Rattus norvegicus

37 known processes

Shank3

SH3 and multiple ankyrin repeat domains 3

(Aliases: Prosap2)

Shank3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of proteasomal protein catabolic process GO:0061136 4 0.379
organophosphate catabolic process GO:0046434 148 0.326
catabolic process GO:0009056 351 0.182
intracellular signal transduction GO:0035556 314 0.158
Mouse
synapse organization GO:0050808 46 0.152
Mouse Rat
cellular component biogenesis GO:0044085 368 0.126
cellular catabolic process GO:0044248 295 0.124
regulation of cellular catabolic process GO:0031329 101 0.111
organic substance catabolic process GO:1901575 316 0.106
regulation of catabolic process GO:0009894 113 0.096
cellular component assembly GO:0022607 360 0.093
regulation of molecular function GO:0065009 398 0.091
Mouse
protein complex assembly GO:0006461 263 0.087
regulation of cellular protein metabolic process GO:0032268 267 0.084
protein localization GO:0008104 191 0.084
Mouse
small gtpase mediated signal transduction GO:0007264 36 0.072
organophosphate metabolic process GO:0019637 370 0.070
nucleobase containing small molecule metabolic process GO:0055086 316 0.068
protein complex biogenesis GO:0070271 263 0.068
regulation of signal transduction GO:0009966 318 0.063
nucleoside phosphate catabolic process GO:1901292 140 0.062
regulation of rna biosynthetic process GO:2001141 381 0.059
regulation of rna metabolic process GO:0051252 391 0.056
regulation of protein metabolic process GO:0051246 289 0.052
purine ribonucleotide catabolic process GO:0009154 136 0.052
nucleotide metabolic process GO:0009117 279 0.050
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.050
aromatic compound catabolic process GO:0019439 168 0.049
purine nucleotide metabolic process GO:0006163 229 0.048
cellular nitrogen compound catabolic process GO:0044270 163 0.048
ras protein signal transduction GO:0007265 29 0.046
regulation of cellular localization GO:0060341 263 0.046
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.046
axis specification GO:0009798 4 0.046
macromolecule localization GO:0033036 252 0.045
Mouse
cellular macromolecule localization GO:0070727 122 0.045
Mouse
synaptic growth at neuromuscular junction GO:0051124 1 0.045
purine containing compound metabolic process GO:0072521 253 0.043
programmed cell death GO:0012501 392 0.042
regulation of purine nucleotide metabolic process GO:1900542 115 0.042
positive regulation of multicellular organismal process GO:0051240 387 0.042
Mouse Rat
nucleoside phosphate metabolic process GO:0006753 283 0.041
lipid metabolic process GO:0006629 283 0.041
regulation of cellular component organization GO:0051128 368 0.041
Mouse Rat
transcription dna templated GO:0006351 377 0.040
cell projection organization GO:0030030 302 0.040
Mouse Rat
rna biosynthetic process GO:0032774 380 0.040
protein complex subunit organization GO:0071822 302 0.039
ribonucleotide metabolic process GO:0009259 231 0.039
regulation of nervous system development GO:0051960 264 0.038
Mouse Rat
neuron projection development GO:0031175 273 0.037
Mouse Rat
regulation of cell development GO:0060284 263 0.036
Mouse Rat
organic cyclic compound catabolic process GO:1901361 175 0.035
regulation of phosphorus metabolic process GO:0051174 349 0.035
purine nucleotide catabolic process GO:0006195 136 0.035
nucleobase containing compound catabolic process GO:0034655 152 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.035
regulation of nucleic acid templated transcription GO:1903506 380 0.034
ribose phosphate metabolic process GO:0019693 235 0.034
brain development GO:0007420 247 0.033
Mouse Rat
purine containing compound catabolic process GO:0072523 138 0.032
ion transmembrane transport GO:0034220 365 0.032
Mouse
regulation of catalytic activity GO:0050790 304 0.032
regulation of small gtpase mediated signal transduction GO:0051056 48 0.031
regulation of cell projection organization GO:0031344 175 0.031
Mouse Rat
response to potassium ion GO:0035864 9 0.031
ribonucleotide catabolic process GO:0009261 136 0.031
rna metabolic process GO:0016070 406 0.031
organic acid metabolic process GO:0006082 292 0.031
regulation of cellular amino acid metabolic process GO:0006521 2 0.030
heterocycle catabolic process GO:0046700 167 0.030
nucleic acid templated transcription GO:0097659 379 0.030
purine ribonucleoside catabolic process GO:0046130 124 0.030
regulation of neuron projection development GO:0010975 161 0.030
Mouse Rat
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.030
purine ribonucleotide metabolic process GO:0009150 227 0.029
transmembrane transport GO:0055085 412 0.029
Mouse
hematopoietic progenitor cell differentiation GO:0002244 2 0.029
protein phosphorylation GO:0006468 345 0.029
organonitrogen compound catabolic process GO:1901565 179 0.028
regulation of glutamate receptor signaling pathway GO:1900449 17 0.028
cell adhesion GO:0007155 110 0.028
nucleoside metabolic process GO:0009116 179 0.028
regulation of gtpase activity GO:0043087 57 0.028
single organism biosynthetic process GO:0044711 342 0.027
neuron differentiation GO:0030182 368 0.027
Mouse Rat
cellular amino acid metabolic process GO:0006520 107 0.026
proteolysis GO:0006508 175 0.026
positive regulation of gene expression GO:0010628 244 0.026
regulation of intracellular signal transduction GO:1902531 218 0.025
regulation of multicellular organismal development GO:2000026 376 0.025
Mouse Rat
cell projection morphogenesis GO:0048858 123 0.025
Mouse
positive regulation of neuron projection development GO:0010976 99 0.025
Mouse Rat
negative regulation of cell communication GO:0010648 158 0.025
Mouse
carbohydrate derivative metabolic process GO:1901135 346 0.024
ribonucleoside triphosphate catabolic process GO:0009203 122 0.024
transcription from rna polymerase ii promoter GO:0006366 252 0.024
biological adhesion GO:0022610 110 0.024
positive regulation of synapse maturation GO:0090129 2 0.024
positive regulation of ras gtpase activity GO:0032320 28 0.024
regulation of cellular component biogenesis GO:0044087 86 0.024
Mouse
calcium mediated signaling using intracellular calcium source GO:0035584 1 0.024
positive regulation of catalytic activity GO:0043085 184 0.024
positive regulation of rna metabolic process GO:0051254 203 0.023
cellular amine metabolic process GO:0044106 38 0.023
ribonucleoside metabolic process GO:0009119 174 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.023
carbohydrate derivative catabolic process GO:1901136 147 0.023
oxoacid metabolic process GO:0043436 290 0.023
ribonucleoside triphosphate metabolic process GO:0009199 141 0.022
nucleotide catabolic process GO:0009166 139 0.022
epithelium development GO:0060429 96 0.022
Mouse
positive regulation of cellular catabolic process GO:0031331 71 0.022
anatomical structure morphogenesis GO:0009653 298 0.022
Mouse
purine ribonucleoside metabolic process GO:0046128 168 0.022
amine metabolic process GO:0009308 38 0.021
guanosine containing compound catabolic process GO:1901069 71 0.021
single organism reproductive process GO:0044702 297 0.021
regulation of proteolysis GO:0030162 66 0.021
protein oligomerization GO:0051259 191 0.021
central nervous system development GO:0007417 311 0.021
Mouse Rat
anterior posterior pattern specification GO:0009952 1 0.021
regulation of nucleoside metabolic process GO:0009118 66 0.021
positive regulation of cellular component organization GO:0051130 200 0.020
Mouse Rat
regulation of cellular ketone metabolic process GO:0010565 27 0.020
positive regulation of cell projection organization GO:0031346 111 0.020
Mouse Rat
positive regulation of gtpase activity GO:0043547 47 0.020
regulation of nucleotide catabolic process GO:0030811 65 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
positive regulation of developmental process GO:0051094 283 0.019
Mouse Rat
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
positive regulation of biosynthetic process GO:0009891 319 0.019
positive regulation of cellular component movement GO:0051272 102 0.019
cytoskeleton organization GO:0007010 111 0.019
Mouse
guanosine containing compound metabolic process GO:1901068 74 0.019
purine nucleoside catabolic process GO:0006152 124 0.019
macromolecule catabolic process GO:0009057 58 0.019
carboxylic acid metabolic process GO:0019752 289 0.019
positive regulation of phosphate metabolic process GO:0045937 262 0.018
cyclic nucleotide metabolic process GO:0009187 80 0.018
negative regulation of metabolic process GO:0009892 331 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
tissue development GO:0009888 252 0.018
Mouse
regulation of nucleotide metabolic process GO:0006140 117 0.018
negative regulation of protein import into nucleus translocation GO:0033159 1 0.018
regulation of protein catabolic process GO:0042176 16 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
head development GO:0060322 247 0.018
Mouse Rat
positive regulation of nucleotide catabolic process GO:0030813 53 0.018
response to biotic stimulus GO:0009607 226 0.018
circadian regulation of gene expression GO:0032922 3 0.018
localization of cell GO:0051674 202 0.017
nucleoside triphosphate metabolic process GO:0009141 144 0.017
positive regulation of molecular function GO:0044093 230 0.017
Mouse
regulation of cell migration GO:0030334 128 0.017
regulation of purine nucleotide catabolic process GO:0033121 65 0.017
cellular ketone metabolic process GO:0042180 51 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
cell cell signaling GO:0007267 335 0.017
Mouse
negative regulation of transport GO:0051051 136 0.017
cellular component movement GO:0006928 248 0.016
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
Mouse
regulation of transferase activity GO:0051338 123 0.016
regulation of anatomical structure size GO:0090066 135 0.016
purine nucleoside triphosphate metabolic process GO:0009144 141 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
nucleotide biosynthetic process GO:0009165 98 0.016
regulation of cell motility GO:2000145 131 0.016
regulation of synapse maturation GO:0090128 2 0.016
immune system development GO:0002520 41 0.016
single organism catabolic process GO:0044712 283 0.016
glycosyl compound catabolic process GO:1901658 126 0.016
negative regulation of vascular permeability GO:0043116 3 0.015
immune system process GO:0002376 204 0.015
regulation of gtp catabolic process GO:0033124 58 0.015
positive regulation of cell development GO:0010720 176 0.015
Mouse Rat
cell morphogenesis involved in differentiation GO:0000904 119 0.015
Mouse
glycosyl compound metabolic process GO:1901657 182 0.015
circulatory system process GO:0003013 183 0.015
regulation of receptor activity GO:0010469 29 0.015
Mouse
positive regulation of catabolic process GO:0009896 78 0.015
neuron development GO:0048666 286 0.015
Mouse Rat
regulation of protein kinase activity GO:0045859 105 0.015
response to bacterium GO:0009617 200 0.015
purine nucleoside metabolic process GO:0042278 169 0.015
cellular homeostasis GO:0019725 252 0.015
Mouse
defense response GO:0006952 194 0.015
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.015
Mouse
regulation of phosphate metabolic process GO:0019220 349 0.015
leukocyte differentiation GO:0002521 30 0.014
autophagic cell death GO:0048102 4 0.014
regulation of cellular protein catabolic process GO:1903362 7 0.014
macromolecular complex assembly GO:0065003 273 0.014
regulation of neurogenesis GO:0050767 247 0.014
Mouse Rat
response to metal ion GO:0010038 253 0.014
macromolecular complex subunit organization GO:0043933 339 0.014
hematopoietic or lymphoid organ development GO:0048534 36 0.014
reproductive process GO:0022414 372 0.014
regulation of cellular component movement GO:0051270 150 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
positive regulation of nervous system development GO:0051962 178 0.014
Mouse Rat
regulation of cell differentiation GO:0045595 320 0.014
Mouse Rat
positive regulation of rna biosynthetic process GO:1902680 197 0.014
positive regulation of neurogenesis GO:0050769 165 0.014
Mouse Rat
neurotransmitter gated ion channel clustering GO:0072578 3 0.014
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 122 0.013
protein localization to synapse GO:0035418 5 0.013
gamete generation GO:0007276 124 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
negative regulation of cellular metabolic process GO:0031324 281 0.013
secretion by cell GO:0032940 248 0.013
apoptotic process GO:0006915 381 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
positive regulation of gtp catabolic process GO:0033126 48 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
regulation of heart contraction GO:0008016 48 0.013
cortical actin cytoskeleton organization GO:0030866 2 0.012
nucleoside catabolic process GO:0009164 126 0.012
t cell selection GO:0045058 1 0.012
cellular component morphogenesis GO:0032989 155 0.012
Mouse
rho protein signal transduction GO:0007266 11 0.012
regulation of ras gtpase activity GO:0032318 32 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
actin filament based process GO:0030029 86 0.012
Mouse
organophosphate biosynthetic process GO:0090407 143 0.012
positive regulation of response to stimulus GO:0048584 285 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
regulation of transcription dna templated GO:0006355 374 0.012
positive regulation of transcription dna templated GO:0045893 197 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
glycerolipid metabolic process GO:0046486 67 0.012
cell migration GO:0016477 197 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
forebrain development GO:0030900 98 0.011
Mouse
positive regulation of hydrolase activity GO:0051345 86 0.011
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.011
single organism behavior GO:0044708 130 0.011
Mouse
developmental growth GO:0048589 100 0.011
cytoplasmic transport GO:0016482 115 0.011
chemical homeostasis GO:0048878 292 0.011
regulation of blood vessel size GO:0050880 89 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
Mouse Rat
locomotion GO:0040011 237 0.011
positive regulation of neuron migration GO:2001224 2 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
aggresome assembly GO:0070842 1 0.011
response to external biotic stimulus GO:0043207 221 0.011
cellular protein catabolic process GO:0044257 19 0.011
regulation of defense response GO:0031347 68 0.011
Mouse
defense response to gram negative bacterium GO:0050829 3 0.010
heart morphogenesis GO:0003007 3 0.010
circadian rhythm GO:0007623 88 0.010
regulation of synapse structure and activity GO:0050803 21 0.010
Mouse
ribonucleotide biosynthetic process GO:0009260 85 0.010
negative regulation of signaling GO:0023057 157 0.010
Mouse
cellular response to organic cyclic compound GO:0071407 202 0.010
male gamete generation GO:0048232 99 0.010
negative regulation of biosynthetic process GO:0009890 168 0.010
multicellular organism growth GO:0035264 1 0.010
regulation of ras protein signal transduction GO:0046578 45 0.010
sexual reproduction GO:0019953 148 0.010
cellular chemical homeostasis GO:0055082 247 0.010
cellular lipid metabolic process GO:0044255 208 0.010
response to decreased oxygen levels GO:0036293 237 0.010

Shank3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
nervous system disease DOID:863 0 0.029
central nervous system disease DOID:331 0 0.015
sensory system disease DOID:0050155 0 0.015