Rattus norvegicus

0 known processes

Akt1s1

AKT1 substrate 1 (proline-rich)

(Aliases: PRAS40)

Akt1s1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
vesicle mediated transport GO:0016192 181 0.281
gtp catabolic process GO:0006184 71 0.189
positive regulation of nucleic acid templated transcription GO:1903508 197 0.162
single organism intracellular transport GO:1902582 166 0.155
regulation of signal transduction GO:0009966 318 0.140
cellular macromolecule localization GO:0070727 122 0.127
regulation of nucleic acid templated transcription GO:1903506 380 0.125
protein targeting GO:0006605 61 0.119
cellular protein localization GO:0034613 122 0.119
cellular component assembly GO:0022607 360 0.117
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.115
intracellular protein transport GO:0006886 79 0.108
regulation of proteasomal protein catabolic process GO:0061136 4 0.105
positive regulation of transcription factor import into nucleus GO:0042993 4 0.103
secretion GO:0046903 307 0.102
regulation of cell proliferation GO:0042127 359 0.102
nucleic acid templated transcription GO:0097659 379 0.099
positive regulation of rna metabolic process GO:0051254 203 0.098
carboxylic acid metabolic process GO:0019752 289 0.098
establishment of protein localization GO:0045184 141 0.088
protein transport GO:0015031 132 0.086
regulation of protein metabolic process GO:0051246 289 0.082
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.082
lipid metabolic process GO:0006629 283 0.082
carboxylic acid transport GO:0046942 115 0.081
rna biosynthetic process GO:0032774 380 0.080
ensheathment of neurons GO:0007272 40 0.079
positive regulation of signaling GO:0023056 270 0.078
regulation of rna metabolic process GO:0051252 391 0.075
cellular response to endogenous stimulus GO:0071495 377 0.075
rna metabolic process GO:0016070 406 0.075
programmed cell death GO:0012501 392 0.075
positive regulation of cellular biosynthetic process GO:0031328 295 0.074
apoptotic process GO:0006915 381 0.074
macromolecule localization GO:0033036 252 0.072
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.072
regulation of molecular function GO:0065009 398 0.071
intracellular transport GO:0046907 185 0.069
positive regulation of transcription dna templated GO:0045893 197 0.067
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.067
neurological system process GO:0050877 219 0.063
regulation of rna biosynthetic process GO:2001141 381 0.062
positive regulation of gene expression GO:0010628 244 0.061
anion transport GO:0006820 178 0.061
protein localization GO:0008104 191 0.059
aromatic compound catabolic process GO:0019439 168 0.059
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.056
negative regulation of transcription dna templated GO:0045892 116 0.055
multi multicellular organism process GO:0044706 138 0.054
regulation of transcription dna templated GO:0006355 374 0.054
single organism catabolic process GO:0044712 283 0.053
positive regulation of phosphorus metabolic process GO:0010562 262 0.053
positive regulation of rna biosynthetic process GO:1902680 197 0.052
neuron death GO:0070997 127 0.051
positive regulation of cell communication GO:0010647 271 0.050
purine nucleoside triphosphate metabolic process GO:0009144 141 0.050
purine containing compound catabolic process GO:0072523 138 0.050
synaptic transmission GO:0007268 235 0.050
transcription dna templated GO:0006351 377 0.048
organophosphate catabolic process GO:0046434 148 0.048
regulation of cellular catabolic process GO:0031329 101 0.047
cellular response to starvation GO:0009267 27 0.047
organelle organization GO:0006996 266 0.046
macromolecular complex assembly GO:0065003 273 0.046
single organism reproductive process GO:0044702 297 0.046
positive regulation of transport GO:0051050 245 0.046
rhythmic process GO:0048511 156 0.046
anion transmembrane transport GO:0098656 77 0.045
tissue development GO:0009888 252 0.044
negative regulation of gene expression GO:0010629 199 0.044
cellular response to oxygen containing compound GO:1901701 386 0.044
regulation of synaptic transmission GO:0050804 141 0.043
single organism membrane organization GO:0044802 74 0.043
response to ethanol GO:0045471 162 0.041
muscle cell proliferation GO:0033002 84 0.041
cellular protein catabolic process GO:0044257 19 0.041
regulation of phosphorus metabolic process GO:0051174 349 0.040
regulation of cellular protein metabolic process GO:0032268 267 0.040
negative regulation of rna metabolic process GO:0051253 123 0.040
regulation of cellular localization GO:0060341 263 0.040
protein oligomerization GO:0051259 191 0.039
amino acid transport GO:0006865 70 0.039
cellular component biogenesis GO:0044085 368 0.038
regulation of apoptotic process GO:0042981 335 0.038
protein complex assembly GO:0006461 263 0.037
membrane organization GO:0061024 94 0.037
positive regulation of cellular protein metabolic process GO:0032270 167 0.037
cytoplasmic transport GO:0016482 115 0.036
positive regulation of cell proliferation GO:0008284 249 0.036
positive regulation of apoptotic process GO:0043065 154 0.036
regulation of programmed cell death GO:0043067 341 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.036
circadian rhythm GO:0007623 88 0.035
proteolysis GO:0006508 175 0.035
negative regulation of transport GO:0051051 136 0.035
signal transduction by phosphorylation GO:0023014 144 0.035
anatomical structure morphogenesis GO:0009653 298 0.035
negative regulation of biosynthetic process GO:0009890 168 0.035
regulation of protein import into nucleus GO:0042306 24 0.035
purine nucleotide catabolic process GO:0006195 136 0.035
response to growth factor GO:0070848 189 0.034
cell type specific apoptotic process GO:0097285 134 0.034
positive regulation of programmed cell death GO:0043068 157 0.034
oxoacid metabolic process GO:0043436 290 0.034
positive regulation of response to stimulus GO:0048584 285 0.033
positive regulation of cell death GO:0010942 184 0.033
organophosphate metabolic process GO:0019637 370 0.033
positive regulation of molecular function GO:0044093 230 0.032
gtp metabolic process GO:0046039 72 0.032
protein complex biogenesis GO:0070271 263 0.032
nucleotide catabolic process GO:0009166 139 0.032
cellular response to organonitrogen compound GO:0071417 197 0.031
cellular response to hormone stimulus GO:0032870 247 0.031
nucleobase containing compound catabolic process GO:0034655 152 0.031
positive regulation of protein metabolic process GO:0051247 178 0.031
endocytosis GO:0006897 84 0.031
locomotion GO:0040011 237 0.031
cellular macromolecule catabolic process GO:0044265 29 0.031
regulation of neuronal synaptic plasticity GO:0048168 31 0.031
negative regulation of programmed cell death GO:0043069 183 0.030
positive regulation of secretion GO:0051047 140 0.030
regulation of cell differentiation GO:0045595 320 0.030
cellular response to extracellular stimulus GO:0031668 73 0.029
protein localization to organelle GO:0033365 57 0.029
response to inorganic substance GO:0010035 377 0.029
behavior GO:0007610 205 0.029
regulation of gtpase activity GO:0043087 57 0.028
regulation of lipid metabolic process GO:0019216 68 0.028
cellular catabolic process GO:0044248 295 0.028
positive regulation of cellular component movement GO:0051272 102 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.028
organic substance catabolic process GO:1901575 316 0.028
glycosyl compound catabolic process GO:1901658 126 0.028
cellular response to growth factor stimulus GO:0071363 162 0.028
neuronal action potential GO:0019228 35 0.028
response to extracellular stimulus GO:0009991 380 0.027
reproduction GO:0000003 245 0.027
cell cell signaling GO:0007267 335 0.027
guanosine containing compound catabolic process GO:1901069 71 0.027
wound healing GO:0042060 122 0.027
regulation of neuron death GO:1901214 115 0.027
chemical homeostasis GO:0048878 292 0.027
regulation of secretion GO:0051046 224 0.027
protein catabolic process GO:0030163 30 0.026
heterocycle catabolic process GO:0046700 167 0.026
myelination GO:0042552 39 0.026
negative regulation of nucleic acid templated transcription GO:1903507 117 0.026
lipid storage GO:0019915 1 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.026
transmission of nerve impulse GO:0019226 42 0.026
cellular response to organic cyclic compound GO:0071407 202 0.026
transcription from rna polymerase ii promoter GO:0006366 252 0.026
localization of cell GO:0051674 202 0.026
cell motility GO:0048870 202 0.025
enzyme linked receptor protein signaling pathway GO:0007167 116 0.025
purine nucleoside catabolic process GO:0006152 124 0.025
purine ribonucleoside metabolic process GO:0046128 168 0.025
immune system process GO:0002376 204 0.025
regulation of protein modification process GO:0031399 194 0.025
nucleoside triphosphate catabolic process GO:0009143 123 0.024
regulation of establishment of protein localization GO:0070201 69 0.024
regulation of protein targeting GO:1903533 28 0.024
signal release GO:0023061 145 0.024
regulation of catabolic process GO:0009894 113 0.024
positive regulation of nf kappab import into nucleus GO:0042346 2 0.024
cellular chemical homeostasis GO:0055082 247 0.024
regulation of neurogenesis GO:0050767 247 0.024
catabolic process GO:0009056 351 0.023
reactive oxygen species metabolic process GO:0072593 37 0.023
regulation of synaptic plasticity GO:0048167 70 0.023
central nervous system neuron axonogenesis GO:0021955 1 0.023
multicellular organism reproduction GO:0032504 233 0.023
organic cyclic compound catabolic process GO:1901361 175 0.023
response to nutrient levels GO:0031667 370 0.023
cellular response to nutrient levels GO:0031669 60 0.023
multi organism reproductive process GO:0044703 262 0.023
regulation of reactive oxygen species metabolic process GO:2000377 26 0.023
response to peptide GO:1901652 292 0.023
negative regulation of signaling GO:0023057 157 0.022
organonitrogen compound catabolic process GO:1901565 179 0.022
glycosyl compound metabolic process GO:1901657 182 0.022
negative regulation of rna biosynthetic process GO:1902679 118 0.022
positive regulation of catalytic activity GO:0043085 184 0.022
negative regulation of macromolecule metabolic process GO:0010605 260 0.022
sexual reproduction GO:0019953 148 0.022
negative regulation of cellular protein metabolic process GO:0032269 106 0.022
purine ribonucleotide catabolic process GO:0009154 136 0.022
epithelium development GO:0060429 96 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.021
vesicle fusion GO:0006906 14 0.021
reproductive process GO:0022414 372 0.021
cellular response to peptide GO:1901653 133 0.021
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.021
multicellular organismal signaling GO:0035637 44 0.021
regulation of intracellular protein transport GO:0033157 34 0.021
ribonucleoside metabolic process GO:0009119 174 0.021
organic acid metabolic process GO:0006082 292 0.020
regulation of multicellular organismal development GO:2000026 376 0.020
regulation of nucleotide catabolic process GO:0030811 65 0.020
secretion by cell GO:0032940 248 0.020
ribonucleoside triphosphate metabolic process GO:0009199 141 0.020
regulation of peptide transport GO:0090087 87 0.020
cellular response to external stimulus GO:0071496 118 0.020
regulation of phosphate metabolic process GO:0019220 349 0.020
axon ensheathment GO:0008366 40 0.020
protein import GO:0017038 37 0.020
positive regulation of multicellular organismal process GO:0051240 387 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.019
negative regulation of protein metabolic process GO:0051248 114 0.019
cellular response to cytokine stimulus GO:0071345 127 0.019
regulation of cell cycle g2 m phase transition GO:1902749 4 0.019
negative regulation of cell development GO:0010721 82 0.018
female pregnancy GO:0007565 122 0.018
multicellular organism growth GO:0035264 1 0.018
single organism cellular localization GO:1902580 102 0.018
regulation of nucleocytoplasmic transport GO:0046822 28 0.018
nucleoside metabolic process GO:0009116 179 0.018
positive regulation of cell development GO:0010720 176 0.018
cellular response to peptide hormone stimulus GO:0071375 120 0.018
negative regulation of metabolic process GO:0009892 331 0.018
glycerolipid metabolic process GO:0046486 67 0.018
learning or memory GO:0007611 90 0.018
positive regulation of biosynthetic process GO:0009891 319 0.018
developmental process involved in reproduction GO:0003006 159 0.018
response to starvation GO:0042594 59 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
protein complex subunit organization GO:0071822 302 0.018
purine ribonucleotide metabolic process GO:0009150 227 0.018
jnk cascade GO:0007254 28 0.018
protein heterooligomerization GO:0051291 89 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.018
antigen processing and presentation GO:0019882 2 0.018
peptide transport GO:0015833 97 0.018
nucleoside phosphate catabolic process GO:1901292 140 0.017
action potential GO:0001508 54 0.017
single organism organelle organization GO:1902589 180 0.017
response to heat GO:0009408 60 0.017
hormone transport GO:0009914 121 0.017
regulation of nervous system development GO:0051960 264 0.017
regulation of cellular component biogenesis GO:0044087 86 0.017
response to glucose GO:0009749 136 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
nuclear transport GO:0051169 49 0.017
negative regulation of nervous system development GO:0051961 79 0.017
regulation of protein kinase activity GO:0045859 105 0.016
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.016
smooth muscle cell proliferation GO:0048659 77 0.016
negative regulation of cellular metabolic process GO:0031324 281 0.016
regulation of phosphorylation GO:0042325 248 0.016
cellular amine metabolic process GO:0044106 38 0.016
response to glucocorticoid GO:0051384 223 0.016
protein import into nucleus GO:0006606 35 0.016
positive regulation of odontogenesis of dentin containing tooth GO:0042488 1 0.016
maintenance of location GO:0051235 17 0.016
regulation of protein transport GO:0051223 68 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.016
macromolecule catabolic process GO:0009057 58 0.016
central nervous system development GO:0007417 311 0.016
establishment of protein localization to organelle GO:0072594 44 0.016
positive regulation of protein modification process GO:0031401 142 0.016
positive regulation of transferase activity GO:0051347 81 0.016
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.016
response to corticosteroid GO:0031960 235 0.016
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.016
macroautophagy GO:0016236 4 0.015
modification dependent macromolecule catabolic process GO:0043632 14 0.015
anterior posterior pattern specification GO:0009952 1 0.015
organic acid catabolic process GO:0016054 49 0.015
activation of phospholipase d activity GO:0031584 2 0.015
carbohydrate derivative metabolic process GO:1901135 346 0.015
positive regulation of developmental process GO:0051094 283 0.015
response to nutrient GO:0007584 248 0.015
hexose metabolic process GO:0019318 58 0.015
cellular lipid metabolic process GO:0044255 208 0.015
response to wounding GO:0009611 254 0.015
positive regulation of signal transduction GO:0009967 175 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
regulation of smooth muscle cell proliferation GO:0048660 75 0.015
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.015
chemosensory behavior GO:0007635 2 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
cell cycle GO:0007049 101 0.015
regulation of jnk cascade GO:0046328 19 0.015
regulation of catalytic activity GO:0050790 304 0.015
homeostatic process GO:0042592 331 0.015
regulation of intracellular transport GO:0032386 65 0.014
intracellular signal transduction GO:0035556 314 0.014
cellular homeostasis GO:0019725 252 0.014
positive regulation of secretion by cell GO:1903532 128 0.014
nucleocytoplasmic transport GO:0006913 48 0.014
positive regulation of cellular catabolic process GO:0031331 71 0.014
aging GO:0007568 241 0.014
organelle localization GO:0051640 55 0.014
positive regulation of nervous system development GO:0051962 178 0.014
amide transport GO:0042886 105 0.014
head development GO:0060322 247 0.014
positive regulation of catabolic process GO:0009896 78 0.014
nuclear import GO:0051170 35 0.014
regulation of fat cell differentiation GO:0045598 3 0.014
regulation of nf kappab import into nucleus GO:0042345 5 0.013
response to hypoxia GO:0001666 231 0.013
lipid biosynthetic process GO:0008610 128 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
regulation of cell cycle GO:0051726 73 0.013
ras protein signal transduction GO:0007265 29 0.013
regulation of protein maturation GO:1903317 50 0.013
defense response GO:0006952 194 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
dephosphorylation GO:0016311 98 0.013
response to hexose GO:0009746 144 0.013
positive regulation of locomotion GO:0040017 102 0.013
olfactory behavior GO:0042048 2 0.013
neuromuscular synaptic transmission GO:0007274 2 0.013
monocarboxylic acid transport GO:0015718 52 0.013
positive regulation of neuron death GO:1901216 43 0.013
single organism nuclear import GO:1902593 35 0.012
single organism behavior GO:0044708 130 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
energy derivation by oxidation of organic compounds GO:0015980 46 0.012
regulation of hydrolase activity GO:0051336 143 0.012
nucleotide metabolic process GO:0009117 279 0.012
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
neuron apoptotic process GO:0051402 88 0.012
protein targeting to nucleus GO:0044744 35 0.012
negative regulation of apoptotic process GO:0043066 181 0.012
organic acid transport GO:0015849 116 0.012
salivary gland morphogenesis GO:0007435 1 0.012
response to carbohydrate GO:0009743 183 0.012
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
regulation of cell development GO:0060284 263 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
endosomal transport GO:0016197 14 0.012
response to monosaccharide GO:0034284 159 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
memory GO:0007613 54 0.012
nucleoside catabolic process GO:0009164 126 0.012
regulation of purine nucleotide catabolic process GO:0033121 65 0.012
response to transforming growth factor beta GO:0071559 46 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 5 0.012
response to cytokine GO:0034097 215 0.012
cellular macromolecular complex assembly GO:0034622 58 0.012
cellular response to stress GO:0033554 269 0.012
regulation of cellular ketone metabolic process GO:0010565 27 0.012
cell projection organization GO:0030030 302 0.011
axonogenesis GO:0007409 71 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
cell cycle g1 s phase transition GO:0044843 13 0.011
sulfur compound metabolic process GO:0006790 70 0.011
regulation of body fluid levels GO:0050878 90 0.011
regulation of proteolysis GO:0030162 66 0.011
ribonucleotide metabolic process GO:0009259 231 0.011
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.011
cation transport GO:0006812 382 0.011
cation homeostasis GO:0055080 195 0.011
protein localization to nucleus GO:0034504 39 0.011
multicellular organismal reproductive process GO:0048609 233 0.011
organic anion transport GO:0015711 132 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
gamete generation GO:0007276 124 0.011
membrane fusion GO:0061025 26 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
behavioral response to ethanol GO:0048149 1 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.011
cellular ketone metabolic process GO:0042180 51 0.011
cellular protein complex assembly GO:0043623 44 0.011
vesicle organization GO:0016050 29 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
response to antibiotic GO:0046677 39 0.011
amine metabolic process GO:0009308 38 0.011
cellular response to biotic stimulus GO:0071216 59 0.011
purine nucleoside triphosphate catabolic process GO:0009146 122 0.011
reproductive structure development GO:0048608 128 0.011
reproductive system development GO:0061458 128 0.011
sensory organ development GO:0007423 74 0.011
phospholipid biosynthetic process GO:0008654 29 0.011
macromolecular complex subunit organization GO:0043933 339 0.011
response to peptide hormone GO:0043434 278 0.011
positive regulation of hormone secretion GO:0046887 65 0.011
regulation of odontogenesis of dentin containing tooth GO:0042487 2 0.011
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 3 0.010
regulation of neuron projection development GO:0010975 161 0.010
motor neuron axon guidance GO:0008045 1 0.010
glial cell differentiation GO:0010001 65 0.010
regulation of epithelial cell proliferation GO:0050678 49 0.010
proteasomal protein catabolic process GO:0010498 8 0.010
biological adhesion GO:0022610 110 0.010
negative regulation of molecular function GO:0044092 133 0.010
glucose metabolic process GO:0006006 52 0.010
guanosine containing compound metabolic process GO:1901068 74 0.010
negative regulation of jnk cascade GO:0046329 4 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010
negative regulation of cell communication GO:0010648 158 0.010
regulation of notch signaling pathway GO:0008593 3 0.010
gliogenesis GO:0042063 93 0.010
tube development GO:0035295 89 0.010
ubiquitin dependent protein catabolic process GO:0006511 14 0.010

Akt1s1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.032
nervous system disease DOID:863 0 0.032
gastrointestinal system cancer DOID:3119 0 0.026
cancer DOID:162 0 0.026
disease of cellular proliferation DOID:14566 0 0.026
organ system cancer DOID:0050686 0 0.026
disease of metabolism DOID:0014667 0 0.014
musculoskeletal system disease DOID:17 0 0.012
connective tissue disease DOID:65 0 0.012
intestinal cancer DOID:10155 0 0.012