Rattus norvegicus

83 known processes

Slc11a2

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

(Aliases: Dmt1,Nramp2)

Slc11a2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell projection organization GO:0030030 302 0.066
response to inorganic substance GO:0010035 377 0.058
chemical homeostasis GO:0048878 292 0.056
oxoacid metabolic process GO:0043436 290 0.054
response to extracellular stimulus GO:0009991 380 0.053
carboxylic acid metabolic process GO:0019752 289 0.052
single organism biosynthetic process GO:0044711 342 0.052
cation transport GO:0006812 382 0.050
organic acid metabolic process GO:0006082 292 0.050
response to nutrient levels GO:0031667 370 0.048
cellular response to oxygen containing compound GO:1901701 386 0.047
secretion GO:0046903 307 0.045
organonitrogen compound biosynthetic process GO:1901566 167 0.044
organophosphate metabolic process GO:0019637 370 0.041
central nervous system development GO:0007417 311 0.041
cellular response to stress GO:0033554 269 0.040
macromolecular complex subunit organization GO:0043933 339 0.040
vesicle mediated transport GO:0016192 181 0.040
neuron projection development GO:0031175 273 0.039
cellular amino acid metabolic process GO:0006520 107 0.039
monocarboxylic acid metabolic process GO:0032787 152 0.039
macromolecule localization GO:0033036 252 0.038
gland development GO:0048732 155 0.036
regulation of neurogenesis GO:0050767 247 0.036
regulation of cell proliferation GO:0042127 359 0.036
lipid biosynthetic process GO:0008610 128 0.036
lipid metabolic process GO:0006629 283 0.036
anion transport GO:0006820 178 0.035
regulation of cellular component organization GO:0051128 368 0.035
protein localization GO:0008104 191 0.035
organophosphate biosynthetic process GO:0090407 143 0.034
regulation of cell development GO:0060284 263 0.033
cell cell signaling GO:0007267 335 0.033
hepaticobiliary system development GO:0061008 90 0.033
regulation of apoptotic process GO:0042981 335 0.032
Human
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.032
regulation of programmed cell death GO:0043067 341 0.032
Human
positive regulation of developmental process GO:0051094 283 0.032
response to hypoxia GO:0001666 231 0.032
ion transmembrane transport GO:0034220 365 0.032
neuron differentiation GO:0030182 368 0.031
programmed cell death GO:0012501 392 0.031
Human
reproductive process GO:0022414 372 0.030
positive regulation of multicellular organismal process GO:0051240 387 0.030
regulation of multicellular organismal development GO:2000026 376 0.030
ras protein signal transduction GO:0007265 29 0.030
regulation of transcription dna templated GO:0006355 374 0.030
protein transport GO:0015031 132 0.029
secretion by cell GO:0032940 248 0.028
cellular amine metabolic process GO:0044106 38 0.028
cellular protein localization GO:0034613 122 0.028
inorganic ion transmembrane transport GO:0098660 229 0.028
cellular component biogenesis GO:0044085 368 0.028
ion homeostasis GO:0050801 212 0.028
macromolecular complex assembly GO:0065003 273 0.028
homeostatic process GO:0042592 331 0.028
liver development GO:0001889 90 0.027
signal release GO:0023061 145 0.027
regulation of nervous system development GO:0051960 264 0.027
organic anion transport GO:0015711 132 0.027
protein complex biogenesis GO:0070271 263 0.027
intracellular signal transduction GO:0035556 314 0.026
multi organism reproductive process GO:0044703 262 0.026
aging GO:0007568 241 0.026
positive regulation of cell differentiation GO:0045597 217 0.026
positive regulation of nervous system development GO:0051962 178 0.026
response to decreased oxygen levels GO:0036293 237 0.026
amine metabolic process GO:0009308 38 0.026
response to peptide GO:1901652 292 0.025
rna biosynthetic process GO:0032774 380 0.025
regulation of rna metabolic process GO:0051252 391 0.025
synaptic transmission GO:0007268 235 0.025
response to oxygen levels GO:0070482 265 0.025
regulation of cellular localization GO:0060341 263 0.025
regulation of neuron projection development GO:0010975 161 0.025
transmembrane transport GO:0055085 412 0.025
cellular response to endogenous stimulus GO:0071495 377 0.024
nucleobase containing small molecule metabolic process GO:0055086 316 0.024
single organism carbohydrate metabolic process GO:0044723 118 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.024
carbohydrate derivative metabolic process GO:1901135 346 0.024
carboxylic acid transport GO:0046942 115 0.024
positive regulation of neurogenesis GO:0050769 165 0.024
reproduction GO:0000003 245 0.024
oxidation reduction process GO:0055114 304 0.024
nucleotide metabolic process GO:0009117 279 0.024
proteolysis GO:0006508 175 0.023
Human
regulation of catalytic activity GO:0050790 304 0.022
Human
cellular lipid metabolic process GO:0044255 208 0.022
positive regulation of cell development GO:0010720 176 0.022
response to peptide hormone GO:0043434 278 0.022
negative regulation of metabolic process GO:0009892 331 0.022
multicellular organismal reproductive process GO:0048609 233 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.022
cofactor metabolic process GO:0051186 95 0.022
cellular chemical homeostasis GO:0055082 247 0.022
cellular component movement GO:0006928 248 0.021
negative regulation of cellular metabolic process GO:0031324 281 0.021
cellular response to peptide GO:1901653 133 0.021
catabolic process GO:0009056 351 0.021
regulation of signal transduction GO:0009966 318 0.021
ribose phosphate metabolic process GO:0019693 235 0.021
protein complex subunit organization GO:0071822 302 0.021
regulation of cell projection organization GO:0031344 175 0.021
single organism reproductive process GO:0044702 297 0.021
protein complex assembly GO:0006461 263 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
carbohydrate metabolic process GO:0005975 130 0.021
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
cellular macromolecule localization GO:0070727 122 0.021
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
regulation of rna biosynthetic process GO:2001141 381 0.020
regulation of neuron differentiation GO:0045664 208 0.020
cellular response to growth factor stimulus GO:0071363 162 0.020
regulation of anatomical structure size GO:0090066 135 0.020
nitrogen compound transport GO:0071705 229 0.020
head development GO:0060322 247 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.020
transcription dna templated GO:0006351 377 0.020
cellular ion homeostasis GO:0006873 184 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
response to acid chemical GO:0001101 222 0.020
regulation of secretion GO:0051046 224 0.020
regulation of nucleic acid templated transcription GO:1903506 380 0.020
carbohydrate derivative biosynthetic process GO:1901137 124 0.020
cellular response to external stimulus GO:0071496 118 0.020
response to lipopolysaccharide GO:0032496 191 0.020
rhythmic process GO:0048511 156 0.020
cellular ketone metabolic process GO:0042180 51 0.019
multicellular organism reproduction GO:0032504 233 0.019
cell motility GO:0048870 202 0.019
cation homeostasis GO:0055080 195 0.019
response to ethanol GO:0045471 162 0.019
organelle organization GO:0006996 266 0.019
cellular homeostasis GO:0019725 252 0.019
metal ion homeostasis GO:0055065 186 0.019
regulation of ion transport GO:0043269 245 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.019
brain development GO:0007420 247 0.019
single organism cellular localization GO:1902580 102 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
metal ion transport GO:0030001 289 0.018
cellular catabolic process GO:0044248 295 0.018
regulation of molecular function GO:0065009 398 0.018
Human
protein phosphorylation GO:0006468 345 0.018
divalent inorganic cation homeostasis GO:0072507 165 0.018
Yeast
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
embryonic pattern specification GO:0009880 1 0.018
alpha amino acid metabolic process GO:1901605 71 0.018
blood circulation GO:0008015 183 0.017
rna metabolic process GO:0016070 406 0.017
gastrulation GO:0007369 2 0.017
single organism intracellular transport GO:1902582 166 0.017
response to insulin GO:0032868 133 0.017
anion transmembrane transport GO:0098656 77 0.017
establishment of protein localization GO:0045184 141 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
response to growth factor GO:0070848 189 0.017
organic substance catabolic process GO:1901575 316 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.017
response to nutrient GO:0007584 248 0.017
positive regulation of cellular component organization GO:0051130 200 0.017
intracellular transport GO:0046907 185 0.017
negative regulation of biosynthetic process GO:0009890 168 0.017
nucleic acid templated transcription GO:0097659 379 0.016
positive regulation of response to stimulus GO:0048584 285 0.016
axis specification GO:0009798 4 0.016
cellular component assembly GO:0022607 360 0.016
small molecule biosynthetic process GO:0044283 124 0.016
negative regulation of gene expression GO:0010629 199 0.016
cytoplasmic transport GO:0016482 115 0.016
coenzyme metabolic process GO:0006732 86 0.016
positive regulation of biosynthetic process GO:0009891 319 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
eye morphogenesis GO:0048592 4 0.016
response to carbohydrate GO:0009743 183 0.016
regulation of cellular component movement GO:0051270 150 0.016
hormone secretion GO:0046879 115 0.016
response to radiation GO:0009314 137 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
negative regulation of cell communication GO:0010648 158 0.016
negative regulation of cell death GO:0060548 229 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
response to bacterium GO:0009617 200 0.016
response to estrogen GO:0043627 232 0.016
protein oligomerization GO:0051259 191 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
circulatory system process GO:0003013 183 0.016
neuron development GO:0048666 286 0.016
membrane organization GO:0061024 94 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
response to hexose GO:0009746 144 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
asymmetric protein localization GO:0008105 2 0.015
single organism membrane organization GO:0044802 74 0.015
organic acid transport GO:0015849 116 0.015
anterior posterior pattern specification GO:0009952 1 0.015
purine containing compound metabolic process GO:0072521 253 0.015
monovalent inorganic cation transport GO:0015672 172 0.015
Human Yeast
regulation of cellular amine metabolic process GO:0033238 8 0.015
cellular response to organic cyclic compound GO:0071407 202 0.015
ribonucleotide biosynthetic process GO:0009260 85 0.015
sexual reproduction GO:0019953 148 0.015
regulation of secretion by cell GO:1903530 208 0.015
nucleoside metabolic process GO:0009116 179 0.015
tissue development GO:0009888 252 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
regulation of synaptic transmission GO:0050804 141 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
regulation of nucleotide metabolic process GO:0006140 117 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
regulation of cell differentiation GO:0045595 320 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
Human
peptide transport GO:0015833 97 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
transcription from rna polymerase ii promoter GO:0006366 252 0.015
cellular response to insulin stimulus GO:0032869 81 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
anatomical structure morphogenesis GO:0009653 298 0.015
response to metal ion GO:0010038 253 0.015
cellular response to cytokine stimulus GO:0071345 127 0.015
response to retinoic acid GO:0032526 63 0.015
neurological system process GO:0050877 219 0.015
single organism catabolic process GO:0044712 283 0.014
regulation of intracellular signal transduction GO:1902531 218 0.014
regulation of phosphorus metabolic process GO:0051174 349 0.014
defense response GO:0006952 194 0.014
forebrain development GO:0030900 98 0.014
regulation of system process GO:0044057 208 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
cellular component morphogenesis GO:0032989 155 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
Human
response to cytokine GO:0034097 215 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
cellular response to peptide hormone stimulus GO:0071375 120 0.014
response to oxidative stress GO:0006979 186 0.014
Human
cellular cation homeostasis GO:0030003 180 0.014
calcium ion homeostasis GO:0055074 162 0.014
positive regulation of cell communication GO:0010647 271 0.014
ribose phosphate biosynthetic process GO:0046390 87 0.014
positive regulation of signaling GO:0023056 270 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.014
amide transport GO:0042886 105 0.014
cellular divalent inorganic cation homeostasis GO:0072503 162 0.014
Yeast
cell migration GO:0016477 197 0.014
locomotion GO:0040011 237 0.014
regulation of phosphorylation GO:0042325 248 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
regulation of hormone levels GO:0010817 187 0.013
chemosensory behavior GO:0007635 2 0.013
apoptotic process GO:0006915 381 0.013
Human
response to monosaccharide GO:0034284 159 0.013
olfactory behavior GO:0042048 2 0.013
positive regulation of ion transport GO:0043270 94 0.013
generation of precursor metabolites and energy GO:0006091 62 0.013
peptide secretion GO:0002790 86 0.013
positive regulation of phosphate metabolic process GO:0045937 262 0.013
gamete generation GO:0007276 124 0.013
hormone transport GO:0009914 121 0.013
sex differentiation GO:0007548 113 0.013
regulation of protein metabolic process GO:0051246 289 0.013
Human
glycosyl compound metabolic process GO:1901657 182 0.013
positive regulation of secretion by cell GO:1903532 128 0.013
multicellular organism growth GO:0035264 1 0.013
negative regulation of innate immune response GO:0045824 4 0.013
purine ribonucleoside metabolic process GO:0046128 168 0.013
circadian rhythm GO:0007623 88 0.013
purine containing compound biosynthetic process GO:0072522 85 0.013
cellular carbohydrate metabolic process GO:0044262 72 0.013
positive regulation of transport GO:0051050 245 0.013
multicellular organismal homeostasis GO:0048871 49 0.013
Human
cellular response to lipid GO:0071396 201 0.013
regulation of peptide secretion GO:0002791 82 0.013
response to ionizing radiation GO:0010212 59 0.013
response to other organism GO:0051707 220 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
tube development GO:0035295 89 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
actin cytoskeleton organization GO:0030036 73 0.012
response to transition metal nanoparticle GO:1990267 122 0.012
regulation of cell cycle GO:0051726 73 0.012
cellular modified amino acid metabolic process GO:0006575 61 0.012
regulation of hormone secretion GO:0046883 106 0.012
epithelial cell differentiation GO:0030855 71 0.012
endoplasmic reticulum organization GO:0007029 1 0.012
localization of cell GO:0051674 202 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
neuron death GO:0070997 127 0.012
inflammatory response GO:0006954 150 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
negative regulation of apoptotic process GO:0043066 181 0.012
intracellular protein transport GO:0006886 79 0.012
developmental process involved in reproduction GO:0003006 159 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
negative regulation of transport GO:0051051 136 0.012
response to molecule of bacterial origin GO:0002237 194 0.012
response to glucose GO:0009749 136 0.012
response to biotic stimulus GO:0009607 226 0.012
positive regulation of rna metabolic process GO:0051254 203 0.011
cation transmembrane transport GO:0098655 263 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.011
response to reactive oxygen species GO:0000302 120 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
Human
negative regulation of signaling GO:0023057 157 0.011
positive regulation of gene expression GO:0010628 244 0.011
peptide hormone secretion GO:0030072 84 0.011
cellular response to reactive oxygen species GO:0034614 55 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
actin filament based process GO:0030029 86 0.011
regulation of peptide transport GO:0090087 87 0.011
protein homooligomerization GO:0051260 91 0.011
negative regulation of nucleic acid templated transcription GO:1903507 117 0.011
regulation of body fluid levels GO:0050878 90 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
sensory organ development GO:0007423 74 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
dephosphorylation GO:0016311 98 0.011
response to hydrogen peroxide GO:0042542 89 0.011
positive regulation of transcription dna templated GO:0045893 197 0.011
negative regulation of molecular function GO:0044092 133 0.011
response to toxic substance GO:0009636 133 0.011
regulation of neuron death GO:1901214 115 0.011
salivary gland development GO:0007431 3 0.011
regulation of locomotion GO:0040012 148 0.011
potassium ion transport GO:0006813 97 0.011
negative regulation of developmental process GO:0051093 125 0.011
positive regulation of signal transduction GO:0009967 175 0.011
spermatogenesis GO:0007283 99 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
glycogen metabolic process GO:0005977 23 0.011
peptidyl amino acid modification GO:0018193 126 0.011
gonad development GO:0008406 104 0.010
cellular response to extracellular stimulus GO:0031668 73 0.010
response to external biotic stimulus GO:0043207 221 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
sodium ion transmembrane transport GO:0035725 67 0.010
glucose metabolic process GO:0006006 52 0.010
embryonic axis specification GO:0000578 1 0.010
negative regulation of rna biosynthetic process GO:1902679 118 0.010
nucleoside phosphate biosynthetic process GO:1901293 102 0.010
carbohydrate homeostasis GO:0033500 75 0.010
heart morphogenesis GO:0003007 3 0.010
response to estradiol GO:0032355 164 0.010
negative regulation of signal transduction GO:0009968 83 0.010
growth GO:0040007 165 0.010
cellular amide metabolic process GO:0043603 44 0.010
action potential GO:0001508 54 0.010
response to amine GO:0014075 46 0.010
spindle organization GO:0007051 2 0.010
organic acid biosynthetic process GO:0016053 83 0.010
reproductive structure development GO:0048608 128 0.010
regulation of growth GO:0040008 105 0.010
glucose homeostasis GO:0042593 75 0.010
male gamete generation GO:0048232 99 0.010

Slc11a2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
Human
nervous system disease DOID:863 0 0.022
disease of metabolism DOID:0014667 0 0.020
inherited metabolic disorder DOID:655 0 0.020
central nervous system disease DOID:331 0 0.014
musculoskeletal system disease DOID:17 0 0.013
disease of cellular proliferation DOID:14566 0 0.010