Rattus norvegicus

0 known processes

Bace2

beta-site APP-cleaving enzyme 2

Bace2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of signaling GO:0023056 270 0.052
cellular amino acid metabolic process GO:0006520 107 0.048
organic acid metabolic process GO:0006082 292 0.048
carboxylic acid metabolic process GO:0019752 289 0.047
cellular response to stress GO:0033554 269 0.043
nucleoside phosphate metabolic process GO:0006753 283 0.042
nucleotide metabolic process GO:0009117 279 0.040
response to nutrient levels GO:0031667 370 0.038
organic substance catabolic process GO:1901575 316 0.038
catabolic process GO:0009056 351 0.038
rna biosynthetic process GO:0032774 380 0.037
programmed cell death GO:0012501 392 0.037
response to inorganic substance GO:0010035 377 0.035
central nervous system development GO:0007417 311 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.035
regulation of multicellular organismal development GO:2000026 376 0.035
single organism biosynthetic process GO:0044711 342 0.035
oxoacid metabolic process GO:0043436 290 0.035
cellular ketone metabolic process GO:0042180 51 0.035
organophosphate metabolic process GO:0019637 370 0.035
response to cytokine GO:0034097 215 0.035
purine containing compound catabolic process GO:0072523 138 0.035
reproductive process GO:0022414 372 0.034
cellular amine metabolic process GO:0044106 38 0.034
circulatory system development GO:0072359 134 0.033
carbohydrate derivative metabolic process GO:1901135 346 0.033
Human
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.032
transcription dna templated GO:0006351 377 0.032
response to bacterium GO:0009617 200 0.031
nucleobase containing small molecule metabolic process GO:0055086 316 0.031
purine containing compound metabolic process GO:0072521 253 0.030
amine metabolic process GO:0009308 38 0.030
rna metabolic process GO:0016070 406 0.030
response to hypoxia GO:0001666 231 0.030
oxidation reduction process GO:0055114 304 0.030
response to lipopolysaccharide GO:0032496 191 0.029
organelle organization GO:0006996 266 0.029
positive regulation of phosphorus metabolic process GO:0010562 262 0.029
cellular component biogenesis GO:0044085 368 0.028
cellular catabolic process GO:0044248 295 0.028
single organism reproductive process GO:0044702 297 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.028
protein complex subunit organization GO:0071822 302 0.027
purine nucleoside metabolic process GO:0042278 169 0.027
regulation of programmed cell death GO:0043067 341 0.027
organonitrogen compound catabolic process GO:1901565 179 0.027
regulation of signal transduction GO:0009966 318 0.027
regulation of catalytic activity GO:0050790 304 0.026
regulation of protein metabolic process GO:0051246 289 0.026
Human
multi organism reproductive process GO:0044703 262 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
regulation of apoptotic process GO:0042981 335 0.026
secretion by cell GO:0032940 248 0.026
regulation of rna metabolic process GO:0051252 391 0.025
purine ribonucleotide metabolic process GO:0009150 227 0.025
protein phosphorylation GO:0006468 345 0.025
secretion GO:0046903 307 0.024
nucleoside monophosphate metabolic process GO:0009123 93 0.024
regulation of molecular function GO:0065009 398 0.024
negative regulation of multicellular organismal process GO:0051241 203 0.024
glycosyl compound metabolic process GO:1901657 182 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.023
regulation of cell development GO:0060284 263 0.023
response to external biotic stimulus GO:0043207 221 0.023
nucleic acid templated transcription GO:0097659 379 0.023
response to extracellular stimulus GO:0009991 380 0.023
ribonucleoside catabolic process GO:0042454 126 0.023
organonitrogen compound biosynthetic process GO:1901566 167 0.023
regulation of rna biosynthetic process GO:2001141 381 0.023
response to organophosphorus GO:0046683 102 0.023
response to metal ion GO:0010038 253 0.023
ribonucleotide metabolic process GO:0009259 231 0.022
chemical homeostasis GO:0048878 292 0.022
ribose phosphate metabolic process GO:0019693 235 0.022
response to ketone GO:1901654 182 0.022
homeostatic process GO:0042592 331 0.022
cation homeostasis GO:0055080 195 0.022
positive regulation of response to stimulus GO:0048584 285 0.022
ras protein signal transduction GO:0007265 29 0.022
ribonucleoside metabolic process GO:0009119 174 0.022
aging GO:0007568 241 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
apoptotic process GO:0006915 381 0.021
single organism catabolic process GO:0044712 283 0.021
protein complex biogenesis GO:0070271 263 0.021
cellular homeostasis GO:0019725 252 0.021
heterocycle catabolic process GO:0046700 167 0.020
nucleoside metabolic process GO:0009116 179 0.020
response to nutrient GO:0007584 248 0.020
organic cyclic compound catabolic process GO:1901361 175 0.020
positive regulation of developmental process GO:0051094 283 0.020
positive regulation of molecular function GO:0044093 230 0.020
response to oxidative stress GO:0006979 186 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
cellular component assembly GO:0022607 360 0.019
response to biotic stimulus GO:0009607 226 0.019
anatomical structure morphogenesis GO:0009653 298 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
purine nucleoside triphosphate metabolic process GO:0009144 141 0.019
calcium ion homeostasis GO:0055074 162 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
cellular response to oxygen containing compound GO:1901701 386 0.019
negative regulation of gene expression GO:0010629 199 0.019
response to decreased oxygen levels GO:0036293 237 0.019
cellular nitrogen compound catabolic process GO:0044270 163 0.018
positive regulation of neurogenesis GO:0050769 165 0.018
regulation of nucleotide metabolic process GO:0006140 117 0.018
response to oxygen levels GO:0070482 265 0.018
purine ribonucleoside metabolic process GO:0046128 168 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.018
negative regulation of response to stimulus GO:0048585 155 0.018
regulation of phosphorus metabolic process GO:0051174 349 0.018
regulation of nervous system development GO:0051960 264 0.018
glycosyl compound catabolic process GO:1901658 126 0.018
regulation of secretion GO:0051046 224 0.018
regulation of cellular protein metabolic process GO:0032268 267 0.018
circulatory system process GO:0003013 183 0.018
lipid metabolic process GO:0006629 283 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.018
regulation of canonical wnt signaling pathway GO:0060828 4 0.018
regulation of cellular component organization GO:0051128 368 0.018
cellular component movement GO:0006928 248 0.018
neuron projection development GO:0031175 273 0.018
cell projection organization GO:0030030 302 0.018
cell motility GO:0048870 202 0.017
cell cell signaling GO:0007267 335 0.017
regulation of neurogenesis GO:0050767 247 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.017
regulation of secretion by cell GO:1903530 208 0.017
head development GO:0060322 247 0.017
protein complex assembly GO:0006461 263 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
Human
peptidyl amino acid modification GO:0018193 126 0.017
brain development GO:0007420 247 0.017
carbohydrate metabolic process GO:0005975 130 0.017
regulation of purine nucleotide metabolic process GO:1900542 115 0.017
cellular lipid metabolic process GO:0044255 208 0.017
nucleoside triphosphate metabolic process GO:0009141 144 0.017
cellular response to endogenous stimulus GO:0071495 377 0.017
negative regulation of metabolic process GO:0009892 331 0.017
Human
purine ribonucleoside catabolic process GO:0046130 124 0.017
ribonucleoside triphosphate metabolic process GO:0009199 141 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
intracellular signal transduction GO:0035556 314 0.017
cellular calcium ion homeostasis GO:0006874 160 0.016
purine nucleoside triphosphate catabolic process GO:0009146 122 0.016
macromolecular complex assembly GO:0065003 273 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
enzyme linked receptor protein signaling pathway GO:0007167 116 0.016
response to acid chemical GO:0001101 222 0.016
negative regulation of cell death GO:0060548 229 0.016
vesicle mediated transport GO:0016192 181 0.016
response to molecule of bacterial origin GO:0002237 194 0.016
cation transport GO:0006812 382 0.016
biological adhesion GO:0022610 110 0.016
response to ethanol GO:0045471 162 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
regulation of cellular catabolic process GO:0031329 101 0.016
negative regulation of molecular function GO:0044092 133 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.015
cardiovascular system development GO:0072358 134 0.015
metal ion homeostasis GO:0055065 186 0.015
purine nucleotide catabolic process GO:0006195 136 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
establishment of protein localization GO:0045184 141 0.015
regulation of system process GO:0044057 208 0.015
regulation of neuron projection development GO:0010975 161 0.015
cell migration GO:0016477 197 0.015
regulation of cell proliferation GO:0042127 359 0.015
intracellular transport GO:0046907 185 0.015
actin cytoskeleton organization GO:0030036 73 0.015
aromatic compound catabolic process GO:0019439 168 0.015
negative regulation of cell communication GO:0010648 158 0.015
regulation of cell differentiation GO:0045595 320 0.015
negative regulation of signal transduction GO:0009968 83 0.015
regeneration GO:0031099 163 0.015
positive regulation of cell proliferation GO:0008284 249 0.014
ribonucleotide catabolic process GO:0009261 136 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
negative regulation of signaling GO:0023057 157 0.014
regulation of response to stress GO:0080134 126 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.014
ion homeostasis GO:0050801 212 0.014
response to other organism GO:0051707 220 0.014
positive regulation of nucleotide metabolic process GO:0045981 91 0.014
cellular response to hormone stimulus GO:0032870 247 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
neuron differentiation GO:0030182 368 0.014
response to peptide hormone GO:0043434 278 0.014
regulation of transcription dna templated GO:0006355 374 0.014
regulation of locomotion GO:0040012 148 0.014
actin filament based process GO:0030029 86 0.014
nucleoside phosphate catabolic process GO:1901292 140 0.014
purine nucleoside catabolic process GO:0006152 124 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
response to peptide GO:1901652 292 0.014
positive regulation of signal transduction GO:0009967 175 0.014
single organism intracellular transport GO:1902582 166 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
cellular response to peptide GO:1901653 133 0.013
response to growth factor GO:0070848 189 0.013
cellular response to cytokine stimulus GO:0071345 127 0.013
proteolysis GO:0006508 175 0.013
Human Rat
nucleotide catabolic process GO:0009166 139 0.013
behavior GO:0007610 205 0.013
cellular response to oxidative stress GO:0034599 76 0.013
protein transport GO:0015031 132 0.013
regulation of cell projection organization GO:0031344 175 0.013
neuron development GO:0048666 286 0.013
female pregnancy GO:0007565 122 0.013
localization of cell GO:0051674 202 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
negative regulation of macromolecule metabolic process GO:0010605 260 0.013
Human
negative regulation of programmed cell death GO:0043069 183 0.013
regulation of catabolic process GO:0009894 113 0.013
regulation of neuron differentiation GO:0045664 208 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
positive regulation of cell death GO:0010942 184 0.013
heart development GO:0007507 72 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
positive regulation of phosphorylation GO:0042327 177 0.012
innate immune response GO:0045087 35 0.012
positive regulation of transport GO:0051050 245 0.012
locomotion GO:0040011 237 0.012
nucleoside triphosphate catabolic process GO:0009143 123 0.012
blood vessel morphogenesis GO:0048514 58 0.012
transcription from rna polymerase ii promoter GO:0006366 252 0.012
cellular ion homeostasis GO:0006873 184 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
cellular cation homeostasis GO:0030003 180 0.012
multi multicellular organism process GO:0044706 138 0.012
ribonucleoside triphosphate catabolic process GO:0009203 122 0.012
regulation of protein localization GO:0032880 81 0.012
regulation of hydrolase activity GO:0051336 143 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
single organism carbohydrate metabolic process GO:0044723 118 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
regulation of protein transport GO:0051223 68 0.012
immune effector process GO:0002252 53 0.012
purine nucleoside monophosphate metabolic process GO:0009126 84 0.012
carbohydrate derivative catabolic process GO:1901136 147 0.012
response to purine containing compound GO:0014074 126 0.012
positive regulation of nucleic acid templated transcription GO:1903508 197 0.012
protein localization GO:0008104 191 0.012
cell cycle GO:0007049 101 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
ribonucleoside monophosphate metabolic process GO:0009161 88 0.011
regulation of purine nucleotide catabolic process GO:0033121 65 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
purine nucleotide biosynthetic process GO:0006164 83 0.011
regulation of proteasomal protein catabolic process GO:0061136 4 0.011
metal ion transport GO:0030001 289 0.011
response to monosaccharide GO:0034284 159 0.011
dendrite development GO:0016358 72 0.011
anterior posterior pattern specification GO:0009952 1 0.011
synaptic transmission GO:0007268 235 0.011
developmental growth GO:0048589 100 0.011
reproductive structure development GO:0048608 128 0.011
regulation of phosphorylation GO:0042325 248 0.011
ion transmembrane transport GO:0034220 365 0.011
multicellular organism reproduction GO:0032504 233 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
cytoskeleton organization GO:0007010 111 0.011
nitrogen compound transport GO:0071705 229 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
regulation of nucleoside metabolic process GO:0009118 66 0.011
cellular response to lipid GO:0071396 201 0.011
cell adhesion GO:0007155 110 0.011
organophosphate catabolic process GO:0046434 148 0.011
multicellular organismal reproductive process GO:0048609 233 0.011
lipid storage GO:0019915 1 0.011
regulation of immune system process GO:0002682 123 0.011
positive regulation of cell development GO:0010720 176 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
growth GO:0040007 165 0.011
sex differentiation GO:0007548 113 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
reproduction GO:0000003 245 0.011
nucleoside catabolic process GO:0009164 126 0.010
developmental process involved in reproduction GO:0003006 159 0.010
regulation of nucleotide catabolic process GO:0030811 65 0.010
signal release GO:0023061 145 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
response to glucocorticoid GO:0051384 223 0.010
organophosphate biosynthetic process GO:0090407 143 0.010
response to radiation GO:0009314 137 0.010
response to camp GO:0051591 91 0.010
atp metabolic process GO:0046034 72 0.010
response to transition metal nanoparticle GO:1990267 122 0.010
maintenance of location GO:0051235 17 0.010
positive regulation of gene expression GO:0010628 244 0.010
regulation of growth GO:0040008 105 0.010
regulation of cell motility GO:2000145 131 0.010
sexual reproduction GO:0019953 148 0.010
negative regulation of developmental process GO:0051093 125 0.010
divalent inorganic cation transport GO:0072511 134 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
Human
cytokine production GO:0001816 61 0.010

Bace2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.015
central nervous system disease DOID:331 0 0.011