Rattus norvegicus

126 known processes

Top2a

topoisomerase (DNA) II alpha

Top2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromosome segregation GO:0007059 2 0.777
regulation of chromosome segregation GO:0051983 1 0.759
dna packaging GO:0006323 4 0.563
positive regulation of cardiac muscle cell proliferation GO:0060045 4 0.552
cell cycle g1 s phase transition GO:0044843 13 0.549
g1 s transition of mitotic cell cycle GO:0000082 12 0.546
mitotic cell cycle phase transition GO:0044772 20 0.494
chromosome condensation GO:0030261 3 0.490
histone phosphorylation GO:0016572 6 0.477
negative regulation of chromosome organization GO:2001251 1 0.462
mitotic sister chromatid separation GO:0051306 1 0.452
meiosis i GO:0007127 2 0.427
single organism reproductive process GO:0044702 297 0.402
double strand break repair GO:0006302 1 0.386
cell cycle GO:0007049 101 0.380
dna metabolic process GO:0006259 96 0.370
ventricular cardiac muscle cell development GO:0055015 2 0.334
histone serine phosphorylation GO:0035404 1 0.318
meiotic cell cycle process GO:1903046 3 0.317
cell cycle dna replication GO:0044786 1 0.314
cell cycle phase transition GO:0044770 21 0.303
regulation of cellular component organization GO:0051128 368 0.298
negative regulation of metabolic process GO:0009892 331 0.290
metaphase anaphase transition of cell cycle GO:0044784 1 0.287
positive regulation of developmental process GO:0051094 283 0.287
positive regulation of multicellular organismal process GO:0051240 387 0.282
macromolecule catabolic process GO:0009057 58 0.271
regulation of cell proliferation GO:0042127 359 0.265
regulation of organelle organization GO:0033043 80 0.248
mitotic sister chromatid segregation GO:0000070 1 0.244
regulation of cardiac muscle cell proliferation GO:0060043 6 0.222
regulation of chromosome organization GO:0033044 9 0.220
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.220
single organism organelle organization GO:1902589 180 0.219
negative regulation of cellular metabolic process GO:0031324 281 0.208
response to ddt GO:0046680 1 0.205
striated muscle cell proliferation GO:0014855 9 0.204
regulation of nuclear cell cycle dna replication GO:0033262 1 0.204
protein localization to chromosome centromeric region GO:0071459 1 0.203
sexual reproduction GO:0019953 148 0.199
multi organism reproductive process GO:0044703 262 0.195
cell cycle checkpoint GO:0000075 2 0.192
aging GO:0007568 241 0.187
chromosome organization GO:0051276 36 0.187
regulation of multicellular organismal development GO:2000026 376 0.186
negative regulation of cell cycle phase transition GO:1901988 4 0.185
gamete generation GO:0007276 124 0.184
protein phosphorylation GO:0006468 345 0.184
negative regulation of macromolecule metabolic process GO:0010605 260 0.182
cell cycle process GO:0022402 57 0.179
mitotic spindle organization GO:0007052 2 0.177
regeneration GO:0031099 163 0.175
organelle organization GO:0006996 266 0.175
multicellular organism reproduction GO:0032504 233 0.167
sister chromatid segregation GO:0000819 1 0.167
cellular catabolic process GO:0044248 295 0.166
hepaticobiliary system development GO:0061008 90 0.165
reproductive process GO:0022414 372 0.164
regulation of cardiac muscle tissue development GO:0055024 12 0.163
positive regulation of protein import into nucleus translocation GO:0033160 7 0.159
negative regulation of gene expression GO:0010629 199 0.159
regulation of cell cycle GO:0051726 73 0.156
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.152
chromatin organization GO:0006325 34 0.152
mitotic cell cycle process GO:1903047 35 0.147
reproduction GO:0000003 245 0.147
cellular component biogenesis GO:0044085 368 0.147
response to inorganic substance GO:0010035 377 0.146
response to high density lipoprotein particle GO:0055099 2 0.139
regulation of mitotic sister chromatid separation GO:0010965 1 0.139
tetrahydrofolate metabolic process GO:0046653 9 0.138
cardiac muscle cell development GO:0055013 16 0.135
response to metal ion GO:0010038 253 0.130
regulation of proteasomal protein catabolic process GO:0061136 4 0.129
response to purine containing compound GO:0014074 126 0.127
positive regulation of triglyceride metabolic process GO:0090208 4 0.126
single organism catabolic process GO:0044712 283 0.125
ventricular cardiac muscle cell differentiation GO:0055012 2 0.123
positive regulation of dna metabolic process GO:0051054 39 0.123
multicellular organismal reproductive process GO:0048609 233 0.122
macromolecular complex subunit organization GO:0043933 339 0.122
response to estradiol GO:0032355 164 0.122
cardiac muscle cell proliferation GO:0060038 6 0.121
organic substance catabolic process GO:1901575 316 0.117
developmental process involved in reproduction GO:0003006 159 0.115
mitotic cell cycle GO:0000278 49 0.115
negative regulation of cellular biosynthetic process GO:0031327 161 0.113
positive regulation of cell proliferation GO:0008284 249 0.113
regulation of molecular function GO:0065009 398 0.112
transcription dna templated GO:0006351 377 0.112
catabolic process GO:0009056 351 0.109
cardiac muscle tissue growth GO:0055017 20 0.102
regulation of dna metabolic process GO:0051052 60 0.099
regulation of microtubule polymerization or depolymerization GO:0031110 12 0.098
cellular component movement GO:0006928 248 0.097
spindle organization GO:0007051 2 0.096
chromatin modification GO:0016568 33 0.095
response to organophosphorus GO:0046683 102 0.095
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.095
regulation of cellular catabolic process GO:0031329 101 0.095
regulation of cell cycle phase transition GO:1901987 12 0.094
cellular response to stress GO:0033554 269 0.093
reproductive structure development GO:0048608 128 0.093
response to toxic substance GO:0009636 133 0.091
positive regulation of lipid catabolic process GO:0050996 4 0.091
cellular response to peptide hormone stimulus GO:0071375 120 0.089
tissue development GO:0009888 252 0.089
negative regulation of cell death GO:0060548 229 0.088
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.088
regulation of transcription dna templated GO:0006355 374 0.087
regulation of heart growth GO:0060420 12 0.087
rna metabolic process GO:0016070 406 0.086
response to transition metal nanoparticle GO:1990267 122 0.086
protein complex subunit organization GO:0071822 302 0.082
protein complex assembly GO:0006461 263 0.081
pyrimidine nucleobase metabolic process GO:0006206 8 0.081
reproductive system development GO:0061458 128 0.081
cellular response to oxygen containing compound GO:1901701 386 0.080
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.079
positive regulation of cellular catabolic process GO:0031331 71 0.078
regulation of cell cycle process GO:0010564 31 0.077
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 1 0.077
regulation of sister chromatid segregation GO:0033045 1 0.076
response to estrogen GO:0043627 232 0.075
peptidyl serine phosphorylation GO:0018105 33 0.075
peptidyl serine modification GO:0018209 34 0.075
regulation of phosphorus metabolic process GO:0051174 349 0.075
positive regulation of cardiac muscle tissue growth GO:0055023 9 0.074
growth GO:0040007 165 0.073
cytoskeleton organization GO:0007010 111 0.072
regulation of rna metabolic process GO:0051252 391 0.072
regulation of protein metabolic process GO:0051246 289 0.072
cardiac cell development GO:0055006 16 0.071
organ growth GO:0035265 24 0.071
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.071
regulation of catabolic process GO:0009894 113 0.070
microtubule cytoskeleton organization GO:0000226 25 0.070
organ regeneration GO:0031100 101 0.068
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.066
regulation of muscle tissue development GO:1901861 25 0.063
striated muscle tissue development GO:0014706 58 0.062
regulation of kinase activity GO:0043549 117 0.061
muscle tissue development GO:0060537 58 0.061
aromatic compound catabolic process GO:0019439 168 0.061
programmed cell death GO:0012501 392 0.060
regulation of phosphate metabolic process GO:0019220 349 0.060
regulation of synapse maturation GO:0090128 2 0.060
positive regulation of proteasomal protein catabolic process GO:1901800 3 0.060
regulation of cardiac muscle tissue growth GO:0055021 12 0.060
oxoacid metabolic process GO:0043436 290 0.060
protein complex biogenesis GO:0070271 263 0.059
positive regulation of synaptic plasticity GO:0031915 3 0.058
regulation of protein phosphorylation GO:0001932 183 0.058
regulation of cellular localization GO:0060341 263 0.058
regulation of phosphorylation GO:0042325 248 0.057
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.057
negative regulation of transcription dna templated GO:0045892 116 0.056
positive regulation of nucleic acid templated transcription GO:1903508 197 0.055
positive regulation of histone phosphorylation GO:0033129 3 0.055
regulation of catalytic activity GO:0050790 304 0.055
negative regulation of rna metabolic process GO:0051253 123 0.054
positive regulation of catabolic process GO:0009896 78 0.054
positive regulation of cellular biosynthetic process GO:0031328 295 0.054
response to insulin GO:0032868 133 0.054
response to ethanol GO:0045471 162 0.054
cellular component assembly GO:0022607 360 0.053
nucleobase containing small molecule metabolic process GO:0055086 316 0.053
regulation of rna biosynthetic process GO:2001141 381 0.053
regulation of nucleic acid templated transcription GO:1903506 380 0.053
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.052
intracellular signal transduction GO:0035556 314 0.051
centrosome cycle GO:0007098 1 0.051
positive regulation of cytoskeleton organization GO:0051495 26 0.051
centrosome organization GO:0051297 1 0.051
negative regulation of protein metabolic process GO:0051248 114 0.050
heart growth GO:0060419 20 0.049
regulation of cellular protein metabolic process GO:0032268 267 0.049
regulation of mitotic sister chromatid segregation GO:0033047 1 0.048
positive regulation of cellular protein metabolic process GO:0032270 167 0.048
regulation of organ growth GO:0046620 13 0.047
regulation of mitotic cell cycle phase transition GO:1901990 11 0.047
microtubule based process GO:0007017 36 0.047
response to decreased oxygen levels GO:0036293 237 0.046
negative regulation of apoptotic process GO:0043066 181 0.046
chromosome separation GO:0051304 1 0.046
negative regulation of neutrophil apoptotic process GO:0033030 3 0.046
response to oxygen levels GO:0070482 265 0.046
cell cycle g2 m phase transition GO:0044839 6 0.046
regulation of growth GO:0040008 105 0.045
cardiocyte differentiation GO:0035051 22 0.045
development of primary sexual characteristics GO:0045137 107 0.045
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.044
cellular process involved in reproduction in multicellular organism GO:0022412 35 0.044
macromolecule localization GO:0033036 252 0.043
organelle fission GO:0048285 25 0.043
positive regulation of heart growth GO:0060421 9 0.043
protein localization GO:0008104 191 0.042
organophosphate metabolic process GO:0019637 370 0.042
response to oxidative stress GO:0006979 186 0.042
regulation of cell differentiation GO:0045595 320 0.042
spermatogenesis GO:0007283 99 0.042
regulation of protein modification process GO:0031399 194 0.042
response to ketone GO:1901654 182 0.041
regulation of exit from mitosis GO:0007096 1 0.041
microtubule organizing center organization GO:0031023 1 0.040
regulation of signal transduction GO:0009966 318 0.040
regulation of microtubule based process GO:0032886 14 0.040
mitotic dna damage checkpoint GO:0044773 1 0.040
positive regulation of protein metabolic process GO:0051247 178 0.040
regulation of programmed cell death GO:0043067 341 0.040
digestive tract development GO:0048565 39 0.040
regulation of protein serine threonine kinase activity GO:0071900 64 0.040
negative regulation of rna biosynthetic process GO:1902679 118 0.039
muscle cell proliferation GO:0033002 84 0.039
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.039
negative regulation of cellular protein metabolic process GO:0032269 106 0.039
positive regulation of biosynthetic process GO:0009891 319 0.039
negative regulation of biosynthetic process GO:0009890 168 0.038
regulation of cytoskeleton organization GO:0051493 49 0.038
regulation of apoptotic process GO:0042981 335 0.038
cellular nitrogen compound catabolic process GO:0044270 163 0.038
negative regulation of programmed cell death GO:0043069 183 0.038
positive regulation of rna metabolic process GO:0051254 203 0.038
regulation of cellular protein catabolic process GO:1903362 7 0.037
cellular amino acid metabolic process GO:0006520 107 0.037
positive regulation of intracellular protein transport GO:0090316 20 0.036
negative regulation of protein phosphorylation GO:0001933 44 0.036
regulation of chronic inflammatory response to non antigenic stimulus GO:0002880 1 0.036
heart development GO:0007507 72 0.036
circulatory system development GO:0072359 134 0.036
regulation of neurogenesis GO:0050767 247 0.035
positive regulation of growth GO:0045927 55 0.035
anatomical structure morphogenesis GO:0009653 298 0.035
negative regulation of cellular component organization GO:0051129 83 0.034
negative regulation of phosphate metabolic process GO:0045936 80 0.034
localization of cell GO:0051674 202 0.034
homeostatic process GO:0042592 331 0.034
dna replication GO:0006260 37 0.033
response to molecule of bacterial origin GO:0002237 194 0.033
response to cytokine GO:0034097 215 0.033
nucleic acid templated transcription GO:0097659 379 0.033
protein catabolic process GO:0030163 30 0.033
g2 m transition of mitotic cell cycle GO:0000086 6 0.033
negative regulation of nucleic acid templated transcription GO:1903507 117 0.032
negative regulation of mitotic cell cycle GO:0045930 6 0.032
positive regulation of gene expression GO:0010628 244 0.032
response to reactive oxygen species GO:0000302 120 0.032
deoxyribonucleoside monophosphate biosynthetic process GO:0009157 4 0.032
negative regulation of phosphorus metabolic process GO:0010563 80 0.032
purine containing compound metabolic process GO:0072521 253 0.032
negative regulation of cell communication GO:0010648 158 0.032
regulation of transferase activity GO:0051338 123 0.032
gland development GO:0048732 155 0.031
negative regulation of response to stimulus GO:0048585 155 0.031
cellular response to organonitrogen compound GO:0071417 197 0.031
small gtpase mediated signal transduction GO:0007264 36 0.030
neuron differentiation GO:0030182 368 0.030
dna dependent dna replication GO:0006261 5 0.030
response to iron iii ion GO:0010041 6 0.030
cellular response to cytokine stimulus GO:0071345 127 0.030
regulation of microtubule cytoskeleton organization GO:0070507 14 0.030
female gonad development GO:0008585 53 0.030
negative regulation of protein modification process GO:0031400 52 0.030
mitotic cell cycle checkpoint GO:0007093 1 0.030
organic cyclic compound catabolic process GO:1901361 175 0.030
positive regulation of cellular component organization GO:0051130 200 0.029
organelle assembly GO:0070925 22 0.029
male gamete generation GO:0048232 99 0.029
response to peptide hormone GO:0043434 278 0.029
sex differentiation GO:0007548 113 0.029
nucleotide metabolic process GO:0009117 279 0.029
establishment of organelle localization GO:0051656 37 0.029
microtubule anchoring GO:0034453 1 0.028
organic acid metabolic process GO:0006082 292 0.028
carboxylic acid metabolic process GO:0019752 289 0.028
response to peptide GO:1901652 292 0.028
nucleoside phosphate metabolic process GO:0006753 283 0.028
proteolysis GO:0006508 175 0.028
positive regulation of apoptotic process GO:0043065 154 0.028
cellular response to organic cyclic compound GO:0071407 202 0.028
cardiovascular system development GO:0072358 134 0.028
response to corticosteroid GO:0031960 235 0.028
mrna processing GO:0006397 14 0.028
macromolecular complex assembly GO:0065003 273 0.027
regulation of protein kinase activity GO:0045859 105 0.027
negative regulation of signaling GO:0023057 157 0.027
cellular macromolecule localization GO:0070727 122 0.027
mrna metabolic process GO:0016071 20 0.026
regulation of meiotic cell cycle GO:0051445 3 0.026
cellular response to iron iii ion GO:0071283 3 0.026
sensory organ development GO:0007423 74 0.026
positive regulation of molecular function GO:0044093 230 0.026
rna biosynthetic process GO:0032774 380 0.026
response to nutrient levels GO:0031667 370 0.026
actin filament based process GO:0030029 86 0.026
negative regulation of cell division GO:0051782 1 0.026
cell projection organization GO:0030030 302 0.026
cellular macromolecule catabolic process GO:0044265 29 0.025
cellular response to lipopolysaccharide GO:0071222 55 0.025
asymmetric protein localization GO:0008105 2 0.025
nucleotide biosynthetic process GO:0009165 98 0.025
response to wounding GO:0009611 254 0.025
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.025
cardiac muscle tissue development GO:0048738 26 0.025
positive regulation of muscle organ development GO:0048636 13 0.025
striated muscle cell development GO:0055002 26 0.025
nucleoside triphosphate metabolic process GO:0009141 144 0.024
protein autophosphorylation GO:0046777 66 0.024
positive regulation of phosphorylation GO:0042327 177 0.024
regulation of developmental growth GO:0048638 45 0.024
cell fate determination GO:0001709 2 0.024
cellular response to abiotic stimulus GO:0071214 85 0.024
cellular response to dna damage stimulus GO:0006974 19 0.024
glycosyl compound catabolic process GO:1901658 126 0.024
regulation of g2 m transition of mitotic cell cycle GO:0010389 4 0.023
positive regulation of protein phosphorylation GO:0001934 135 0.023
triglyceride metabolic process GO:0006641 21 0.023
positive regulation of protein modification process GO:0031401 142 0.023
ras protein signal transduction GO:0007265 29 0.023
response to camp GO:0051591 91 0.023
neuroblast differentiation GO:0014016 1 0.023
single organism biosynthetic process GO:0044711 342 0.023
cellular response to external stimulus GO:0071496 118 0.022
eye development GO:0001654 50 0.022
rhythmic process GO:0048511 156 0.022
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.022
purine ribonucleoside metabolic process GO:0046128 168 0.022
heterocycle catabolic process GO:0046700 167 0.022
regulation of centrosome cycle GO:0046605 1 0.022
purine ribonucleotide catabolic process GO:0009154 136 0.022
covalent chromatin modification GO:0016569 30 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.022
wound healing GO:0042060 122 0.022
positive regulation of catalytic activity GO:0043085 184 0.021
glycerolipid metabolic process GO:0046486 67 0.021
carbohydrate derivative metabolic process GO:1901135 346 0.021
cellular response to nitrogen compound GO:1901699 210 0.021
negative regulation of cell cycle GO:0045786 21 0.021
regulation of nervous system development GO:0051960 264 0.021
ribonucleotide metabolic process GO:0009259 231 0.021
response to radiation GO:0009314 137 0.021
somatic stem cell division GO:0048103 2 0.021
muscle cell differentiation GO:0042692 52 0.021
ovulation cycle GO:0042698 67 0.021
cell migration GO:0016477 197 0.020
negative regulation of protein maturation GO:1903318 47 0.020
atp catabolic process GO:0006200 54 0.020
tube development GO:0035295 89 0.020
cellular amine metabolic process GO:0044106 38 0.020
dna integrity checkpoint GO:0031570 2 0.020
response to acid chemical GO:0001101 222 0.020
regulation of mrna 3 end processing GO:0031440 1 0.020
gonad development GO:0008406 104 0.020
response to extracellular stimulus GO:0009991 380 0.020
transcription from rna polymerase ii promoter GO:0006366 252 0.020
regulation of protein localization GO:0032880 81 0.020
developmental growth GO:0048589 100 0.019
modification dependent protein catabolic process GO:0019941 14 0.019
phenylpropanoid catabolic process GO:0046271 3 0.019
regulation of muscle organ development GO:0048634 26 0.019
response to lipopolysaccharide GO:0032496 191 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
positive regulation of phosphate metabolic process GO:0045937 262 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.019
negative regulation of nuclear division GO:0051784 1 0.019
glycosyl compound metabolic process GO:1901657 182 0.019
dna conformation change GO:0071103 10 0.019
response to vitamin GO:0033273 131 0.019
positive regulation of transcription dna templated GO:0045893 197 0.019
purine nucleoside triphosphate catabolic process GO:0009146 122 0.019
microtubule polymerization or depolymerization GO:0031109 13 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
ribonucleoside catabolic process GO:0042454 126 0.018
response to glucocorticoid GO:0051384 223 0.018
positive regulation of transferase activity GO:0051347 81 0.018
positive regulation of cardiac muscle tissue development GO:0055025 9 0.018
regulation of protein depolymerization GO:1901879 8 0.018
protein dephosphorylation GO:0006470 38 0.018
response to hydrogen peroxide GO:0042542 89 0.018
peptidyl amino acid modification GO:0018193 126 0.018
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.018
response to biotic stimulus GO:0009607 226 0.017
positive regulation of protein import into nucleus GO:0042307 14 0.017
carbohydrate derivative catabolic process GO:1901136 147 0.017
response to nutrient GO:0007584 248 0.017
response to progesterone GO:0032570 48 0.017
muscle structure development GO:0061061 87 0.017
nucleoside triphosphate catabolic process GO:0009143 123 0.017
purine nucleotide metabolic process GO:0006163 229 0.017
female sex differentiation GO:0046660 59 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
positive regulation of t cell migration GO:2000406 1 0.016
leukocyte aggregation GO:0070486 1 0.016
epithelium development GO:0060429 96 0.016
response to heat GO:0009408 60 0.016
cellular response to metal ion GO:0071248 55 0.016
meiotic nuclear division GO:0007126 8 0.016
response to hypoxia GO:0001666 231 0.016
response to cadmium ion GO:0046686 35 0.016
pteridine containing compound metabolic process GO:0042558 14 0.016
proteasomal protein catabolic process GO:0010498 8 0.016
ribonucleoside monophosphate metabolic process GO:0009161 88 0.016
nucleotide catabolic process GO:0009166 139 0.016
negative regulation of molecular function GO:0044092 133 0.015
microglial cell activation GO:0001774 14 0.015
transformation of host cell by virus GO:0019087 4 0.015
histone modification GO:0016570 30 0.015
negative regulation of phosphorylation GO:0042326 57 0.015
nuclear division GO:0000280 22 0.015
metal ion homeostasis GO:0055065 186 0.015
cellular ion homeostasis GO:0006873 184 0.015
maintenance of location GO:0051235 17 0.015
somatic stem cell maintenance GO:0035019 2 0.015
cell motility GO:0048870 202 0.015
regulation of nucleocytoplasmic transport GO:0046822 28 0.015
response to amine GO:0014075 46 0.015
regulation of synaptic transmission GO:0050804 141 0.015
developmental maturation GO:0021700 25 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 7 0.014
response to antibiotic GO:0046677 39 0.014
circulatory system process GO:0003013 183 0.014
asymmetric stem cell division GO:0098722 2 0.014
embryo development GO:0009790 49 0.014
defense response GO:0006952 194 0.014
male meiosis GO:0007140 1 0.014
cellular response to insulin stimulus GO:0032869 81 0.014
regulation of striated muscle tissue development GO:0016202 25 0.014
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.014
muscle cell development GO:0055001 26 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
negative regulation of developmental process GO:0051093 125 0.014
nucleosome organization GO:0034728 1 0.014
regulation of response to stress GO:0080134 126 0.014
cytoskeleton dependent cytokinesis GO:0061640 2 0.014
chromatin remodeling GO:0006338 3 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
regulation of establishment of protein localization GO:0070201 69 0.013
positive regulation of synapse maturation GO:0090129 2 0.013
organophosphate catabolic process GO:0046434 148 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
regulation of protein catabolic process GO:0042176 16 0.013
locomotion GO:0040011 237 0.013
establishment of chromosome localization GO:0051303 1 0.013
response to insecticide GO:0017085 21 0.013
apoptotic signaling pathway GO:0097190 27 0.013
cytoplasmic transport GO:0016482 115 0.013
camera type eye development GO:0043010 48 0.013
regulation of tight junction assembly GO:2000810 2 0.013
cellular ketone metabolic process GO:0042180 51 0.013
response to amino acid GO:0043200 75 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
chromatin assembly or disassembly GO:0006333 1 0.013
regulation of intracellular signal transduction GO:1902531 218 0.013
synapse maturation GO:0060074 5 0.013
cell type specific apoptotic process GO:0097285 134 0.012
cellular response to endogenous stimulus GO:0071495 377 0.012
cellular response to lipid GO:0071396 201 0.012
positive regulation of nervous system development GO:0051962 178 0.012
nucleoside metabolic process GO:0009116 179 0.012
uracil metabolic process GO:0019860 3 0.012
pyrimidine containing compound metabolic process GO:0072527 20 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
erythrocyte homeostasis GO:0034101 2 0.012
regulation of cell motility GO:2000145 131 0.012
ubiquitin dependent protein catabolic process GO:0006511 14 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
cell morphogenesis GO:0000902 142 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
endoplasmic reticulum to cytosol transport GO:1903513 4 0.012
axis specification GO:0009798 4 0.012
muscle organ development GO:0007517 50 0.012
regulation of protein transport GO:0051223 68 0.012
regulation of ubiquitin protein transferase activity GO:0051438 1 0.012
response to bacterium GO:0009617 200 0.012
positive regulation of lymphocyte migration GO:2000403 1 0.012
interleukin 1 beta secretion GO:0050702 3 0.012
regulation of ligase activity GO:0051340 3 0.012
amine metabolic process GO:0009308 38 0.012
head development GO:0060322 247 0.012
ovulation cycle process GO:0022602 50 0.012
negative regulation of signal transduction GO:0009968 83 0.012
protein targeting GO:0006605 61 0.012
positive regulation of cell differentiation GO:0045597 217 0.012
cellular response to acid chemical GO:0071229 75 0.011
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.011
regulation of protein import into nucleus GO:0042306 24 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
intracellular transport GO:0046907 185 0.011
central nervous system development GO:0007417 311 0.011
dna recombination GO:0006310 3 0.011
cellular response to hydrogen peroxide GO:0070301 42 0.011
response to iron ion GO:0010039 28 0.011
cellular response to iron ion GO:0071281 5 0.011
regulation of cellular extravasation GO:0002691 2 0.011
chlorinated hydrocarbon metabolic process GO:0042196 4 0.011
protein modification by small protein conjugation GO:0032446 31 0.011

Top2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org