Rattus norvegicus

157 known processes

Tyms

thymidylate synthetase

(Aliases: MGC156654)

Tyms biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
single organism reproductive process GO:0044702 297 0.164
negative regulation of cellular metabolic process GO:0031324 281 0.104
organic acid metabolic process GO:0006082 292 0.103
negative regulation of metabolic process GO:0009892 331 0.098
double strand break repair GO:0006302 1 0.096
organophosphate metabolic process GO:0019637 370 0.094
oxoacid metabolic process GO:0043436 290 0.091
carboxylic acid metabolic process GO:0019752 289 0.087
negative regulation of gene expression GO:0010629 199 0.084
multi organism reproductive process GO:0044703 262 0.080
multicellular organismal reproductive process GO:0048609 233 0.077
reproductive process GO:0022414 372 0.075
macromolecular complex subunit organization GO:0043933 339 0.074
multicellular organism reproduction GO:0032504 233 0.073
negative regulation of macromolecule metabolic process GO:0010605 260 0.073
regulation of cellular protein metabolic process GO:0032268 267 0.070
cellular component biogenesis GO:0044085 368 0.069
regulation of phosphate metabolic process GO:0019220 349 0.068
nucleoside phosphate metabolic process GO:0006753 283 0.068
nucleobase containing small molecule metabolic process GO:0055086 316 0.067
rna metabolic process GO:0016070 406 0.067
transcription dna templated GO:0006351 377 0.066
single organism biosynthetic process GO:0044711 342 0.062
nucleotide metabolic process GO:0009117 279 0.060
cellular response to stress GO:0033554 269 0.060
response to estrogen GO:0043627 232 0.059
regulation of cellular component organization GO:0051128 368 0.059
regulation of phosphorylation GO:0042325 248 0.058
response to ketone GO:1901654 182 0.058
reproduction GO:0000003 245 0.058
g protein coupled receptor signaling pathway GO:0007186 242 0.057
cellular amino acid metabolic process GO:0006520 107 0.056
cellular response to nitrogen compound GO:1901699 210 0.056
cellular response to endogenous stimulus GO:0071495 377 0.052
catabolic process GO:0009056 351 0.051
intracellular signal transduction GO:0035556 314 0.051
programmed cell death GO:0012501 392 0.050
regulation of molecular function GO:0065009 398 0.050
positive regulation of biosynthetic process GO:0009891 319 0.049
regulation of phosphorus metabolic process GO:0051174 349 0.048
response to nutrient levels GO:0031667 370 0.047
brain development GO:0007420 247 0.047
cellular response to organonitrogen compound GO:0071417 197 0.046
head development GO:0060322 247 0.046
organic substance catabolic process GO:1901575 316 0.046
cardiovascular system development GO:0072358 134 0.046
negative regulation of apoptotic process GO:0043066 181 0.045
regulation of programmed cell death GO:0043067 341 0.045
protein phosphorylation GO:0006468 345 0.045
cellular response to oxygen containing compound GO:1901701 386 0.045
nucleic acid templated transcription GO:0097659 379 0.044
cellular component assembly GO:0022607 360 0.044
aromatic compound catabolic process GO:0019439 168 0.043
lipid metabolic process GO:0006629 283 0.043
purine containing compound metabolic process GO:0072521 253 0.043
tetrahydrofolate metabolic process GO:0046653 9 0.042
defense response GO:0006952 194 0.042
neuron differentiation GO:0030182 368 0.041
sexual reproduction GO:0019953 148 0.041
regulation of signal transduction GO:0009966 318 0.040
regulation of protein metabolic process GO:0051246 289 0.040
cellular catabolic process GO:0044248 295 0.040
organelle organization GO:0006996 266 0.040
response to oxidative stress GO:0006979 186 0.040
cellular amine metabolic process GO:0044106 38 0.039
carbohydrate derivative metabolic process GO:1901135 346 0.039
response to extracellular stimulus GO:0009991 380 0.039
negative regulation of cellular protein metabolic process GO:0032269 106 0.039
regulation of chromosome segregation GO:0051983 1 0.039
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.038
ribose phosphate metabolic process GO:0019693 235 0.038
protein complex assembly GO:0006461 263 0.038
cellular nitrogen compound catabolic process GO:0044270 163 0.038
purine nucleotide metabolic process GO:0006163 229 0.038
rna biosynthetic process GO:0032774 380 0.037
regulation of nucleic acid templated transcription GO:1903506 380 0.037
rhythmic process GO:0048511 156 0.037
macromolecule localization GO:0033036 252 0.036
positive regulation of retinal cell programmed cell death GO:0046670 1 0.036
purine containing compound catabolic process GO:0072523 138 0.035
central nervous system development GO:0007417 311 0.035
negative regulation of response to stimulus GO:0048585 155 0.035
regulation of rna metabolic process GO:0051252 391 0.034
single organism catabolic process GO:0044712 283 0.034
response to metal ion GO:0010038 253 0.034
regulation of transcription dna templated GO:0006355 374 0.033
regulation of cell differentiation GO:0045595 320 0.032
folic acid containing compound metabolic process GO:0006760 10 0.032
cellular response to oxidative stress GO:0034599 76 0.031
amine metabolic process GO:0009308 38 0.031
regulation of cellular localization GO:0060341 263 0.031
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.031
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.031
regulation of rna biosynthetic process GO:2001141 381 0.031
circulatory system development GO:0072359 134 0.031
aging GO:0007568 241 0.030
nucleobase containing compound catabolic process GO:0034655 152 0.030
cellular ketone metabolic process GO:0042180 51 0.030
positive regulation of intracellular signal transduction GO:1902533 138 0.030
negative regulation of protein metabolic process GO:0051248 114 0.029
reproductive structure development GO:0048608 128 0.029
cellular response to insulin stimulus GO:0032869 81 0.029
positive regulation of molecular function GO:0044093 230 0.029
response to vitamin GO:0033273 131 0.029
regulation of apoptotic process GO:0042981 335 0.029
cell cycle process GO:0022402 57 0.028
developmental process involved in reproduction GO:0003006 159 0.028
negative regulation of cellular component organization GO:0051129 83 0.028
protein complex biogenesis GO:0070271 263 0.028
transcription from rna polymerase ii promoter GO:0006366 252 0.028
negative regulation of programmed cell death GO:0043069 183 0.027
positive regulation of developmental process GO:0051094 283 0.027
cellular response to hormone stimulus GO:0032870 247 0.027
response to oxygen levels GO:0070482 265 0.027
chromosome segregation GO:0007059 2 0.026
response to decreased oxygen levels GO:0036293 237 0.026
inflammatory response GO:0006954 150 0.026
response to nutrient GO:0007584 248 0.026
response to peptide GO:1901652 292 0.026
positive regulation of response to stimulus GO:0048584 285 0.026
regulation of catalytic activity GO:0050790 304 0.025
response to ethanol GO:0045471 162 0.025
dna metabolic process GO:0006259 96 0.025
negative regulation of biosynthetic process GO:0009890 168 0.025
positive regulation of gene expression GO:0010628 244 0.025
positive regulation of cellular component organization GO:0051130 200 0.025
cellular response to peptide hormone stimulus GO:0071375 120 0.025
heterocycle catabolic process GO:0046700 167 0.024
cell differentiation in hindbrain GO:0021533 2 0.024
protein complex subunit organization GO:0071822 302 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.024
regulation of cellular amino acid metabolic process GO:0006521 2 0.024
development of primary sexual characteristics GO:0045137 107 0.024
gamete generation GO:0007276 124 0.024
response to corticosteroid GO:0031960 235 0.024
organic cyclic compound catabolic process GO:1901361 175 0.024
positive regulation of signaling GO:0023056 270 0.024
macromolecular complex assembly GO:0065003 273 0.024
protein autophosphorylation GO:0046777 66 0.023
cellular response to organic cyclic compound GO:0071407 202 0.023
response to reactive oxygen species GO:0000302 120 0.023
negative regulation of cell death GO:0060548 229 0.023
regulation of mitotic sister chromatid separation GO:0010965 1 0.023
negative regulation of cellular biosynthetic process GO:0031327 161 0.023
response to peptide hormone GO:0043434 278 0.023
response to hexose GO:0009746 144 0.023
signal transduction by phosphorylation GO:0023014 144 0.023
maintenance of location GO:0051235 17 0.023
organonitrogen compound catabolic process GO:1901565 179 0.022
regulation of cell proliferation GO:0042127 359 0.022
purine ribonucleotide metabolic process GO:0009150 227 0.022
protein localization GO:0008104 191 0.022
positive regulation of phosphate metabolic process GO:0045937 262 0.022
positive regulation of signal transduction GO:0009967 175 0.022
muscle cell proliferation GO:0033002 84 0.022
regulation of intracellular signal transduction GO:1902531 218 0.022
development of primary female sexual characteristics GO:0046545 56 0.022
apoptotic process GO:0006915 381 0.021
regulation of neurogenesis GO:0050767 247 0.021
organophosphate catabolic process GO:0046434 148 0.021
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.021
cellular lipid metabolic process GO:0044255 208 0.021
nucleoside triphosphate catabolic process GO:0009143 123 0.021
ion homeostasis GO:0050801 212 0.021
regulation of response to stress GO:0080134 126 0.020
positive regulation of cell differentiation GO:0045597 217 0.020
regulation of multicellular organismal development GO:2000026 376 0.020
purine ribonucleotide catabolic process GO:0009154 136 0.020
regulation of cellular ketone metabolic process GO:0010565 27 0.020
response to growth factor GO:0070848 189 0.020
ovulation cycle process GO:0022602 50 0.020
response to insulin GO:0032868 133 0.020
response to estradiol GO:0032355 164 0.020
regulation of protein phosphorylation GO:0001932 183 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
hindbrain morphogenesis GO:0021575 2 0.020
negative regulation of cell communication GO:0010648 158 0.020
organophosphate biosynthetic process GO:0090407 143 0.020
cellular modified amino acid metabolic process GO:0006575 61 0.019
dna integrity checkpoint GO:0031570 2 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
carbohydrate derivative catabolic process GO:1901136 147 0.019
histone serine phosphorylation GO:0035404 1 0.019
gland development GO:0048732 155 0.019
regulation of neuron differentiation GO:0045664 208 0.019
nucleotide catabolic process GO:0009166 139 0.019
response to toxic substance GO:0009636 133 0.019
nucleoside metabolic process GO:0009116 179 0.019
positive regulation of cellular biosynthetic process GO:0031328 295 0.019
cofactor metabolic process GO:0051186 95 0.019
localization of cell GO:0051674 202 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.018
intracellular transport GO:0046907 185 0.018
ovulation cycle GO:0042698 67 0.018
female gonad development GO:0008585 53 0.018
axis specification GO:0009798 4 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
response to transition metal nanoparticle GO:1990267 122 0.018
sex differentiation GO:0007548 113 0.018
homeostatic process GO:0042592 331 0.018
female sex differentiation GO:0046660 59 0.018
cellular response to reactive oxygen species GO:0034614 55 0.018
response to acid chemical GO:0001101 222 0.018
ribonucleotide metabolic process GO:0009259 231 0.018
cell cycle GO:0007049 101 0.018
vesicle mediated transport GO:0016192 181 0.018
response to inorganic substance GO:0010035 377 0.018
ribonucleoside triphosphate catabolic process GO:0009203 122 0.018
response to molecule of bacterial origin GO:0002237 194 0.018
gonad development GO:0008406 104 0.017
anion transport GO:0006820 178 0.017
anatomical structure formation involved in morphogenesis GO:0048646 83 0.017
heart development GO:0007507 72 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.017
ras protein signal transduction GO:0007265 29 0.017
negative regulation of molecular function GO:0044092 133 0.017
biological adhesion GO:0022610 110 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
positive regulation of cell communication GO:0010647 271 0.017
response to biotic stimulus GO:0009607 226 0.016
response to purine containing compound GO:0014074 126 0.016
learning or memory GO:0007611 90 0.016
spermatogenesis GO:0007283 99 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
regulation of protein modification process GO:0031399 194 0.016
ribonucleotide catabolic process GO:0009261 136 0.016
chemical homeostasis GO:0048878 292 0.016
purine nucleoside catabolic process GO:0006152 124 0.016
coenzyme metabolic process GO:0006732 86 0.016
regulation of growth GO:0040008 105 0.016
positive regulation of lipid catabolic process GO:0050996 4 0.016
regulation of secretion GO:0051046 224 0.016
regulation of homeostatic process GO:0032844 101 0.016
purine nucleoside triphosphate metabolic process GO:0009144 141 0.016
small molecule biosynthetic process GO:0044283 124 0.016
positive regulation of secretion GO:0051047 140 0.016
purine nucleoside metabolic process GO:0042278 169 0.015
cellular response to dna damage stimulus GO:0006974 19 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
male gamete generation GO:0048232 99 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
response to bacterium GO:0009617 200 0.015
regulation of cell development GO:0060284 263 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
secretion GO:0046903 307 0.015
cellular response to peptide GO:1901653 133 0.015
cell projection organization GO:0030030 302 0.015
response to wounding GO:0009611 254 0.015
liver development GO:0001889 90 0.015
multi multicellular organism process GO:0044706 138 0.015
regulation of cell projection organization GO:0031344 175 0.015
negative regulation of signaling GO:0023057 157 0.015
regeneration GO:0031099 163 0.015
mitotic sister chromatid separation GO:0051306 1 0.015
nucleoside triphosphate metabolic process GO:0009141 144 0.015
regulation of body fluid levels GO:0050878 90 0.015
response to monosaccharide GO:0034284 159 0.014
cellular component movement GO:0006928 248 0.014
translation GO:0006412 35 0.014
purine nucleoside triphosphate catabolic process GO:0009146 122 0.014
negative regulation of protein phosphorylation GO:0001933 44 0.014
anatomical structure morphogenesis GO:0009653 298 0.014
cell morphogenesis GO:0000902 142 0.014
protein transport GO:0015031 132 0.014
negative regulation of signal transduction GO:0009968 83 0.014
negative regulation of cell cycle phase transition GO:1901988 4 0.014
alpha amino acid metabolic process GO:1901605 71 0.014
urogenital system development GO:0001655 78 0.014
negative regulation of transport GO:0051051 136 0.014
neuron development GO:0048666 286 0.014
peptidyl serine phosphorylation GO:0018105 33 0.014
cell cycle checkpoint GO:0000075 2 0.014
regulation of immune system process GO:0002682 123 0.014
nucleotide biosynthetic process GO:0009165 98 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
regulation of cell cycle process GO:0010564 31 0.013
proteolysis GO:0006508 175 0.013
positive regulation of multicellular organismal process GO:0051240 387 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
reproductive system development GO:0061458 128 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
ovarian follicle development GO:0001541 31 0.013
regulation of catabolic process GO:0009894 113 0.013
locomotion GO:0040011 237 0.013
negative regulation of rna biosynthetic process GO:1902679 118 0.013
regulation of cell cycle g2 m phase transition GO:1902749 4 0.013
protein oligomerization GO:0051259 191 0.013
forebrain development GO:0030900 98 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
purine nucleotide catabolic process GO:0006195 136 0.013
regulation of kinase activity GO:0043549 117 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
cellular response to lipid GO:0071396 201 0.013
cellular chemical homeostasis GO:0055082 247 0.013
neuron projection development GO:0031175 273 0.013
glycerolipid metabolic process GO:0046486 67 0.013
response to tumor cell GO:0002347 4 0.013
regulation of neuron projection development GO:0010975 161 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
peptidyl amino acid modification GO:0018193 126 0.013
glycosyl compound catabolic process GO:1901658 126 0.013
eye morphogenesis GO:0048592 4 0.012
cytoplasmic transport GO:0016482 115 0.012
synaptic transmission GO:0007268 235 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
metaphase anaphase transition of cell cycle GO:0044784 1 0.012
peptide biosynthetic process GO:0043043 3 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
lipid storage GO:0019915 1 0.012
organic acid biosynthetic process GO:0016053 83 0.012
muscle structure development GO:0061061 87 0.012
female pregnancy GO:0007565 122 0.012
cellular macromolecule localization GO:0070727 122 0.012
cerebellar cortex formation GO:0021697 2 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
anterior posterior pattern specification GO:0009952 1 0.012
organic anion transport GO:0015711 132 0.012
nucleoside catabolic process GO:0009164 126 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
single organism intracellular transport GO:1902582 166 0.012
cellular process involved in reproduction in multicellular organism GO:0022412 35 0.012
behavior GO:0007610 205 0.011
regulation of muscle tissue development GO:1901861 25 0.011
regulation of cellular component movement GO:0051270 150 0.011
multicellular organism growth GO:0035264 1 0.011
cellular response to metal ion GO:0071248 55 0.011
response to lipopolysaccharide GO:0032496 191 0.011
centrosome organization GO:0051297 1 0.011
glycosyl compound metabolic process GO:1901657 182 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
response to organophosphorus GO:0046683 102 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
kidney development GO:0001822 67 0.011
response to alkaloid GO:0043279 132 0.011
mapk cascade GO:0000165 140 0.011
regulation of nervous system development GO:0051960 264 0.011
activation of cysteine type endopeptidase activity GO:0097202 4 0.011
regulation of mapk cascade GO:0043408 116 0.011
regulation of hormone levels GO:0010817 187 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
regulation of transferase activity GO:0051338 123 0.011
hepaticobiliary system development GO:0061008 90 0.011
response to external biotic stimulus GO:0043207 221 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
regulation of sister chromatid segregation GO:0033045 1 0.010
immune system process GO:0002376 204 0.010
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.010
regulation of membrane potential GO:0042391 110 0.010
mitotic cell cycle checkpoint GO:0007093 1 0.010
fatty acid metabolic process GO:0006631 99 0.010
taxis GO:0042330 67 0.010
metal ion homeostasis GO:0055065 186 0.010
growth GO:0040007 165 0.010
nucleoside phosphate catabolic process GO:1901292 140 0.010
regulation of meiotic cell cycle GO:0051445 3 0.010
response to other organism GO:0051707 220 0.010
positive regulation of protein modification process GO:0031401 142 0.010
cellular macromolecular complex assembly GO:0034622 58 0.010
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.010
cell type specific apoptotic process GO:0097285 134 0.010
response to hypoxia GO:0001666 231 0.010
nucleoside phosphate biosynthetic process GO:1901293 102 0.010
ribonucleoside metabolic process GO:0009119 174 0.010
positive regulation of dna metabolic process GO:0051054 39 0.010
positive regulation of cell death GO:0010942 184 0.010
lipid biosynthetic process GO:0008610 128 0.010

Tyms disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
nervous system disease DOID:863 0 0.020
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.013
sensory system disease DOID:0050155 0 0.010