Rattus norvegicus

7 known processes

Psen2

presenilin 2

Psen2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
metal ion transport GO:0030001 289 0.107
positive regulation of multicellular organismal process GO:0051240 387 0.084
negative regulation of macromolecule metabolic process GO:0010605 260 0.084
cation transport GO:0006812 382 0.079
cellular ion homeostasis GO:0006873 184 0.071
negative regulation of cellular metabolic process GO:0031324 281 0.067
negative regulation of metabolic process GO:0009892 331 0.064
cellular response to oxygen containing compound GO:1901701 386 0.062
cellular response to endogenous stimulus GO:0071495 377 0.059
regulation of cellular component organization GO:0051128 368 0.058
chemical homeostasis GO:0048878 292 0.058
positive regulation of cell communication GO:0010647 271 0.055
regulation of catalytic activity GO:0050790 304 0.055
intracellular signal transduction GO:0035556 314 0.053
positive regulation of signaling GO:0023056 270 0.053
response to external biotic stimulus GO:0043207 221 0.052
multi organism reproductive process GO:0044703 262 0.052
regulation of multicellular organismal development GO:2000026 376 0.052
organelle organization GO:0006996 266 0.051
regulation of signal transduction GO:0009966 318 0.051
programmed cell death GO:0012501 392 0.049
regulation of ion transport GO:0043269 245 0.049
single organism intracellular transport GO:1902582 166 0.048
cellular chemical homeostasis GO:0055082 247 0.047
positive regulation of response to stimulus GO:0048584 285 0.047
response to mechanical stimulus GO:0009612 134 0.047
oxoacid metabolic process GO:0043436 290 0.046
response to inorganic substance GO:0010035 377 0.046
response to extracellular stimulus GO:0009991 380 0.046
homeostatic process GO:0042592 331 0.045
response to nutrient levels GO:0031667 370 0.044
neuron differentiation GO:0030182 368 0.044
anion transport GO:0006820 178 0.044
regulation of cell differentiation GO:0045595 320 0.042
organic acid metabolic process GO:0006082 292 0.042
defense response GO:0006952 194 0.042
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.042
intracellular transport GO:0046907 185 0.042
neurological system process GO:0050877 219 0.042
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.041
apoptotic process GO:0006915 381 0.041
cellular homeostasis GO:0019725 252 0.041
cellular response to hormone stimulus GO:0032870 247 0.041
response to biotic stimulus GO:0009607 226 0.041
ion transmembrane transport GO:0034220 365 0.040
response to peptide GO:1901652 292 0.040
response to lipopolysaccharide GO:0032496 191 0.039
cellular amino acid metabolic process GO:0006520 107 0.039
negative regulation of biosynthetic process GO:0009890 168 0.038
positive regulation of cell differentiation GO:0045597 217 0.038
regulation of protein metabolic process GO:0051246 289 0.038
regulation of neurogenesis GO:0050767 247 0.038
positive regulation of intracellular signal transduction GO:1902533 138 0.038
response to other organism GO:0051707 220 0.038
regulation of nervous system development GO:0051960 264 0.038
transcription dna templated GO:0006351 377 0.037
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.037
cellular component biogenesis GO:0044085 368 0.037
negative regulation of multicellular organismal process GO:0051241 203 0.036
regulation of molecular function GO:0065009 398 0.036
carbohydrate derivative metabolic process GO:1901135 346 0.036
regulation of cell development GO:0060284 263 0.035
positive regulation of programmed cell death GO:0043068 157 0.035
regulation of transcription dna templated GO:0006355 374 0.035
regulation of cellular protein metabolic process GO:0032268 267 0.035
positive regulation of signal transduction GO:0009967 175 0.035
response to peptide hormone GO:0043434 278 0.035
regulation of neuron differentiation GO:0045664 208 0.034
reproductive process GO:0022414 372 0.034
cellular cation homeostasis GO:0030003 180 0.034
rna metabolic process GO:0016070 406 0.034
cellular response to lipid GO:0071396 201 0.034
negative regulation of gene expression GO:0010629 199 0.034
response to molecule of bacterial origin GO:0002237 194 0.033
positive regulation of cellular biosynthetic process GO:0031328 295 0.033
positive regulation of neurogenesis GO:0050769 165 0.033
single organism organelle organization GO:1902589 180 0.033
positive regulation of cell proliferation GO:0008284 249 0.033
circulatory system process GO:0003013 183 0.033
carboxylic acid metabolic process GO:0019752 289 0.032
protein phosphorylation GO:0006468 345 0.032
positive regulation of nervous system development GO:0051962 178 0.032
central nervous system development GO:0007417 311 0.032
regulation of phosphorus metabolic process GO:0051174 349 0.031
positive regulation of cell development GO:0010720 176 0.031
cellular response to organic cyclic compound GO:0071407 202 0.031
cation homeostasis GO:0055080 195 0.031
regulation of rna metabolic process GO:0051252 391 0.031
nucleic acid templated transcription GO:0097659 379 0.031
cellular response to peptide hormone stimulus GO:0071375 120 0.030
response to metal ion GO:0010038 253 0.030
positive regulation of molecular function GO:0044093 230 0.030
regulation of nucleic acid templated transcription GO:1903506 380 0.030
response to cytokine GO:0034097 215 0.030
regulation of cellular amine metabolic process GO:0033238 8 0.030
regulation of cell proliferation GO:0042127 359 0.030
organic acid transport GO:0015849 116 0.030
cell projection organization GO:0030030 302 0.030
ion homeostasis GO:0050801 212 0.029
response to acid chemical GO:0001101 222 0.029
single organism biosynthetic process GO:0044711 342 0.029
positive regulation of phosphorus metabolic process GO:0010562 262 0.029
negative regulation of cellular biosynthetic process GO:0031327 161 0.029
positive regulation of phosphate metabolic process GO:0045937 262 0.029
positive regulation of biosynthetic process GO:0009891 319 0.029
regulation of rna biosynthetic process GO:2001141 381 0.029
negative regulation of transcription dna templated GO:0045892 116 0.027
regulation of apoptotic process GO:0042981 335 0.027
positive regulation of cell death GO:0010942 184 0.027
cellular response to stress GO:0033554 269 0.027
rna biosynthetic process GO:0032774 380 0.027
response to bacterium GO:0009617 200 0.027
cellular response to organonitrogen compound GO:0071417 197 0.027
cell type specific apoptotic process GO:0097285 134 0.026
negative regulation of cell communication GO:0010648 158 0.026
transmembrane transport GO:0055085 412 0.026
cellular amine metabolic process GO:0044106 38 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
regulation of programmed cell death GO:0043067 341 0.026
establishment of protein localization GO:0045184 141 0.026
carboxylic acid transport GO:0046942 115 0.026
regulation of intracellular signal transduction GO:1902531 218 0.025
cellular component assembly GO:0022607 360 0.025
positive regulation of developmental process GO:0051094 283 0.024
small gtpase mediated signal transduction GO:0007264 36 0.024
aging GO:0007568 241 0.024
mapk cascade GO:0000165 140 0.024
negative regulation of protein metabolic process GO:0051248 114 0.024
response to carbohydrate GO:0009743 183 0.024
regulation of immune system process GO:0002682 123 0.024
vesicle mediated transport GO:0016192 181 0.023
cellular response to nitrogen compound GO:1901699 210 0.023
divalent inorganic cation transport GO:0072511 134 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
purine containing compound metabolic process GO:0072521 253 0.023
macromolecular complex subunit organization GO:0043933 339 0.023
organic substance catabolic process GO:1901575 316 0.022
macromolecule localization GO:0033036 252 0.022
divalent inorganic cation homeostasis GO:0072507 165 0.022
inflammatory response GO:0006954 150 0.022
oxidation reduction process GO:0055114 304 0.022
cytosolic calcium ion homeostasis GO:0051480 140 0.022
muscle system process GO:0003012 115 0.022
nucleoside phosphate metabolic process GO:0006753 283 0.022
brain development GO:0007420 247 0.022
cellular response to cytokine stimulus GO:0071345 127 0.022
positive regulation of apoptotic process GO:0043065 154 0.022
cell migration GO:0016477 197 0.022
regulation of phosphorylation GO:0042325 248 0.022
response to ketone GO:1901654 182 0.022
reactive oxygen species metabolic process GO:0072593 37 0.022
negative regulation of cell death GO:0060548 229 0.021
metal ion homeostasis GO:0055065 186 0.021
nitrogen compound transport GO:0071705 229 0.021
regulation of system process GO:0044057 208 0.021
blood circulation GO:0008015 183 0.021
organophosphate metabolic process GO:0019637 370 0.021
amine metabolic process GO:0009308 38 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.021
nucleobase containing small molecule metabolic process GO:0055086 316 0.021
anatomical structure morphogenesis GO:0009653 298 0.021
neuron death GO:0070997 127 0.021
regulation of membrane potential GO:0042391 110 0.021
organonitrogen compound biosynthetic process GO:1901566 167 0.020
maintenance of location GO:0051235 17 0.020
negative regulation of developmental process GO:0051093 125 0.020
growth GO:0040007 165 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
negative regulation of apoptotic process GO:0043066 181 0.020
reproduction GO:0000003 245 0.020
g protein coupled receptor signaling pathway GO:0007186 242 0.020
single organism reproductive process GO:0044702 297 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
nucleotide metabolic process GO:0009117 279 0.020
single organism catabolic process GO:0044712 283 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.020
regulation of cell projection organization GO:0031344 175 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
membrane organization GO:0061024 94 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
response to vitamin GO:0033273 131 0.019
actin filament based process GO:0030029 86 0.019
negative regulation of signaling GO:0023057 157 0.019
cellular response to biotic stimulus GO:0071216 59 0.019
regulation of nucleotide metabolic process GO:0006140 117 0.019
catabolic process GO:0009056 351 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.019
protein localization GO:0008104 191 0.019
organic anion transport GO:0015711 132 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
cellular catabolic process GO:0044248 295 0.019
ras protein signal transduction GO:0007265 29 0.018
regulation of reactive oxygen species metabolic process GO:2000377 26 0.018
positive regulation of gene expression GO:0010628 244 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
response to oxygen levels GO:0070482 265 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.018
cytoplasmic transport GO:0016482 115 0.018
neuron development GO:0048666 286 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
immune system process GO:0002376 204 0.018
regulation of neuron death GO:1901214 115 0.018
response to hypoxia GO:0001666 231 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
response to insulin GO:0032868 133 0.018
cellular divalent inorganic cation homeostasis GO:0072503 162 0.018
cell cell signaling GO:0007267 335 0.018
tissue development GO:0009888 252 0.018
neuron projection development GO:0031175 273 0.018
inorganic ion transmembrane transport GO:0098660 229 0.018
organic hydroxy compound transport GO:0015850 77 0.018
multicellular organismal signaling GO:0035637 44 0.018
signal transduction by phosphorylation GO:0023014 144 0.018
regulation of protein modification process GO:0031399 194 0.018
reactive nitrogen species metabolic process GO:2001057 1 0.017
regulation of cell migration GO:0030334 128 0.017
positive regulation of transport GO:0051050 245 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
positive regulation of rna metabolic process GO:0051254 203 0.017
transmission of nerve impulse GO:0019226 42 0.017
head development GO:0060322 247 0.017
divalent metal ion transport GO:0070838 132 0.017
behavior GO:0007610 205 0.017
sexual reproduction GO:0019953 148 0.017
multicellular organism reproduction GO:0032504 233 0.017
cellular response to abiotic stimulus GO:0071214 85 0.017
cellular response to external stimulus GO:0071496 118 0.017
positive regulation of rna biosynthetic process GO:1902680 197 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.017
negative regulation of rna biosynthetic process GO:1902679 118 0.017
monovalent inorganic cation transport GO:0015672 172 0.017
lipid metabolic process GO:0006629 283 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
gastrulation GO:0007369 2 0.017
gamete generation GO:0007276 124 0.016
regulation of response to stress GO:0080134 126 0.016
negative regulation of cell proliferation GO:0008285 119 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
response to oxidative stress GO:0006979 186 0.016
nucleoside phosphate biosynthetic process GO:1901293 102 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
positive regulation of protein phosphorylation GO:0001934 135 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
protein transport GO:0015031 132 0.016
regulation of cell motility GO:2000145 131 0.016
regulation of neuron projection development GO:0010975 161 0.016
regulation of secretion by cell GO:1903530 208 0.016
regulation of purine nucleotide metabolic process GO:1900542 115 0.016
localization of cell GO:0051674 202 0.016
cyclic nucleotide biosynthetic process GO:0009190 63 0.015
negative regulation of nucleic acid templated transcription GO:1903507 117 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
anion transmembrane transport GO:0098656 77 0.015
regulation of metal ion transport GO:0010959 118 0.015
cellular component movement GO:0006928 248 0.015
response to ethanol GO:0045471 162 0.015
regulation of cellular localization GO:0060341 263 0.015
cellular ketone metabolic process GO:0042180 51 0.015
response to growth factor GO:0070848 189 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
glial cell differentiation GO:0010001 65 0.015
cytokine production GO:0001816 61 0.015
response to estrogen GO:0043627 232 0.015
regulation of blood pressure GO:0008217 83 0.015
action potential GO:0001508 54 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.015
calcium ion transport GO:0006816 131 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
nucleotide biosynthetic process GO:0009165 98 0.015
kidney development GO:0001822 67 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
multicellular organism growth GO:0035264 1 0.014
chemosensory behavior GO:0007635 2 0.014
single organism cellular localization GO:1902580 102 0.014
developmental process involved in reproduction GO:0003006 159 0.014
regulation of neuron apoptotic process GO:0043523 83 0.014
regulation of catabolic process GO:0009894 113 0.014
nucleoside metabolic process GO:0009116 179 0.014
response to transition metal nanoparticle GO:1990267 122 0.014
cellular response to acid chemical GO:0071229 75 0.014
embryonic pattern specification GO:0009880 1 0.014
cellular response to peptide GO:1901653 133 0.014
cardiac chamber development GO:0003205 1 0.014
protein localization to organelle GO:0033365 57 0.014
cellular metal ion homeostasis GO:0006875 172 0.014
muscle contraction GO:0006936 88 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
regulation of synaptic transmission GO:0050804 141 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
salivary gland development GO:0007431 3 0.014
positive regulation of ion transport GO:0043270 94 0.014
renal system development GO:0072001 67 0.014
response to decreased oxygen levels GO:0036293 237 0.013
positive regulation of cell projection organization GO:0031346 111 0.013
cellular response to tumor necrosis factor GO:0071356 46 0.013
single organism behavior GO:0044708 130 0.013
regulation of blood circulation GO:1903522 110 0.013
response to glucocorticoid GO:0051384 223 0.013
cellular protein localization GO:0034613 122 0.013
purine ribonucleotide metabolic process GO:0009150 227 0.013
response to wounding GO:0009611 254 0.013
regeneration GO:0031099 163 0.013
nucleobase containing compound catabolic process GO:0034655 152 0.013
regulation of hydrolase activity GO:0051336 143 0.013
axis specification GO:0009798 4 0.013
locomotion GO:0040011 237 0.013
amide transport GO:0042886 105 0.013
gland development GO:0048732 155 0.013
positive regulation of locomotion GO:0040017 102 0.013
response to nutrient GO:0007584 248 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
calcium ion homeostasis GO:0055074 162 0.013
response to hexose GO:0009746 144 0.013
organonitrogen compound catabolic process GO:1901565 179 0.013
peptide metabolic process GO:0006518 32 0.013
negative regulation of cell development GO:0010721 82 0.013
positive regulation of neuron projection development GO:0010976 99 0.013
regulation of nucleotide catabolic process GO:0030811 65 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
development of primary sexual characteristics GO:0045137 107 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
response to tumor necrosis factor GO:0034612 56 0.013
positive regulation of protein modification process GO:0031401 142 0.013
response to corticosteroid GO:0031960 235 0.012
cell growth GO:0016049 104 0.012
regulation of cellular component movement GO:0051270 150 0.012
intracellular protein transport GO:0006886 79 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
regulation of hormone levels GO:0010817 187 0.012
negative regulation of transport GO:0051051 136 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
positive regulation of secretion by cell GO:1903532 128 0.012
heart morphogenesis GO:0003007 3 0.012
secretion by cell GO:0032940 248 0.012
regulation of growth GO:0040008 105 0.012
protein complex assembly GO:0006461 263 0.012
regulation of defense response GO:0031347 68 0.012
response to radiation GO:0009314 137 0.012
actin mediated cell contraction GO:0070252 12 0.012
neuron apoptotic process GO:0051402 88 0.012
response to glucose GO:0009749 136 0.012
learning or memory GO:0007611 90 0.012
synaptic transmission GO:0007268 235 0.012
neuronal action potential GO:0019228 35 0.012
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.012
secretion GO:0046903 307 0.012
protein complex biogenesis GO:0070271 263 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.012
regulation of locomotion GO:0040012 148 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
lipid storage GO:0019915 1 0.012
negative regulation of innate immune response GO:0045824 4 0.012
cell motility GO:0048870 202 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.012
transcription from rna polymerase ii promoter GO:0006366 252 0.012
negative regulation of signal transduction GO:0009968 83 0.012
regulation of protein kinase activity GO:0045859 105 0.012
positive regulation of nucleic acid templated transcription GO:1903508 197 0.012
negative regulation of kidney development GO:0090185 2 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
purine containing compound biosynthetic process GO:0072522 85 0.012
lipid transport GO:0006869 61 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
cytokine mediated signaling pathway GO:0019221 43 0.011
cell activation GO:0001775 97 0.011
cation transmembrane transport GO:0098655 263 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
response to fatty acid GO:0070542 65 0.011
inorganic cation transmembrane transport GO:0098662 202 0.011
sequestering of calcium ion GO:0051208 8 0.011
carbohydrate homeostasis GO:0033500 75 0.011
negative regulation of molecular function GO:0044092 133 0.011
male gamete generation GO:0048232 99 0.011
protein oligomerization GO:0051259 191 0.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.011
multi multicellular organism process GO:0044706 138 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
response to estradiol GO:0032355 164 0.011
rhythmic process GO:0048511 156 0.011
cellular response to molecule of bacterial origin GO:0071219 56 0.011
macromolecular complex assembly GO:0065003 273 0.011
response to toxic substance GO:0009636 133 0.011
cellular response to lipopolysaccharide GO:0071222 55 0.011
regulation of calcium ion transport GO:0051924 77 0.011
spermatogenesis GO:0007283 99 0.011
chromosome segregation GO:0007059 2 0.011
eye morphogenesis GO:0048592 4 0.010
negative regulation of neuron differentiation GO:0045665 62 0.010
anatomical structure formation involved in morphogenesis GO:0048646 83 0.010
cellular amide metabolic process GO:0043603 44 0.010
gliogenesis GO:0042063 93 0.010
response to alkaloid GO:0043279 132 0.010
steroid metabolic process GO:0008202 73 0.010
sensory perception GO:0007600 101 0.010
reproductive system development GO:0061458 128 0.010
regulation of transferase activity GO:0051338 123 0.010
purine ribonucleoside metabolic process GO:0046128 168 0.010
regulation of cell growth GO:0001558 85 0.010
nucleoside phosphate catabolic process GO:1901292 140 0.010
circulatory system development GO:0072359 134 0.010
response to purine containing compound GO:0014074 126 0.010
heterocycle catabolic process GO:0046700 167 0.010
developmental growth GO:0048589 100 0.010
cytoskeleton dependent cytokinesis GO:0061640 2 0.010
regulation of cell morphogenesis GO:0022604 77 0.010
peptide transport GO:0015833 97 0.010
ribonucleotide biosynthetic process GO:0009260 85 0.010
regulation of secretion GO:0051046 224 0.010
cellular response to alcohol GO:0097306 87 0.010
response to monosaccharide GO:0034284 159 0.010

Psen2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.033
inherited metabolic disorder DOID:655 0 0.033
disease of anatomical entity DOID:7 0 0.029
nervous system disease DOID:863 0 0.029
musculoskeletal system disease DOID:17 0 0.015
cardiovascular system disease DOID:1287 0 0.011