Rattus norvegicus

0 known processes

Pcolce

procollagen C-endopeptidase enhancer

(Aliases: MGC105446,PCPE)

Pcolce biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic skeletal system development GO:0048706 3 0.663
response to fluoride GO:1902617 3 0.570
response to corticosteroid GO:0031960 235 0.497
response to cytokine GO:0034097 215 0.422
response to monosaccharide GO:0034284 159 0.377
response to estradiol GO:0032355 164 0.349
response to peptide GO:1901652 292 0.336
response to estrogen GO:0043627 232 0.327
response to nutrient GO:0007584 248 0.309
skeletal system morphogenesis GO:0048705 12 0.261
positive regulation of response to stimulus GO:0048584 285 0.238
response to extracellular stimulus GO:0009991 380 0.232
cellular response to organonitrogen compound GO:0071417 197 0.230
response to peptide hormone GO:0043434 278 0.229
response to biotic stimulus GO:0009607 226 0.212
skeletal system development GO:0001501 41 0.196
cellular response to hormone stimulus GO:0032870 247 0.193
response to radiation GO:0009314 137 0.190
response to wounding GO:0009611 254 0.187
peptide cross linking GO:0018149 1 0.180
embryonic cranial skeleton morphogenesis GO:0048701 2 0.176
tissue development GO:0009888 252 0.164
cellular component assembly GO:0022607 360 0.153
response to nutrient levels GO:0031667 370 0.152
cellular response to oxygen containing compound GO:1901701 386 0.149
protein complex subunit organization GO:0071822 302 0.145
response to purine containing compound GO:0014074 126 0.141
collagen fibril organization GO:0030199 1 0.138
regulation of rna metabolic process GO:0051252 391 0.138
macromolecular complex subunit organization GO:0043933 339 0.136
response to acid chemical GO:0001101 222 0.133
response to reactive oxygen species GO:0000302 120 0.132
protein complex biogenesis GO:0070271 263 0.131
cellular response to organic cyclic compound GO:0071407 202 0.130
response to organophosphorus GO:0046683 102 0.128
extracellular fibril organization GO:0043206 1 0.125
response to mechanical stimulus GO:0009612 134 0.125
response to transforming growth factor beta GO:0071559 46 0.125
regulation of multicellular organismal development GO:2000026 376 0.124
response to hexose GO:0009746 144 0.123
response to inorganic substance GO:0010035 377 0.119
response to other organism GO:0051707 220 0.118
response to lipopolysaccharide GO:0032496 191 0.113
macromolecular complex assembly GO:0065003 273 0.111
endochondral ossification GO:0001958 2 0.109
cellular response to nitrogen compound GO:1901699 210 0.108
protein oligomerization GO:0051259 191 0.107
cellular response to cytokine stimulus GO:0071345 127 0.107
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.105
response to external biotic stimulus GO:0043207 221 0.104
positive regulation of developmental process GO:0051094 283 0.104
reproductive process GO:0022414 372 0.104
response to oxidative stress GO:0006979 186 0.103
aging GO:0007568 241 0.101
response to oxygen levels GO:0070482 265 0.100
response to glucose GO:0009749 136 0.100
cellular response to peptide GO:1901653 133 0.097
locomotion GO:0040011 237 0.097
immune response GO:0006955 104 0.096
response to camp GO:0051591 91 0.095
response to glucocorticoid GO:0051384 223 0.094
endochondral bone morphogenesis GO:0060350 7 0.092
response to amino acid GO:0043200 75 0.092
reproductive system development GO:0061458 128 0.088
cellular response to lipid GO:0071396 201 0.085
circulatory system development GO:0072359 134 0.085
wound healing GO:0042060 122 0.083
protein complex assembly GO:0006461 263 0.080
nucleic acid templated transcription GO:0097659 379 0.078
carbohydrate derivative metabolic process GO:1901135 346 0.077
regulation of rna biosynthetic process GO:2001141 381 0.074
female pregnancy GO:0007565 122 0.070
cell motility GO:0048870 202 0.070
growth plate cartilage development GO:0003417 2 0.068
positive regulation of gene expression GO:0010628 244 0.066
reproductive structure development GO:0048608 128 0.066
bone development GO:0060348 25 0.065
neuron projection development GO:0031175 273 0.063
positive regulation of rna biosynthetic process GO:1902680 197 0.062
anatomical structure morphogenesis GO:0009653 298 0.060
response to molecule of bacterial origin GO:0002237 194 0.059
cellular response to peptide hormone stimulus GO:0071375 120 0.058
protein heterooligomerization GO:0051291 89 0.056
developmental growth involved in morphogenesis GO:0060560 33 0.056
vasculature development GO:0001944 70 0.056
cellular component biogenesis GO:0044085 368 0.055
cellular response to vitamin e GO:0071306 3 0.055
response to growth factor GO:0070848 189 0.055
response to nicotine GO:0035094 51 0.055
cartilage development involved in endochondral bone morphogenesis GO:0060351 3 0.052
response to carbohydrate GO:0009743 183 0.052
homeostatic process GO:0042592 331 0.052
positive regulation of cell differentiation GO:0045597 217 0.051
transcription from rna polymerase ii promoter GO:0006366 252 0.050
immune system process GO:0002376 204 0.050
response to epidermal growth factor GO:0070849 18 0.050
connective tissue development GO:0061448 33 0.050
intracellular signal transduction GO:0035556 314 0.048
response to hydrogen peroxide GO:0042542 89 0.048
regulation of nervous system development GO:0051960 264 0.048
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.048
response to tumor necrosis factor GO:0034612 56 0.047
response to interleukin 1 GO:0070555 55 0.047
cellular response to acid chemical GO:0071229 75 0.047
regeneration GO:0031099 163 0.046
negative regulation of metabolic process GO:0009892 331 0.046
transcription dna templated GO:0006351 377 0.046
negative regulation of multicellular organismal process GO:0051241 203 0.046
response to hyperoxia GO:0055093 45 0.044
regulation of transcription dna templated GO:0006355 374 0.044
rna metabolic process GO:0016070 406 0.044
response to vitamin GO:0033273 131 0.044
gastrulation GO:0007369 2 0.044
protein heterotrimerization GO:0070208 2 0.043
negative regulation of gene expression GO:0010629 199 0.043
developmental process involved in reproduction GO:0003006 159 0.043
positive regulation of transcription dna templated GO:0045893 197 0.043
cartilage development GO:0051216 22 0.042
positive regulation of rna metabolic process GO:0051254 203 0.042
positive regulation of stem cell differentiation GO:2000738 2 0.041
multi organism reproductive process GO:0044703 262 0.041
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.041
regulation of cell development GO:0060284 263 0.040
cardiovascular system development GO:0072358 134 0.040
response to metal ion GO:0010038 253 0.040
small gtpase mediated signal transduction GO:0007264 36 0.039
single organism reproductive process GO:0044702 297 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.039
single organism biosynthetic process GO:0044711 342 0.039
response to increased oxygen levels GO:0036296 45 0.039
artery development GO:0060840 3 0.039
cellular component movement GO:0006928 248 0.039
response to retinoic acid GO:0032526 63 0.038
head development GO:0060322 247 0.038
ras protein signal transduction GO:0007265 29 0.038
cellular response to tumor necrosis factor GO:0071356 46 0.037
negative regulation of programmed cell death GO:0043069 183 0.037
rna biosynthetic process GO:0032774 380 0.036
regulation of cell differentiation GO:0045595 320 0.036
response to transition metal nanoparticle GO:1990267 122 0.036
replacement ossification GO:0036075 2 0.036
positive regulation of multicellular organismal process GO:0051240 387 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.035
cellular response to growth factor stimulus GO:0071363 162 0.034
cellular response to nicotine GO:0071316 7 0.034
embryonic skeletal system morphogenesis GO:0048704 3 0.034
striated muscle tissue development GO:0014706 58 0.033
blood vessel development GO:0001568 69 0.033
reproduction GO:0000003 245 0.033
gland development GO:0048732 155 0.033
cellular response to external stimulus GO:0071496 118 0.033
development of primary sexual characteristics GO:0045137 107 0.032
response to vitamin e GO:0033197 24 0.032
negative regulation of cell death GO:0060548 229 0.031
enzyme linked receptor protein signaling pathway GO:0007167 116 0.031
cell projection organization GO:0030030 302 0.031
neuron differentiation GO:0030182 368 0.031
establishment of protein localization GO:0045184 141 0.031
multicellular organismal reproductive process GO:0048609 233 0.031
digestive tract development GO:0048565 39 0.030
positive regulation of cellular biosynthetic process GO:0031328 295 0.030
cellular response to metal ion GO:0071248 55 0.030
regulation of molecular function GO:0065009 398 0.030
Human
positive regulation of signal transduction GO:0009967 175 0.029
growth GO:0040007 165 0.029
embryo development GO:0009790 49 0.029
nucleotide metabolic process GO:0009117 279 0.028
nucleoside phosphate metabolic process GO:0006753 283 0.028
regulation of anatomical structure morphogenesis GO:0022603 141 0.027
regulation of secretion by cell GO:1903530 208 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
tissue morphogenesis GO:0048729 22 0.027
negative regulation of cellular metabolic process GO:0031324 281 0.027
renal system development GO:0072001 67 0.027
muscle organ development GO:0007517 50 0.027
carboxylic acid metabolic process GO:0019752 289 0.026
regulation of viral transcription GO:0046782 2 0.026
positive regulation of apoptotic process GO:0043065 154 0.026
positive regulation of cell communication GO:0010647 271 0.026
cell migration GO:0016477 197 0.026
organonitrogen compound biosynthetic process GO:1901566 167 0.026
cellular response to glucocorticoid stimulus GO:0071385 68 0.026
positive regulation of nucleic acid templated transcription GO:1903508 197 0.026
regulation of secretion GO:0051046 224 0.025
regulation of signal transduction GO:0009966 318 0.025
regulation of cell projection organization GO:0031344 175 0.025
eye development GO:0001654 50 0.025
organ morphogenesis GO:0009887 75 0.025
regulation of intracellular signal transduction GO:1902531 218 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.025
Human
central nervous system development GO:0007417 311 0.024
positive regulation of biosynthetic process GO:0009891 319 0.024
negative regulation of macromolecule metabolic process GO:0010605 260 0.023
bone morphogenesis GO:0060349 11 0.023
regulation of cell motility GO:2000145 131 0.023
oxoacid metabolic process GO:0043436 290 0.023
rhythmic process GO:0048511 156 0.023
response to ionizing radiation GO:0010212 59 0.023
programmed cell death GO:0012501 392 0.023
positive regulation of cellular component movement GO:0051272 102 0.023
regulation of hormone levels GO:0010817 187 0.023
protein localization GO:0008104 191 0.022
negative regulation of developmental process GO:0051093 125 0.022
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 1 0.022
regulation of apoptotic process GO:0042981 335 0.022
negative regulation of apoptotic process GO:0043066 181 0.022
cellular response to extracellular stimulus GO:0031668 73 0.021
reactive oxygen species metabolic process GO:0072593 37 0.021
cellular response to stress GO:0033554 269 0.021
regulation of phosphorylation GO:0042325 248 0.021
organophosphate metabolic process GO:0019637 370 0.021
negative regulation of biosynthetic process GO:0009890 168 0.021
multicellular organism reproduction GO:0032504 233 0.021
protein transport GO:0015031 132 0.021
positive regulation of phosphorus metabolic process GO:0010562 262 0.021
cellular response to abiotic stimulus GO:0071214 85 0.020
cell growth GO:0016049 104 0.020
apoptotic process GO:0006915 381 0.020
rho protein signal transduction GO:0007266 11 0.020
response to bacterium GO:0009617 200 0.020
cellular response to fibroblast growth factor stimulus GO:0044344 24 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
response to hypoxia GO:0001666 231 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
Human
cellular ketone metabolic process GO:0042180 51 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
response to alkaloid GO:0043279 132 0.020
regulation of locomotion GO:0040012 148 0.020
regulation of protein transport GO:0051223 68 0.020
response to interleukin 2 GO:0070669 1 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
tooth eruption GO:0044691 1 0.019
muscle structure development GO:0061061 87 0.019
negative regulation of molecular function GO:0044092 133 0.019
regulation of hydrolase activity GO:0051336 143 0.019
Human
negative regulation of cell proliferation GO:0008285 119 0.019
muscle tissue development GO:0060537 58 0.019
amine metabolic process GO:0009308 38 0.018
positive regulation of cell development GO:0010720 176 0.018
cellular response to fluoride GO:1902618 1 0.018
epiboly involved in wound healing GO:0090505 2 0.018
secretion GO:0046903 307 0.018
anatomical structure formation involved in morphogenesis GO:0048646 83 0.018
glycosaminoglycan biosynthetic process GO:0006024 4 0.018
response to ethanol GO:0045471 162 0.018
response to fibroblast growth factor GO:0071774 29 0.018
regulation of programmed cell death GO:0043067 341 0.018
telencephalon development GO:0021537 62 0.018
formation of primary germ layer GO:0001704 1 0.018
localization of cell GO:0051674 202 0.018
cellular chemical homeostasis GO:0055082 247 0.018
kidney development GO:0001822 67 0.018
regulation of growth GO:0040008 105 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
Human
cellular homeostasis GO:0019725 252 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
negative regulation of protein metabolic process GO:0051248 114 0.017
cellular response to retinoic acid GO:0071300 27 0.017
negative regulation of response to stimulus GO:0048585 155 0.017
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.017
camp metabolic process GO:0046058 63 0.016
adrenal gland development GO:0030325 11 0.016
cellular response to nutrient levels GO:0031669 60 0.016
elastic fiber assembly GO:0048251 1 0.016
tube development GO:0035295 89 0.016
positive regulation of cell growth GO:0030307 44 0.016
cellular response to mechanical stimulus GO:0071260 48 0.016
sex differentiation GO:0007548 113 0.016
heart development GO:0007507 72 0.016
forebrain development GO:0030900 98 0.016
peptidyl amino acid modification GO:0018193 126 0.016
protein processing GO:0016485 68 0.016
organic acid metabolic process GO:0006082 292 0.016
tissue remodeling GO:0048771 40 0.016
digestive system development GO:0055123 41 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
camera type eye development GO:0043010 48 0.016
blood vessel morphogenesis GO:0048514 58 0.016
regulation of cellular ketone metabolic process GO:0010565 27 0.016
carbohydrate derivative biosynthetic process GO:1901137 124 0.016
nucleobase containing small molecule metabolic process GO:0055086 316 0.015
negative regulation of nervous system development GO:0051961 79 0.015
regulation of neuron differentiation GO:0045664 208 0.015
secretion by cell GO:0032940 248 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
camera type eye morphogenesis GO:0048593 2 0.015
positive regulation of epithelial to mesenchymal transition GO:0010718 2 0.015
response to insulin GO:0032868 133 0.015
gamete generation GO:0007276 124 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
developmental growth GO:0048589 100 0.015
negative regulation of catalytic activity GO:0043086 103 0.014
gonad development GO:0008406 104 0.014
macromolecule localization GO:0033036 252 0.014
regulation of epithelial to mesenchymal transition GO:0010717 2 0.014
development of primary male sexual characteristics GO:0046546 59 0.014
lipid biosynthetic process GO:0008610 128 0.014
regulation of cytokine production GO:0001817 56 0.014
regulation of cell proliferation GO:0042127 359 0.014
regulation of protein modification process GO:0031399 194 0.014
neuron development GO:0048666 286 0.014
regulation of cell migration GO:0030334 128 0.014
appendage morphogenesis GO:0035107 4 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
Human
cell cell signaling GO:0007267 335 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
regulation of catalytic activity GO:0050790 304 0.014
Human
cellular response to platelet derived growth factor stimulus GO:0036120 7 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.013
cellular response to carbohydrate stimulus GO:0071322 72 0.013
innate immune response GO:0045087 35 0.013
carbohydrate homeostasis GO:0033500 75 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
positive regulation of secretion by cell GO:1903532 128 0.013
epithelial cell differentiation GO:0030855 71 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
urogenital system development GO:0001655 78 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
regulation of cellular amino acid metabolic process GO:0006521 2 0.013
response to thyroid hormone GO:0097066 17 0.013
brain development GO:0007420 247 0.013
cytoplasmic transport GO:0016482 115 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
cellular amino acid metabolic process GO:0006520 107 0.013
muscle organ morphogenesis GO:0048644 1 0.013
embryo development ending in birth or egg hatching GO:0009792 22 0.012
cation homeostasis GO:0055080 195 0.012
response to zinc ion GO:0010043 39 0.012
cellular amine metabolic process GO:0044106 38 0.012
cellular response to inorganic substance GO:0071241 65 0.012
cyclic nucleotide metabolic process GO:0009187 80 0.012
positive regulation of molecular function GO:0044093 230 0.012
Human
regulation of protein localization GO:0032880 81 0.012
cellular response to glucose stimulus GO:0071333 65 0.012
negative regulation of cell differentiation GO:0045596 99 0.012
regulation of cellular component movement GO:0051270 150 0.012
embryonic morphogenesis GO:0048598 14 0.012
cellular response to monosaccharide stimulus GO:0071326 67 0.012
ossification GO:0001503 70 0.012
positive regulation of nervous system development GO:0051962 178 0.012
spermatogenesis GO:0007283 99 0.012
negative regulation of immune response GO:0050777 15 0.012
neurological system process GO:0050877 219 0.012
positive regulation of growth GO:0045927 55 0.012
response to monoamine GO:0071867 17 0.011
intramembranous ossification GO:0001957 1 0.011
male gamete generation GO:0048232 99 0.011
odontogenesis GO:0042476 32 0.011
craniofacial suture morphogenesis GO:0097094 4 0.011
maternal process involved in female pregnancy GO:0060135 38 0.011
endocrine system development GO:0035270 30 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
response to catecholamine GO:0071869 16 0.011
positive regulation of cell death GO:0010942 184 0.011
positive regulation of cytokine production GO:0001819 42 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
multicellular organism growth GO:0035264 1 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
regulation of nucleic acid templated transcription GO:1903506 380 0.011
response to decreased oxygen levels GO:0036293 237 0.011
regulation of transferase activity GO:0051338 123 0.011
cellular catabolic process GO:0044248 295 0.011
epithelium development GO:0060429 96 0.011
cell cycle checkpoint GO:0000075 2 0.010
cell matrix adhesion GO:0007160 19 0.010
cellular response to vitamin GO:0071295 21 0.010
regulation of protein phosphorylation GO:0001932 183 0.010
protein phosphorylation GO:0006468 345 0.010
regulation of small gtpase mediated signal transduction GO:0051056 48 0.010
signal transduction by phosphorylation GO:0023014 144 0.010
regulation of cell growth GO:0001558 85 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
negative regulation of cell communication GO:0010648 158 0.010
proteolysis GO:0006508 175 0.010
Human Mouse
cell adhesion GO:0007155 110 0.010
regulation of angiogenesis GO:0045765 39 0.010
multi multicellular organism process GO:0044706 138 0.010
cellular response to nutrient GO:0031670 30 0.010
regulation of protein metabolic process GO:0051246 289 0.010
Human

Pcolce disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.646
musculoskeletal system disease DOID:17 0 0.646
bone development disease DOID:0080006 0 0.136
bone disease DOID:0080001 0 0.136
connective tissue disease DOID:65 0 0.136
osteochondrodysplasia DOID:2256 0 0.053
osteogenesis imperfecta DOID:12347 0 0.022
collagen disease DOID:854 0 0.017
ehlers danlos syndrome DOID:13359 0 0.017
nervous system disease DOID:863 0 0.013