Rattus norvegicus

30 known processes

Mlh1

mutL homolog 1 (E. coli)

Mlh1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
pteridine containing compound metabolic process GO:0042558 14 0.184
single organism biosynthetic process GO:0044711 342 0.135
oxoacid metabolic process GO:0043436 290 0.110
response to inorganic substance GO:0010035 377 0.096
response to estrogen GO:0043627 232 0.095
carboxylic acid metabolic process GO:0019752 289 0.094
single organism reproductive process GO:0044702 297 0.085
response to metal ion GO:0010038 253 0.078
dna metabolic process GO:0006259 96 0.077
apoptotic process GO:0006915 381 0.074
nucleoside phosphate metabolic process GO:0006753 283 0.071
response to acid chemical GO:0001101 222 0.071
cellular response to organic cyclic compound GO:0071407 202 0.070
response to decreased oxygen levels GO:0036293 237 0.070
organic acid metabolic process GO:0006082 292 0.066
nucleobase containing small molecule metabolic process GO:0055086 316 0.064
catabolic process GO:0009056 351 0.064
response to amino acid GO:0043200 75 0.061
organophosphate metabolic process GO:0019637 370 0.060
response to oxygen levels GO:0070482 265 0.060
protein complex subunit organization GO:0071822 302 0.059
cellular amino acid metabolic process GO:0006520 107 0.058
response to nutrient GO:0007584 248 0.058
reproductive process GO:0022414 372 0.056
nucleic acid templated transcription GO:0097659 379 0.054
macromolecular complex subunit organization GO:0043933 339 0.053
nucleotide metabolic process GO:0009117 279 0.051
cellular response to oxygen containing compound GO:1901701 386 0.051
folic acid containing compound metabolic process GO:0006760 10 0.049
response to nutrient levels GO:0031667 370 0.049
regulation of cellular localization GO:0060341 263 0.048
regulation of transcription dna templated GO:0006355 374 0.048
positive regulation of transport GO:0051050 245 0.048
regulation of cellular component organization GO:0051128 368 0.048
protein phosphorylation GO:0006468 345 0.048
cellular ketone metabolic process GO:0042180 51 0.047
positive regulation of cell proliferation GO:0008284 249 0.047
regulation of apoptotic process GO:0042981 335 0.047
response to ketone GO:1901654 182 0.046
response to extracellular stimulus GO:0009991 380 0.046
cellular component assembly GO:0022607 360 0.046
regulation of programmed cell death GO:0043067 341 0.046
regulation of multicellular organismal development GO:2000026 376 0.045
organic substance catabolic process GO:1901575 316 0.045
organelle organization GO:0006996 266 0.045
response to growth factor GO:0070848 189 0.045
cellular response to endogenous stimulus GO:0071495 377 0.045
reproduction GO:0000003 245 0.044
cellular catabolic process GO:0044248 295 0.041
protein complex assembly GO:0006461 263 0.041
neuron differentiation GO:0030182 368 0.039
regulation of signal transduction GO:0009966 318 0.038
tissue development GO:0009888 252 0.038
regulation of molecular function GO:0065009 398 0.038
response to hypoxia GO:0001666 231 0.038
alpha amino acid metabolic process GO:1901605 71 0.037
positive regulation of multicellular organismal process GO:0051240 387 0.037
homeostatic process GO:0042592 331 0.036
regulation of cellular protein metabolic process GO:0032268 267 0.036
regulation of anatomical structure morphogenesis GO:0022603 141 0.036
nucleobase containing compound catabolic process GO:0034655 152 0.036
macromolecule localization GO:0033036 252 0.036
response to corticosteroid GO:0031960 235 0.035
central nervous system development GO:0007417 311 0.035
positive regulation of phosphorus metabolic process GO:0010562 262 0.034
positive regulation of developmental process GO:0051094 283 0.034
positive regulation of response to stimulus GO:0048584 285 0.034
head development GO:0060322 247 0.034
ribose phosphate metabolic process GO:0019693 235 0.034
multicellular organism reproduction GO:0032504 233 0.033
regeneration GO:0031099 163 0.033
regulation of cellular amine metabolic process GO:0033238 8 0.033
regulation of cell proliferation GO:0042127 359 0.033
response to carbohydrate GO:0009743 183 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.033
growth GO:0040007 165 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.032
programmed cell death GO:0012501 392 0.032
response to transition metal nanoparticle GO:1990267 122 0.032
secretion GO:0046903 307 0.032
protein complex biogenesis GO:0070271 263 0.032
intracellular signal transduction GO:0035556 314 0.032
regulation of cell differentiation GO:0045595 320 0.032
cellular amine metabolic process GO:0044106 38 0.031
defense response GO:0006952 194 0.031
anatomical structure morphogenesis GO:0009653 298 0.031
amine metabolic process GO:0009308 38 0.031
carbohydrate derivative metabolic process GO:1901135 346 0.031
single organism catabolic process GO:0044712 283 0.031
brain development GO:0007420 247 0.031
cofactor metabolic process GO:0051186 95 0.030
response to monosaccharide GO:0034284 159 0.030
response to radiation GO:0009314 137 0.030
positive regulation of cell communication GO:0010647 271 0.030
coenzyme metabolic process GO:0006732 86 0.030
single organism organelle organization GO:1902589 180 0.030
nucleotide biosynthetic process GO:0009165 98 0.029
regulation of cell development GO:0060284 263 0.029
cellular response to nitrogen compound GO:1901699 210 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.029
negative regulation of metabolic process GO:0009892 331 0.029
organ regeneration GO:0031100 101 0.029
rhythmic process GO:0048511 156 0.029
response to toxic substance GO:0009636 133 0.028
positive regulation of signaling GO:0023056 270 0.028
cell projection organization GO:0030030 302 0.028
response to wounding GO:0009611 254 0.027
response to bacterium GO:0009617 200 0.027
regulation of cellular ketone metabolic process GO:0010565 27 0.027
cellular response to lipid GO:0071396 201 0.027
cell cell signaling GO:0007267 335 0.027
cellular response to organonitrogen compound GO:0071417 197 0.026
positive regulation of nervous system development GO:0051962 178 0.026
purine containing compound metabolic process GO:0072521 253 0.026
positive regulation of protein modification process GO:0031401 142 0.026
organophosphate catabolic process GO:0046434 148 0.026
regulation of system process GO:0044057 208 0.026
hepaticobiliary system development GO:0061008 90 0.026
rna biosynthetic process GO:0032774 380 0.026
single organism cellular localization GO:1902580 102 0.026
response to peptide hormone GO:0043434 278 0.026
regulation of rna biosynthetic process GO:2001141 381 0.025
organonitrogen compound biosynthetic process GO:1901566 167 0.025
cardiovascular system development GO:0072358 134 0.025
cellular component biogenesis GO:0044085 368 0.025
positive regulation of signal transduction GO:0009967 175 0.025
response to molecule of bacterial origin GO:0002237 194 0.025
reproductive system development GO:0061458 128 0.025
macromolecular complex assembly GO:0065003 273 0.024
response to lipopolysaccharide GO:0032496 191 0.024
negative regulation of cell death GO:0060548 229 0.024
organic acid biosynthetic process GO:0016053 83 0.024
establishment of protein localization GO:0045184 141 0.024
cellular response to growth factor stimulus GO:0071363 162 0.024
regulation of protein phosphorylation GO:0001932 183 0.024
response to glucocorticoid GO:0051384 223 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
organic cyclic compound catabolic process GO:1901361 175 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
cellular component movement GO:0006928 248 0.024
regulation of secretion GO:0051046 224 0.024
neuron development GO:0048666 286 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.024
heterocycle catabolic process GO:0046700 167 0.024
chemical homeostasis GO:0048878 292 0.023
purine ribonucleotide metabolic process GO:0009150 227 0.023
axis specification GO:0009798 4 0.023
cellular homeostasis GO:0019725 252 0.023
positive regulation of phosphate metabolic process GO:0045937 262 0.023
positive regulation of cellular protein metabolic process GO:0032270 167 0.023
transmembrane transport GO:0055085 412 0.023
negative regulation of programmed cell death GO:0043069 183 0.022
regulation of protein metabolic process GO:0051246 289 0.022
positive regulation of phosphorylation GO:0042327 177 0.022
response to hexose GO:0009746 144 0.022
response to ethanol GO:0045471 162 0.022
mesoderm development GO:0007498 2 0.022
response to vitamin GO:0033273 131 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
small molecule biosynthetic process GO:0044283 124 0.022
negative regulation of macromolecule metabolic process GO:0010605 260 0.021
cellular response to steroid hormone stimulus GO:0071383 93 0.021
rna metabolic process GO:0016070 406 0.021
neuron projection development GO:0031175 273 0.021
protein transport GO:0015031 132 0.021
organ morphogenesis GO:0009887 75 0.021
response to estradiol GO:0032355 164 0.021
cell migration GO:0016477 197 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
positive regulation of protein phosphorylation GO:0001934 135 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
negative regulation of rna metabolic process GO:0051253 123 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
intracellular transport GO:0046907 185 0.020
nucleoside phosphate biosynthetic process GO:1901293 102 0.020
regulation of protein modification process GO:0031399 194 0.020
sex differentiation GO:0007548 113 0.020
response to external biotic stimulus GO:0043207 221 0.020
negative regulation of apoptotic process GO:0043066 181 0.020
response to glucose GO:0009749 136 0.020
ion transmembrane transport GO:0034220 365 0.020
response to biotic stimulus GO:0009607 226 0.020
purine ribonucleoside metabolic process GO:0046128 168 0.020
double strand break repair GO:0006302 1 0.020
transcription dna templated GO:0006351 377 0.020
response to other organism GO:0051707 220 0.020
regulation of catalytic activity GO:0050790 304 0.020
vasculogenesis GO:0001570 3 0.020
negative regulation of signaling GO:0023057 157 0.020
response to transforming growth factor beta GO:0071559 46 0.019
liver development GO:0001889 90 0.019
cellular nitrogen compound catabolic process GO:0044270 163 0.019
negative regulation of gene expression GO:0010629 199 0.019
negative regulation of cell communication GO:0010648 158 0.019
positive regulation of programmed cell death GO:0043068 157 0.019
single organism intracellular transport GO:1902582 166 0.019
positive regulation of rna metabolic process GO:0051254 203 0.019
regulation of neuron projection development GO:0010975 161 0.019
organophosphate biosynthetic process GO:0090407 143 0.019
regulation of establishment of protein localization GO:0070201 69 0.019
protein localization GO:0008104 191 0.019
regulation of nucleic acid templated transcription GO:1903506 380 0.018
positive regulation of cell differentiation GO:0045597 217 0.018
multicellular organism growth GO:0035264 1 0.018
cellular lipid metabolic process GO:0044255 208 0.018
spermatogenesis GO:0007283 99 0.018
cellular macromolecule localization GO:0070727 122 0.018
anterior posterior pattern specification GO:0009952 1 0.018
cellular response to cytokine stimulus GO:0071345 127 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
alpha amino acid biosynthetic process GO:1901607 23 0.018
glycosyl compound metabolic process GO:1901657 182 0.018
developmental process involved in reproduction GO:0003006 159 0.018
multi organism reproductive process GO:0044703 262 0.018
aromatic compound catabolic process GO:0019439 168 0.018
reproductive structure development GO:0048608 128 0.018
chromosome segregation GO:0007059 2 0.017
inflammatory response GO:0006954 150 0.017
regulation of phosphorus metabolic process GO:0051174 349 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
oxidation reduction process GO:0055114 304 0.017
tube development GO:0035295 89 0.017
nucleoside metabolic process GO:0009116 179 0.017
gamete generation GO:0007276 124 0.017
positive regulation of retinal cell programmed cell death GO:0046670 1 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
regulation of secretion by cell GO:1903530 208 0.017
positive regulation of molecular function GO:0044093 230 0.017
cell cycle checkpoint GO:0000075 2 0.017
carboxylic acid biosynthetic process GO:0046394 83 0.017
purine nucleoside metabolic process GO:0042278 169 0.016
positive regulation of gene expression GO:0010628 244 0.016
regulation of retinal cell programmed cell death GO:0046668 1 0.016
regulation of membrane potential GO:0042391 110 0.016
response to ionizing radiation GO:0010212 59 0.016
ribonucleoside monophosphate metabolic process GO:0009161 88 0.016
negative regulation of biosynthetic process GO:0009890 168 0.016
regulation of neuron differentiation GO:0045664 208 0.016
protein oligomerization GO:0051259 191 0.016
carboxylic acid catabolic process GO:0046395 49 0.015
purine nucleoside triphosphate metabolic process GO:0009144 141 0.015
purine nucleoside monophosphate metabolic process GO:0009126 84 0.015
dna replication GO:0006260 37 0.015
lipid metabolic process GO:0006629 283 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
regulation of nervous system development GO:0051960 264 0.015
synaptic transmission GO:0007268 235 0.015
urogenital system development GO:0001655 78 0.015
circulatory system process GO:0003013 183 0.015
response to oxidative stress GO:0006979 186 0.015
positive regulation of apoptotic process GO:0043065 154 0.015
response to cytokine GO:0034097 215 0.015
behavior GO:0007610 205 0.015
nucleocytoplasmic transport GO:0006913 48 0.015
response to purine containing compound GO:0014074 126 0.015
regulation of phosphorylation GO:0042325 248 0.015
cellular response to stress GO:0033554 269 0.015
cofactor biosynthetic process GO:0051188 28 0.015
cytoplasmic transport GO:0016482 115 0.015
protein tetramerization GO:0051262 38 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.015
sexual reproduction GO:0019953 148 0.015
regulation of rna metabolic process GO:0051252 391 0.015
protein maturation GO:0051604 68 0.015
cellular chemical homeostasis GO:0055082 247 0.015
nucleoside triphosphate metabolic process GO:0009141 144 0.015
forebrain development GO:0030900 98 0.015
tetrahydrofolate metabolic process GO:0046653 9 0.015
development of primary sexual characteristics GO:0045137 107 0.014
response to peptide GO:1901652 292 0.014
cell growth GO:0016049 104 0.014
metal ion transport GO:0030001 289 0.014
protein targeting GO:0006605 61 0.014
gland development GO:0048732 155 0.014
neurological system process GO:0050877 219 0.014
generation of precursor metabolites and energy GO:0006091 62 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
locomotion GO:0040011 237 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
lipid biosynthetic process GO:0008610 128 0.014
positive regulation of cell death GO:0010942 184 0.014
positive regulation of cell development GO:0010720 176 0.014
eye development GO:0001654 50 0.014
cellular response to peptide GO:1901653 133 0.014
mitochondrial rna metabolic process GO:0000959 1 0.014
circulatory system development GO:0072359 134 0.014
secretion by cell GO:0032940 248 0.014
negative regulation of transport GO:0051051 136 0.013
response to alkaloid GO:0043279 132 0.013
response to reactive oxygen species GO:0000302 120 0.013
dephosphorylation GO:0016311 98 0.013
eye morphogenesis GO:0048592 4 0.013
lipid catabolic process GO:0016042 46 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
biological adhesion GO:0022610 110 0.013
response to mechanical stimulus GO:0009612 134 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
peptidyl amino acid modification GO:0018193 126 0.013
cytoskeleton organization GO:0007010 111 0.013
regulation of protein localization GO:0032880 81 0.013
muscle cell proliferation GO:0033002 84 0.013
nucleoside monophosphate metabolic process GO:0009123 93 0.013
aging GO:0007568 241 0.013
cellular protein localization GO:0034613 122 0.013
positive regulation of secretion GO:0051047 140 0.013
single organism carbohydrate metabolic process GO:0044723 118 0.013
cell motility GO:0048870 202 0.013
immune system process GO:0002376 204 0.013
positive regulation of secretion by cell GO:1903532 128 0.013
epithelium development GO:0060429 96 0.013
regulation of cell projection organization GO:0031344 175 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
heart development GO:0007507 72 0.013
gastrulation GO:0007369 2 0.013
cation transport GO:0006812 382 0.013
female sex differentiation GO:0046660 59 0.013
heart morphogenesis GO:0003007 3 0.012
gonad development GO:0008406 104 0.012
embryonic pattern specification GO:0009880 1 0.012
developmental growth GO:0048589 100 0.012
regulation of hormone levels GO:0010817 187 0.012
male gamete generation GO:0048232 99 0.012
negative regulation of cellular component organization GO:0051129 83 0.012
regulation of growth GO:0040008 105 0.012
muscle structure development GO:0061061 87 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
localization of cell GO:0051674 202 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
ras protein signal transduction GO:0007265 29 0.012
cellular response to alcohol GO:0097306 87 0.012
proteolysis GO:0006508 175 0.012
vesicle mediated transport GO:0016192 181 0.012
actin filament based process GO:0030029 86 0.012
renal system development GO:0072001 67 0.012
bmp signaling pathway GO:0030509 4 0.012
monocarboxylic acid metabolic process GO:0032787 152 0.012
transcription from rna polymerase ii promoter GO:0006366 252 0.012
cellular response to metal ion GO:0071248 55 0.012
regulation of response to stress GO:0080134 126 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.012
response to fatty acid GO:0070542 65 0.012
muscle system process GO:0003012 115 0.012
response to cobalt ion GO:0032025 12 0.012
cellular component morphogenesis GO:0032989 155 0.012
regulation of epithelial cell proliferation GO:0050678 49 0.012
regulation of cellular component movement GO:0051270 150 0.012
regulation of response to external stimulus GO:0032101 106 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
anatomical structure formation involved in morphogenesis GO:0048646 83 0.011
regulation of cell motility GO:2000145 131 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
cell adhesion GO:0007155 110 0.011
regulation of neurogenesis GO:0050767 247 0.011
cytoskeleton dependent cytokinesis GO:0061640 2 0.011
inorganic cation transmembrane transport GO:0098662 202 0.011
meiotic cell cycle process GO:1903046 3 0.011
protein import GO:0017038 37 0.011
sensory perception GO:0007600 101 0.011
cellular response to inorganic substance GO:0071241 65 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
cellular modified amino acid metabolic process GO:0006575 61 0.011
regulation of kinase activity GO:0043549 117 0.011
circadian rhythm GO:0007623 88 0.011
pallium development GO:0021543 42 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
intracellular protein transport GO:0006886 79 0.011
regulation of anatomical structure size GO:0090066 135 0.011
germ cell migration GO:0008354 1 0.011
single organism nuclear import GO:1902593 35 0.011
regulation of protein transport GO:0051223 68 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
regulation of cell migration GO:0030334 128 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
signal release GO:0023061 145 0.011
ovulation cycle process GO:0022602 50 0.010
learning or memory GO:0007611 90 0.010
regulation of hormone secretion GO:0046883 106 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010
camera type eye development GO:0043010 48 0.010
positive regulation of cell migration GO:0030335 96 0.010
cellular response to corticosteroid stimulus GO:0071384 69 0.010
wound healing GO:0042060 122 0.010
cognition GO:0050890 92 0.010
sensory organ development GO:0007423 74 0.010
ion homeostasis GO:0050801 212 0.010
cellular response to glucocorticoid stimulus GO:0071385 68 0.010
glial cell differentiation GO:0010001 65 0.010
cell cycle GO:0007049 101 0.010
cell part morphogenesis GO:0032990 123 0.010
small molecule catabolic process GO:0044282 59 0.010

Mlh1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012