Rattus norvegicus

21 known processes

D2hgdh

D-2-hydroxyglutarate dehydrogenase

(Aliases: RGD1307976)

D2hgdh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 292 0.080
single organism catabolic process GO:0044712 283 0.080
carboxylic acid metabolic process GO:0019752 289 0.072
catabolic process GO:0009056 351 0.067
lipid metabolic process GO:0006629 283 0.061
oxoacid metabolic process GO:0043436 290 0.057
organophosphate metabolic process GO:0019637 370 0.047
cellular catabolic process GO:0044248 295 0.047
organic substance catabolic process GO:1901575 316 0.045
carbohydrate derivative metabolic process GO:1901135 346 0.044
cellular lipid metabolic process GO:0044255 208 0.043
programmed cell death GO:0012501 392 0.040
nucleoside phosphate metabolic process GO:0006753 283 0.040
central nervous system development GO:0007417 311 0.039
cellular component biogenesis GO:0044085 368 0.039
organelle organization GO:0006996 266 0.038
regulation of phosphorus metabolic process GO:0051174 349 0.038
macromolecular complex subunit organization GO:0043933 339 0.037
organophosphate catabolic process GO:0046434 148 0.035
ribonucleotide metabolic process GO:0009259 231 0.035
ribose phosphate metabolic process GO:0019693 235 0.034
regulation of signal transduction GO:0009966 318 0.034
cellular ketone metabolic process GO:0042180 51 0.033
fatty acid metabolic process GO:0006631 99 0.033
cellular amino acid metabolic process GO:0006520 107 0.033
phosphatidylinositol dephosphorylation GO:0046856 4 0.032
response to metal ion GO:0010038 253 0.031
regulation of cellular amino acid metabolic process GO:0006521 2 0.031
rna biosynthetic process GO:0032774 380 0.031
amine metabolic process GO:0009308 38 0.030
nucleoside metabolic process GO:0009116 179 0.030
single organism biosynthetic process GO:0044711 342 0.029
cellular nitrogen compound catabolic process GO:0044270 163 0.029
response to nutrient levels GO:0031667 370 0.029
response to purine containing compound GO:0014074 126 0.029
nucleotide metabolic process GO:0009117 279 0.028
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
apoptotic process GO:0006915 381 0.027
regulation of cellular ketone metabolic process GO:0010565 27 0.027
protein complex subunit organization GO:0071822 302 0.027
response to extracellular stimulus GO:0009991 380 0.027
purine nucleotide catabolic process GO:0006195 136 0.027
regulation of nucleic acid templated transcription GO:1903506 380 0.027
oxidation reduction process GO:0055114 304 0.027
ribonucleoside triphosphate catabolic process GO:0009203 122 0.027
aromatic compound catabolic process GO:0019439 168 0.026
organonitrogen compound catabolic process GO:1901565 179 0.026
protein complex biogenesis GO:0070271 263 0.026
purine ribonucleotide catabolic process GO:0009154 136 0.026
monocarboxylic acid metabolic process GO:0032787 152 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.025
cell projection organization GO:0030030 302 0.025
single organism reproductive process GO:0044702 297 0.025
organic cyclic compound catabolic process GO:1901361 175 0.025
cellular amine metabolic process GO:0044106 38 0.025
purine nucleotide metabolic process GO:0006163 229 0.025
response to nutrient GO:0007584 248 0.025
purine containing compound metabolic process GO:0072521 253 0.024
purine nucleoside triphosphate catabolic process GO:0009146 122 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
regulation of apoptotic process GO:0042981 335 0.024
head development GO:0060322 247 0.024
reproduction GO:0000003 245 0.024
single organism organelle organization GO:1902589 180 0.024
monovalent inorganic cation transport GO:0015672 172 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
organonitrogen compound biosynthetic process GO:1901566 167 0.023
cellular component assembly GO:0022607 360 0.023
nucleotide catabolic process GO:0009166 139 0.023
positive regulation of cell communication GO:0010647 271 0.023
response to inorganic substance GO:0010035 377 0.023
regulation of cellular component organization GO:0051128 368 0.023
nucleoside phosphate catabolic process GO:1901292 140 0.022
multicellular organism reproduction GO:0032504 233 0.022
lipid modification GO:0030258 52 0.022
ribonucleoside metabolic process GO:0009119 174 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
regulation of organelle organization GO:0033043 80 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.022
reproductive process GO:0022414 372 0.022
macromolecular complex assembly GO:0065003 273 0.022
ribonucleotide catabolic process GO:0009261 136 0.021
small gtpase mediated signal transduction GO:0007264 36 0.021
multicellular organism growth GO:0035264 1 0.021
chemical homeostasis GO:0048878 292 0.021
cation transport GO:0006812 382 0.021
purine nucleoside triphosphate metabolic process GO:0009144 141 0.021
inorganic ion transmembrane transport GO:0098660 229 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
multicellular organismal reproductive process GO:0048609 233 0.021
purine containing compound catabolic process GO:0072523 138 0.020
nucleoside triphosphate metabolic process GO:0009141 144 0.020
regulation of cell differentiation GO:0045595 320 0.020
multi organism reproductive process GO:0044703 262 0.020
purine ribonucleoside catabolic process GO:0046130 124 0.020
purine nucleoside metabolic process GO:0042278 169 0.020
regulation of membrane potential GO:0042391 110 0.020
ribonucleoside triphosphate metabolic process GO:0009199 141 0.020
metal ion transport GO:0030001 289 0.020
carbohydrate derivative catabolic process GO:1901136 147 0.020
response to external biotic stimulus GO:0043207 221 0.019
nucleoside triphosphate catabolic process GO:0009143 123 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
neuronal action potential GO:0019228 35 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
protein phosphorylation GO:0006468 345 0.019
nucleobase containing compound catabolic process GO:0034655 152 0.019
response to decreased oxygen levels GO:0036293 237 0.019
glycosyl compound metabolic process GO:1901657 182 0.019
rna metabolic process GO:0016070 406 0.019
protein oligomerization GO:0051259 191 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.018
fatty acid catabolic process GO:0009062 26 0.018
locomotion GO:0040011 237 0.018
intracellular signal transduction GO:0035556 314 0.018
protein complex assembly GO:0006461 263 0.018
negative regulation of metabolic process GO:0009892 331 0.018
purine ribonucleoside metabolic process GO:0046128 168 0.018
transcription dna templated GO:0006351 377 0.018
response to organophosphorus GO:0046683 102 0.018
heterocycle catabolic process GO:0046700 167 0.018
cellular component movement GO:0006928 248 0.018
ras protein signal transduction GO:0007265 29 0.018
regulation of neuron projection development GO:0010975 161 0.017
nucleic acid templated transcription GO:0097659 379 0.017
secretion GO:0046903 307 0.017
regulation of programmed cell death GO:0043067 341 0.017
cellular response to oxygen containing compound GO:1901701 386 0.017
positive regulation of phosphate metabolic process GO:0045937 262 0.017
brain development GO:0007420 247 0.017
regulation of rna metabolic process GO:0051252 391 0.017
positive regulation of response to stimulus GO:0048584 285 0.017
cellular response to endogenous stimulus GO:0071495 377 0.017
neurological system process GO:0050877 219 0.017
action potential GO:0001508 54 0.017
neuron differentiation GO:0030182 368 0.017
regulation of rna biosynthetic process GO:2001141 381 0.017
nucleoside catabolic process GO:0009164 126 0.017
organic acid catabolic process GO:0016054 49 0.017
regulation of cell projection organization GO:0031344 175 0.016
aging GO:0007568 241 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
vesicle mediated transport GO:0016192 181 0.016
positive regulation of phosphorus metabolic process GO:0010562 262 0.016
small molecule catabolic process GO:0044282 59 0.016
regulation of ion transport GO:0043269 245 0.015
purine nucleoside catabolic process GO:0006152 124 0.015
regulation of cellular localization GO:0060341 263 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
response to bacterium GO:0009617 200 0.015
membrane organization GO:0061024 94 0.015
response to oxygen levels GO:0070482 265 0.015
regeneration GO:0031099 163 0.015
positive regulation of signal transduction GO:0009967 175 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
response to hypoxia GO:0001666 231 0.015
regulation of transcription dna templated GO:0006355 374 0.015
regulation of cell proliferation GO:0042127 359 0.015
protein homooligomerization GO:0051260 91 0.015
ion transmembrane transport GO:0034220 365 0.015
tissue development GO:0009888 252 0.015
intracellular transport GO:0046907 185 0.014
regulation of neurogenesis GO:0050767 247 0.014
response to starvation GO:0042594 59 0.014
glycosyl compound catabolic process GO:1901658 126 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.014
nitrogen compound transport GO:0071705 229 0.014
gland development GO:0048732 155 0.014
regulation of system process GO:0044057 208 0.014
neuron development GO:0048666 286 0.014
adult locomotory behavior GO:0008344 4 0.014
regulation of purine nucleotide metabolic process GO:1900542 115 0.014
sexual reproduction GO:0019953 148 0.014
cofactor metabolic process GO:0051186 95 0.014
peptidyl amino acid modification GO:0018193 126 0.014
cellular homeostasis GO:0019725 252 0.014
lipid catabolic process GO:0016042 46 0.013
response to corticosteroid GO:0031960 235 0.013
ensheathment of neurons GO:0007272 40 0.013
hormone transport GO:0009914 121 0.013
peptide secretion GO:0002790 86 0.013
regulation of hormone levels GO:0010817 187 0.013
negative regulation of macromolecule metabolic process GO:0010605 260 0.013
growth GO:0040007 165 0.013
telencephalon development GO:0021537 62 0.013
cellular response to stress GO:0033554 269 0.013
homeostatic process GO:0042592 331 0.013
response to carbohydrate GO:0009743 183 0.013
single organism membrane organization GO:0044802 74 0.013
negative regulation of cellular metabolic process GO:0031324 281 0.013
inorganic cation transmembrane transport GO:0098662 202 0.013
cell morphogenesis GO:0000902 142 0.013
response to biotic stimulus GO:0009607 226 0.013
regulation of phosphorylation GO:0042325 248 0.013
amide transport GO:0042886 105 0.013
guanosine containing compound metabolic process GO:1901068 74 0.013
response to acid chemical GO:0001101 222 0.013
blood circulation GO:0008015 183 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
dephosphorylation GO:0016311 98 0.012
multi multicellular organism process GO:0044706 138 0.012
transmission of nerve impulse GO:0019226 42 0.012
cation transmembrane transport GO:0098655 263 0.012
cell adhesion GO:0007155 110 0.012
gtp metabolic process GO:0046039 72 0.012
regulation of peptide transport GO:0090087 87 0.012
macromolecule localization GO:0033036 252 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
negative regulation of cell death GO:0060548 229 0.012
gamete generation GO:0007276 124 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
regulation of secretion GO:0051046 224 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
cellular response to lipid GO:0071396 201 0.012
regulation of catabolic process GO:0009894 113 0.012
ion homeostasis GO:0050801 212 0.012
transcription from rna polymerase ii promoter GO:0006366 252 0.012
regulation of multicellular organismal development GO:2000026 376 0.012
transmembrane transport GO:0055085 412 0.011
axon ensheathment GO:0008366 40 0.011
cell part morphogenesis GO:0032990 123 0.011
regulation of neuron differentiation GO:0045664 208 0.011
cellular response to nutrient levels GO:0031669 60 0.011
rho protein signal transduction GO:0007266 11 0.011
peptide hormone secretion GO:0030072 84 0.011
cellular response to metal ion GO:0071248 55 0.011
cellular response to external stimulus GO:0071496 118 0.011
regulation of peptide hormone secretion GO:0090276 80 0.011
hormone secretion GO:0046879 115 0.011
response to vitamin GO:0033273 131 0.011
peptide transport GO:0015833 97 0.011
cell cell signaling GO:0007267 335 0.011
regulation of hormone secretion GO:0046883 106 0.011
negative regulation of transport GO:0051051 136 0.011
developmental process involved in reproduction GO:0003006 159 0.011
embryonic pattern specification GO:0009880 1 0.011
metal ion homeostasis GO:0055065 186 0.011
response to peptide GO:1901652 292 0.011
regulation of catalytic activity GO:0050790 304 0.011
cellular lipid catabolic process GO:0044242 37 0.011
response to peptide hormone GO:0043434 278 0.011
cellular macromolecule localization GO:0070727 122 0.011
localization of cell GO:0051674 202 0.011
regulation of phosphatidylinositol dephosphorylation GO:0060304 1 0.011
cellular response to hormone stimulus GO:0032870 247 0.011
protein targeting GO:0006605 61 0.011
negative regulation of cellular component organization GO:0051129 83 0.010
regulation of nucleotide metabolic process GO:0006140 117 0.010
anion transport GO:0006820 178 0.010
cellular protein localization GO:0034613 122 0.010
response to ethanol GO:0045471 162 0.010
signal release GO:0023061 145 0.010
positive regulation of protein metabolic process GO:0051247 178 0.010
protein localization GO:0008104 191 0.010
establishment of protein localization GO:0045184 141 0.010
cytoplasmic transport GO:0016482 115 0.010
single organism intracellular transport GO:1902582 166 0.010
g protein coupled receptor signaling pathway GO:0007186 242 0.010
regulation of cell growth GO:0001558 85 0.010
female pregnancy GO:0007565 122 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.010
olfactory behavior GO:0042048 2 0.010
regulation of nucleotide catabolic process GO:0030811 65 0.010
lipid storage GO:0019915 1 0.010
cellular component maintenance GO:0043954 4 0.010
synaptic transmission GO:0007268 235 0.010
nucleotide biosynthetic process GO:0009165 98 0.010
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.010
actin filament based process GO:0030029 86 0.010

D2hgdh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.023
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
inherited metabolic disorder DOID:655 0 0.016
central nervous system disease DOID:331 0 0.015
disease of cellular proliferation DOID:14566 0 0.011
cancer DOID:162 0 0.011
organ system cancer DOID:0050686 0 0.010