Rattus norvegicus

0 known processes

Oplah

5-oxoprolinase (ATP-hydrolysing)

(Aliases: MGC105359)

Oplah biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 292 0.475
carboxylic acid biosynthetic process GO:0046394 83 0.355
organic acid biosynthetic process GO:0016053 83 0.288
carboxylic acid metabolic process GO:0019752 289 0.235
cellular amino acid biosynthetic process GO:0008652 32 0.202
carboxylic acid catabolic process GO:0046395 49 0.197
monocarboxylic acid metabolic process GO:0032787 152 0.194
response to nutrient levels GO:0031667 370 0.164
organic acid catabolic process GO:0016054 49 0.163
catabolic process GO:0009056 351 0.158
oxoacid metabolic process GO:0043436 290 0.155
small molecule biosynthetic process GO:0044283 124 0.121
organonitrogen compound biosynthetic process GO:1901566 167 0.110
oxidation reduction process GO:0055114 304 0.108
single organism biosynthetic process GO:0044711 342 0.101
fatty acid metabolic process GO:0006631 99 0.100
fatty acid beta oxidation GO:0006635 22 0.100
cellular lipid catabolic process GO:0044242 37 0.086
cellular lipid metabolic process GO:0044255 208 0.082
organic substance catabolic process GO:1901575 316 0.080
single organism catabolic process GO:0044712 283 0.076
response to extracellular stimulus GO:0009991 380 0.074
cellular catabolic process GO:0044248 295 0.072
monocarboxylic acid catabolic process GO:0072329 28 0.072
response to nutrient GO:0007584 248 0.071
neurological system process GO:0050877 219 0.071
organophosphate metabolic process GO:0019637 370 0.071
negative regulation of multicellular organismal process GO:0051241 203 0.061
lipid metabolic process GO:0006629 283 0.061
regulation of intracellular signal transduction GO:1902531 218 0.060
response to other organism GO:0051707 220 0.058
coenzyme metabolic process GO:0006732 86 0.058
protein complex assembly GO:0006461 263 0.056
regulation of neurogenesis GO:0050767 247 0.053
cellular response to hormone stimulus GO:0032870 247 0.048
fatty acid oxidation GO:0019395 29 0.047
cellular component assembly GO:0022607 360 0.046
small molecule catabolic process GO:0044282 59 0.046
response to glucocorticoid GO:0051384 223 0.046
positive regulation of multicellular organismal process GO:0051240 387 0.046
response to external biotic stimulus GO:0043207 221 0.045
ion transmembrane transport GO:0034220 365 0.044
protein homooligomerization GO:0051260 91 0.044
cellular component biogenesis GO:0044085 368 0.043
lipid modification GO:0030258 52 0.043
regulation of cell development GO:0060284 263 0.042
transmembrane transport GO:0055085 412 0.041
regulation of nervous system development GO:0051960 264 0.041
cellular amino acid metabolic process GO:0006520 107 0.041
nucleotide metabolic process GO:0009117 279 0.040
protein homotetramerization GO:0051289 25 0.039
cellular response to oxygen containing compound GO:1901701 386 0.037
nucleoside phosphate metabolic process GO:0006753 283 0.037
cation transport GO:0006812 382 0.037
response to acid chemical GO:0001101 222 0.037
gland development GO:0048732 155 0.037
nucleobase containing small molecule metabolic process GO:0055086 316 0.037
cellular protein localization GO:0034613 122 0.037
macromolecular complex subunit organization GO:0043933 339 0.037
protein oligomerization GO:0051259 191 0.037
cellular amine metabolic process GO:0044106 38 0.036
negative regulation of cell differentiation GO:0045596 99 0.036
regulation of molecular function GO:0065009 398 0.036
organophosphate biosynthetic process GO:0090407 143 0.035
negative regulation of metabolic process GO:0009892 331 0.034
brain development GO:0007420 247 0.033
macromolecular complex assembly GO:0065003 273 0.033
regulation of cellular localization GO:0060341 263 0.032
pyridine containing compound metabolic process GO:0072524 32 0.032
cellular component morphogenesis GO:0032989 155 0.032
response to ethanol GO:0045471 162 0.031
positive regulation of cellular component organization GO:0051130 200 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
response to peptide GO:1901652 292 0.030
intracellular signal transduction GO:0035556 314 0.030
negative regulation of developmental process GO:0051093 125 0.030
fatty acid catabolic process GO:0009062 26 0.030
response to biotic stimulus GO:0009607 226 0.029
chemical homeostasis GO:0048878 292 0.029
regulation of cellular component organization GO:0051128 368 0.029
nicotinamide nucleotide metabolic process GO:0046496 28 0.029
response to vitamin GO:0033273 131 0.029
regulation of cell differentiation GO:0045595 320 0.028
cation transmembrane transport GO:0098655 263 0.028
response to lipopolysaccharide GO:0032496 191 0.028
carbohydrate derivative biosynthetic process GO:1901137 124 0.028
multicellular organismal reproductive process GO:0048609 233 0.028
lipid biosynthetic process GO:0008610 128 0.028
signal release GO:0023061 145 0.028
protein tetramerization GO:0051262 38 0.028
protein phosphorylation GO:0006468 345 0.028
dicarboxylic acid catabolic process GO:0043649 1 0.027
regulation of signal transduction GO:0009966 318 0.027
urogenital system development GO:0001655 78 0.027
neuron differentiation GO:0030182 368 0.027
secretion GO:0046903 307 0.027
regulation of cell projection organization GO:0031344 175 0.027
cellular response to organic cyclic compound GO:0071407 202 0.027
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.027
positive regulation of biosynthetic process GO:0009891 319 0.026
purine nucleotide metabolic process GO:0006163 229 0.026
purine ribonucleotide metabolic process GO:0009150 227 0.026
metal ion homeostasis GO:0055065 186 0.026
monovalent inorganic cation transport GO:0015672 172 0.026
nucleic acid templated transcription GO:0097659 379 0.026
regulation of multicellular organismal development GO:2000026 376 0.025
rna metabolic process GO:0016070 406 0.025
protein complex biogenesis GO:0070271 263 0.025
metal ion transport GO:0030001 289 0.025
regulation of neuron differentiation GO:0045664 208 0.025
response to hyperoxia GO:0055093 45 0.025
protein complex subunit organization GO:0071822 302 0.025
cell projection morphogenesis GO:0048858 123 0.025
purine containing compound metabolic process GO:0072521 253 0.025
regulation of phosphorylation GO:0042325 248 0.025
organonitrogen compound catabolic process GO:1901565 179 0.025
cellular response to lipid GO:0071396 201 0.024
transcription dna templated GO:0006351 377 0.024
monocarboxylic acid biosynthetic process GO:0072330 48 0.024
central nervous system development GO:0007417 311 0.024
positive regulation of phosphate metabolic process GO:0045937 262 0.024
glutamate catabolic process GO:0006538 1 0.024
sensory perception GO:0007600 101 0.024
regulation of secretion by cell GO:1903530 208 0.024
tube development GO:0035295 89 0.024
carbohydrate derivative metabolic process GO:1901135 346 0.024
reproductive process GO:0022414 372 0.023
apoptotic process GO:0006915 381 0.023
inorganic cation transmembrane transport GO:0098662 202 0.023
cell cell signaling GO:0007267 335 0.023
negative regulation of cellular biosynthetic process GO:0031327 161 0.023
regulation of neuron projection development GO:0010975 161 0.023
neuron projection development GO:0031175 273 0.023
homeostatic process GO:0042592 331 0.023
multicellular organism reproduction GO:0032504 233 0.023
regulation of canonical wnt signaling pathway GO:0060828 4 0.023
negative regulation of cellular metabolic process GO:0031324 281 0.023
positive regulation of nervous system development GO:0051962 178 0.023
cellular amino acid catabolic process GO:0009063 21 0.023
single organism reproductive process GO:0044702 297 0.023
cell projection organization GO:0030030 302 0.022
cardiovascular system development GO:0072358 134 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
positive regulation of phosphorus metabolic process GO:0010562 262 0.022
negative regulation of biosynthetic process GO:0009890 168 0.022
programmed cell death GO:0012501 392 0.022
organic hydroxy compound metabolic process GO:1901615 115 0.022
cell morphogenesis involved in differentiation GO:0000904 119 0.021
lipid catabolic process GO:0016042 46 0.021
nucleoside phosphate biosynthetic process GO:1901293 102 0.021
response to corticosteroid GO:0031960 235 0.021
response to organophosphorus GO:0046683 102 0.021
cofactor metabolic process GO:0051186 95 0.021
cofactor biosynthetic process GO:0051188 28 0.021
hexose metabolic process GO:0019318 58 0.021
inorganic ion transmembrane transport GO:0098660 229 0.021
cellular response to peptide hormone stimulus GO:0071375 120 0.021
response to cytokine GO:0034097 215 0.021
positive regulation of intracellular signal transduction GO:1902533 138 0.021
regulation of cellular protein metabolic process GO:0032268 267 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
regulation of hormone levels GO:0010817 187 0.020
immune system process GO:0002376 204 0.020
response to molecule of bacterial origin GO:0002237 194 0.020
cellular macromolecule localization GO:0070727 122 0.020
circulatory system development GO:0072359 134 0.020
regulation of protein metabolic process GO:0051246 289 0.020
response to mechanical stimulus GO:0009612 134 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
response to camp GO:0051591 91 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
positive regulation of protein metabolic process GO:0051247 178 0.019
cellular response to nitrogen compound GO:1901699 210 0.019
negative regulation of signaling GO:0023057 157 0.019
nucleoside monophosphate metabolic process GO:0009123 93 0.019
hepaticobiliary system development GO:0061008 90 0.019
regulation of programmed cell death GO:0043067 341 0.019
cellular response to stress GO:0033554 269 0.019
positive regulation of developmental process GO:0051094 283 0.019
single organism membrane organization GO:0044802 74 0.019
regulation of cell proliferation GO:0042127 359 0.019
multicellular organism growth GO:0035264 1 0.019
nucleotide biosynthetic process GO:0009165 98 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
regeneration GO:0031099 163 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
negative regulation of cell communication GO:0010648 158 0.018
regulation of phosphorus metabolic process GO:0051174 349 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
regulation of phosphate metabolic process GO:0019220 349 0.018
regulation of apoptotic process GO:0042981 335 0.018
multi organism reproductive process GO:0044703 262 0.018
gastrulation GO:0007369 2 0.018
blood circulation GO:0008015 183 0.018
response to insulin GO:0032868 133 0.018
nitrogen compound transport GO:0071705 229 0.018
synaptic transmission GO:0007268 235 0.018
cellular ketone metabolic process GO:0042180 51 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
digestive system development GO:0055123 41 0.017
multicellular organismal signaling GO:0035637 44 0.017
positive regulation of transport GO:0051050 245 0.017
macromolecule localization GO:0033036 252 0.017
alpha amino acid catabolic process GO:1901606 20 0.017
single organism carbohydrate metabolic process GO:0044723 118 0.017
digestive tract development GO:0048565 39 0.017
carbohydrate metabolic process GO:0005975 130 0.017
defense response GO:0006952 194 0.017
nadp metabolic process GO:0006739 13 0.017
cellular response to acid chemical GO:0071229 75 0.017
response to peptide hormone GO:0043434 278 0.017
response to oxygen levels GO:0070482 265 0.017
purine nucleotide biosynthetic process GO:0006164 83 0.017
heart morphogenesis GO:0003007 3 0.017
regulation of proteasomal protein catabolic process GO:0061136 4 0.017
neuron development GO:0048666 286 0.017
negative regulation of cell death GO:0060548 229 0.017
positive regulation of ion transport GO:0043270 94 0.016
rna biosynthetic process GO:0032774 380 0.016
growth GO:0040007 165 0.016
liver development GO:0001889 90 0.016
ion homeostasis GO:0050801 212 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
response to purine containing compound GO:0014074 126 0.016
behavior GO:0007610 205 0.016
regulation of response to stress GO:0080134 126 0.016
response to retinoic acid GO:0032526 63 0.016
muscle contraction GO:0006936 88 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
negative regulation of molecular function GO:0044092 133 0.016
regulation of protein modification process GO:0031399 194 0.016
amine metabolic process GO:0009308 38 0.016
regulation of ion transport GO:0043269 245 0.016
localization of cell GO:0051674 202 0.016
cellular ion homeostasis GO:0006873 184 0.015
anion transport GO:0006820 178 0.015
organic acid transport GO:0015849 116 0.015
acetyl coa metabolic process GO:0006084 17 0.015
cellular homeostasis GO:0019725 252 0.015
positive regulation of signaling GO:0023056 270 0.015
amine catabolic process GO:0009310 9 0.015
locomotion GO:0040011 237 0.015
response to testosterone GO:0033574 55 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
positive regulation of molecular function GO:0044093 230 0.015
inflammatory response GO:0006954 150 0.015
regulation of secretion GO:0051046 224 0.015
secretion by cell GO:0032940 248 0.015
reproduction GO:0000003 245 0.015
axonogenesis GO:0007409 71 0.015
acetate metabolic process GO:0006083 2 0.015
positive regulation of protein modification process GO:0031401 142 0.015
neuron neuron synaptic transmission GO:0007270 60 0.015
cellular response to drug GO:0035690 30 0.015
negative regulation of apoptotic process GO:0043066 181 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
neuron projection morphogenesis GO:0048812 122 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
protein localization GO:0008104 191 0.015
regulation of nucleic acid templated transcription GO:1903506 380 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
response to ketone GO:1901654 182 0.014
positive regulation of cell development GO:0010720 176 0.014
circulatory system process GO:0003013 183 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
tissue development GO:0009888 252 0.014
negative regulation of nervous system development GO:0051961 79 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
cellular calcium ion homeostasis GO:0006874 160 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
response to inorganic substance GO:0010035 377 0.014
alpha amino acid metabolic process GO:1901605 71 0.014
regulation of cellular ketone metabolic process GO:0010565 27 0.014
proteolysis GO:0006508 175 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.014
negative regulation of cellular component organization GO:0051129 83 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
calcium ion homeostasis GO:0055074 162 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
regulation of catabolic process GO:0009894 113 0.013
hormone transport GO:0009914 121 0.013
aging GO:0007568 241 0.013
head development GO:0060322 247 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
renal system development GO:0072001 67 0.013
response to fatty acid GO:0070542 65 0.013
response to vitamin a GO:0033189 36 0.013
developmental induction GO:0031128 2 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
cellular chemical homeostasis GO:0055082 247 0.013
regulation of system process GO:0044057 208 0.013
negative regulation of neuron projection development GO:0010977 46 0.013
regulation of transcription dna templated GO:0006355 374 0.013
organic anion transport GO:0015711 132 0.013
membrane organization GO:0061024 94 0.013
regulation of catalytic activity GO:0050790 304 0.013
cellular component movement GO:0006928 248 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.013
intracellular transport GO:0046907 185 0.013
protein localization to membrane GO:0072657 36 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
regulation of rna biosynthetic process GO:2001141 381 0.012
cyclic nucleotide biosynthetic process GO:0009190 63 0.012
cellular response to peptide GO:1901653 133 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
chromosome segregation GO:0007059 2 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
muscle system process GO:0003012 115 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
cation homeostasis GO:0055080 195 0.012
regulation of blood pressure GO:0008217 83 0.012
heterocycle catabolic process GO:0046700 167 0.012
epithelium development GO:0060429 96 0.012
positive regulation of homeostatic process GO:0032846 49 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
heart development GO:0007507 72 0.012
regulation of rna metabolic process GO:0051252 391 0.012
response to alkaloid GO:0043279 132 0.012
response to radiation GO:0009314 137 0.012
negative regulation of gene expression GO:0010629 199 0.012
ras protein signal transduction GO:0007265 29 0.012
negative regulation of synaptic transmission GO:0050805 29 0.012
glycosyl compound metabolic process GO:1901657 182 0.011
lipid transport GO:0006869 61 0.011
gamete generation GO:0007276 124 0.011
carboxylic acid transport GO:0046942 115 0.011
regulation of membrane potential GO:0042391 110 0.011
regulation of axonogenesis GO:0050770 37 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
response to bacterium GO:0009617 200 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
regulation of body fluid levels GO:0050878 90 0.011
pyridine nucleotide metabolic process GO:0019362 28 0.011
negative regulation of signal transduction GO:0009968 83 0.011
single organism cellular localization GO:1902580 102 0.011
lipid oxidation GO:0034440 30 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
response to hypoxia GO:0001666 231 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
oligopeptide transport GO:0006857 4 0.011
response to decreased oxygen levels GO:0036293 237 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
regulation of hormone secretion GO:0046883 106 0.011
establishment of planar polarity GO:0001736 1 0.011
response to wounding GO:0009611 254 0.011
developmental growth GO:0048589 100 0.011
cellular response to alcohol GO:0097306 87 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
oxidoreduction coenzyme metabolic process GO:0006733 31 0.011
single organism intracellular transport GO:1902582 166 0.011
negative regulation of secretion by cell GO:1903531 72 0.011
actin filament based process GO:0030029 86 0.011
dephosphorylation GO:0016311 98 0.011
cell motility GO:0048870 202 0.011
cytoplasmic transport GO:0016482 115 0.011
regulation of immune system process GO:0002682 123 0.011
sex differentiation GO:0007548 113 0.011
positive regulation of cell death GO:0010942 184 0.011
nucleoside metabolic process GO:0009116 179 0.011
regulation of cellular response to stress GO:0080135 49 0.011
positive regulation of transferase activity GO:0051347 81 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
axon development GO:0061564 96 0.011
cell cycle checkpoint GO:0000075 2 0.011
cellular biogenic amine metabolic process GO:0006576 30 0.011
cell migration GO:0016477 197 0.010
anion transmembrane transport GO:0098656 77 0.010
positive regulation of secretion by cell GO:1903532 128 0.010
developmental process involved in reproduction GO:0003006 159 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
purine nucleoside triphosphate metabolic process GO:0009144 141 0.010
mechanoreceptor differentiation GO:0042490 2 0.010
sulfur compound biosynthetic process GO:0044272 19 0.010
regulation of transferase activity GO:0051338 123 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
purine ribonucleotide biosynthetic process GO:0009152 81 0.010
sensory organ development GO:0007423 74 0.010
thioester biosynthetic process GO:0035384 7 0.010
cellular nitrogen compound catabolic process GO:0044270 163 0.010
positive regulation of catabolic process GO:0009896 78 0.010
response to osmotic stress GO:0006970 42 0.010
synaptic growth at neuromuscular junction GO:0051124 1 0.010
cellular response to cytokine stimulus GO:0071345 127 0.010
very long chain fatty acid metabolic process GO:0000038 3 0.010
regulation of homeostatic process GO:0032844 101 0.010
spindle organization GO:0007051 2 0.010
neuron projection regeneration GO:0031102 35 0.010

Oplah disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.045
inherited metabolic disorder DOID:655 0 0.045
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
musculoskeletal system disease DOID:17 0 0.014
central nervous system disease DOID:331 0 0.012