Rattus norvegicus

152 known processes

Kng1

kininogen 1

(Aliases: Tkg,KINKH,Kng_v1,Kng,Kngt1,Kngt,Kngk,Map1,TKG6,MGC93589,Kng1_v1,KINT1G,KINKG)

Kng1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to other organism GO:0051707 220 0.452
response to lipopolysaccharide GO:0032496 191 0.366
response to extracellular stimulus GO:0009991 380 0.351
response to biotic stimulus GO:0009607 226 0.330
response to bacterium GO:0009617 200 0.323
response to molecule of bacterial origin GO:0002237 194 0.294
response to peptide GO:1901652 292 0.272
organic acid metabolic process GO:0006082 292 0.258
regeneration GO:0031099 163 0.256
response to peptide hormone GO:0043434 278 0.255
inflammatory response GO:0006954 150 0.240
response to external biotic stimulus GO:0043207 221 0.237
regulation of immunoglobulin mediated immune response GO:0002889 2 0.214
response to inorganic substance GO:0010035 377 0.203
oxoacid metabolic process GO:0043436 290 0.201
response to nutrient GO:0007584 248 0.189
cellular response to organic cyclic compound GO:0071407 202 0.181
gland development GO:0048732 155 0.180
cellular response to oxygen containing compound GO:1901701 386 0.172
regulation of b cell mediated immunity GO:0002712 2 0.172
defense response GO:0006952 194 0.171
regulation of endothelial cell apoptotic process GO:2000351 3 0.170
carboxylic acid metabolic process GO:0019752 289 0.168
response to cytokine GO:0034097 215 0.155
macromolecule localization GO:0033036 252 0.147
cellular response to hormone stimulus GO:0032870 247 0.142
secretion GO:0046903 307 0.141
b cell mediated immunity GO:0019724 4 0.135
response to nutrient levels GO:0031667 370 0.129
wound healing GO:0042060 122 0.118
cellular response to cytokine stimulus GO:0071345 127 0.114
response to wounding GO:0009611 254 0.112
cellular response to lipid GO:0071396 201 0.109
regulation of serine type peptidase activity GO:1902571 1 0.106
response to camp GO:0051591 91 0.097
positive regulation of response to stimulus GO:0048584 285 0.097
intracellular signal transduction GO:0035556 314 0.092
positive regulation of signaling GO:0023056 270 0.087
multicellular organism reproduction GO:0032504 233 0.087
cellular response to peptide hormone stimulus GO:0071375 120 0.086
positive regulation of heterotypic cell cell adhesion GO:0034116 1 0.083
response to ketone GO:1901654 182 0.081
secretion by cell GO:0032940 248 0.079
regulation of cell proliferation GO:0042127 359 0.078
cellular response to organonitrogen compound GO:0071417 197 0.076
reproduction GO:0000003 245 0.075
immune response GO:0006955 104 0.075
regulation of cellular component organization GO:0051128 368 0.074
response to hexose GO:0009746 144 0.072
regulation of hormone levels GO:0010817 187 0.072
response to metal ion GO:0010038 253 0.071
response to estrogen GO:0043627 232 0.070
cellular response to molecule of bacterial origin GO:0071219 56 0.070
cellular response to endogenous stimulus GO:0071495 377 0.069
hormone metabolic process GO:0042445 69 0.068
cellular amino acid metabolic process GO:0006520 107 0.068
endothelial cell apoptotic process GO:0072577 3 0.067
organ regeneration GO:0031100 101 0.066
response to vitamin GO:0033273 131 0.066
protein maturation GO:0051604 68 0.065
response to oxidative stress GO:0006979 186 0.063
blood coagulation GO:0007596 26 0.061
hepaticobiliary system development GO:0061008 90 0.061
response to monosaccharide GO:0034284 159 0.060
response to carbohydrate GO:0009743 183 0.059
positive regulation of multicellular organismal process GO:0051240 387 0.058
immunoglobulin mediated immune response GO:0016064 4 0.058
single organism reproductive process GO:0044702 297 0.057
response to tumor necrosis factor GO:0034612 56 0.057
regulation of cellular amine metabolic process GO:0033238 8 0.056
response to glucocorticoid GO:0051384 223 0.055
negative regulation of response to stimulus GO:0048585 155 0.054
cellular response to steroid hormone stimulus GO:0071383 93 0.053
regulation of cellular localization GO:0060341 263 0.053
regulation of secretion GO:0051046 224 0.053
cellular response to interferon gamma GO:0071346 14 0.053
response to insulin GO:0032868 133 0.050
regulation of peptide transport GO:0090087 87 0.048
aging GO:0007568 241 0.048
catabolic process GO:0009056 351 0.047
regulation of transcription dna templated GO:0006355 374 0.047
tetrapyrrole metabolic process GO:0033013 11 0.047
cellular response to nitrogen compound GO:1901699 210 0.046
regulation of heterotypic cell cell adhesion GO:0034114 2 0.046
regulation of apoptotic process GO:0042981 335 0.046
regulation of rna biosynthetic process GO:2001141 381 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.045
response to corticosteroid GO:0031960 235 0.045
response to interleukin 1 GO:0070555 55 0.045
regulation of protein transport GO:0051223 68 0.044
positive regulation of signal transduction GO:0009967 175 0.044
negative regulation of protein metabolic process GO:0051248 114 0.044
regulation of cellular ketone metabolic process GO:0010565 27 0.044
monocarboxylic acid metabolic process GO:0032787 152 0.044
urogenital system development GO:0001655 78 0.043
response to glucose GO:0009749 136 0.042
lipid localization GO:0010876 62 0.042
response to acid chemical GO:0001101 222 0.041
peptidyl amino acid modification GO:0018193 126 0.041
kidney development GO:0001822 67 0.040
regulation of molecular function GO:0065009 398 0.039
coagulation GO:0050817 28 0.039
macromolecular complex assembly GO:0065003 273 0.039
regulation of secretion by cell GO:1903530 208 0.039
positive regulation of cellular amine metabolic process GO:0033240 3 0.039
neuron differentiation GO:0030182 368 0.039
positive regulation of phosphate metabolic process GO:0045937 262 0.039
regulation of cellular amino acid metabolic process GO:0006521 2 0.039
cellular response to stress GO:0033554 269 0.039
response to purine containing compound GO:0014074 126 0.038
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.037
response to organophosphorus GO:0046683 102 0.036
multi organism reproductive process GO:0044703 262 0.036
apoptotic process GO:0006915 381 0.036
vasculature development GO:0001944 70 0.036
oxidation reduction process GO:0055114 304 0.036
response to decreased oxygen levels GO:0036293 237 0.035
reproductive process GO:0022414 372 0.035
response to ionizing radiation GO:0010212 59 0.035
cell cell signaling GO:0007267 335 0.034
steroid metabolic process GO:0008202 73 0.034
cellular response to biotic stimulus GO:0071216 59 0.034
negative regulation of macromolecule metabolic process GO:0010605 260 0.034
positive regulation of cell communication GO:0010647 271 0.034
regulation of signal transduction GO:0009966 318 0.033
programmed cell death GO:0012501 392 0.033
regulation of peptide secretion GO:0002791 82 0.033
tissue regeneration GO:0042246 36 0.033
single organism biosynthetic process GO:0044711 342 0.033
negative regulation of cell communication GO:0010648 158 0.033
positive regulation of secretion GO:0051047 140 0.032
organic hydroxy compound metabolic process GO:1901615 115 0.032
cellular response to growth factor stimulus GO:0071363 162 0.032
reactive oxygen species metabolic process GO:0072593 37 0.032
blood vessel morphogenesis GO:0048514 58 0.031
negative regulation of programmed cell death GO:0043069 183 0.031
establishment of protein localization GO:0045184 141 0.031
organic substance catabolic process GO:1901575 316 0.031
response to mechanical stimulus GO:0009612 134 0.031
response to estradiol GO:0032355 164 0.031
cellular hormone metabolic process GO:0034754 49 0.030
cellular component assembly GO:0022607 360 0.029
negative regulation of apoptotic process GO:0043066 181 0.029
protein localization GO:0008104 191 0.029
regulation of phosphate metabolic process GO:0019220 349 0.029
regulation of protein metabolic process GO:0051246 289 0.028
brain development GO:0007420 247 0.028
positive regulation of cell proliferation GO:0008284 249 0.028
cellular amine metabolic process GO:0044106 38 0.028
macromolecular complex subunit organization GO:0043933 339 0.028
response to reactive oxygen species GO:0000302 120 0.028
negative regulation of cell death GO:0060548 229 0.028
reactive nitrogen species metabolic process GO:2001057 1 0.028
gamete generation GO:0007276 124 0.028
single organism catabolic process GO:0044712 283 0.027
steroid biosynthetic process GO:0006694 48 0.027
limb morphogenesis GO:0035108 4 0.027
immune system process GO:0002376 204 0.027
positive regulation of immunoglobulin production GO:0002639 4 0.027
protein complex assembly GO:0006461 263 0.027
amine metabolic process GO:0009308 38 0.027
response to interferon gamma GO:0034341 20 0.027
negative regulation of metabolic process GO:0009892 331 0.026
amide transport GO:0042886 105 0.026
neuron development GO:0048666 286 0.026
anatomical structure formation involved in morphogenesis GO:0048646 83 0.026
regulation of body fluid levels GO:0050878 90 0.026
spermatogenesis GO:0007283 99 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.026
proteolysis GO:0006508 175 0.026
cellular response to lipopolysaccharide GO:0071222 55 0.025
sexual reproduction GO:0019953 148 0.025
cofactor metabolic process GO:0051186 95 0.025
positive regulation of intracellular signal transduction GO:1902533 138 0.025
response to heat GO:0009408 60 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
reactive oxygen species biosynthetic process GO:1903409 8 0.024
negative regulation of serine type peptidase activity GO:1902572 1 0.024
liver development GO:0001889 90 0.024
extracellular matrix constituent secretion GO:0070278 4 0.024
positive regulation of transport GO:0051050 245 0.024
carboxylic acid biosynthetic process GO:0046394 83 0.024
humoral immune response GO:0006959 12 0.024
immune effector process GO:0002252 53 0.024
cellular response to peptide GO:1901653 133 0.024
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.024
head development GO:0060322 247 0.023
regulation of nucleic acid templated transcription GO:1903506 380 0.023
response to oxygen levels GO:0070482 265 0.023
response to hypoxia GO:0001666 231 0.023
negative regulation of gene expression GO:0010629 199 0.023
regulation of intracellular signal transduction GO:1902531 218 0.023
regulation of cellular protein metabolic process GO:0032268 267 0.022
neuron projection development GO:0031175 273 0.022
response to radiation GO:0009314 137 0.022
peptide transport GO:0015833 97 0.022
protein complex biogenesis GO:0070271 263 0.022
response to temperature stimulus GO:0009266 94 0.022
epithelial cell proliferation GO:0050673 54 0.021
cell projection organization GO:0030030 302 0.021
nucleic acid templated transcription GO:0097659 379 0.021
multicellular organismal reproductive process GO:0048609 233 0.021
positive regulation of fibroblast proliferation GO:0048146 15 0.021
regulation of immunoglobulin production GO:0002637 4 0.021
tissue development GO:0009888 252 0.021
positive regulation of developmental process GO:0051094 283 0.021
mapk cascade GO:0000165 140 0.020
regulation of peptide hormone secretion GO:0090276 80 0.020
cation transport GO:0006812 382 0.020
nitrogen compound transport GO:0071705 229 0.020
porphyrin containing compound metabolic process GO:0006778 8 0.020
regulation of nervous system development GO:0051960 264 0.020
regulation of proteolysis GO:0030162 66 0.020
jak stat cascade GO:0007259 26 0.020
cellular response to mechanical stimulus GO:0071260 48 0.020
response to transition metal nanoparticle GO:1990267 122 0.019
regulation of reactive oxygen species metabolic process GO:2000377 26 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
single organism carbohydrate metabolic process GO:0044723 118 0.019
lipid transport GO:0006869 61 0.019
cell differentiation involved in kidney development GO:0061005 4 0.019
reproductive structure development GO:0048608 128 0.019
cellular ketone metabolic process GO:0042180 51 0.019
regulation of immune system process GO:0002682 123 0.019
lipid biosynthetic process GO:0008610 128 0.019
transcription from rna polymerase ii promoter GO:0006366 252 0.019
defense response to other organism GO:0098542 17 0.019
cellular response to insulin stimulus GO:0032869 81 0.019
hemostasis GO:0007599 26 0.019
small molecule biosynthetic process GO:0044283 124 0.019
regulation of establishment of protein localization GO:0070201 69 0.019
blood vessel development GO:0001568 69 0.019
innate immune response GO:0045087 35 0.019
regulation of cell projection organization GO:0031344 175 0.018
regulation of programmed cell death GO:0043067 341 0.018
organic acid biosynthetic process GO:0016053 83 0.018
blood circulation GO:0008015 183 0.018
negative regulation of protein maturation GO:1903318 47 0.018
response to fatty acid GO:0070542 65 0.018
cellular response to interleukin 1 GO:0071347 37 0.018
central nervous system development GO:0007417 311 0.018
male gamete generation GO:0048232 99 0.018
cellular component biogenesis GO:0044085 368 0.018
homeostatic process GO:0042592 331 0.018
positive regulation of biosynthetic process GO:0009891 319 0.018
negative regulation of signaling GO:0023057 157 0.018
protein oligomerization GO:0051259 191 0.017
regulation of protein processing GO:0070613 50 0.017
protein homooligomerization GO:0051260 91 0.017
transcription dna templated GO:0006351 377 0.017
gonad development GO:0008406 104 0.017
regulation of rna metabolic process GO:0051252 391 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.017
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
regulation of jak stat cascade GO:0046425 21 0.017
regulation of protein localization GO:0032880 81 0.017
regulation of catalytic activity GO:0050790 304 0.017
positive regulation of cell differentiation GO:0045597 217 0.016
regulation of hormone secretion GO:0046883 106 0.016
negative regulation of humoral immune response GO:0002921 4 0.016
rna biosynthetic process GO:0032774 380 0.016
rna metabolic process GO:0016070 406 0.016
peptide hormone secretion GO:0030072 84 0.016
monosaccharide metabolic process GO:0005996 61 0.016
cardiovascular system development GO:0072358 134 0.016
protein processing GO:0016485 68 0.016
fibrinolysis GO:0042730 2 0.016
negative regulation of protein processing GO:0010955 47 0.016
carbohydrate derivative metabolic process GO:1901135 346 0.016
response to retinoic acid GO:0032526 63 0.016
leukocyte mediated immunity GO:0002443 28 0.016
positive regulation of b cell mediated immunity GO:0002714 2 0.016
cellular response to glucocorticoid stimulus GO:0071385 68 0.016
regulation of growth GO:0040008 105 0.016
cellular catabolic process GO:0044248 295 0.015
camera type eye development GO:0043010 48 0.015
angiogenesis GO:0001525 53 0.015
regulation of neuron differentiation GO:0045664 208 0.015
response to corticosterone GO:0051412 40 0.015
exocytosis GO:0006887 60 0.015
protein transport GO:0015031 132 0.015
regulation of protein maturation GO:1903317 50 0.015
positive regulation of blood coagulation GO:0030194 4 0.015
signal release GO:0023061 145 0.015
hormone transport GO:0009914 121 0.015
regulation of cell growth GO:0001558 85 0.015
negative regulation of nucleic acid templated transcription GO:1903507 117 0.015
response to hydrogen peroxide GO:0042542 89 0.015
cell growth GO:0016049 104 0.015
activation of immune response GO:0002253 26 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.014
cellular response to abiotic stimulus GO:0071214 85 0.014
retina morphogenesis in camera type eye GO:0060042 1 0.014
protein secretion GO:0009306 34 0.014
response to growth factor GO:0070848 189 0.014
cellular response to oxidative stress GO:0034599 76 0.014
cytokine mediated signaling pathway GO:0019221 43 0.014
regulation of cell adhesion GO:0030155 52 0.014
positive regulation of cell death GO:0010942 184 0.014
reproductive system development GO:0061458 128 0.014
regulation of neuronal synaptic plasticity GO:0048168 31 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
response to lead ion GO:0010288 33 0.014
regulation of multicellular organismal development GO:2000026 376 0.014
regulation of neurogenesis GO:0050767 247 0.014
plasminogen activation GO:0031639 2 0.014
protein activation cascade GO:0072376 12 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
biological adhesion GO:0022610 110 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
cellular response to reactive oxygen species GO:0034614 55 0.013
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.013
tube development GO:0035295 89 0.013
negative regulation of developmental process GO:0051093 125 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
circulatory system process GO:0003013 183 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.013
regulation of immune effector process GO:0002697 32 0.013
positive regulation of catabolic process GO:0009896 78 0.013
vesicle mediated transport GO:0016192 181 0.013
axis specification GO:0009798 4 0.013
regulation of cell differentiation GO:0045595 320 0.013
negative regulation of transport GO:0051051 136 0.013
cellular homeostasis GO:0019725 252 0.013
organic anion transport GO:0015711 132 0.013
regulation of protein secretion GO:0050708 28 0.013
cell activation GO:0001775 97 0.013
defense response to gram negative bacterium GO:0050829 3 0.013
hormone secretion GO:0046879 115 0.013
positive regulation of cell development GO:0010720 176 0.013
cellular protein complex assembly GO:0043623 44 0.013
regulation of phosphorylation GO:0042325 248 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.013
sulfur compound metabolic process GO:0006790 70 0.013
positive regulation of humoral immune response GO:0002922 2 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
positive regulation of blood circulation GO:1903524 65 0.012
positive regulation of secretion by cell GO:1903532 128 0.012
regulation of response to external stimulus GO:0032101 106 0.012
positive regulation of immune system process GO:0002684 90 0.012
negative regulation of proteolysis GO:0045861 41 0.012
peptide secretion GO:0002790 86 0.012
response to testosterone GO:0033574 55 0.012
cellular response to external stimulus GO:0071496 118 0.012
epithelium development GO:0060429 96 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
cellular amide metabolic process GO:0043603 44 0.012
cellular modified amino acid metabolic process GO:0006575 61 0.012
carboxylic acid transport GO:0046942 115 0.012
positive regulation of molecular function GO:0044093 230 0.012
regulation of catabolic process GO:0009894 113 0.012
cellular lipid metabolic process GO:0044255 208 0.012
cellular response to tumor necrosis factor GO:0071356 46 0.012
appendage morphogenesis GO:0035107 4 0.012
cellular chemical homeostasis GO:0055082 247 0.012
platelet aggregation GO:0070527 4 0.012
response to platinum ion GO:0070541 4 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.011
eye morphogenesis GO:0048592 4 0.011
calcium ion transport GO:0006816 131 0.011
monocarboxylic acid biosynthetic process GO:0072330 48 0.011
regulation of blood circulation GO:1903522 110 0.011
carbohydrate homeostasis GO:0033500 75 0.011
organophosphate metabolic process GO:0019637 370 0.011
transmembrane transport GO:0055085 412 0.011
anion transport GO:0006820 178 0.011
regulation of cell migration GO:0030334 128 0.011
single organism cellular localization GO:1902580 102 0.011
protein import GO:0017038 37 0.011
regulation of hydrolase activity GO:0051336 143 0.011
cellular macromolecular complex assembly GO:0034622 58 0.011
purine containing compound metabolic process GO:0072521 253 0.011
embryonic pattern specification GO:0009880 1 0.011
nuclear transport GO:0051169 49 0.011
muscle tissue development GO:0060537 58 0.011
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.011
sex differentiation GO:0007548 113 0.011
regulation of cell development GO:0060284 263 0.011
regulation of phosphorus metabolic process GO:0051174 349 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
rhythmic process GO:0048511 156 0.011
dephosphorylation GO:0016311 98 0.011
intracellular transport GO:0046907 185 0.011
negative regulation of molecular function GO:0044092 133 0.011
positive regulation of gene expression GO:0010628 244 0.011
chemosensory behavior GO:0007635 2 0.011
regulation of neuron projection development GO:0010975 161 0.011
positive regulation of hormone secretion GO:0046887 65 0.011
extrinsic apoptotic signaling pathway GO:0097191 10 0.011
ion transmembrane transport GO:0034220 365 0.010
alpha amino acid catabolic process GO:1901606 20 0.010
localization of cell GO:0051674 202 0.010
regulation of smooth muscle cell proliferation GO:0048660 75 0.010
organonitrogen compound catabolic process GO:1901565 179 0.010
interleukin 12 production GO:0032615 3 0.010
cellular component movement GO:0006928 248 0.010
cytoplasmic transport GO:0016482 115 0.010
response to amino acid GO:0043200 75 0.010
ribonucleoside metabolic process GO:0009119 174 0.010
cardiac chamber development GO:0003205 1 0.010
rna localization GO:0006403 4 0.010
positive regulation of catalytic activity GO:0043085 184 0.010
cell type specific apoptotic process GO:0097285 134 0.010
developmental process involved in reproduction GO:0003006 159 0.010
protein phosphorylation GO:0006468 345 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
positive regulation of tyrosine phosphorylation of stat1 protein GO:0042511 1 0.010
response to starvation GO:0042594 59 0.010
complement activation GO:0006956 11 0.010

Kng1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.146
disease of anatomical entity DOID:7 0 0.146
blood coagulation disease DOID:1247 0 0.146
inherited blood coagulation disease DOID:2214 0 0.146
hematopoietic system disease DOID:74 0 0.146
disease of metabolism DOID:0014667 0 0.112
inherited metabolic disorder DOID:655 0 0.046
acquired metabolic disease DOID:0060158 0 0.013
cardiovascular system disease DOID:1287 0 0.011