Rattus norvegicus

94 known processes

Smad7

SMAD family member 7

(Aliases: Madh7)

Smad7 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
anatomical structure morphogenesis GO:0009653 298 0.665
Rat Fly
positive regulation of phosphorus metabolic process GO:0010562 262 0.655
Rat
localization of cell GO:0051674 202 0.637
Rat Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.614
negative regulation of transcription dna templated GO:0045892 116 0.588
positive regulation of response to stimulus GO:0048584 285 0.494
Rat
protein phosphorylation GO:0006468 345 0.489
negative regulation of gene expression GO:0010629 199 0.479
developmental process involved in reproduction GO:0003006 159 0.479
Rat
enzyme linked receptor protein signaling pathway GO:0007167 116 0.469
positive regulation of phosphate metabolic process GO:0045937 262 0.466
Rat
cell migration GO:0016477 197 0.449
Rat Fly
protein autophosphorylation GO:0046777 66 0.443
renal system development GO:0072001 67 0.439
Rat Fly
cellular component movement GO:0006928 248 0.433
Rat Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.425
negative regulation of biosynthetic process GO:0009890 168 0.421
response to glucocorticoid GO:0051384 223 0.413
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.411
Rat
vesicle mediated transport GO:0016192 181 0.410
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.387
Rat Fly
response to monosaccharide GO:0034284 159 0.386
response to oxygen levels GO:0070482 265 0.375
Rat
tissue development GO:0009888 252 0.375
Rat Fly
positive regulation of signal transduction GO:0009967 175 0.368
Rat
cell morphogenesis GO:0000902 142 0.365
Rat Fly
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.362
regulation of intracellular signal transduction GO:1902531 218 0.360
cellular component assembly GO:0022607 360 0.358
Rat Fly
negative regulation of cellular metabolic process GO:0031324 281 0.356
gland development GO:0048732 155 0.351
mesoderm development GO:0007498 2 0.345
cell motility GO:0048870 202 0.335
Rat Fly
regulation of transcription dna templated GO:0006355 374 0.317
regeneration GO:0031099 163 0.313
neuron differentiation GO:0030182 368 0.313
Rat Fly
regulation of cellular component movement GO:0051270 150 0.313
Rat
negative regulation of rna metabolic process GO:0051253 123 0.307
bmp signaling pathway GO:0030509 4 0.306
Rat Fly
regulation of cell proliferation GO:0042127 359 0.297
Rat
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.296
macromolecular complex assembly GO:0065003 273 0.292
Rat
axon development GO:0061564 96 0.291
Fly
positive regulation of cell differentiation GO:0045597 217 0.289
Rat
negative regulation of metabolic process GO:0009892 331 0.288
organ regeneration GO:0031100 101 0.287
intracellular signal transduction GO:0035556 314 0.286
reproductive structure development GO:0048608 128 0.285
peptidyl amino acid modification GO:0018193 126 0.280
regulation of cell cycle GO:0051726 73 0.278
response to corticosteroid GO:0031960 235 0.276
positive regulation of locomotion GO:0040017 102 0.273
Rat
cellular protein localization GO:0034613 122 0.272
response to hypoxia GO:0001666 231 0.272
Rat
kidney development GO:0001822 67 0.269
Rat
transcription dna templated GO:0006351 377 0.269
rna biosynthetic process GO:0032774 380 0.267
reproductive system development GO:0061458 128 0.259
regulation of rna metabolic process GO:0051252 391 0.255
nucleic acid templated transcription GO:0097659 379 0.253
signal transduction by phosphorylation GO:0023014 144 0.250
Rat
programmed cell death GO:0012501 392 0.250
Rat
positive regulation of multicellular organismal process GO:0051240 387 0.248
Rat
single organism organelle organization GO:1902589 180 0.244
Rat
cardiac muscle cell proliferation GO:0060038 6 0.243
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.241
Rat
positive regulation of protein phosphorylation GO:0001934 135 0.235
regulation of phosphorylation GO:0042325 248 0.233
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.232
positive regulation of nucleic acid templated transcription GO:1903508 197 0.232
Rat
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.231
urogenital system development GO:0001655 78 0.228
Rat Fly
regulation of multicellular organismal development GO:2000026 376 0.223
Rat Fly
response to decreased oxygen levels GO:0036293 237 0.222
Rat
regulation of apoptotic process GO:0042981 335 0.222
Rat
behavior GO:0007610 205 0.220
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.219
negative regulation of nucleic acid templated transcription GO:1903507 117 0.218
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.217
Rat
macromolecular complex subunit organization GO:0043933 339 0.216
Rat
cellular response to endogenous stimulus GO:0071495 377 0.214
macromolecule localization GO:0033036 252 0.212
regulation of rna biosynthetic process GO:2001141 381 0.209
reproductive process GO:0022414 372 0.207
Rat
development of primary sexual characteristics GO:0045137 107 0.207
cellular response to hormone stimulus GO:0032870 247 0.205
cell morphogenesis involved in differentiation GO:0000904 119 0.205
Rat Fly
muscle cell proliferation GO:0033002 84 0.203
epithelium development GO:0060429 96 0.202
Fly
transcription from rna polymerase ii promoter GO:0006366 252 0.202
Rat Fly
regulation of anatomical structure morphogenesis GO:0022603 141 0.201
Rat
neuron projection morphogenesis GO:0048812 122 0.200
Rat Fly
negative regulation of cellular biosynthetic process GO:0031327 161 0.199
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 6 0.198
cell part morphogenesis GO:0032990 123 0.198
Rat Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.197
Rat
female gonad development GO:0008585 53 0.196
cellular amino acid metabolic process GO:0006520 107 0.193
regulation of mesenchymal cell proliferation GO:0010464 4 0.189
cellular component biogenesis GO:0044085 368 0.188
Rat Fly
embryo development GO:0009790 49 0.187
Fly
response to nutrient GO:0007584 248 0.187
negative regulation of macromolecule metabolic process GO:0010605 260 0.186
organelle organization GO:0006996 266 0.185
Rat
positive regulation of rna biosynthetic process GO:1902680 197 0.184
Rat
regulation of cell differentiation GO:0045595 320 0.184
Rat Fly
positive regulation of cell communication GO:0010647 271 0.180
Rat
locomotion GO:0040011 237 0.178
Rat Fly
regulation of cell adhesion GO:0030155 52 0.178
Rat
tube development GO:0035295 89 0.177
Fly
regulation of phosphate metabolic process GO:0019220 349 0.175
Rat Fly
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.174
regulation of cellular component organization GO:0051128 368 0.174
Rat Fly
single organism reproductive process GO:0044702 297 0.172
Rat
positive regulation of developmental process GO:0051094 283 0.171
Rat
cell cell signaling GO:0007267 335 0.170
Fly
regulation of smooth muscle cell proliferation GO:0048660 75 0.170
developmental growth GO:0048589 100 0.168
Fly
negative regulation of signal transduction GO:0009968 83 0.166
Fly
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.165
positive regulation of phosphorylation GO:0042327 177 0.163
positive regulation of catalytic activity GO:0043085 184 0.163
Rat
organ morphogenesis GO:0009887 75 0.163
Fly
negative regulation of cell death GO:0060548 229 0.162
Rat
common partner smad protein phosphorylation GO:0007182 1 0.162
negative regulation of cell communication GO:0010648 158 0.160
Fly
positive regulation of gene expression GO:0010628 244 0.160
Rat
positive regulation of signaling GO:0023056 270 0.160
Rat
regulation of nervous system development GO:0051960 264 0.160
Rat Fly
regulation of protein phosphorylation GO:0001932 183 0.157
regulation of protein modification process GO:0031399 194 0.157
negative regulation of rna biosynthetic process GO:1902679 118 0.153
regulation of cell migration GO:0030334 128 0.153
Rat
regulation of cell morphogenesis GO:0022604 77 0.153
Rat
negative regulation of cell proliferation GO:0008285 119 0.152
Rat
apoptotic process GO:0006915 381 0.151
Rat
rhythmic process GO:0048511 156 0.149
response to hexose GO:0009746 144 0.146
sex differentiation GO:0007548 113 0.146
Rat
regulation of phosphorus metabolic process GO:0051174 349 0.145
Rat Fly
regulation of programmed cell death GO:0043067 341 0.145
Rat
protein complex subunit organization GO:0071822 302 0.145
Rat
smooth muscle cell proliferation GO:0048659 77 0.145
taxis GO:0042330 67 0.144
Rat Fly
response to nutrient levels GO:0031667 370 0.144
positive regulation of intracellular protein transport GO:0090316 20 0.144
cell type specific apoptotic process GO:0097285 134 0.143
Rat
regulation of protein metabolic process GO:0051246 289 0.143
Rat
response to carbohydrate GO:0009743 183 0.142
gliogenesis GO:0042063 93 0.141
negative regulation of programmed cell death GO:0043069 183 0.140
Rat
response to ketone GO:1901654 182 0.139
negative regulation of signaling GO:0023057 157 0.138
Fly
regulation of cellular localization GO:0060341 263 0.135
extrinsic apoptotic signaling pathway GO:0097191 10 0.135
response to other organism GO:0051707 220 0.134
cell projection organization GO:0030030 302 0.134
Rat Fly
carboxylic acid metabolic process GO:0019752 289 0.133
cellular response to insulin stimulus GO:0032869 81 0.133
heart morphogenesis GO:0003007 3 0.130
tissue regeneration GO:0042246 36 0.130
growth GO:0040007 165 0.128
Fly
endothelium development GO:0003158 12 0.128
multicellular organismal reproductive process GO:0048609 233 0.126
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.124
Rat Fly
response to wounding GO:0009611 254 0.124
Rat
regulation of locomotion GO:0040012 148 0.124
Rat
aging GO:0007568 241 0.123
response to vitamin GO:0033273 131 0.122
negative regulation of organ growth GO:0046621 3 0.122
regulation of membrane potential GO:0042391 110 0.121
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.121
Rat
response to extracellular stimulus GO:0009991 380 0.121
protein localization GO:0008104 191 0.120
cellular amine metabolic process GO:0044106 38 0.120
apoptotic signaling pathway GO:0097190 27 0.120
Rat
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.119
embryonic cranial skeleton morphogenesis GO:0048701 2 0.119
regulation of catalytic activity GO:0050790 304 0.119
Rat
positive regulation of cell migration GO:0030335 96 0.118
Rat
regulation of cellular protein metabolic process GO:0032268 267 0.117
Rat
cellular component morphogenesis GO:0032989 155 0.117
Rat Fly
gonad development GO:0008406 104 0.116
regulation of cellular amino acid metabolic process GO:0006521 2 0.115
positive regulation of cellular component organization GO:0051130 200 0.113
Rat
response to glucose GO:0009749 136 0.112
development of primary female sexual characteristics GO:0046545 56 0.112
regulation of mapk cascade GO:0043408 116 0.111
cellular response to growth factor stimulus GO:0071363 162 0.111
response to estrogen GO:0043627 232 0.111
Rat
striated muscle cell proliferation GO:0014855 9 0.109
ovulation cycle process GO:0022602 50 0.108
reproduction GO:0000003 245 0.108
negative regulation of osteoblast differentiation GO:0045668 2 0.107
positive regulation of cell proliferation GO:0008284 249 0.107
regulation of epithelial cell differentiation GO:0030856 12 0.106
multi multicellular organism process GO:0044706 138 0.106
positive regulation of mapk cascade GO:0043410 92 0.105
response to growth factor GO:0070848 189 0.105
organic substance catabolic process GO:1901575 316 0.104
regulation of neurogenesis GO:0050767 247 0.103
Rat
cellular response to corticosteroid stimulus GO:0071384 69 0.102
regulation of cell development GO:0060284 263 0.102
Rat
positive regulation of biosynthetic process GO:0009891 319 0.101
Rat
regulation of bmp signaling pathway GO:0030510 2 0.101
regulation of signal transduction GO:0009966 318 0.101
neuron development GO:0048666 286 0.100
Rat Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.100
Rat
cell matrix adhesion GO:0007160 19 0.099
Rat
regulation of cell growth GO:0001558 85 0.099
tissue morphogenesis GO:0048729 22 0.098
Fly
cellular ketone metabolic process GO:0042180 51 0.098
negative regulation of response to stimulus GO:0048585 155 0.098
Fly
positive regulation of nervous system development GO:0051962 178 0.097
Rat
cellular response to glucocorticoid stimulus GO:0071385 68 0.097
positive regulation of cellular protein metabolic process GO:0032270 167 0.096
Rat
epithelial cell differentiation GO:0030855 71 0.096
regulation of cell motility GO:2000145 131 0.095
Rat
regulation of establishment of protein localization GO:0070201 69 0.095
regulation of cell projection organization GO:0031344 175 0.095
Rat
rna metabolic process GO:0016070 406 0.093
receptor mediated endocytosis GO:0006898 42 0.093
positive regulation of cell death GO:0010942 184 0.091
Rat
positive regulation of protein kinase activity GO:0045860 73 0.091
positive regulation of transport GO:0051050 245 0.091
positive regulation of intracellular signal transduction GO:1902533 138 0.091
glial cell differentiation GO:0010001 65 0.090
multi organism reproductive process GO:0044703 262 0.090
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.090
amine metabolic process GO:0009308 38 0.090
head development GO:0060322 247 0.089
neuron projection development GO:0031175 273 0.089
Rat Fly
anterior posterior pattern specification GO:0009952 1 0.089
Fly
negative regulation of developmental growth GO:0048640 15 0.088
Fly
regulation of organ growth GO:0046620 13 0.088
muscle structure development GO:0061061 87 0.087
Fly
mesoderm morphogenesis GO:0048332 1 0.087
positive regulation of protein modification process GO:0031401 142 0.086
response to radiation GO:0009314 137 0.086
regulation of protein localization GO:0032880 81 0.085
response to peptide GO:1901652 292 0.085
positive regulation of transferase activity GO:0051347 81 0.085
regulation of cellular ketone metabolic process GO:0010565 27 0.084
catabolic process GO:0009056 351 0.084
immune system process GO:0002376 204 0.084
branching morphogenesis of an epithelial tube GO:0048754 14 0.083
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.081
response to peptide hormone GO:0043434 278 0.080
regulation of transferase activity GO:0051338 123 0.080
positive regulation of cellular component movement GO:0051272 102 0.080
Rat
cell growth GO:0016049 104 0.079
Fly
response to insulin GO:0032868 133 0.077
regulation of molecular function GO:0065009 398 0.077
Rat
response to transforming growth factor beta GO:0071559 46 0.076
mesoderm formation GO:0001707 1 0.076
response to cytokine GO:0034097 215 0.076
regulation of endothelial cell differentiation GO:0045601 4 0.075
female sex differentiation GO:0046660 59 0.075
immune system development GO:0002520 41 0.074
vasculogenesis GO:0001570 3 0.073
regulation of organelle organization GO:0033043 80 0.073
Rat
ribonucleoside triphosphate metabolic process GO:0009199 141 0.073
formation of primary germ layer GO:0001704 1 0.073
negative regulation of nervous system development GO:0051961 79 0.073
Fly
negative regulation of developmental process GO:0051093 125 0.073
Fly
endocytosis GO:0006897 84 0.072
anatomical structure formation involved in morphogenesis GO:0048646 83 0.072
multicellular organism reproduction GO:0032504 233 0.072
cellular macromolecular complex assembly GO:0034622 58 0.072
Rat
regulation of system process GO:0044057 208 0.071
biological adhesion GO:0022610 110 0.071
Rat
regulation of skeletal muscle tissue regeneration GO:0043416 2 0.070
negative regulation of heart growth GO:0061117 3 0.069
central nervous system development GO:0007417 311 0.069
negative regulation of cell differentiation GO:0045596 99 0.069
Fly
vasculature development GO:0001944 70 0.069
positive regulation of cellular biosynthetic process GO:0031328 295 0.068
Rat
regulation of cellular amine metabolic process GO:0033238 8 0.068
positive regulation of protein transport GO:0051222 41 0.068
cellular response to peptide GO:1901653 133 0.068
cell cell junction organization GO:0045216 20 0.067
Rat
response to heat GO:0009408 60 0.067
protein targeting GO:0006605 61 0.066
positive regulation of map kinase activity GO:0043406 46 0.066
multicellular organism growth GO:0035264 1 0.066
positive regulation of rna metabolic process GO:0051254 203 0.065
Rat
regulation of neuron differentiation GO:0045664 208 0.065
Rat
digestive system development GO:0055123 41 0.065
Fly
cell adhesion GO:0007155 110 0.065
Rat
positive regulation of apoptotic process GO:0043065 154 0.065
Rat
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.064
regulation of growth GO:0040008 105 0.064
Fly
intracellular protein transport GO:0006886 79 0.064
positive regulation of neurogenesis GO:0050769 165 0.063
Rat
regulation of cellular catabolic process GO:0031329 101 0.063
positive regulation of molecular function GO:0044093 230 0.063
Rat
olfactory bulb interneuron differentiation GO:0021889 1 0.063
protein localization to organelle GO:0033365 57 0.063
transforming growth factor beta receptor complex assembly GO:0007181 2 0.063
response to external biotic stimulus GO:0043207 221 0.062
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 1 0.062
Rat
positive regulation of biomineral tissue development GO:0070169 4 0.062
Rat
response to biotic stimulus GO:0009607 226 0.062
single organism cellular localization GO:1902580 102 0.062
cellular response to steroid hormone stimulus GO:0071383 93 0.061
oxoacid metabolic process GO:0043436 290 0.061
ribonucleoside metabolic process GO:0009119 174 0.061
positive regulation of protein metabolic process GO:0051247 178 0.061
Rat
regulation of protein import into nucleus GO:0042306 24 0.060
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.060
response to mineralocorticoid GO:0051385 49 0.060
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.059
Fly
ureteric bud development GO:0001657 14 0.059
organ formation GO:0048645 3 0.059
digestive tract development GO:0048565 39 0.058
Fly
regulation of response to stress GO:0080134 126 0.058
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.058
Fly
positive regulation of cell development GO:0010720 176 0.058
Rat
hair follicle development GO:0001942 2 0.058
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 1 0.058
response to acid chemical GO:0001101 222 0.057
secretion by cell GO:0032940 248 0.057
single organism nuclear import GO:1902593 35 0.057
carbohydrate derivative metabolic process GO:1901135 346 0.057
generation of precursor metabolites and energy GO:0006091 62 0.057
protein import into nucleus GO:0006606 35 0.056
establishment of protein localization to organelle GO:0072594 44 0.056
cellular response to organonitrogen compound GO:0071417 197 0.056
regulation of kinase activity GO:0043549 117 0.056
gastrulation GO:0007369 2 0.056
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.055
mesenchymal cell proliferation GO:0010463 4 0.055
peptidyl serine phosphorylation GO:0018105 33 0.055
negative regulation of cellular component organization GO:0051129 83 0.055
Fly
response to electrical stimulus GO:0051602 56 0.054
circulatory system development GO:0072359 134 0.054
cytoskeleton organization GO:0007010 111 0.054
Rat
single organism biosynthetic process GO:0044711 342 0.053
single organism behavior GO:0044708 130 0.053
negative regulation of protein metabolic process GO:0051248 114 0.053
immune response GO:0006955 104 0.053
sensory organ development GO:0007423 74 0.053
mammary gland epithelium development GO:0061180 1 0.053
regulation of protein kinase activity GO:0045859 105 0.052
cardiac ventricle development GO:0003231 1 0.052
cellular protein complex assembly GO:0043623 44 0.052
Rat
protein complex biogenesis GO:0070271 263 0.052
Rat
macromolecule catabolic process GO:0009057 58 0.052
negative regulation of neuron apoptotic process GO:0043524 45 0.051
negative regulation of growth GO:0045926 37 0.051
Fly
negative regulation of cell development GO:0010721 82 0.051
ameboidal type cell migration GO:0001667 26 0.051
stem cell maintenance GO:0019827 6 0.050
Fly
regulation of muscle tissue development GO:1901861 25 0.050
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 3 0.050
positive regulation of growth GO:0045927 55 0.050
actomyosin structure organization GO:0031032 22 0.050
Rat
negative regulation of cardiac muscle tissue development GO:0055026 3 0.050
dendrite morphogenesis GO:0048813 43 0.050
Rat
gamete generation GO:0007276 124 0.050
intracellular transport GO:0046907 185 0.049
positive regulation of kinase activity GO:0033674 77 0.049
response to hydrogen peroxide GO:0042542 89 0.049
nucleoside triphosphate metabolic process GO:0009141 144 0.049
response to ionizing radiation GO:0010212 59 0.049
regulation of protein maturation GO:1903317 50 0.049
cellular response to peptide hormone stimulus GO:0071375 120 0.048
blood vessel development GO:0001568 69 0.048
regulation of map kinase activity GO:0043405 53 0.048
peptidyl serine modification GO:0018209 34 0.047
negative regulation of multicellular organismal process GO:0051241 203 0.047
Fly
positive regulation of catabolic process GO:0009896 78 0.047
tube morphogenesis GO:0035239 23 0.047
Fly
protein import GO:0017038 37 0.047
salivary gland morphogenesis GO:0007435 1 0.047
brain development GO:0007420 247 0.047
axonogenesis GO:0007409 71 0.047
Fly
regulation of protein serine threonine kinase activity GO:0071900 64 0.047
regulation of actin filament based process GO:0032970 42 0.047
Rat
response to vitamin d GO:0033280 34 0.047
skeletal muscle tissue regeneration GO:0043403 10 0.047
hepaticobiliary system development GO:0061008 90 0.047
single organism intracellular transport GO:1902582 166 0.047
cell differentiation involved in kidney development GO:0061005 4 0.047
establishment of protein localization GO:0045184 141 0.047
actin filament based process GO:0030029 86 0.046
Rat
purine ribonucleotide metabolic process GO:0009150 227 0.046
regulation of transforming growth factor beta3 production GO:0032910 2 0.046
Rat
response to purine containing compound GO:0014074 126 0.046
mesonephros development GO:0001823 14 0.045
axon guidance GO:0007411 24 0.045
Fly
organ growth GO:0035265 24 0.045
response to uv GO:0009411 8 0.045
protein complex assembly GO:0006461 263 0.044
Rat
regulation of organ formation GO:0003156 2 0.044
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.044
ossification GO:0001503 70 0.044
Rat
regulation of stem cell proliferation GO:0072091 14 0.044
ovulation cycle GO:0042698 67 0.044
negative regulation of molecular function GO:0044092 133 0.044
liver development GO:0001889 90 0.044
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.044
regulation of protein targeting GO:1903533 28 0.044
wound healing GO:0042060 122 0.044
Rat
positive regulation of bone mineralization GO:0030501 4 0.043
Rat
postnatal olfactory bulb interneuron migration GO:0021827 1 0.043
bone mineralization GO:0030282 11 0.043
Rat
mesodermal cell differentiation GO:0048333 1 0.043
cellular response to organic cyclic compound GO:0071407 202 0.042
cellular response to oxygen containing compound GO:1901701 386 0.042
nucleotide metabolic process GO:0009117 279 0.042
germ cell migration GO:0008354 1 0.042
organophosphate metabolic process GO:0019637 370 0.042
nuclear import GO:0051170 35 0.042
muscle cell differentiation GO:0042692 52 0.042
heart valve morphogenesis GO:0003179 1 0.042
osteoblast differentiation GO:0001649 26 0.042
organic acid metabolic process GO:0006082 292 0.041
defense response to other organism GO:0098542 17 0.041
specification of organ identity GO:0010092 2 0.041
regulation of nucleotide metabolic process GO:0006140 117 0.041
salivary gland development GO:0007431 3 0.041
embryonic skeletal system morphogenesis GO:0048704 3 0.040
single organism carbohydrate metabolic process GO:0044723 118 0.040
single organism catabolic process GO:0044712 283 0.040
cell junction organization GO:0034330 21 0.040
Rat
neuron fate commitment GO:0048663 4 0.040
response to mechanical stimulus GO:0009612 134 0.040
positive regulation of secretion GO:0051047 140 0.040
cardiac chamber development GO:0003205 1 0.040
response to temperature stimulus GO:0009266 94 0.040
ion homeostasis GO:0050801 212 0.040
synaptic growth at neuromuscular junction GO:0051124 1 0.040
Fly
protein targeting to nucleus GO:0044744 35 0.039
muscle tissue development GO:0060537 58 0.039
exocytosis GO:0006887 60 0.039
purine ribonucleoside metabolic process GO:0046128 168 0.039
positive regulation of skeletal muscle tissue regeneration GO:0043415 1 0.039
hair cell differentiation GO:0035315 2 0.039
negative regulation of transport GO:0051051 136 0.039
cell fate determination GO:0001709 2 0.039
positive regulation of immunoglobulin production GO:0002639 4 0.039
cell projection morphogenesis GO:0048858 123 0.039
Rat Fly
cell cycle process GO:0022402 57 0.039
peptidyl tyrosine phosphorylation GO:0018108 72 0.039
embryonic pattern specification GO:0009880 1 0.039
regulation of chemotaxis GO:0050920 29 0.039
Rat
response to toxic substance GO:0009636 133 0.038
myeloid cell differentiation GO:0030099 22 0.038
response to amino acid GO:0043200 75 0.038
protein catabolic process GO:0030163 30 0.038
response to corticosterone GO:0051412 40 0.038
actin cytoskeleton organization GO:0030036 73 0.038
Rat
regulation of vesicle mediated transport GO:0060627 81 0.038
negative regulation of cellular protein metabolic process GO:0032269 106 0.037
regulation of catabolic process GO:0009894 113 0.037
negative regulation of cellular response to insulin stimulus GO:1900077 11 0.037
organelle localization GO:0051640 55 0.037
cellular response to ketone GO:1901655 51 0.037
mapk cascade GO:0000165 140 0.037
Rat
nucleoside triphosphate catabolic process GO:0009143 123 0.037
mitotic cell cycle GO:0000278 49 0.037
mitotic cell cycle phase transition GO:0044772 20 0.037
positive regulation of programmed cell death GO:0043068 157 0.037
Rat
mesonephric tubule development GO:0072164 14 0.037
regulation of secretion by cell GO:1903530 208 0.036
circulatory system process GO:0003013 183 0.036
positive regulation of apoptotic signaling pathway GO:2001235 6 0.036
Rat
kidney epithelium development GO:0072073 19 0.036
mesonephric epithelium development GO:0072163 14 0.036
neuronal action potential GO:0019228 35 0.036
regulation of neuron death GO:1901214 115 0.036
multicellular organismal signaling GO:0035637 44 0.035
axis specification GO:0009798 4 0.035
response to camp GO:0051591 91 0.035
ras protein signal transduction GO:0007265 29 0.035
cardiovascular system development GO:0072358 134 0.035
regulation of dendrite development GO:0050773 59 0.035
Rat
protein processing GO:0016485 68 0.035
Rat
regulation of protein transport GO:0051223 68 0.035
action potential GO:0001508 54 0.035
positive regulation of neuron projection development GO:0010976 99 0.035
Rat
cerebral cortex tangential migration using cell cell interactions GO:0021823 1 0.035
forebrain development GO:0030900 98 0.035
molting cycle process GO:0022404 2 0.034
response to estradiol GO:0032355 164 0.034
neuron death GO:0070997 127 0.034

Smad7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.120
vascular disease DOID:178 0 0.120
cardiovascular system disease DOID:1287 0 0.120
musculoskeletal system disease DOID:17 0 0.096
disease of cellular proliferation DOID:14566 0 0.060
cancer DOID:162 0 0.059
organ system cancer DOID:0050686 0 0.059
connective tissue disease DOID:65 0 0.046