Rattus norvegicus

17 known processes

Hlcs

holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)

(Aliases: RGD1565360)

Hlcs biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of molecular function GO:0065009 398 0.055
regulation of catalytic activity GO:0050790 304 0.051
organic acid metabolic process GO:0006082 292 0.050
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.048
regulation of phosphorus metabolic process GO:0051174 349 0.048
regulation of phosphate metabolic process GO:0019220 349 0.047
intracellular signal transduction GO:0035556 314 0.047
transcription dna templated GO:0006351 377 0.041
catabolic process GO:0009056 351 0.041
central nervous system development GO:0007417 311 0.041
positive regulation of phosphate metabolic process GO:0045937 262 0.040
regulation of protein metabolic process GO:0051246 289 0.040
oxoacid metabolic process GO:0043436 290 0.037
nucleotide metabolic process GO:0009117 279 0.037
nucleoside phosphate metabolic process GO:0006753 283 0.036
positive regulation of molecular function GO:0044093 230 0.036
cellular response to endogenous stimulus GO:0071495 377 0.036
positive regulation of phosphorus metabolic process GO:0010562 262 0.035
carboxylic acid metabolic process GO:0019752 289 0.035
cation transport GO:0006812 382 0.035
regulation of cellular protein metabolic process GO:0032268 267 0.034
cellular response to oxygen containing compound GO:1901701 386 0.034
positive regulation of catalytic activity GO:0043085 184 0.033
nucleobase containing small molecule metabolic process GO:0055086 316 0.033
response to extracellular stimulus GO:0009991 380 0.033
single organism biosynthetic process GO:0044711 342 0.032
organophosphate metabolic process GO:0019637 370 0.032
response to corticosteroid GO:0031960 235 0.032
aromatic compound catabolic process GO:0019439 168 0.032
response to nutrient levels GO:0031667 370 0.031
response to inorganic substance GO:0010035 377 0.031
negative regulation of cellular metabolic process GO:0031324 281 0.031
single organism catabolic process GO:0044712 283 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.031
protein phosphorylation GO:0006468 345 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
cellular amine metabolic process GO:0044106 38 0.029
cellular response to nitrogen compound GO:1901699 210 0.029
amine metabolic process GO:0009308 38 0.029
regulation of rna biosynthetic process GO:2001141 381 0.029
cellular component assembly GO:0022607 360 0.028
proteolysis GO:0006508 175 0.028
rna metabolic process GO:0016070 406 0.028
multi organism reproductive process GO:0044703 262 0.028
response to metal ion GO:0010038 253 0.028
organelle organization GO:0006996 266 0.028
nucleic acid templated transcription GO:0097659 379 0.028
rna biosynthetic process GO:0032774 380 0.028
cell projection organization GO:0030030 302 0.028
response to nutrient GO:0007584 248 0.028
response to acid chemical GO:0001101 222 0.027
positive regulation of biosynthetic process GO:0009891 319 0.027
regulation of cellular ketone metabolic process GO:0010565 27 0.027
purine containing compound metabolic process GO:0072521 253 0.027
macromolecular complex subunit organization GO:0043933 339 0.027
cellular catabolic process GO:0044248 295 0.027
ribose phosphate metabolic process GO:0019693 235 0.027
purine nucleotide metabolic process GO:0006163 229 0.026
negative regulation of metabolic process GO:0009892 331 0.026
oxidation reduction process GO:0055114 304 0.026
negative regulation of cell death GO:0060548 229 0.026
regulation of phosphorylation GO:0042325 248 0.025
regulation of signal transduction GO:0009966 318 0.025
heterocycle catabolic process GO:0046700 167 0.025
ribonucleotide metabolic process GO:0009259 231 0.025
cellular response to stress GO:0033554 269 0.025
homeostatic process GO:0042592 331 0.025
small gtpase mediated signal transduction GO:0007264 36 0.025
secretion GO:0046903 307 0.025
regulation of cell proliferation GO:0042127 359 0.025
negative regulation of gene expression GO:0010629 199 0.024
nucleoside phosphate catabolic process GO:1901292 140 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
cellular amino acid metabolic process GO:0006520 107 0.024
apoptotic process GO:0006915 381 0.024
regulation of rna metabolic process GO:0051252 391 0.024
lipid metabolic process GO:0006629 283 0.023
response to peptide hormone GO:0043434 278 0.023
regulation of cellular component organization GO:0051128 368 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
cellular component biogenesis GO:0044085 368 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.023
nitrogen compound transport GO:0071705 229 0.023
ribonucleoside metabolic process GO:0009119 174 0.023
reproduction GO:0000003 245 0.023
purine ribonucleotide metabolic process GO:0009150 227 0.023
positive regulation of cell communication GO:0010647 271 0.023
ras protein signal transduction GO:0007265 29 0.022
organic substance catabolic process GO:1901575 316 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
glycosyl compound metabolic process GO:1901657 182 0.022
single organism reproductive process GO:0044702 297 0.022
regulation of catabolic process GO:0009894 113 0.022
regulation of nucleic acid templated transcription GO:1903506 380 0.021
nucleoside metabolic process GO:0009116 179 0.021
neuron differentiation GO:0030182 368 0.021
cellular ketone metabolic process GO:0042180 51 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.021
regulation of protein phosphorylation GO:0001932 183 0.021
regulation of transcription dna templated GO:0006355 374 0.021
regulation of protein modification process GO:0031399 194 0.021
cellular homeostasis GO:0019725 252 0.021
purine nucleoside metabolic process GO:0042278 169 0.021
organonitrogen compound catabolic process GO:1901565 179 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.020
anatomical structure morphogenesis GO:0009653 298 0.020
transmembrane transport GO:0055085 412 0.020
nucleoside catabolic process GO:0009164 126 0.020
head development GO:0060322 247 0.020
regulation of apoptotic process GO:0042981 335 0.020
secretion by cell GO:0032940 248 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
response to peptide GO:1901652 292 0.019
response to oxidative stress GO:0006979 186 0.019
positive regulation of cell proliferation GO:0008284 249 0.019
regulation of nucleotide metabolic process GO:0006140 117 0.019
cellular nitrogen compound catabolic process GO:0044270 163 0.019
regulation of intracellular signal transduction GO:1902531 218 0.019
cell cell signaling GO:0007267 335 0.019
organophosphate catabolic process GO:0046434 148 0.019
purine ribonucleoside metabolic process GO:0046128 168 0.019
negative regulation of biosynthetic process GO:0009890 168 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
transcription from rna polymerase ii promoter GO:0006366 252 0.019
multicellular organismal reproductive process GO:0048609 233 0.019
multicellular organism reproduction GO:0032504 233 0.019
nucleobase containing compound catabolic process GO:0034655 152 0.019
organic cyclic compound catabolic process GO:1901361 175 0.019
nucleotide catabolic process GO:0009166 139 0.018
anion transport GO:0006820 178 0.018
regulation of programmed cell death GO:0043067 341 0.018
aging GO:0007568 241 0.018
reproductive process GO:0022414 372 0.018
protein complex subunit organization GO:0071822 302 0.018
ribonucleotide catabolic process GO:0009261 136 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
tissue development GO:0009888 252 0.018
brain development GO:0007420 247 0.018
programmed cell death GO:0012501 392 0.018
chemical homeostasis GO:0048878 292 0.018
positive regulation of gene expression GO:0010628 244 0.018
glycosyl compound catabolic process GO:1901658 126 0.018
regulation of cellular catabolic process GO:0031329 101 0.017
response to decreased oxygen levels GO:0036293 237 0.017
response to growth factor GO:0070848 189 0.017
localization of cell GO:0051674 202 0.017
nucleoside triphosphate metabolic process GO:0009141 144 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
regulation of purine nucleotide metabolic process GO:1900542 115 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.017
macromolecule localization GO:0033036 252 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.017
positive regulation of phosphorylation GO:0042327 177 0.017
regulation of cellular localization GO:0060341 263 0.017
positive regulation of cell death GO:0010942 184 0.017
positive regulation of nucleotide metabolic process GO:0045981 91 0.017
response to vitamin GO:0033273 131 0.017
regulation of hydrolase activity GO:0051336 143 0.017
cellular response to hormone stimulus GO:0032870 247 0.017
negative regulation of cellular biosynthetic process GO:0031327 161 0.017
synaptic transmission GO:0007268 235 0.016
organic anion transport GO:0015711 132 0.016
neuron death GO:0070997 127 0.016
response to hypoxia GO:0001666 231 0.016
cellular response to lipid GO:0071396 201 0.016
positive regulation of response to stimulus GO:0048584 285 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
carbohydrate derivative catabolic process GO:1901136 147 0.016
eye morphogenesis GO:0048592 4 0.016
positive regulation of cellular protein metabolic process GO:0032270 167 0.016
negative regulation of cell communication GO:0010648 158 0.016
cellular lipid metabolic process GO:0044255 208 0.016
regulation of ion transport GO:0043269 245 0.016
lipid biosynthetic process GO:0008610 128 0.016
purine ribonucleoside catabolic process GO:0046130 124 0.016
ion transmembrane transport GO:0034220 365 0.016
protein complex biogenesis GO:0070271 263 0.016
neuron development GO:0048666 286 0.016
negative regulation of signaling GO:0023057 157 0.016
neuron projection development GO:0031175 273 0.016
purine nucleoside triphosphate metabolic process GO:0009144 141 0.016
response to estrogen GO:0043627 232 0.016
gastrulation GO:0007369 2 0.015
regulation of hormone levels GO:0010817 187 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
regulation of purine nucleotide catabolic process GO:0033121 65 0.015
small molecule biosynthetic process GO:0044283 124 0.015
purine nucleotide catabolic process GO:0006195 136 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
metal ion transport GO:0030001 289 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
positive regulation of signaling GO:0023056 270 0.015
cellular chemical homeostasis GO:0055082 247 0.015
ribonucleoside triphosphate metabolic process GO:0009199 141 0.015
response to oxygen levels GO:0070482 265 0.015
purine containing compound catabolic process GO:0072523 138 0.015
vesicle mediated transport GO:0016192 181 0.015
regulation of system process GO:0044057 208 0.014
regulation of multicellular organismal development GO:2000026 376 0.014
multicellular organism growth GO:0035264 1 0.014
nucleoside triphosphate catabolic process GO:0009143 123 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
intracellular transport GO:0046907 185 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
cell type specific apoptotic process GO:0097285 134 0.014
organonitrogen compound biosynthetic process GO:1901566 167 0.014
cell migration GO:0016477 197 0.014
regulation of membrane potential GO:0042391 110 0.014
response to mechanical stimulus GO:0009612 134 0.014
ribonucleoside triphosphate catabolic process GO:0009203 122 0.014
regulation of nervous system development GO:0051960 264 0.014
mapk cascade GO:0000165 140 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
regulation of cell motility GO:2000145 131 0.013
cellular cation homeostasis GO:0030003 180 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
regulation of secretion GO:0051046 224 0.013
regulation of gtpase activity GO:0043087 57 0.013
regulation of nucleotide catabolic process GO:0030811 65 0.013
regulation of anatomical structure size GO:0090066 135 0.013
protein complex assembly GO:0006461 263 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
purine nucleoside triphosphate catabolic process GO:0009146 122 0.013
cellular ion homeostasis GO:0006873 184 0.013
response to ketone GO:1901654 182 0.013
positive regulation of cellular catabolic process GO:0031331 71 0.013
ion homeostasis GO:0050801 212 0.013
positive regulation of hydrolase activity GO:0051345 86 0.013
response to cytokine GO:0034097 215 0.013
response to wounding GO:0009611 254 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
cellular response to external stimulus GO:0071496 118 0.013
multicellular organismal signaling GO:0035637 44 0.013
rhythmic process GO:0048511 156 0.013
negative regulation of transport GO:0051051 136 0.013
metal ion homeostasis GO:0055065 186 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
cellular response to peptide GO:1901653 133 0.013
macromolecular complex assembly GO:0065003 273 0.013
growth GO:0040007 165 0.013
amide transport GO:0042886 105 0.013
single organism organelle organization GO:1902589 180 0.013
response to glucose GO:0009749 136 0.013
regulation of secretion by cell GO:1903530 208 0.013
positive regulation of nucleoside metabolic process GO:0045979 55 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.013
positive regulation of ion transport GO:0043270 94 0.013
developmental process involved in reproduction GO:0003006 159 0.013
regulation of synaptic transmission GO:0050804 141 0.012
regulation of neuron death GO:1901214 115 0.012
protein localization GO:0008104 191 0.012
positive regulation of protein modification process GO:0031401 142 0.012
regulation of cell development GO:0060284 263 0.012
positive regulation of transport GO:0051050 245 0.012
locomotion GO:0040011 237 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
purine ribonucleotide catabolic process GO:0009154 136 0.012
carbohydrate metabolic process GO:0005975 130 0.012
inorganic ion transmembrane transport GO:0098660 229 0.012
sexual reproduction GO:0019953 148 0.012
neurological system process GO:0050877 219 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 53 0.012
cellular component movement GO:0006928 248 0.012
single organism intracellular transport GO:1902582 166 0.012
positive regulation of nucleotide catabolic process GO:0030813 53 0.012
lipid storage GO:0019915 1 0.012
cell motility GO:0048870 202 0.012
positive regulation of developmental process GO:0051094 283 0.012
response to monosaccharide GO:0034284 159 0.012
axis specification GO:0009798 4 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
regulation of cell differentiation GO:0045595 320 0.012
regulation of nucleoside metabolic process GO:0009118 66 0.012
regulation of cell projection organization GO:0031344 175 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
cell growth GO:0016049 104 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
protein oligomerization GO:0051259 191 0.012
negative regulation of rna metabolic process GO:0051253 123 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
response to ethanol GO:0045471 162 0.012
regulation of cell growth GO:0001558 85 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
positive regulation of transcription dna templated GO:0045893 197 0.011
negative regulation of nucleic acid templated transcription GO:1903507 117 0.011
regulation of kinase activity GO:0043549 117 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
organic acid transport GO:0015849 116 0.011
cellular component morphogenesis GO:0032989 155 0.011
carboxylic acid transport GO:0046942 115 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
positive regulation of multicellular organismal process GO:0051240 387 0.011
response to glucocorticoid GO:0051384 223 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
response to hexose GO:0009746 144 0.011
transmission of nerve impulse GO:0019226 42 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
positive regulation of signal transduction GO:0009967 175 0.011
behavior GO:0007610 205 0.011
rho protein signal transduction GO:0007266 11 0.011
regulation of cellular component movement GO:0051270 150 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
developmental growth GO:0048589 100 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
cation homeostasis GO:0055080 195 0.011
gland development GO:0048732 155 0.011
cardiovascular system development GO:0072358 134 0.011
regulation of transferase activity GO:0051338 123 0.011
circulatory system development GO:0072359 134 0.011
positive regulation of nervous system development GO:0051962 178 0.011
male gamete generation GO:0048232 99 0.011
response to toxic substance GO:0009636 133 0.011
hormone transport GO:0009914 121 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
neuromuscular process GO:0050905 2 0.011
forebrain development GO:0030900 98 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
heart morphogenesis GO:0003007 3 0.011
response to purine containing compound GO:0014074 126 0.011
divalent metal ion transport GO:0070838 132 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
response to carbohydrate GO:0009743 183 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
sex differentiation GO:0007548 113 0.011
negative regulation of rna biosynthetic process GO:1902679 118 0.011
adult locomotory behavior GO:0008344 4 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
regulation of growth GO:0040008 105 0.010
positive regulation of gtp catabolic process GO:0033126 48 0.010
reproductive structure development GO:0048608 128 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
muscle structure development GO:0061061 87 0.010
organic hydroxy compound transport GO:0015850 77 0.010
positive regulation of cell development GO:0010720 176 0.010
organic acid biosynthetic process GO:0016053 83 0.010
cellular response to peptide hormone stimulus GO:0071375 120 0.010
peptide transport GO:0015833 97 0.010
camera type eye morphogenesis GO:0048593 2 0.010
inorganic cation transmembrane transport GO:0098662 202 0.010
regulation of neurogenesis GO:0050767 247 0.010

Hlcs disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
disease of metabolism DOID:0014667 0 0.021
inherited metabolic disorder DOID:655 0 0.014
musculoskeletal system disease DOID:17 0 0.013
sensory system disease DOID:0050155 0 0.011