Rattus norvegicus

0 known processes

Psmb8

proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

(Aliases: Lmp7,Ring10,MGC124945)

Psmb8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of tolerance induction GO:0002645 1 0.384
response to cytokine GO:0034097 215 0.355
proteolysis GO:0006508 175 0.327
Yeast
positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 0.252
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.248
cellular amino acid metabolic process GO:0006520 107 0.204
immune system process GO:0002376 204 0.193
Mouse
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 7 0.187
Yeast
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.184
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.177
antigen processing and presentation GO:0019882 2 0.173
Mouse
antigen processing and presentation of endogenous peptide antigen via mhc class i GO:0019885 1 0.169
cellular catabolic process GO:0044248 295 0.167
Yeast
modification dependent protein catabolic process GO:0019941 14 0.166
Yeast
response to other organism GO:0051707 220 0.160
macromolecular complex subunit organization GO:0043933 339 0.156
Yeast Fly
cellular response to stress GO:0033554 269 0.139
Fly
cellular component biogenesis GO:0044085 368 0.131
Yeast
negative regulation of actin nucleation GO:0051126 1 0.129
intracellular signal transduction GO:0035556 314 0.127
immune effector process GO:0002252 53 0.126
t cell mediated cytotoxicity GO:0001913 5 0.120
protein complex biogenesis GO:0070271 263 0.116
Yeast
macromolecular complex assembly GO:0065003 273 0.115
Yeast
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.114
cellular response to peptide hormone stimulus GO:0071375 120 0.106
negative regulation of cell killing GO:0031342 5 0.106
rhythmic process GO:0048511 156 0.105
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.100
Yeast
gland development GO:0048732 155 0.098
immune response GO:0006955 104 0.097
t cell tolerance induction GO:0002517 3 0.091
cellular response to cytokine stimulus GO:0071345 127 0.087
cellular protein catabolic process GO:0044257 19 0.087
Yeast
regulation of tolerance induction to nonself antigen GO:0002655 1 0.086
innate immune response GO:0045087 35 0.086
positive regulation of cellular component organization GO:0051130 200 0.086
proteasomal protein catabolic process GO:0010498 8 0.086
Yeast
catabolic process GO:0009056 351 0.084
Yeast
macromolecule catabolic process GO:0009057 58 0.083
Yeast
amide biosynthetic process GO:0043604 10 0.081
tolerance induction to nonself antigen GO:0002462 2 0.076
reproductive process GO:0022414 372 0.071
actin cytoskeleton organization GO:0030036 73 0.070
multicellular organismal reproductive process GO:0048609 233 0.070
response to external biotic stimulus GO:0043207 221 0.070
response to purine containing compound GO:0014074 126 0.070
carbohydrate derivative metabolic process GO:1901135 346 0.070
reproduction GO:0000003 245 0.067
cellular response to iron ion starvation GO:0010106 1 0.066
multicellular organism reproduction GO:0032504 233 0.066
glycosyl compound metabolic process GO:1901657 182 0.065
regulation of protein metabolic process GO:0051246 289 0.064
regulation of phosphate metabolic process GO:0019220 349 0.062
cellular response to organonitrogen compound GO:0071417 197 0.061
cell killing GO:0001906 13 0.060
regulation of programmed cell death GO:0043067 341 0.060
negative regulation of rna metabolic process GO:0051253 123 0.059
regulation of cellular component organization GO:0051128 368 0.059
positive regulation of response to stimulus GO:0048584 285 0.059
lymphocyte activation GO:0046649 43 0.058
cellular response to peptide GO:1901653 133 0.058
cellular response to nitrogen compound GO:1901699 210 0.058
protein complex assembly GO:0006461 263 0.057
Yeast
regulation of rna biosynthetic process GO:2001141 381 0.056
negative regulation of macromolecule metabolic process GO:0010605 260 0.056
negative regulation of arp2 3 complex mediated actin nucleation GO:0034316 1 0.055
cellular response to endogenous stimulus GO:0071495 377 0.055
response to acid chemical GO:0001101 222 0.055
cellular component assembly GO:0022607 360 0.054
Yeast
cellular ketone metabolic process GO:0042180 51 0.053
sensory organ development GO:0007423 74 0.052
negative regulation of metabolic process GO:0009892 331 0.052
organ regeneration GO:0031100 101 0.052
regulation of cellular amine metabolic process GO:0033238 8 0.051
protein complex subunit organization GO:0071822 302 0.051
Yeast Fly
response to wounding GO:0009611 254 0.050
female pregnancy GO:0007565 122 0.049
positive regulation of catalytic activity GO:0043085 184 0.049
response to hexose GO:0009746 144 0.049
response to estradiol GO:0032355 164 0.049
positive regulation of biosynthetic process GO:0009891 319 0.048
liver development GO:0001889 90 0.048
response to peptide hormone GO:0043434 278 0.047
multi organism reproductive process GO:0044703 262 0.047
cell activation GO:0001775 97 0.046
jak stat cascade GO:0007259 26 0.045
regulation of multicellular organismal development GO:2000026 376 0.044
negative regulation of cellular metabolic process GO:0031324 281 0.043
nitrogen compound transport GO:0071705 229 0.043
cell morphogenesis GO:0000902 142 0.043
cellular response to organic cyclic compound GO:0071407 202 0.042
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.042
single organism reproductive process GO:0044702 297 0.042
mononuclear cell proliferation GO:0032943 29 0.042
regulation of cellular ketone metabolic process GO:0010565 27 0.042
regulation of cell differentiation GO:0045595 320 0.041
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 1 0.041
developmental process involved in reproduction GO:0003006 159 0.041
leukocyte mediated cytotoxicity GO:0001909 10 0.041
nucleoside catabolic process GO:0009164 126 0.041
regulation of nucleic acid templated transcription GO:1903506 380 0.040
positive regulation of nucleic acid templated transcription GO:1903508 197 0.040
regulation of protein kinase activity GO:0045859 105 0.040
modification dependent macromolecule catabolic process GO:0043632 14 0.039
Yeast
nucleoside metabolic process GO:0009116 179 0.039
regulation of immune response GO:0050776 55 0.039
peptidyl tyrosine phosphorylation GO:0018108 72 0.039
cellular component morphogenesis GO:0032989 155 0.038
response to interferon beta GO:0035456 1 0.038
regulation of phosphorylation GO:0042325 248 0.038
neurological system process GO:0050877 219 0.037
rna biosynthetic process GO:0032774 380 0.037
single organism organelle organization GO:1902589 180 0.036
Fly
protein catabolic process GO:0030163 30 0.036
Yeast
regulation of catalytic activity GO:0050790 304 0.036
regulation of cell killing GO:0031341 12 0.036
cellular amine metabolic process GO:0044106 38 0.035
regulation of immune system process GO:0002682 123 0.035
cellular response to hormone stimulus GO:0032870 247 0.035
regulation of body fluid levels GO:0050878 90 0.035
mitochondrion organization GO:0007005 35 0.035
oxoacid metabolic process GO:0043436 290 0.035
chemical homeostasis GO:0048878 292 0.035
regulation of cellular protein metabolic process GO:0032268 267 0.034
response to biotic stimulus GO:0009607 226 0.034
response to inorganic substance GO:0010035 377 0.034
regulation of cellular amino acid metabolic process GO:0006521 2 0.033
nucleoside phosphate metabolic process GO:0006753 283 0.033
gonad development GO:0008406 104 0.033
positive regulation of immune system process GO:0002684 90 0.033
single organism biosynthetic process GO:0044711 342 0.033
development of primary sexual characteristics GO:0045137 107 0.033
protein localization GO:0008104 191 0.033
leukocyte activation GO:0045321 76 0.033
response to decreased oxygen levels GO:0036293 237 0.032
homeostatic process GO:0042592 331 0.032
regulation of cell proliferation GO:0042127 359 0.032
secretion GO:0046903 307 0.031
biological adhesion GO:0022610 110 0.031
aromatic compound catabolic process GO:0019439 168 0.031
intracellular transport GO:0046907 185 0.030
negative regulation of cell communication GO:0010648 158 0.030
response to carbohydrate GO:0009743 183 0.030
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.030
response to nicotine GO:0035094 51 0.030
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.030
regulation of protein modification process GO:0031399 194 0.030
nucleobase containing small molecule metabolic process GO:0055086 316 0.030
cell cell signaling GO:0007267 335 0.029
protein transport GO:0015031 132 0.029
regulation of satellite cell proliferation GO:0014842 1 0.029
peptide biosynthetic process GO:0043043 3 0.029
single organism intracellular transport GO:1902582 166 0.029
carboxylic acid metabolic process GO:0019752 289 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
protein maturation GO:0051604 68 0.028
response to metal ion GO:0010038 253 0.028
tolerance induction dependent upon immune response GO:0002461 2 0.028
adaptive immune response GO:0002250 14 0.028
amine metabolic process GO:0009308 38 0.028
ubiquitin dependent protein catabolic process GO:0006511 14 0.028
Yeast
purine ribonucleoside metabolic process GO:0046128 168 0.027
positive regulation of developmental process GO:0051094 283 0.027
actin filament based process GO:0030029 86 0.027
macromolecule localization GO:0033036 252 0.027
rna metabolic process GO:0016070 406 0.027
response to nutrient levels GO:0031667 370 0.026
regulation of organelle organization GO:0033043 80 0.026
aging GO:0007568 241 0.026
multi multicellular organism process GO:0044706 138 0.026
brain development GO:0007420 247 0.026
response to heat GO:0009408 60 0.026
regulation of intracellular signal transduction GO:1902531 218 0.026
cellular protein localization GO:0034613 122 0.026
regulation of cellular localization GO:0060341 263 0.025
purine ribonucleotide metabolic process GO:0009150 227 0.025
head development GO:0060322 247 0.025
single organism behavior GO:0044708 130 0.025
cell projection organization GO:0030030 302 0.025
response to monosaccharide GO:0034284 159 0.025
positive regulation of molecular function GO:0044093 230 0.024
intracellular protein transport GO:0006886 79 0.024
negative regulation of signaling GO:0023057 157 0.024
regulation of neuron death GO:1901214 115 0.024
regulation of adaptive immune response GO:0002819 8 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
apoptotic process GO:0006915 381 0.024
cellular response to oxygen containing compound GO:1901701 386 0.024
ribonucleotide metabolic process GO:0009259 231 0.024
regulation of molecular function GO:0065009 398 0.024
negative regulation of response to stimulus GO:0048585 155 0.023
programmed cell death GO:0012501 392 0.023
cellular protein complex assembly GO:0043623 44 0.023
Yeast
hepaticobiliary system development GO:0061008 90 0.023
negative regulation of peptidase activity GO:0010466 38 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.023
atp metabolic process GO:0046034 72 0.022
neuron differentiation GO:0030182 368 0.022
olfactory learning GO:0008355 1 0.022
nephron tubule epithelial cell differentiation GO:0072160 1 0.022
regulation of response to stress GO:0080134 126 0.022
peptide transport GO:0015833 97 0.022
protein oligomerization GO:0051259 191 0.022
cellular response to tumor necrosis factor GO:0071356 46 0.022
negative regulation of kidney development GO:0090185 2 0.021
negative regulation of signal transduction GO:0009968 83 0.021
ribonucleoside triphosphate metabolic process GO:0009199 141 0.021
ribonucleoside metabolic process GO:0009119 174 0.021
female gonad development GO:0008585 53 0.021
organophosphate metabolic process GO:0019637 370 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
regulation of signal transduction GO:0009966 318 0.021
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.021
blood circulation GO:0008015 183 0.021
cation homeostasis GO:0055080 195 0.020
response to organophosphorus GO:0046683 102 0.020
cellular macromolecular complex assembly GO:0034622 58 0.020
Yeast
organic acid metabolic process GO:0006082 292 0.020
negative regulation of cellular component organization GO:0051129 83 0.020
cell cycle GO:0007049 101 0.020
Fly
regulation of interleukin 1 beta secretion GO:0050706 3 0.020
amide transport GO:0042886 105 0.020
nucleotide catabolic process GO:0009166 139 0.020
neuron development GO:0048666 286 0.020
ovulation cycle GO:0042698 67 0.020
glycosyl compound catabolic process GO:1901658 126 0.019
negative regulation of innate immune response GO:0045824 4 0.019
ribose phosphate metabolic process GO:0019693 235 0.019
negative regulation of phosphate metabolic process GO:0045936 80 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
purine nucleoside monophosphate metabolic process GO:0009126 84 0.019
response to glucose GO:0009749 136 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.018
positive regulation of cell proliferation GO:0008284 249 0.018
tube development GO:0035295 89 0.018
negative regulation of gene expression GO:0010629 199 0.018
purine nucleoside triphosphate metabolic process GO:0009144 141 0.018
positive regulation of leukocyte mediated immunity GO:0002705 13 0.018
t cell proliferation GO:0042098 19 0.018
cell morphogenesis involved in differentiation GO:0000904 119 0.018
positive regulation of protein kinase activity GO:0045860 73 0.018
muscle structure development GO:0061061 87 0.018
regulation of cell morphogenesis GO:0022604 77 0.018
protein polymerization GO:0051258 22 0.018
cell part morphogenesis GO:0032990 123 0.018
positive regulation of protein phosphorylation GO:0001934 135 0.018
negative regulation of protein metabolic process GO:0051248 114 0.017
organonitrogen compound catabolic process GO:1901565 179 0.017
carbohydrate derivative biosynthetic process GO:1901137 124 0.017
purine nucleoside catabolic process GO:0006152 124 0.017
regulation of apoptotic process GO:0042981 335 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
positive regulation of gene expression GO:0010628 244 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
regulation of natural killer cell mediated cytotoxicity GO:0042269 6 0.017
negative regulation of biosynthetic process GO:0009890 168 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
transcription dna templated GO:0006351 377 0.017
cell adhesion GO:0007155 110 0.017
arp2 3 complex mediated actin nucleation GO:0034314 2 0.017
ovulation cycle process GO:0022602 50 0.016
response to hydrogen peroxide GO:0042542 89 0.016
organelle organization GO:0006996 266 0.016
Fly
positive regulation of rna metabolic process GO:0051254 203 0.016
regulation of cell adhesion GO:0030155 52 0.016
negative regulation of cell development GO:0010721 82 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
positive regulation of organelle organization GO:0010638 48 0.016
nucleic acid templated transcription GO:0097659 379 0.016
negative regulation of leukocyte mediated immunity GO:0002704 6 0.016
response to reactive oxygen species GO:0000302 120 0.016
cellular amide metabolic process GO:0043603 44 0.016
negative regulation of defense response GO:0031348 19 0.016
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902728 1 0.016
neuron projection development GO:0031175 273 0.016
positive regulation of cell killing GO:0031343 9 0.015
tissue development GO:0009888 252 0.015
negative regulation of immune system process GO:0002683 39 0.015
regulation of transcription dna templated GO:0006355 374 0.015
response to bacterium GO:0009617 200 0.015
positive regulation of tolerance induction to nonself antigen GO:0002657 1 0.015
negative regulation of catalytic activity GO:0043086 103 0.015
cellular response to retinoic acid GO:0071300 27 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
positive regulation of kinase activity GO:0033674 77 0.015
cell motility GO:0048870 202 0.015
leukocyte proliferation GO:0070661 29 0.015
regulation of secretion by cell GO:1903530 208 0.015
negative regulation of molecular function GO:0044092 133 0.014
response to transition metal nanoparticle GO:1990267 122 0.014
regulation of intracellular transport GO:0032386 65 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
regulation of establishment of protein localization GO:0070201 69 0.014
locomotion GO:0040011 237 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
salivary gland morphogenesis GO:0007435 1 0.014
metal ion homeostasis GO:0055065 186 0.014
response to tumor necrosis factor GO:0034612 56 0.014
salivary gland development GO:0007431 3 0.014
nucleoside monophosphate metabolic process GO:0009123 93 0.014
regulation of interleukin 1 secretion GO:0050704 3 0.014
response to estrogen GO:0043627 232 0.014
negative regulation of protein modification process GO:0031400 52 0.014
antigen processing and presentation of exogenous antigen GO:0019884 1 0.014
glucose homeostasis GO:0042593 75 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
regulation of leukocyte mediated immunity GO:0002703 19 0.014
lymphocyte homeostasis GO:0002260 2 0.014
regulation of actin cytoskeleton organization GO:0032956 30 0.014
cellular component movement GO:0006928 248 0.014
cellular nitrogen compound catabolic process GO:0044270 163 0.014
cytoplasmic transport GO:0016482 115 0.013
circulatory system process GO:0003013 183 0.013
regulation of smooth muscle cell proliferation GO:0048660 75 0.013
regulation of anatomical structure size GO:0090066 135 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
muscle tissue development GO:0060537 58 0.013
cellular response to dna damage stimulus GO:0006974 19 0.013
Fly
negative regulation of cell cycle phase transition GO:1901988 4 0.013
protein phosphorylation GO:0006468 345 0.013
negative regulation of protein phosphorylation GO:0001933 44 0.013
ribonucleotide catabolic process GO:0009261 136 0.013
regulation of defense response GO:0031347 68 0.013
regulation of transferase activity GO:0051338 123 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.013
purine nucleoside monophosphate catabolic process GO:0009128 55 0.013
inorganic ion transmembrane transport GO:0098660 229 0.013
cell cycle checkpoint GO:0000075 2 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
skeletal muscle satellite cell proliferation GO:0014841 1 0.013
response to insulin GO:0032868 133 0.013
cellular macromolecule catabolic process GO:0044265 29 0.013
Yeast
positive regulation of protein metabolic process GO:0051247 178 0.012
rho protein signal transduction GO:0007266 11 0.012
cellular ion homeostasis GO:0006873 184 0.012
response to ketone GO:1901654 182 0.012
negative regulation of transport GO:0051051 136 0.012
response to ethanol GO:0045471 162 0.012
negative regulation of cell death GO:0060548 229 0.012
negative regulation of jak stat cascade GO:0046426 3 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
peptidyl amino acid modification GO:0018193 126 0.012
positive regulation of response to wounding GO:1903036 34 0.012
platelet aggregation GO:0070527 4 0.012
negative regulation of apoptotic process GO:0043066 181 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
negative regulation of secretion GO:0051048 82 0.012
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.012
cellular chemical homeostasis GO:0055082 247 0.012
negative regulation of homeostatic process GO:0032845 47 0.012
interleukin 1 beta secretion GO:0050702 3 0.012
response to cadmium ion GO:0046686 35 0.012
gtp catabolic process GO:0006184 71 0.012
regulation of cell development GO:0060284 263 0.012
regulation of actin filament based process GO:0032970 42 0.012
regulation of tolerance induction GO:0002643 2 0.012
interleukin 1 secretion GO:0050701 3 0.012
nucleotide metabolic process GO:0009117 279 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
positive regulation of interleukin 1 beta secretion GO:0050718 3 0.012
single organism catabolic process GO:0044712 283 0.012
positive regulation of neuron apoptotic process GO:0043525 33 0.011
regulation of protein localization GO:0032880 81 0.011
response to amino acid GO:0043200 75 0.011
neuron death GO:0070997 127 0.011
reproductive structure development GO:0048608 128 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
regulation of protein complex assembly GO:0043254 33 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
regulation of leukocyte mediated cytotoxicity GO:0001910 10 0.011
reproductive system development GO:0061458 128 0.011
positive regulation of cellular component biogenesis GO:0044089 55 0.011
purine containing compound metabolic process GO:0072521 253 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
positive regulation of signaling GO:0023056 270 0.011
defense response GO:0006952 194 0.011
cellular response to acid chemical GO:0071229 75 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
response to camp GO:0051591 91 0.011
negative regulation of rna biosynthetic process GO:1902679 118 0.011
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.010
positive regulation of cell communication GO:0010647 271 0.010
negative regulation of cellular carbohydrate metabolic process GO:0010677 7 0.010
nucleoside triphosphate catabolic process GO:0009143 123 0.010
cellular response to insulin stimulus GO:0032869 81 0.010
negative regulation of nervous system development GO:0051961 79 0.010
actin filament polymerization GO:0030041 11 0.010
renal sodium excretion GO:0035812 20 0.010
regulation of hydrolase activity GO:0051336 143 0.010
response to interferon alpha GO:0035455 1 0.010
anatomical structure morphogenesis GO:0009653 298 0.010
negative regulation of phosphorylation GO:0042326 57 0.010
male sex differentiation GO:0046661 64 0.010
membrane organization GO:0061024 94 0.010
positive regulation of circadian sleep wake cycle sleep GO:0045938 9 0.010

Psmb8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
primary immunodeficiency disease DOID:612 0 0.016
severe combined immunodeficiency DOID:627 0 0.016
combined t cell and b cell immunodeficiency DOID:628 0 0.016
immune system disease DOID:2914 0 0.016
disease of anatomical entity DOID:7 0 0.016