Rattus norvegicus

9 known processes

Slc12a7

solute carrier family 12 (potassium/chloride transporters), member 7

(Aliases: Kcc4)

Slc12a7 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron differentiation GO:0030182 368 0.089
cellular component biogenesis GO:0044085 368 0.060
cellular amino acid metabolic process GO:0006520 107 0.058
oxoacid metabolic process GO:0043436 290 0.057
cellular component assembly GO:0022607 360 0.056
regulation of phosphate metabolic process GO:0019220 349 0.052
macromolecular complex subunit organization GO:0043933 339 0.051
anatomical structure morphogenesis GO:0009653 298 0.051
secretion GO:0046903 307 0.050
cell communication involved in cardiac conduction GO:0086065 2 0.050
homeostatic process GO:0042592 331 0.048
cellular response to endogenous stimulus GO:0071495 377 0.048
regulation of phosphorus metabolic process GO:0051174 349 0.047
organic acid metabolic process GO:0006082 292 0.046
cell projection organization GO:0030030 302 0.045
protein phosphorylation GO:0006468 345 0.045
carboxylic acid metabolic process GO:0019752 289 0.043
positive regulation of multicellular organismal process GO:0051240 387 0.043
regulation of cellular amine metabolic process GO:0033238 8 0.042
single organism biosynthetic process GO:0044711 342 0.041
cardiac chamber development GO:0003205 1 0.040
blood circulation GO:0008015 183 0.039
regulation of molecular function GO:0065009 398 0.039
regulation of membrane potential GO:0042391 110 0.039
circulatory system process GO:0003013 183 0.039
regulation of catalytic activity GO:0050790 304 0.039
regulation of transcription dna templated GO:0006355 374 0.038
macromolecule localization GO:0033036 252 0.038
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.038
regulation of cellular amino acid metabolic process GO:0006521 2 0.035
cation transport GO:0006812 382 0.035
Rat
intracellular signal transduction GO:0035556 314 0.034
regulation of multicellular organismal development GO:2000026 376 0.033
regulation of intracellular signal transduction GO:1902531 218 0.033
neuron development GO:0048666 286 0.033
cellular amine metabolic process GO:0044106 38 0.033
muscle contraction GO:0006936 88 0.033
cellular ketone metabolic process GO:0042180 51 0.032
transmembrane transport GO:0055085 412 0.032
Rat
response to peptide GO:1901652 292 0.031
carbohydrate derivative metabolic process GO:1901135 346 0.031
protein complex assembly GO:0006461 263 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.030
positive regulation of phosphorus metabolic process GO:0010562 262 0.030
protein complex biogenesis GO:0070271 263 0.030
response to hypoxia GO:0001666 231 0.030
regulation of cell proliferation GO:0042127 359 0.030
organic substance catabolic process GO:1901575 316 0.030
macromolecular complex assembly GO:0065003 273 0.030
positive regulation of molecular function GO:0044093 230 0.030
lipid metabolic process GO:0006629 283 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.029
regulation of programmed cell death GO:0043067 341 0.029
secretion by cell GO:0032940 248 0.029
cellular component movement GO:0006928 248 0.029
response to inorganic substance GO:0010035 377 0.029
regulation of apoptotic process GO:0042981 335 0.029
organelle organization GO:0006996 266 0.029
cardiac conduction GO:0061337 2 0.028
metal ion transport GO:0030001 289 0.028
Rat
regulation of cellular localization GO:0060341 263 0.028
regulation of cell projection organization GO:0031344 175 0.028
protein complex subunit organization GO:0071822 302 0.028
regulation of system process GO:0044057 208 0.027
neuron projection development GO:0031175 273 0.027
regulation of neurogenesis GO:0050767 247 0.027
transcription dna templated GO:0006351 377 0.026
action potential GO:0001508 54 0.026
response to decreased oxygen levels GO:0036293 237 0.026
regulation of neuron differentiation GO:0045664 208 0.026
muscle system process GO:0003012 115 0.026
regulation of cell differentiation GO:0045595 320 0.026
regulation of secretion by cell GO:1903530 208 0.026
single organism catabolic process GO:0044712 283 0.026
regulation of phosphorylation GO:0042325 248 0.026
response to nutrient levels GO:0031667 370 0.025
positive regulation of catalytic activity GO:0043085 184 0.025
regulation of signal transduction GO:0009966 318 0.025
cellular response to hormone stimulus GO:0032870 247 0.025
rna metabolic process GO:0016070 406 0.025
neurological system process GO:0050877 219 0.025
cellular component morphogenesis GO:0032989 155 0.025
protein oligomerization GO:0051259 191 0.025
organophosphate metabolic process GO:0019637 370 0.024
regulation of nervous system development GO:0051960 264 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
cardiac muscle contraction GO:0060048 27 0.024
cell morphogenesis involved in differentiation GO:0000904 119 0.024
cellular response to oxygen containing compound GO:1901701 386 0.024
amine metabolic process GO:0009308 38 0.024
neuronal action potential GO:0019228 35 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
rna biosynthetic process GO:0032774 380 0.024
regulation of cellular component organization GO:0051128 368 0.024
peptidyl amino acid modification GO:0018193 126 0.023
negative regulation of metabolic process GO:0009892 331 0.023
apoptotic process GO:0006915 381 0.023
regulation of rna biosynthetic process GO:2001141 381 0.023
multicellular organismal signaling GO:0035637 44 0.023
positive regulation of cell communication GO:0010647 271 0.023
regulation of rna metabolic process GO:0051252 391 0.023
positive regulation of developmental process GO:0051094 283 0.023
cell morphogenesis GO:0000902 142 0.022
gland development GO:0048732 155 0.022
positive regulation of cell proliferation GO:0008284 249 0.022
synaptic transmission GO:0007268 235 0.022
striated muscle contraction GO:0006941 44 0.022
protein localization GO:0008104 191 0.022
response to peptide hormone GO:0043434 278 0.022
cell cell signaling GO:0007267 335 0.022
programmed cell death GO:0012501 392 0.021
negative regulation of multicellular organismal process GO:0051241 203 0.021
tissue development GO:0009888 252 0.021
head development GO:0060322 247 0.021
brain development GO:0007420 247 0.021
regulation of protein modification process GO:0031399 194 0.021
nucleoside phosphate metabolic process GO:0006753 283 0.021
cellular response to peptide GO:1901653 133 0.021
ion transmembrane transport GO:0034220 365 0.021
Rat
positive regulation of phosphate metabolic process GO:0045937 262 0.021
regulation of protein phosphorylation GO:0001932 183 0.021
cellular response to nitrogen compound GO:1901699 210 0.021
regulation of cell development GO:0060284 263 0.021
cation transmembrane transport GO:0098655 263 0.020
Rat
lipid biosynthetic process GO:0008610 128 0.020
oxidation reduction process GO:0055114 304 0.020
cardiac muscle cell contraction GO:0086003 10 0.020
regulation of protein metabolic process GO:0051246 289 0.020
ras protein signal transduction GO:0007265 29 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.020
anion transport GO:0006820 178 0.020
Rat
positive regulation of signaling GO:0023056 270 0.020
response to oxygen levels GO:0070482 265 0.020
negative regulation of response to stimulus GO:0048585 155 0.019
neuron projection morphogenesis GO:0048812 122 0.019
regulation of secretion GO:0051046 224 0.019
cell migration GO:0016477 197 0.019
nucleoside metabolic process GO:0009116 179 0.019
positive regulation of transport GO:0051050 245 0.019
cellular homeostasis GO:0019725 252 0.019
vesicle mediated transport GO:0016192 181 0.019
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.019
organic hydroxy compound metabolic process GO:1901615 115 0.019
negative regulation of nervous system development GO:0051961 79 0.018
catabolic process GO:0009056 351 0.018
positive regulation of neurogenesis GO:0050769 165 0.018
cellular response to organic cyclic compound GO:0071407 202 0.018
localization of cell GO:0051674 202 0.018
transmission of nerve impulse GO:0019226 42 0.018
cardiac muscle cell action potential involved in contraction GO:0086002 2 0.018
cell motility GO:0048870 202 0.018
central nervous system development GO:0007417 311 0.018
small gtpase mediated signal transduction GO:0007264 36 0.018
reproductive process GO:0022414 372 0.018
inorganic ion transmembrane transport GO:0098660 229 0.018
Rat
signal release GO:0023061 145 0.018
response to metal ion GO:0010038 253 0.018
axis specification GO:0009798 4 0.018
response to extracellular stimulus GO:0009991 380 0.018
cell part morphogenesis GO:0032990 123 0.017
response to insulin GO:0032868 133 0.017
organophosphate biosynthetic process GO:0090407 143 0.017
actin mediated cell contraction GO:0070252 12 0.017
immune system process GO:0002376 204 0.017
regulation of catabolic process GO:0009894 113 0.017
cellular chemical homeostasis GO:0055082 247 0.017
Rat
multicellular organism growth GO:0035264 1 0.017
cellular cation homeostasis GO:0030003 180 0.016
Rat
hepaticobiliary system development GO:0061008 90 0.016
mesoderm development GO:0007498 2 0.016
nucleobase containing small molecule metabolic process GO:0055086 316 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.016
locomotion GO:0040011 237 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
regulation of mapk cascade GO:0043408 116 0.016
cellular metal ion homeostasis GO:0006875 172 0.016
positive regulation of phosphorylation GO:0042327 177 0.016
cation homeostasis GO:0055080 195 0.016
Rat
cardiac ventricle development GO:0003231 1 0.016
nucleotide metabolic process GO:0009117 279 0.016
oligopeptide transport GO:0006857 4 0.016
reproduction GO:0000003 245 0.016
carbohydrate derivative biosynthetic process GO:1901137 124 0.016
dephosphorylation GO:0016311 98 0.016
regulation of neuron projection development GO:0010975 161 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
gliogenesis GO:0042063 93 0.015
behavior GO:0007610 205 0.015
cellular response to external stimulus GO:0071496 118 0.015
regulation of tube size GO:0035150 89 0.015
negative regulation of cell proliferation GO:0008285 119 0.015
regulation of cellular catabolic process GO:0031329 101 0.015
positive regulation of cellular component organization GO:0051130 200 0.015
motor neuron axon guidance GO:0008045 1 0.015
positive regulation of gene expression GO:0010628 244 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
regulation of purine nucleotide metabolic process GO:1900542 115 0.015
inorganic cation transmembrane transport GO:0098662 202 0.015
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.015
response to growth factor GO:0070848 189 0.015
heart morphogenesis GO:0003007 3 0.015
response to transition metal nanoparticle GO:1990267 122 0.015
organic acid transport GO:0015849 116 0.015
positive regulation of biosynthetic process GO:0009891 319 0.015
regulation of muscle system process GO:0090257 79 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
synaptic growth at neuromuscular junction GO:0051124 1 0.015
intracellular transport GO:0046907 185 0.015
regulation of muscle contraction GO:0006937 53 0.015
positive regulation of protein phosphorylation GO:0001934 135 0.014
cellular response to peptide hormone stimulus GO:0071375 120 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
regulation of neuron apoptotic process GO:0043523 83 0.014
positive regulation of cell development GO:0010720 176 0.014
chemical homeostasis GO:0048878 292 0.014
Rat
purine containing compound metabolic process GO:0072521 253 0.014
response to estrogen GO:0043627 232 0.014
regulation of blood circulation GO:1903522 110 0.014
gastrulation GO:0007369 2 0.014
nucleic acid templated transcription GO:0097659 379 0.014
regeneration GO:0031099 163 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
negative regulation of neurogenesis GO:0050768 78 0.014
establishment of protein localization GO:0045184 141 0.014
cellular response to organonitrogen compound GO:0071417 197 0.014
organic anion transport GO:0015711 132 0.014
growth GO:0040007 165 0.014
protein autophosphorylation GO:0046777 66 0.014
transcription from rna polymerase ii promoter GO:0006366 252 0.014
response to ethanol GO:0045471 162 0.014
cell cell junction organization GO:0045216 20 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
rhythmic process GO:0048511 156 0.013
regulation of cellular component movement GO:0051270 150 0.013
regulation of hormone levels GO:0010817 187 0.013
regulation of protein kinase activity GO:0045859 105 0.013
single organism intracellular transport GO:1902582 166 0.013
regulation of kinase activity GO:0043549 117 0.013
regulation of ion transport GO:0043269 245 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
liver development GO:0001889 90 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.013
regulation of vesicle mediated transport GO:0060627 81 0.013
metal ion homeostasis GO:0055065 186 0.013
anion transmembrane transport GO:0098656 77 0.013
Rat
heart contraction GO:0060047 57 0.013
cellular response to tumor necrosis factor GO:0071356 46 0.013
regulation of hormone secretion GO:0046883 106 0.013
regulation of striated muscle contraction GO:0006942 21 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
single organism reproductive process GO:0044702 297 0.013
neurotransmitter transport GO:0006836 42 0.013
chromosome segregation GO:0007059 2 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
carboxylic acid transport GO:0046942 115 0.013
tube development GO:0035295 89 0.013
regulation of blood vessel size GO:0050880 89 0.013
protein heterooligomerization GO:0051291 89 0.013
negative regulation of transport GO:0051051 136 0.013
response to cytokine GO:0034097 215 0.012
positive regulation of kinase activity GO:0033674 77 0.012
mechanoreceptor differentiation GO:0042490 2 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
negative regulation of developmental process GO:0051093 125 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
cellular lipid metabolic process GO:0044255 208 0.012
positive regulation of secretion by cell GO:1903532 128 0.012
epithelium development GO:0060429 96 0.012
dna metabolic process GO:0006259 96 0.012
membrane organization GO:0061024 94 0.012
cellular ion homeostasis GO:0006873 184 0.012
Rat
positive regulation of programmed cell death GO:0043068 157 0.012
positive regulation of protein modification process GO:0031401 142 0.012
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.012
negative regulation of cell development GO:0010721 82 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
negative regulation of neuron differentiation GO:0045665 62 0.012
positive regulation of nervous system development GO:0051962 178 0.012
heart process GO:0003015 57 0.012
multicellular organism reproduction GO:0032504 233 0.012
negative regulation of phosphorus metabolic process GO:0010563 80 0.012
single organism carbohydrate metabolic process GO:0044723 118 0.012
cell projection morphogenesis GO:0048858 123 0.012
negative regulation of macromolecule metabolic process GO:0010605 260 0.012
negative regulation of cell communication GO:0010648 158 0.012
protein transport GO:0015031 132 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
vascular process in circulatory system GO:0003018 96 0.012
development of primary sexual characteristics GO:0045137 107 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
regulation of blood pressure GO:0008217 83 0.012
positive regulation of protein kinase activity GO:0045860 73 0.012
embryonic pattern specification GO:0009880 1 0.011
sex differentiation GO:0007548 113 0.011
heterocycle catabolic process GO:0046700 167 0.011
cell differentiation involved in kidney development GO:0061005 4 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
Rat
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
negative regulation of programmed cell death GO:0043069 183 0.011
regulation of proteasomal protein catabolic process GO:0061136 4 0.011
single organism behavior GO:0044708 130 0.011
neuron death GO:0070997 127 0.011
regulation of response to stress GO:0080134 126 0.011
ribonucleotide metabolic process GO:0009259 231 0.011
divalent metal ion transport GO:0070838 132 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
choline transport GO:0015871 4 0.011
developmental growth GO:0048589 100 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
adult locomotory behavior GO:0008344 4 0.011
glycosyl compound metabolic process GO:1901657 182 0.011
response to wounding GO:0009611 254 0.011
glycerolipid metabolic process GO:0046486 67 0.011
regulation of transferase activity GO:0051338 123 0.011
appendage morphogenesis GO:0035107 4 0.011
regulation of cardiac muscle contraction GO:0055117 17 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
regulation of locomotion GO:0040012 148 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
eye morphogenesis GO:0048592 4 0.011
alcohol metabolic process GO:0006066 77 0.011
protein homooligomerization GO:0051260 91 0.011
gonad development GO:0008406 104 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
axon development GO:0061564 96 0.011
single organism organelle organization GO:1902589 180 0.011
regulation of synaptic transmission GO:0050804 141 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.011
peptide transport GO:0015833 97 0.010
negative regulation of biosynthetic process GO:0009890 168 0.010
auditory receptor cell differentiation GO:0042491 2 0.010
negative regulation of cellular component organization GO:0051129 83 0.010
regulation of neurotransmitter levels GO:0001505 42 0.010
carbohydrate metabolic process GO:0005975 130 0.010
anterior posterior pattern specification GO:0009952 1 0.010
regulation of hydrolase activity GO:0051336 143 0.010
cellular response to cytokine stimulus GO:0071345 127 0.010
proteolysis GO:0006508 175 0.010
cellular response to stress GO:0033554 269 0.010
organophosphate catabolic process GO:0046434 148 0.010
regulation of neuron death GO:1901214 115 0.010
negative regulation of cell death GO:0060548 229 0.010
nucleoside triphosphate metabolic process GO:0009141 144 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.010
positive regulation of transcription dna templated GO:0045893 197 0.010
ovulation cycle GO:0042698 67 0.010
hormone transport GO:0009914 121 0.010
alpha amino acid metabolic process GO:1901605 71 0.010

Slc12a7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cardiovascular system disease DOID:1287 0 0.053
disease of anatomical entity DOID:7 0 0.053
myopathy DOID:423 0 0.045
muscular disease DOID:0080000 0 0.045
muscle tissue disease DOID:66 0 0.045
musculoskeletal system disease DOID:17 0 0.045
heart disease DOID:114 0 0.028
intrinsic cardiomyopathy DOID:0060036 0 0.020
cardiomyopathy DOID:0050700 0 0.020
nervous system disease DOID:863 0 0.016
arrhythmogenic right ventricular cardiomyopathy DOID:0050431 0 0.015
disease of metabolism DOID:0014667 0 0.012
inherited metabolic disorder DOID:655 0 0.012
disease of cellular proliferation DOID:14566 0 0.010