Rattus norvegicus

119 known processes

Map3k11

mitogen-activated protein kinase kinase kinase 11

(Aliases: Mlk3,RHOE,Mlk-3)

Map3k11 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of apoptotic process GO:0042981 335 0.263
regulation of programmed cell death GO:0043067 341 0.144
signal transduction by phosphorylation GO:0023014 144 0.136
regulation of catalytic activity GO:0050790 304 0.115
intracellular signal transduction GO:0035556 314 0.110
rna metabolic process GO:0016070 406 0.110
regulation of intracellular signal transduction GO:1902531 218 0.107
positive regulation of cell communication GO:0010647 271 0.105
cell projection organization GO:0030030 302 0.105
cellular component biogenesis GO:0044085 368 0.101
protein phosphorylation GO:0006468 345 0.094
regulation of phosphorus metabolic process GO:0051174 349 0.088
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.088
positive regulation of biosynthetic process GO:0009891 319 0.079
positive regulation of signaling GO:0023056 270 0.076
cellular catabolic process GO:0044248 295 0.075
positive regulation of phosphorylation GO:0042327 177 0.075
organophosphate metabolic process GO:0019637 370 0.072
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.072
response to peptide GO:1901652 292 0.071
anatomical structure morphogenesis GO:0009653 298 0.071
Fly
apoptotic process GO:0006915 381 0.070
rna biosynthetic process GO:0032774 380 0.070
regulation of signal transduction GO:0009966 318 0.067
cell migration GO:0016477 197 0.066
positive regulation of cell development GO:0010720 176 0.066
positive regulation of rna metabolic process GO:0051254 203 0.065
regulation of cellular localization GO:0060341 263 0.064
negative regulation of insulin receptor signaling pathway GO:0046627 10 0.064
transcription from rna polymerase ii promoter GO:0006366 252 0.062
cytoskeleton organization GO:0007010 111 0.062
cellular lipid metabolic process GO:0044255 208 0.061
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.059
regulation of phosphate metabolic process GO:0019220 349 0.059
negative regulation of phosphorus metabolic process GO:0010563 80 0.058
cellular protein localization GO:0034613 122 0.058
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.058
programmed cell death GO:0012501 392 0.057
positive regulation of response to stimulus GO:0048584 285 0.057
cell motility GO:0048870 202 0.055
regulation of cell differentiation GO:0045595 320 0.055
negative regulation of cellular metabolic process GO:0031324 281 0.055
positive regulation of protein metabolic process GO:0051247 178 0.054
regulation of nucleic acid templated transcription GO:1903506 380 0.054
positive regulation of gene expression GO:0010628 244 0.054
cell morphogenesis GO:0000902 142 0.053
Fly
response to heat GO:0009408 60 0.053
Fly
carboxylic acid metabolic process GO:0019752 289 0.053
negative regulation of cell death GO:0060548 229 0.052
tissue development GO:0009888 252 0.051
Fly
macromolecular complex subunit organization GO:0043933 339 0.051
regulation of cellular component organization GO:0051128 368 0.051
Fly
cellular response to organonitrogen compound GO:0071417 197 0.049
mapk cascade GO:0000165 140 0.049
catabolic process GO:0009056 351 0.049
cellular response to hormone stimulus GO:0032870 247 0.049
response to nutrient levels GO:0031667 370 0.048
neuron death GO:0070997 127 0.048
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.048
neuron apoptotic process GO:0051402 88 0.048
positive regulation of intracellular signal transduction GO:1902533 138 0.047
cellular response to endogenous stimulus GO:0071495 377 0.047
negative regulation of cellular biosynthetic process GO:0031327 161 0.047
organophosphate catabolic process GO:0046434 148 0.047
regulation of cell proliferation GO:0042127 359 0.046
positive regulation of phosphorus metabolic process GO:0010562 262 0.045
positive regulation of cellular biosynthetic process GO:0031328 295 0.045
regulation of cellular protein metabolic process GO:0032268 267 0.045
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.045
regulation of molecular function GO:0065009 398 0.045
positive regulation of phosphate metabolic process GO:0045937 262 0.045
response to peptide hormone GO:0043434 278 0.044
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.044
lipid metabolic process GO:0006629 283 0.044
enzyme linked receptor protein signaling pathway GO:0007167 116 0.043
regulation of nervous system development GO:0051960 264 0.043
protein complex subunit organization GO:0071822 302 0.042
regulation of rna metabolic process GO:0051252 391 0.042
positive regulation of nucleic acid templated transcription GO:1903508 197 0.041
cellular response to oxygen containing compound GO:1901701 386 0.041
Fly
nucleoside triphosphate metabolic process GO:0009141 144 0.041
positive regulation of cell death GO:0010942 184 0.041
regulation of neuron apoptotic process GO:0043523 83 0.040
regulation of neuron differentiation GO:0045664 208 0.040
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.040
organic substance catabolic process GO:1901575 316 0.039
cellular amine metabolic process GO:0044106 38 0.039
regulation of immune response GO:0050776 55 0.039
negative regulation of programmed cell death GO:0043069 183 0.039
regulation of kinase activity GO:0043549 117 0.038
positive regulation of cellular component organization GO:0051130 200 0.037
nucleic acid templated transcription GO:0097659 379 0.037
negative regulation of cellular response to insulin stimulus GO:1900077 11 0.037
positive regulation of programmed cell death GO:0043068 157 0.037
macromolecule localization GO:0033036 252 0.037
transcription dna templated GO:0006351 377 0.037
regulation of anatomical structure morphogenesis GO:0022603 141 0.037
Fly
negative regulation of metabolic process GO:0009892 331 0.037
cellular response to nitrogen compound GO:1901699 210 0.037
regulation of neurogenesis GO:0050767 247 0.037
response to other organism GO:0051707 220 0.037
regulation of cellular ketone metabolic process GO:0010565 27 0.036
positive regulation of nervous system development GO:0051962 178 0.036
central nervous system development GO:0007417 311 0.036
regulation of protein metabolic process GO:0051246 289 0.036
regulation of cell development GO:0060284 263 0.035
negative regulation of cell differentiation GO:0045596 99 0.035
positive regulation of transcription dna templated GO:0045893 197 0.035
positive regulation of cellular protein metabolic process GO:0032270 167 0.035
cellular component movement GO:0006928 248 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.035
neuron projection development GO:0031175 273 0.035
response to metal ion GO:0010038 253 0.035
immune system process GO:0002376 204 0.034
regulation of hydrolase activity GO:0051336 143 0.034
organelle organization GO:0006996 266 0.033
single organism reproductive process GO:0044702 297 0.033
Fly
positive regulation of catalytic activity GO:0043085 184 0.033
regulation of rna biosynthetic process GO:2001141 381 0.033
positive regulation of developmental process GO:0051094 283 0.032
regulation of cellular amine metabolic process GO:0033238 8 0.032
purine ribonucleoside catabolic process GO:0046130 124 0.032
organ morphogenesis GO:0009887 75 0.032
Fly
organic cyclic compound catabolic process GO:1901361 175 0.032
neuron development GO:0048666 286 0.032
regulation of protein modification process GO:0031399 194 0.031
organic acid metabolic process GO:0006082 292 0.030
regulation of mapk cascade GO:0043408 116 0.030
positive regulation of cell differentiation GO:0045597 217 0.030
cellular ketone metabolic process GO:0042180 51 0.030
circulatory system development GO:0072359 134 0.030
cellular response to peptide GO:1901653 133 0.029
response to acid chemical GO:0001101 222 0.029
purine containing compound catabolic process GO:0072523 138 0.029
regulation of neuron death GO:1901214 115 0.029
oxoacid metabolic process GO:0043436 290 0.029
actin filament organization GO:0007015 42 0.029
amine metabolic process GO:0009308 38 0.028
aromatic compound catabolic process GO:0019439 168 0.028
positive regulation of protein phosphorylation GO:0001934 135 0.028
negative regulation of macromolecule metabolic process GO:0010605 260 0.027
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.027
regulation of cell projection organization GO:0031344 175 0.027
response to reactive oxygen species GO:0000302 120 0.027
secretion GO:0046903 307 0.027
glycosyl compound metabolic process GO:1901657 182 0.027
negative regulation of apoptotic process GO:0043066 181 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
localization of cell GO:0051674 202 0.026
nucleoside metabolic process GO:0009116 179 0.026
gtp catabolic process GO:0006184 71 0.026
multi organism reproductive process GO:0044703 262 0.025
Fly
protein localization GO:0008104 191 0.025
nucleoside catabolic process GO:0009164 126 0.025
positive regulation of cell proliferation GO:0008284 249 0.025
regulation of phosphorylation GO:0042325 248 0.025
negative regulation of molecular function GO:0044092 133 0.025
multicellular organism growth GO:0035264 1 0.025
single organism membrane organization GO:0044802 74 0.025
single organism catabolic process GO:0044712 283 0.024
immune response GO:0006955 104 0.024
response to mechanical stimulus GO:0009612 134 0.024
multicellular organism reproduction GO:0032504 233 0.024
Fly
homeostatic process GO:0042592 331 0.024
positive regulation of neurogenesis GO:0050769 165 0.024
response to camp GO:0051591 91 0.024
nucleobase containing compound catabolic process GO:0034655 152 0.023
organonitrogen compound catabolic process GO:1901565 179 0.023
regulation of protein phosphorylation GO:0001932 183 0.023
positive regulation of apoptotic process GO:0043065 154 0.023
cellular amino acid metabolic process GO:0006520 107 0.023
regulation of protein localization GO:0032880 81 0.023
regulation of transferase activity GO:0051338 123 0.023
regulation of transcription dna templated GO:0006355 374 0.023
single organism carbohydrate metabolic process GO:0044723 118 0.023
carbohydrate metabolic process GO:0005975 130 0.023
neurological system process GO:0050877 219 0.023
ribonucleotide catabolic process GO:0009261 136 0.023
response to wounding GO:0009611 254 0.023
retinoic acid receptor signaling pathway GO:0048384 7 0.023
small gtpase mediated signal transduction GO:0007264 36 0.022
regulation of multicellular organismal development GO:2000026 376 0.022
Fly
positive regulation of rna biosynthetic process GO:1902680 197 0.022
purine nucleoside catabolic process GO:0006152 124 0.022
cellular component morphogenesis GO:0032989 155 0.022
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.022
positive regulation of protein modification process GO:0031401 142 0.022
reproduction GO:0000003 245 0.022
Fly
negative regulation of gene expression GO:0010629 199 0.022
regulation of response to external stimulus GO:0032101 106 0.022
reproductive process GO:0022414 372 0.022
Fly
response to vitamin GO:0033273 131 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
cellular response to lipid GO:0071396 201 0.022
positive regulation of molecular function GO:0044093 230 0.022
negative regulation of cell communication GO:0010648 158 0.021
negative regulation of nervous system development GO:0051961 79 0.021
insulin receptor signaling pathway GO:0008286 24 0.021
cellular component assembly GO:0022607 360 0.021
nucleobase containing small molecule metabolic process GO:0055086 316 0.021
aging GO:0007568 241 0.021
ribonucleotide metabolic process GO:0009259 231 0.021
establishment of protein localization GO:0045184 141 0.021
regulation of cell motility GO:2000145 131 0.020
positive regulation of cellular catabolic process GO:0031331 71 0.020
response to biotic stimulus GO:0009607 226 0.020
lipid biosynthetic process GO:0008610 128 0.020
cellular response to peptide hormone stimulus GO:0071375 120 0.020
cellular response to reactive oxygen species GO:0034614 55 0.020
oxidation reduction process GO:0055114 304 0.020
locomotion GO:0040011 237 0.020
neuron differentiation GO:0030182 368 0.020
cellular homeostasis GO:0019725 252 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
ribonucleoside triphosphate metabolic process GO:0009199 141 0.020
purine nucleoside triphosphate catabolic process GO:0009146 122 0.020
regulation of cellular response to insulin stimulus GO:1900076 16 0.020
intracellular protein transport GO:0006886 79 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
positive regulation of neuron projection development GO:0010976 99 0.019
purine ribonucleoside metabolic process GO:0046128 168 0.019
regulation of membrane potential GO:0042391 110 0.019
response to ketone GO:1901654 182 0.019
negative regulation of cellular protein metabolic process GO:0032269 106 0.019
regulation of locomotion GO:0040012 148 0.019
actin cytoskeleton organization GO:0030036 73 0.019
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.019
secretion by cell GO:0032940 248 0.019
purine ribonucleotide catabolic process GO:0009154 136 0.019
nucleoside phosphate catabolic process GO:1901292 140 0.019
cellular divalent inorganic cation homeostasis GO:0072503 162 0.019
single organism organelle organization GO:1902589 180 0.019
guanosine containing compound metabolic process GO:1901068 74 0.019
negative regulation of cell development GO:0010721 82 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
regulation of cellular catabolic process GO:0031329 101 0.018
response to temperature stimulus GO:0009266 94 0.018
Fly
ribonucleoside triphosphate catabolic process GO:0009203 122 0.018
purine nucleotide catabolic process GO:0006195 136 0.018
regulation of neuron projection development GO:0010975 161 0.018
ribonucleoside metabolic process GO:0009119 174 0.018
positive regulation of cell projection organization GO:0031346 111 0.018
single organism cellular localization GO:1902580 102 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.018
protein transport GO:0015031 132 0.018
regulation of secretion GO:0051046 224 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
purine nucleoside metabolic process GO:0042278 169 0.018
regulation of hormone levels GO:0010817 187 0.018
regulation of cellular response to stress GO:0080135 49 0.018
response to oxidative stress GO:0006979 186 0.018
response to inorganic substance GO:0010035 377 0.018
negative regulation of neuron differentiation GO:0045665 62 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.017
response to nutrient GO:0007584 248 0.017
response to morphine GO:0043278 27 0.017
multi multicellular organism process GO:0044706 138 0.017
heterocycle catabolic process GO:0046700 167 0.017
ras protein signal transduction GO:0007265 29 0.017
actin filament based process GO:0030029 86 0.017
response to insulin GO:0032868 133 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
positive regulation of protein kinase activity GO:0045860 73 0.017
chemical homeostasis GO:0048878 292 0.017
nitrogen compound transport GO:0071705 229 0.017
negative regulation of neurogenesis GO:0050768 78 0.017
glial cell differentiation GO:0010001 65 0.017
gastrulation GO:0007369 2 0.017
positive regulation of transferase activity GO:0051347 81 0.017
macromolecular complex assembly GO:0065003 273 0.016
carbohydrate derivative catabolic process GO:1901136 147 0.016
negative regulation of cell proliferation GO:0008285 119 0.016
ion homeostasis GO:0050801 212 0.016
negative regulation of protein metabolic process GO:0051248 114 0.016
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.016
positive regulation of mapk cascade GO:0043410 92 0.016
organophosphate biosynthetic process GO:0090407 143 0.016
muscle structure development GO:0061061 87 0.016
negative regulation of signaling GO:0023057 157 0.016
regulation of cellular component movement GO:0051270 150 0.016
negative regulation of response to stimulus GO:0048585 155 0.016
purine nucleoside triphosphate metabolic process GO:0009144 141 0.016
purine containing compound metabolic process GO:0072521 253 0.015
lipid transport GO:0006869 61 0.015
response to oxygen levels GO:0070482 265 0.015
regulation of protein serine threonine kinase activity GO:0071900 64 0.015
negative regulation of transport GO:0051051 136 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.015
regulation of response to stress GO:0080134 126 0.015
regulation of catabolic process GO:0009894 113 0.015
proteolysis GO:0006508 175 0.015
brain development GO:0007420 247 0.015
single organism intracellular transport GO:1902582 166 0.015
regulation of growth GO:0040008 105 0.015
lipid storage GO:0019915 1 0.015
response to purine containing compound GO:0014074 126 0.015
cytokine production GO:0001816 61 0.015
gtp metabolic process GO:0046039 72 0.015
organic anion transport GO:0015711 132 0.015
cellular response to insulin stimulus GO:0032869 81 0.014
regulation of cytoskeleton organization GO:0051493 49 0.014
response to estrogen GO:0043627 232 0.014
negative regulation of transcription dna templated GO:0045892 116 0.014
negative regulation of multicellular organismal process GO:0051241 203 0.014
ribonucleoside catabolic process GO:0042454 126 0.014
axis specification GO:0009798 4 0.014
stress activated mapk cascade GO:0051403 35 0.014
negative regulation of intracellular signal transduction GO:1902532 38 0.014
insulin like growth factor receptor signaling pathway GO:0048009 3 0.014
regulation of lipid metabolic process GO:0019216 68 0.014
defense response to gram positive bacterium GO:0050830 2 0.014
intracellular transport GO:0046907 185 0.014
response to bacterium GO:0009617 200 0.014
positive regulation of cellular component movement GO:0051272 102 0.014
negative regulation of developmental process GO:0051093 125 0.014
positive regulation of secretion GO:0051047 140 0.014
positive regulation of neuron death GO:1901216 43 0.014
dna metabolic process GO:0006259 96 0.014
positive regulation of cellular component biogenesis GO:0044089 55 0.014
response to decreased oxygen levels GO:0036293 237 0.014
positive regulation of signal transduction GO:0009967 175 0.014
positive regulation of secretion by cell GO:1903532 128 0.014
cellular ion homeostasis GO:0006873 184 0.013
sensory perception GO:0007600 101 0.013
positive regulation of transport GO:0051050 245 0.013
cellular macromolecule localization GO:0070727 122 0.013
cellular chemical homeostasis GO:0055082 247 0.013
response to ammonium ion GO:0060359 71 0.013
cellular cation homeostasis GO:0030003 180 0.013
developmental growth GO:0048589 100 0.013
Fly
g protein coupled receptor signaling pathway GO:0007186 242 0.013
response to growth factor GO:0070848 189 0.013
tube development GO:0035295 89 0.013
membrane organization GO:0061024 94 0.013
rho protein signal transduction GO:0007266 11 0.013
growth GO:0040007 165 0.013
Fly
developmental process involved in reproduction GO:0003006 159 0.013
Fly
embryo development GO:0009790 49 0.012
Fly
female pregnancy GO:0007565 122 0.012
positive regulation of immunoglobulin mediated immune response GO:0002891 2 0.012
response to hydrogen peroxide GO:0042542 89 0.012
response to tumor necrosis factor GO:0034612 56 0.012
nucleoside triphosphate catabolic process GO:0009143 123 0.012
b cell mediated immunity GO:0019724 4 0.012
carbohydrate derivative metabolic process GO:1901135 346 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
regulation of protein kinase activity GO:0045859 105 0.012
protein complex assembly GO:0006461 263 0.012
regulation of secretion by cell GO:1903530 208 0.012
regulation of homeostatic process GO:0032844 101 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
negative regulation of cellular component organization GO:0051129 83 0.012
chromosome segregation GO:0007059 2 0.012
negative regulation of phosphate metabolic process GO:0045936 80 0.012
metal ion transport GO:0030001 289 0.012
response to cytokine GO:0034097 215 0.012
metal ion homeostasis GO:0055065 186 0.012
learning or memory GO:0007611 90 0.012
cell projection assembly GO:0030031 21 0.012
biological adhesion GO:0022610 110 0.012
regulation of dna metabolic process GO:0051052 60 0.012
cation transmembrane transport GO:0098655 263 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
positive regulation of lipid catabolic process GO:0050996 4 0.012
negative regulation of cell projection organization GO:0031345 50 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
actin filament bundle assembly GO:0051017 19 0.012
cellular response to stress GO:0033554 269 0.011
mesoderm development GO:0007498 2 0.011
cholesterol homeostasis GO:0042632 3 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
maintenance of location GO:0051235 17 0.011
cell adhesion GO:0007155 110 0.011
multicellular organismal reproductive process GO:0048609 233 0.011
Fly
regulation of cellular component biogenesis GO:0044087 86 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
cardiovascular system development GO:0072358 134 0.011
behavior GO:0007610 205 0.011
gliogenesis GO:0042063 93 0.011
adult locomotory behavior GO:0008344 4 0.011
cilium morphogenesis GO:0060271 2 0.011
negative regulation of biosynthetic process GO:0009890 168 0.011
positive regulation of kinase activity GO:0033674 77 0.011
protein complex biogenesis GO:0070271 263 0.011
positive regulation of catabolic process GO:0009896 78 0.011
regulation of platelet derived growth factor receptor signaling pathway GO:0010640 2 0.011
response to organophosphorus GO:0046683 102 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
amide transport GO:0042886 105 0.011
sterol homeostasis GO:0055092 3 0.011
positive regulation of triglyceride metabolic process GO:0090208 4 0.010
regeneration GO:0031099 163 0.010
cell part morphogenesis GO:0032990 123 0.010
cation homeostasis GO:0055080 195 0.010
immunoglobulin mediated immune response GO:0016064 4 0.010
b cell differentiation GO:0030183 2 0.010
acylglycerol metabolic process GO:0006639 21 0.010
regulation of anatomical structure size GO:0090066 135 0.010
cell cell signaling GO:0007267 335 0.010
regulation of immune system process GO:0002682 123 0.010
cellular macromolecular complex assembly GO:0034622 58 0.010
negative regulation of rna metabolic process GO:0051253 123 0.010
guanosine containing compound catabolic process GO:1901069 71 0.010
spindle organization GO:0007051 2 0.010
organic hydroxy compound metabolic process GO:1901615 115 0.010
sensory perception of bitter taste GO:0050913 4 0.010
protein localization to membrane GO:0072657 36 0.010
response to lipopolysaccharide GO:0032496 191 0.010
response to alkaloid GO:0043279 132 0.010
monosaccharide metabolic process GO:0005996 61 0.010
positive regulation of isotype switching GO:0045830 1 0.010
negative regulation of neuron projection development GO:0010977 46 0.010
protein processing GO:0016485 68 0.010

Map3k11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
nervous system disease DOID:863 0 0.044
central nervous system disease DOID:331 0 0.018
sensory system disease DOID:0050155 0 0.013