Rattus norvegicus

55 known processes

Pde8b

phosphodiesterase 8B

(Aliases: RNPDE8B)

Pde8b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
intracellular signal transduction GO:0035556 314 0.156
Rat
regulation of signal transduction GO:0009966 318 0.120
positive regulation of cellular biosynthetic process GO:0031328 295 0.095
regulation of phosphorus metabolic process GO:0051174 349 0.093
protein phosphorylation GO:0006468 345 0.093
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.085
lipid metabolic process GO:0006629 283 0.083
Mouse
regulation of protein metabolic process GO:0051246 289 0.079
metal ion transport GO:0030001 289 0.077
transmembrane transport GO:0055085 412 0.076
positive regulation of nucleic acid templated transcription GO:1903508 197 0.075
positive regulation of cell communication GO:0010647 271 0.074
neuron differentiation GO:0030182 368 0.073
negative regulation of metabolic process GO:0009892 331 0.072
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.071
negative regulation of cellular metabolic process GO:0031324 281 0.070
Mouse
positive regulation of biosynthetic process GO:0009891 319 0.070
regulation of cellular component organization GO:0051128 368 0.069
positive regulation of signaling GO:0023056 270 0.068
chemical homeostasis GO:0048878 292 0.067
calcium ion homeostasis GO:0055074 162 0.067
metal ion homeostasis GO:0055065 186 0.066
cellular metal ion homeostasis GO:0006875 172 0.066
cellular response to oxygen containing compound GO:1901701 386 0.064
homeostatic process GO:0042592 331 0.061
macromolecular complex subunit organization GO:0043933 339 0.060
positive regulation of gene expression GO:0010628 244 0.059
cellular ion homeostasis GO:0006873 184 0.059
programmed cell death GO:0012501 392 0.059
divalent inorganic cation homeostasis GO:0072507 165 0.058
cell cell signaling GO:0007267 335 0.058
regulation of cellular protein metabolic process GO:0032268 267 0.056
ion homeostasis GO:0050801 212 0.056
positive regulation of phosphate metabolic process GO:0045937 262 0.056
regulation of phosphorylation GO:0042325 248 0.055
cellular component biogenesis GO:0044085 368 0.055
cellular divalent inorganic cation homeostasis GO:0072503 162 0.055
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.055
organophosphate metabolic process GO:0019637 370 0.054
Rat
regulation of phosphate metabolic process GO:0019220 349 0.052
brain development GO:0007420 247 0.052
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.051
ribonucleotide metabolic process GO:0009259 231 0.051
Rat
positive regulation of response to stimulus GO:0048584 285 0.051
positive regulation of transcription dna templated GO:0045893 197 0.051
nucleic acid templated transcription GO:0097659 379 0.050
cell projection organization GO:0030030 302 0.049
neurological system process GO:0050877 219 0.049
Mouse Rat
single organism reproductive process GO:0044702 297 0.048
cellular response to endogenous stimulus GO:0071495 377 0.048
positive regulation of rna biosynthetic process GO:1902680 197 0.048
transcription from rna polymerase ii promoter GO:0006366 252 0.047
cation homeostasis GO:0055080 195 0.046
apoptotic process GO:0006915 381 0.046
regulation of multicellular organismal development GO:2000026 376 0.046
rna metabolic process GO:0016070 406 0.045
regulation of rna metabolic process GO:0051252 391 0.044
regulation of apoptotic process GO:0042981 335 0.044
cytosolic calcium ion homeostasis GO:0051480 140 0.044
ion transmembrane transport GO:0034220 365 0.044
cellular cation homeostasis GO:0030003 180 0.043
catabolic process GO:0009056 351 0.043
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.043
regulation of secretion GO:0051046 224 0.043
positive regulation of phosphorylation GO:0042327 177 0.042
macromolecule localization GO:0033036 252 0.041
positive regulation of protein metabolic process GO:0051247 178 0.040
positive regulation of rna metabolic process GO:0051254 203 0.040
rna biosynthetic process GO:0032774 380 0.040
nucleoside phosphate metabolic process GO:0006753 283 0.040
Rat
macromolecular complex assembly GO:0065003 273 0.040
single organism biosynthetic process GO:0044711 342 0.040
Mouse
cellular calcium ion homeostasis GO:0006874 160 0.039
protein complex assembly GO:0006461 263 0.039
organic acid metabolic process GO:0006082 292 0.039
cellular response to hormone stimulus GO:0032870 247 0.039
nitrogen compound transport GO:0071705 229 0.039
regulation of intracellular signal transduction GO:1902531 218 0.039
g protein coupled receptor signaling pathway GO:0007186 242 0.039
regulation of system process GO:0044057 208 0.038
signal transduction by phosphorylation GO:0023014 144 0.038
positive regulation of signal transduction GO:0009967 175 0.038
transcription dna templated GO:0006351 377 0.037
secretion GO:0046903 307 0.037
carboxylic acid metabolic process GO:0019752 289 0.037
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.037
positive regulation of cellular protein metabolic process GO:0032270 167 0.037
neuron development GO:0048666 286 0.036
regulation of rna biosynthetic process GO:2001141 381 0.036
cellular component assembly GO:0022607 360 0.036
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.036
negative regulation of macromolecule metabolic process GO:0010605 260 0.036
cellular chemical homeostasis GO:0055082 247 0.035
positive regulation of phosphorus metabolic process GO:0010562 262 0.035
regulation of transcription dna templated GO:0006355 374 0.035
organelle organization GO:0006996 266 0.035
nucleobase containing small molecule metabolic process GO:0055086 316 0.035
Rat
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.035
regulation of ion transport GO:0043269 245 0.035
response to peptide hormone GO:0043434 278 0.035
tissue development GO:0009888 252 0.035
Fly
negative regulation of signaling GO:0023057 157 0.034
nucleotide metabolic process GO:0009117 279 0.034
Rat
neuron projection development GO:0031175 273 0.034
small molecule biosynthetic process GO:0044283 124 0.034
central nervous system development GO:0007417 311 0.034
purine ribonucleotide metabolic process GO:0009150 227 0.033
Rat
behavior GO:0007610 205 0.033
Mouse
cation transport GO:0006812 382 0.033
regulation of neurogenesis GO:0050767 247 0.032
response to peptide GO:1901652 292 0.032
regulation of molecular function GO:0065009 398 0.032
amine metabolic process GO:0009308 38 0.032
regulation of protein modification process GO:0031399 194 0.032
anatomical structure morphogenesis GO:0009653 298 0.032
regulation of catalytic activity GO:0050790 304 0.032
regulation of cellular localization GO:0060341 263 0.031
growth GO:0040007 165 0.031
mapk cascade GO:0000165 140 0.031
regulation of programmed cell death GO:0043067 341 0.031
regulation of protein phosphorylation GO:0001932 183 0.030
positive regulation of intracellular signal transduction GO:1902533 138 0.030
cellular amine metabolic process GO:0044106 38 0.030
reproductive process GO:0022414 372 0.030
regulation of nervous system development GO:0051960 264 0.030
positive regulation of cell proliferation GO:0008284 249 0.029
positive regulation of catalytic activity GO:0043085 184 0.029
carbohydrate derivative metabolic process GO:1901135 346 0.029
Rat
regulation of cellular ketone metabolic process GO:0010565 27 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
oxoacid metabolic process GO:0043436 290 0.029
ribose phosphate metabolic process GO:0019693 235 0.028
Rat
positive regulation of developmental process GO:0051094 283 0.028
amide transport GO:0042886 105 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
cellular ketone metabolic process GO:0042180 51 0.026
positive regulation of protein phosphorylation GO:0001934 135 0.025
response to external biotic stimulus GO:0043207 221 0.025
negative regulation of cell communication GO:0010648 158 0.025
regulation of cell differentiation GO:0045595 320 0.025
cellular response to abiotic stimulus GO:0071214 85 0.025
regulation of cell proliferation GO:0042127 359 0.024
regulation of mapk cascade GO:0043408 116 0.024
intracellular transport GO:0046907 185 0.024
protein oligomerization GO:0051259 191 0.024
positive regulation of protein modification process GO:0031401 142 0.024
divalent metal ion transport GO:0070838 132 0.024
organonitrogen compound biosynthetic process GO:1901566 167 0.024
positive regulation of programmed cell death GO:0043068 157 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
response to growth factor GO:0070848 189 0.023
ribonucleoside metabolic process GO:0009119 174 0.023
response to lipopolysaccharide GO:0032496 191 0.023
cellular homeostasis GO:0019725 252 0.023
negative regulation of transcription dna templated GO:0045892 116 0.023
calcium ion transport GO:0006816 131 0.023
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.023
anion transport GO:0006820 178 0.023
response to biotic stimulus GO:0009607 226 0.022
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.022
divalent inorganic cation transport GO:0072511 134 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.022
purine nucleotide metabolic process GO:0006163 229 0.022
Rat
head development GO:0060322 247 0.022
protein complex biogenesis GO:0070271 263 0.022
establishment of protein localization GO:0045184 141 0.022
protein complex subunit organization GO:0071822 302 0.022
negative regulation of apoptotic process GO:0043066 181 0.022
negative regulation of cell death GO:0060548 229 0.022
cellular response to nitrogen compound GO:1901699 210 0.022
response to organophosphorus GO:0046683 102 0.021
peptidyl amino acid modification GO:0018193 126 0.021
inorganic ion transmembrane transport GO:0098660 229 0.021
protein localization GO:0008104 191 0.021
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.021
adult locomotory behavior GO:0008344 4 0.021
developmental growth GO:0048589 100 0.021
regulation of neuron death GO:1901214 115 0.021
regulation of cellular amine metabolic process GO:0033238 8 0.021
positive regulation of transport GO:0051050 245 0.021
forebrain development GO:0030900 98 0.021
synaptic transmission GO:0007268 235 0.021
purine containing compound metabolic process GO:0072521 253 0.021
Rat
multicellular organismal reproductive process GO:0048609 233 0.020
response to nutrient levels GO:0031667 370 0.020
positive regulation of molecular function GO:0044093 230 0.020
cellular component movement GO:0006928 248 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
response to extracellular stimulus GO:0009991 380 0.020
blood circulation GO:0008015 183 0.020
regulation of transferase activity GO:0051338 123 0.020
small gtpase mediated signal transduction GO:0007264 36 0.020
secretion by cell GO:0032940 248 0.020
organophosphate biosynthetic process GO:0090407 143 0.020
negative regulation of biosynthetic process GO:0009890 168 0.019
Mouse
cellular nitrogen compound catabolic process GO:0044270 163 0.019
Rat
single organism intracellular transport GO:1902582 166 0.019
positive regulation of cellular component organization GO:0051130 200 0.019
cellular response to stress GO:0033554 269 0.019
cellular catabolic process GO:0044248 295 0.019
Rat
hormone transport GO:0009914 121 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
response to bacterium GO:0009617 200 0.019
response to wounding GO:0009611 254 0.019
ribonucleotide catabolic process GO:0009261 136 0.018
Rat
regulation of protein kinase activity GO:0045859 105 0.018
regulation of peptide hormone secretion GO:0090276 80 0.018
response to estradiol GO:0032355 164 0.018
regulation of kinase activity GO:0043549 117 0.018
regulation of membrane potential GO:0042391 110 0.018
protein autophosphorylation GO:0046777 66 0.018
negative regulation of response to stimulus GO:0048585 155 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
cell morphogenesis involved in differentiation GO:0000904 119 0.017
cellular lipid metabolic process GO:0044255 208 0.017
response to cytokine GO:0034097 215 0.017
embryonic pattern specification GO:0009880 1 0.017
chemosensory behavior GO:0007635 2 0.017
proteolysis GO:0006508 175 0.017
positive regulation of mapk cascade GO:0043410 92 0.017
muscle cell proliferation GO:0033002 84 0.017
protein transport GO:0015031 132 0.017
regulation of purine nucleotide metabolic process GO:1900542 115 0.017
negative regulation of signal transduction GO:0009968 83 0.017
peptide hormone secretion GO:0030072 84 0.017
regulation of neuron differentiation GO:0045664 208 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
Rat
positive regulation of neurogenesis GO:0050769 165 0.016
monovalent inorganic cation transport GO:0015672 172 0.016
negative regulation of gene expression GO:0010629 199 0.016
negative regulation of rna biosynthetic process GO:1902679 118 0.016
cell morphogenesis GO:0000902 142 0.016
nucleoside metabolic process GO:0009116 179 0.016
circulatory system process GO:0003013 183 0.016
negative regulation of secretion by cell GO:1903531 72 0.016
positive regulation of transferase activity GO:0051347 81 0.016
organic substance catabolic process GO:1901575 316 0.016
Rat
glycosyl compound metabolic process GO:1901657 182 0.016
regeneration GO:0031099 163 0.016
inflammatory response GO:0006954 150 0.016
negative regulation of transport GO:0051051 136 0.016
cytoplasmic transport GO:0016482 115 0.016
circulatory system development GO:0072359 134 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
Mouse
regulation of cell development GO:0060284 263 0.016
single organism behavior GO:0044708 130 0.016
Mouse
ras protein signal transduction GO:0007265 29 0.016
developmental process involved in reproduction GO:0003006 159 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
Rat
cell projection morphogenesis GO:0048858 123 0.015
eye morphogenesis GO:0048592 4 0.015
response to other organism GO:0051707 220 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
positive regulation of secretion GO:0051047 140 0.015
regulation of neuron projection development GO:0010975 161 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
response to carbohydrate GO:0009743 183 0.015
neuron death GO:0070997 127 0.015
regulation of calcium ion transport GO:0051924 77 0.015
cellular component morphogenesis GO:0032989 155 0.015
response to estrogen GO:0043627 232 0.015
nucleotide catabolic process GO:0009166 139 0.015
Rat
single organism organelle organization GO:1902589 180 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
positive regulation of cell death GO:0010942 184 0.015
negative regulation of phosphate metabolic process GO:0045936 80 0.015
regulation of cell projection organization GO:0031344 175 0.015
regulation of hormone levels GO:0010817 187 0.015
epithelial cell differentiation GO:0030855 71 0.015
rhythmic process GO:0048511 156 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
Rat
negative regulation of rna metabolic process GO:0051253 123 0.014
positive regulation of kinase activity GO:0033674 77 0.014
peptide secretion GO:0002790 86 0.014
neuron projection morphogenesis GO:0048812 122 0.014
locomotion GO:0040011 237 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
phospholipid metabolic process GO:0006644 61 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
carboxylic acid transport GO:0046942 115 0.014
sequestering of calcium ion GO:0051208 8 0.014
epithelium development GO:0060429 96 0.014
regulation of proteasomal protein catabolic process GO:0061136 4 0.014
regulation of insulin secretion GO:0050796 65 0.014
nucleoside phosphate biosynthetic process GO:1901293 102 0.014
regulation of response to stress GO:0080134 126 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
regulation of growth GO:0040008 105 0.014
axis specification GO:0009798 4 0.014
positive regulation of nervous system development GO:0051962 178 0.014
olfactory behavior GO:0042048 2 0.014
tube development GO:0035295 89 0.014
learning or memory GO:0007611 90 0.014
Mouse
nucleoside phosphate catabolic process GO:1901292 140 0.014
Rat
aging GO:0007568 241 0.014
cardiac chamber development GO:0003205 1 0.013
establishment of planar polarity GO:0001736 1 0.013
regulation of smooth muscle cell proliferation GO:0048660 75 0.013
regulation of secretion by cell GO:1903530 208 0.013
cell migration GO:0016477 197 0.013
salivary gland development GO:0007431 3 0.013
heterocycle catabolic process GO:0046700 167 0.013
Rat
cation transmembrane transport GO:0098655 263 0.013
dendrite development GO:0016358 72 0.013
hormone secretion GO:0046879 115 0.013
multi organism reproductive process GO:0044703 262 0.013
peptide transport GO:0015833 97 0.013
cardiovascular system development GO:0072358 134 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
Rat
regulation of metal ion transport GO:0010959 118 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
single organism cellular localization GO:1902580 102 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
positive regulation of protein kinase activity GO:0045860 73 0.013
aromatic compound catabolic process GO:0019439 168 0.013
Rat
centrosome organization GO:0051297 1 0.013
reproduction GO:0000003 245 0.013
signal release GO:0023061 145 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
inorganic cation transmembrane transport GO:0098662 202 0.012
maintenance of location GO:0051235 17 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
sequestering of metal ion GO:0051238 9 0.012
cellular macromolecule localization GO:0070727 122 0.012
single organism catabolic process GO:0044712 283 0.012
Rat
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
wound healing GO:0042060 122 0.012
regulation of catabolic process GO:0009894 113 0.012
organic acid biosynthetic process GO:0016053 83 0.012
regulation of neuron apoptotic process GO:0043523 83 0.012
organ morphogenesis GO:0009887 75 0.012
peptidyl tyrosine phosphorylation GO:0018108 72 0.012
multicellular organism growth GO:0035264 1 0.012
organic hydroxy compound metabolic process GO:1901615 115 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
striated muscle tissue development GO:0014706 58 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
cytoskeleton organization GO:0007010 111 0.012
vesicle mediated transport GO:0016192 181 0.012
carboxylic acid biosynthetic process GO:0046394 83 0.012
cell type specific apoptotic process GO:0097285 134 0.012
neuron apoptotic process GO:0051402 88 0.012
regulation of lipid metabolic process GO:0019216 68 0.012
Mouse
purine nucleotide biosynthetic process GO:0006164 83 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
development of primary sexual characteristics GO:0045137 107 0.011
olfactory learning GO:0008355 1 0.011
regulation of blood vessel size GO:0050880 89 0.011
sodium ion transport GO:0006814 82 0.011
positive regulation of cell development GO:0010720 176 0.011
leukocyte cell cell adhesion GO:0007159 4 0.011
cellular protein localization GO:0034613 122 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
muscle contraction GO:0006936 88 0.011
lipid transport GO:0006869 61 0.011
response to hydrogen peroxide GO:0042542 89 0.011
muscle structure development GO:0061061 87 0.011
regulation of defense response GO:0031347 68 0.011
anion transmembrane transport GO:0098656 77 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
regulation of homeostatic process GO:0032844 101 0.011
morphogenesis of embryonic epithelium GO:0016331 3 0.011
microtubule organizing center organization GO:0031023 1 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
Rat
cell growth GO:0016049 104 0.011
anatomical structure formation involved in morphogenesis GO:0048646 83 0.011
defense response GO:0006952 194 0.011
Mouse
glycosyl compound catabolic process GO:1901658 126 0.011
negative regulation of cell development GO:0010721 82 0.011
ribonucleoside triphosphate metabolic process GO:0009199 141 0.011
localization of cell GO:0051674 202 0.011
regulation of transmembrane transport GO:0034762 122 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
spindle organization GO:0007051 2 0.011
retina morphogenesis in camera type eye GO:0060042 1 0.010
response to inorganic substance GO:0010035 377 0.010
Rat
cell adhesion GO:0007155 110 0.010
ribonucleotide biosynthetic process GO:0009260 85 0.010
response to transition metal nanoparticle GO:1990267 122 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
heart morphogenesis GO:0003007 3 0.010
membrane organization GO:0061024 94 0.010
pallium development GO:0021543 42 0.010
purine nucleoside triphosphate catabolic process GO:0009146 122 0.010
ribose phosphate biosynthetic process GO:0046390 87 0.010
regulation of synaptic transmission GO:0050804 141 0.010
sensory perception of light stimulus GO:0050953 3 0.010
negative regulation of molecular function GO:0044092 133 0.010
regulation of hormone secretion GO:0046883 106 0.010
guanosine containing compound metabolic process GO:1901068 74 0.010
cell part morphogenesis GO:0032990 123 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
cellular response to organonitrogen compound GO:0071417 197 0.010
response to molecule of bacterial origin GO:0002237 194 0.010
sodium ion transmembrane transport GO:0035725 67 0.010
cell cycle GO:0007049 101 0.010
response to ketone GO:1901654 182 0.010

Pde8b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.066
Human
nervous system disease DOID:863 0 0.066
Human
sensory system disease DOID:0050155 0 0.042
eye and adnexa disease DOID:1492 0 0.019
eye disease DOID:5614 0 0.019
retinal disease DOID:5679 0 0.016
retinal degeneration DOID:8466 0 0.016
retinitis pigmentosa DOID:10584 0 0.016
musculoskeletal system disease DOID:17 0 0.013
disease of metabolism DOID:0014667 0 0.011
inherited metabolic disorder DOID:655 0 0.011