017
neurological system process GO:0050877 219 0.017
single organism catabolic process GO:0044712 283 0.017
positive regulation of endothelial cell migration GO:0010595 4 0.017
response to decreased oxygen levels GO:0036293 237 0.017
regulation of lipid biosynthetic process GO:0046890 38 0.017
positive regulation of intracellular signal transduction GO:1902533 138 0.017
regulation of tube size GO:0035150 89 0.017
negative regulation of cell proliferation GO:0008285 119 0.017
regulation of ion homeostasis GO:2000021 63 0.016
response to ionizing radiation GO:0010212 59 0.016
response to glucose GO:0009749 136 0.016
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.016
cellular response to glucocorticoid stimulus GO:0071385 68 0.016
erk1 and erk2 cascade GO:0070371 48 0.016
organic hydroxy compound transport GO:0015850 77 0.016
metal ion homeostasis GO:0055065 186 0.016
intracellular transport GO:0046907 185 0.016
carbohydrate metabolic process GO:0005975 130 0.016
negative regulation of rna metabolic process GO:0051253 123 0.016
positive regulation of biosynthetic process GO:0009891 319 0.016
cellular homeostasis GO:0019725 252 0.016
axis specification GO:0009798 4 0.016
reactive oxygen species metabolic process GO:0072593 37 0.016
regulation of protein kinase activity GO:0045859 105 0.016
protein oligomerization GO:0051259 191 0.016
rna biosynthetic process GO:0032774 380 0.016
regulation of angiogenesis GO:0045765 39 0.016
tonic smooth muscle contraction GO:0014820 4 0.016
immune response GO:0006955 104 0.015
protein targeting GO:0006605 61 0.015
response to hypoxia GO:0001666 231 0.015
spermatogenesis GO:0007283 99 0.015
response to testosterone GO:0033574 55 0.015
circulatory system process GO:0003013 183 0.015
cellular response to organonitrogen compound GO:0071417 197 0.015
negative regulation of phosphorylation GO:0042326 57 0.015
retinal metabolic process GO:0042574 3 0.015
regulation of renal sodium excretion GO:0035813 20 0.015
cell cell signaling GO:0007267 335 0.015
positive regulation of blood circulation GO:1903524 65 0.015
cellular response to peptide GO:1901653 133 0.015
regulation of endopeptidase activity GO:0052548 51 0.015
norepinephrine secretion GO:0048243 16 0.015
response to bacterium GO:0009617 200 0.015
isoprenoid metabolic process GO:0006720 45 0.015
ion homeostasis GO:0050801 212 0.015
regulation of hormone levels GO:0010817 187 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
negative regulation of transferase activity GO:0051348 29 0.015
positive regulation of cell projection organization GO:0031346 111 0.014
response to cytokine GO:0034097 215 0.014
positive regulation of cellular component organization GO:0051130 200 0.014
positive regulation of programmed cell death GO:0043068 157 0.014
gamete generation GO:0007276 124 0.014
response to temperature stimulus GO:0009266 94 0.014
response to transition metal nanoparticle GO:1990267 122 0.014
vasoconstriction GO:0042310 54 0.014
brain renin angiotensin system GO:0002035 3 0.014
regulation of endothelial cell apoptotic process GO:2000351 3 0.014
cellular response to hormone stimulus GO:0032870 247 0.014
cellular macromolecule localization GO:0070727 122 0.014
response to carbohydrate GO:0009743 183 0.014
positive regulation of lipid biosynthetic process GO:0046889 25 0.014
cell motility GO:0048870 202 0.014
cellular response to corticosteroid stimulus GO:0071384 69 0.014
regulation of neurogenesis GO:0050767 247 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
lipid storage GO:0019915 1 0.013
regulation of vasculature development GO:1901342 44 0.013
regulation of cellular localization GO:0060341 263 0.013
coenzyme metabolic process GO:0006732 86 0.013
action potential GO:0001508 54 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.013
regulation of cell adhesion GO:0030155 52 0.013
negative regulation of serine type peptidase activity GO:1902572 1 0.013
cellular response to reactive oxygen species GO:0034614 55 0.013
negative regulation of hydrolase activity GO:0051346 52 0.013
blood coagulation GO:0007596 26 0.013
response to retinoic acid GO:0032526 63 0.013
negative regulation of cell death GO:0060548 229 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
negative regulation of signaling GO:0023057 157 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
appendage morphogenesis GO:0035107 4 0.013
response to estrogen GO:0043627 232 0.013
embryonic pattern specification GO:0009880 1 0.013
response to purine containing compound GO:0014074 126 0.013
regulation of kinase activity GO:0043549 117 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
regulation of blood circulation GO:1903522 110 0.013
establishment of protein localization to organelle GO:0072594 44 0.013
positive regulation of nitric oxide biosynthetic process GO:0045429 14 0.012
blood circulation GO:0008015 183 0.012
protein import GO:0017038 37 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
protein transport GO:0015031 132 0.012
steroid biosynthetic process GO:0006694 48 0.012
regulation of plasminogen activation GO:0010755 2 0.012
homeostatic process GO:0042592 331 0.012
response to biotic stimulus GO:0009607 226 0.012
regulation of blood pressure GO:0008217 83 0.012
organic acid transport GO:0015849 116 0.012
cell type specific apoptotic process GO:0097285 134 0.012
positive regulation of nervous system development GO:0051962 178 0.012
regulation of secretion GO:0051046 224 0.012
regulation of calcium ion transport GO:0051924 77 0.012
epiboly involved in wound healing GO:0090505 2 0.012
organic hydroxy compound biosynthetic process GO:1901617 51 0.012
muscle cell proliferation GO:0033002 84 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
limb morphogenesis GO:0035108 4 0.012
protein complex subunit organization GO:0071822 302 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.012
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
single organism nuclear import GO:1902593 35 0.012
maintenance of location GO:0051235 17 0.012
regulation of anatomical structure size GO:0090066 135 0.011
cellular response to stress GO:0033554 269 0.011
cellular ion homeostasis GO:0006873 184 0.011
organic anion transport GO:0015711 132 0.011
halogenated hydrocarbon metabolic process GO:0042197 4 0.011
glucose homeostasis GO:0042593 75 0.011
protein activation cascade GO:0072376 12 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
response to mechanical stimulus GO:0009612 134 0.011
b cell mediated immunity GO:0019724 4 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
intracellular protein transport GO:0006886 79 0.011
catenin import into nucleus GO:0035411 1 0.011
transcription from rna polymerase ii promoter GO:0006366 252 0.011
response to hexose GO:0009746 144 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
monosaccharide metabolic process GO:0005996 61 0.011
single organism intracellular transport GO:1902582 166 0.011
cytoplasmic transport GO:0016482 115 0.011
positive regulation of cellular component movement GO:0051272 102 0.011
circadian sleep wake cycle GO:0042745 23 0.011
alcohol biosynthetic process GO:0046165 38 0.011
embryonic appendage morphogenesis GO:0035113 4 0.011
positive regulation of apoptotic process GO:0043065 154 0.011
positive regulation of humoral immune response GO:0002922 2 0.011
regulation of immune system process GO:0002682 123 0.011
response to monosaccharide GO:0034284 159 0.011
transcription dna templated GO:0006351 377 0.011
cellular cation homeostasis GO:0030003 180 0.011
positive regulation of transcription dna templated GO:0045893 197 0.011
organic acid catabolic process GO:0016054 49 0.011
regulation of response to external stimulus GO:0032101 106 0.010
positive regulation of fibroblast proliferation GO:0048146 15 0.010
cholesterol homeostasis GO:0042632 3 0.010
positive regulation of cell migration GO:0030335 96 0.010
regulation of neuron differentiation GO:0045664 208 0.010
positive regulation of phosphorus metabolic process GO:0010562 262 0.010
hepatocyte proliferation GO:0072574 3 0.010
positive regulation of heterotypic cell cell adhesion GO:0034116 1 0.010
cellular lipid catabolic process GO:0044242 37 0.010
fatty acid metabolic process GO:0006631 99 0.010
regulation of cellular component organization GO:0051128 368 0.010
response to vitamin GO:0033273 131 0.010
regulation of endothelial cell proliferation GO:0001936 18 0.010
positive regulation of response to wounding GO:1903036 34 0.010
single organism cellular localization GO:1902580 102 0.010
jak stat cascade GO:0007259 26 0.010
regulation of muscle system process GO:0090257 79 0.010
rna localization GO:0006403 4 0.010
brain development GO:0007420 247 0.010
calcium ion transport GO:0006816 131 0.010
positive regulation of protein metabolic process GO:0051247 178 0.010
response to chromate GO:0046687 3 0.010
response to ethanol GO:0045471 162 0.010
localization of cell GO:0051674 202 0.010

Kng2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.018
disease of metabolism DOID:0014667 0 0.015
inherited metabolic disorder DOID:655 0 0.014
cancer DOID:162 0 0.011
organ system cancer DOID:0050686 0 0.011
disease of anatomical entity DOID:7 0 0.010
musculoskeletal system disease DOID:17 0 0.010