Rattus norvegicus

0 known processes

Smurf2

SMAD specific E3 ubiquitin protein ligase 2

(Aliases: RGD1310067)

Smurf2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of nucleic acid templated transcription GO:1903508 197 0.070
rna biosynthetic process GO:0032774 380 0.062
single organism reproductive process GO:0044702 297 0.050
cellular response to endogenous stimulus GO:0071495 377 0.047
transcription dna templated GO:0006351 377 0.046
nucleic acid templated transcription GO:0097659 379 0.044
regulation of nucleic acid templated transcription GO:1903506 380 0.042
regulation of apoptotic process GO:0042981 335 0.041
regulation of multicellular organismal development GO:2000026 376 0.040
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.040
programmed cell death GO:0012501 392 0.039
positive regulation of cellular biosynthetic process GO:0031328 295 0.038
regulation of phosphorylation GO:0042325 248 0.037
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.036
negative regulation of metabolic process GO:0009892 331 0.036
cellular component biogenesis GO:0044085 368 0.035
regulation of phosphate metabolic process GO:0019220 349 0.035
positive regulation of nervous system development GO:0051962 178 0.034
regulation of molecular function GO:0065009 398 0.034
Rat
positive regulation of transcription dna templated GO:0045893 197 0.033
regulation of phosphorus metabolic process GO:0051174 349 0.033
rna metabolic process GO:0016070 406 0.033
regulation of intracellular signal transduction GO:1902531 218 0.031
reproductive process GO:0022414 372 0.031
apoptotic process GO:0006915 381 0.030
positive regulation of rna biosynthetic process GO:1902680 197 0.030
regulation of cell projection organization GO:0031344 175 0.029
Rat
regulation of cell differentiation GO:0045595 320 0.029
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.029
regulation of transcription dna templated GO:0006355 374 0.028
reproduction GO:0000003 245 0.028
positive regulation of rna metabolic process GO:0051254 203 0.027
positive regulation of biosynthetic process GO:0009891 319 0.027
regulation of catalytic activity GO:0050790 304 0.026
multi organism reproductive process GO:0044703 262 0.026
regulation of response to external stimulus GO:0032101 106 0.026
regulation of programmed cell death GO:0043067 341 0.025
negative regulation of cell differentiation GO:0045596 99 0.025
negative regulation of signaling GO:0023057 157 0.025
negative regulation of cellular metabolic process GO:0031324 281 0.025
negative regulation of response to stimulus GO:0048585 155 0.025
regulation of cellular component organization GO:0051128 368 0.025
Rat
positive regulation of cellular component organization GO:0051130 200 0.024
Rat
positive regulation of apoptotic process GO:0043065 154 0.024
protein complex subunit organization GO:0071822 302 0.024
positive regulation of gene expression GO:0010628 244 0.024
protein complex assembly GO:0006461 263 0.024
cellular component assembly GO:0022607 360 0.023
positive regulation of phosphorylation GO:0042327 177 0.023
carboxylic acid metabolic process GO:0019752 289 0.023
response to oxygen levels GO:0070482 265 0.022
positive regulation of multicellular organismal process GO:0051240 387 0.022
sexual reproduction GO:0019953 148 0.022
positive regulation of phosphate metabolic process GO:0045937 262 0.022
positive regulation of developmental process GO:0051094 283 0.022
sensory organ development GO:0007423 74 0.022
positive regulation of cell projection organization GO:0031346 111 0.022
regulation of signal transduction GO:0009966 318 0.022
developmental process involved in reproduction GO:0003006 159 0.022
regulation of cell morphogenesis GO:0022604 77 0.022
Rat
eye morphogenesis GO:0048592 4 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.022
regulation of protein phosphorylation GO:0001932 183 0.022
response to growth factor GO:0070848 189 0.021
regulation of protein modification process GO:0031399 194 0.021
regulation of cellular protein metabolic process GO:0032268 267 0.021
cellular amine metabolic process GO:0044106 38 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
positive regulation of cell differentiation GO:0045597 217 0.021
protein phosphorylation GO:0006468 345 0.020
enzyme linked receptor protein signaling pathway GO:0007167 116 0.020
positive regulation of cell development GO:0010720 176 0.020
multicellular organism reproduction GO:0032504 233 0.020
negative regulation of cardiac muscle tissue development GO:0055026 3 0.020
neuron projection development GO:0031175 273 0.020
Rat
embryonic skeletal system morphogenesis GO:0048704 3 0.020
positive regulation of molecular function GO:0044093 230 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
regulation of nervous system development GO:0051960 264 0.020
Rat
negative regulation of cell communication GO:0010648 158 0.020
neuron fate commitment GO:0048663 4 0.019
multicellular organismal reproductive process GO:0048609 233 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
regulation of cellular catabolic process GO:0031329 101 0.019
regulation of cellular localization GO:0060341 263 0.019
response to wounding GO:0009611 254 0.019
regulation of neurogenesis GO:0050767 247 0.019
Rat
anterior posterior pattern specification GO:0009952 1 0.019
cellular ketone metabolic process GO:0042180 51 0.019
palate development GO:0060021 2 0.019
intracellular signal transduction GO:0035556 314 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
positive regulation of protein modification process GO:0031401 142 0.018
macromolecular complex assembly GO:0065003 273 0.018
regulation of rna biosynthetic process GO:2001141 381 0.018
protein complex biogenesis GO:0070271 263 0.018
amine metabolic process GO:0009308 38 0.018
regulation of rna metabolic process GO:0051252 391 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
protein autophosphorylation GO:0046777 66 0.018
negative regulation of multicellular organismal process GO:0051241 203 0.017
regulation of cellular ketone metabolic process GO:0010565 27 0.017
regulation of kinase activity GO:0043549 117 0.017
negative regulation of macromolecule metabolic process GO:0010605 260 0.017
cellular response to oxygen containing compound GO:1901701 386 0.017
response to hypoxia GO:0001666 231 0.017
gamete generation GO:0007276 124 0.017
peptidyl amino acid modification GO:0018193 126 0.017
neuron development GO:0048666 286 0.017
Rat
regulation of neuron projection development GO:0010975 161 0.017
Rat
cellular protein localization GO:0034613 122 0.017
response to mechanical stimulus GO:0009612 134 0.017
protein heterooligomerization GO:0051291 89 0.017
regulation of transferase activity GO:0051338 123 0.017
negative regulation of biosynthetic process GO:0009890 168 0.017
positive regulation of response to stimulus GO:0048584 285 0.017
proteolysis GO:0006508 175 0.017
cell projection organization GO:0030030 302 0.016
Rat
response to nutrient levels GO:0031667 370 0.016
spermatogenesis GO:0007283 99 0.016
muscle system process GO:0003012 115 0.016
positive regulation of cell death GO:0010942 184 0.016
response to decreased oxygen levels GO:0036293 237 0.016
regulation of transforming growth factor beta3 production GO:0032910 2 0.016
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.016
Rat
cell part morphogenesis GO:0032990 123 0.016
Rat
negative regulation of apoptotic process GO:0043066 181 0.015
cation transport GO:0006812 382 0.015
Rat
nuclear transport GO:0051169 49 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.015
positive regulation of neurogenesis GO:0050769 165 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
kidney development GO:0001822 67 0.015
germ cell migration GO:0008354 1 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
organelle organization GO:0006996 266 0.015
regulation of protein metabolic process GO:0051246 289 0.015
Rat
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
transcription from rna polymerase ii promoter GO:0006366 252 0.015
carbohydrate derivative metabolic process GO:1901135 346 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
Rat
positive regulation of programmed cell death GO:0043068 157 0.015
cardiac ventricle development GO:0003231 1 0.015
biological adhesion GO:0022610 110 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
negative regulation of signal transduction GO:0009968 83 0.014
neurological system process GO:0050877 219 0.014
neuron projection morphogenesis GO:0048812 122 0.014
Rat
immune system process GO:0002376 204 0.014
Rat
male gamete generation GO:0048232 99 0.014
response to corticosteroid GO:0031960 235 0.014
protein oligomerization GO:0051259 191 0.014
bmp signaling pathway GO:0030509 4 0.014
regulation of system process GO:0044057 208 0.014
Rat
male sex differentiation GO:0046661 64 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
response to extracellular stimulus GO:0009991 380 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
brain development GO:0007420 247 0.013
negative regulation of growth GO:0045926 37 0.013
positive regulation of intracellular protein transport GO:0090316 20 0.013
oxoacid metabolic process GO:0043436 290 0.013
muscle cell proliferation GO:0033002 84 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
cell projection morphogenesis GO:0048858 123 0.013
Rat
sex differentiation GO:0007548 113 0.013
vasculogenesis GO:0001570 3 0.013
response to transforming growth factor beta GO:0071559 46 0.013
ion transmembrane transport GO:0034220 365 0.013
Rat
single organism biosynthetic process GO:0044711 342 0.013
artery development GO:0060840 3 0.013
synaptic growth at neuromuscular junction GO:0051124 1 0.013
signal transduction by phosphorylation GO:0023014 144 0.013
ras protein signal transduction GO:0007265 29 0.013
cellular response to lipid GO:0071396 201 0.013
regulation of response to stress GO:0080134 126 0.012
reproductive structure development GO:0048608 128 0.012
regulation of growth GO:0040008 105 0.012
axonogenesis GO:0007409 71 0.012
male gonad development GO:0008584 59 0.012
nucleoside phosphate metabolic process GO:0006753 283 0.012
protein localization GO:0008104 191 0.012
organophosphate metabolic process GO:0019637 370 0.012
multicellular organism growth GO:0035264 1 0.012
synaptic transmission GO:0007268 235 0.012
mesoderm development GO:0007498 2 0.012
cellular response to glucocorticoid stimulus GO:0071385 68 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.012
Rat
axis specification GO:0009798 4 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
positive regulation of neuron projection development GO:0010976 99 0.012
lipid metabolic process GO:0006629 283 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
response to glucocorticoid GO:0051384 223 0.012
regulation of protein kinase activity GO:0045859 105 0.011
positive regulation of biomineral tissue development GO:0070169 4 0.011
negative regulation of cardiac muscle cell proliferation GO:0060044 2 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
regulation of catabolic process GO:0009894 113 0.011
Rat
macromolecule localization GO:0033036 252 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
female sex differentiation GO:0046660 59 0.011
cell motility GO:0048870 202 0.011
cellular response to corticosteroid stimulus GO:0071384 69 0.011
transmembrane transport GO:0055085 412 0.011
Rat
intracellular transport GO:0046907 185 0.011
growth GO:0040007 165 0.011
regulation of cell growth GO:0001558 85 0.011
single organism organelle organization GO:1902589 180 0.011
positive regulation of cellular component biogenesis GO:0044089 55 0.011
cell growth GO:0016049 104 0.011
regulation of endothelial cell differentiation GO:0045601 4 0.011
negative regulation of gene expression GO:0010629 199 0.011
embryonic skeletal system development GO:0048706 3 0.010
positive regulation of hydrolase activity GO:0051345 86 0.010
negative regulation of heart growth GO:0061117 3 0.010
regulation of intracellular transport GO:0032386 65 0.010
positive regulation of signal transduction GO:0009967 175 0.010
negative regulation of developmental growth GO:0048640 15 0.010
nucleotide metabolic process GO:0009117 279 0.010
regulation of smooth muscle cell proliferation GO:0048660 75 0.010
head development GO:0060322 247 0.010
rna localization GO:0006403 4 0.010
regulation of muscle system process GO:0090257 79 0.010
Rat
locomotion GO:0040011 237 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
cellular component movement GO:0006928 248 0.010
negative regulation of developmental process GO:0051093 125 0.010
response to hexose GO:0009746 144 0.010
catabolic process GO:0009056 351 0.010
Rat

Smurf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016