Rattus norvegicus

4 known processes

Spink4

serine peptidase inhibitor, Kazal type 4

(Aliases: PEC-60)

Spink4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
anatomical structure morphogenesis GO:0009653 298 0.082
cellular homeostasis GO:0019725 252 0.073
intracellular signal transduction GO:0035556 314 0.068
cellular chemical homeostasis GO:0055082 247 0.055
metal ion transport GO:0030001 289 0.051
neuron differentiation GO:0030182 368 0.051
cell projection organization GO:0030030 302 0.050
regulation of multicellular organismal development GO:2000026 376 0.049
regulation of cellular ketone metabolic process GO:0010565 27 0.048
response to other organism GO:0051707 220 0.047
cellular ketone metabolic process GO:0042180 51 0.047
amine metabolic process GO:0009308 38 0.046
regulation of nervous system development GO:0051960 264 0.046
secretion by cell GO:0032940 248 0.044
response to metal ion GO:0010038 253 0.044
signal transduction by phosphorylation GO:0023014 144 0.043
regulation of cell development GO:0060284 263 0.043
cellular response to oxygen containing compound GO:1901701 386 0.042
secretion GO:0046903 307 0.042
tissue development GO:0009888 252 0.041
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.041
cellular metal ion homeostasis GO:0006875 172 0.040
multicellular organismal signaling GO:0035637 44 0.040
positive regulation of signaling GO:0023056 270 0.040
cellular component biogenesis GO:0044085 368 0.039
regulation of phosphorus metabolic process GO:0051174 349 0.039
negative regulation of cell death GO:0060548 229 0.038
oxoacid metabolic process GO:0043436 290 0.038
cellular amine metabolic process GO:0044106 38 0.037
regulation of transcription dna templated GO:0006355 374 0.037
negative regulation of metabolic process GO:0009892 331 0.036
response to inorganic substance GO:0010035 377 0.036
transcription from rna polymerase ii promoter GO:0006366 252 0.036
homeostatic process GO:0042592 331 0.035
positive regulation of secretion by cell GO:1903532 128 0.035
transcription dna templated GO:0006351 377 0.034
programmed cell death GO:0012501 392 0.034
positive regulation of cell communication GO:0010647 271 0.034
cation transport GO:0006812 382 0.034
positive regulation of nucleic acid templated transcription GO:1903508 197 0.033
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.033
negative regulation of multicellular organismal process GO:0051241 203 0.033
response to biotic stimulus GO:0009607 226 0.032
positive regulation of cellular biosynthetic process GO:0031328 295 0.032
carboxylic acid metabolic process GO:0019752 289 0.032
regulation of cellular component organization GO:0051128 368 0.032
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
regulation of cellular amine metabolic process GO:0033238 8 0.032
regulation of protein phosphorylation GO:0001932 183 0.031
neuron projection development GO:0031175 273 0.031
positive regulation of multicellular organismal process GO:0051240 387 0.031
nucleic acid templated transcription GO:0097659 379 0.031
macromolecule localization GO:0033036 252 0.031
positive regulation of phosphorylation GO:0042327 177 0.031
positive regulation of gene expression GO:0010628 244 0.030
cellular component assembly GO:0022607 360 0.030
neurological system process GO:0050877 219 0.029
regulation of protein metabolic process GO:0051246 289 0.029
cellular divalent inorganic cation homeostasis GO:0072503 162 0.029
regulation of nucleic acid templated transcription GO:1903506 380 0.029
chemical homeostasis GO:0048878 292 0.029
response to wounding GO:0009611 254 0.028
purine nucleotide metabolic process GO:0006163 229 0.028
response to extracellular stimulus GO:0009991 380 0.028
locomotion GO:0040011 237 0.028
regulation of catalytic activity GO:0050790 304 0.027
mapk cascade GO:0000165 140 0.027
negative regulation of transport GO:0051051 136 0.027
positive regulation of neurogenesis GO:0050769 165 0.027
positive regulation of nervous system development GO:0051962 178 0.027
response to external biotic stimulus GO:0043207 221 0.026
regulation of cell differentiation GO:0045595 320 0.026
organophosphate metabolic process GO:0019637 370 0.026
calcium ion homeostasis GO:0055074 162 0.026
regulation of molecular function GO:0065009 398 0.025
positive regulation of transcription dna templated GO:0045893 197 0.025
regulation of neuron differentiation GO:0045664 208 0.025
positive regulation of cellular amine metabolic process GO:0033240 3 0.025
purine nucleotide catabolic process GO:0006195 136 0.025
negative regulation of gene expression GO:0010629 199 0.025
response to acid chemical GO:0001101 222 0.025
cellular cation homeostasis GO:0030003 180 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
protein phosphorylation GO:0006468 345 0.024
cellular ion homeostasis GO:0006873 184 0.024
eye morphogenesis GO:0048592 4 0.024
regulation of ion transport GO:0043269 245 0.024
negative regulation of macromolecule metabolic process GO:0010605 260 0.024
positive regulation of developmental process GO:0051094 283 0.024
blood circulation GO:0008015 183 0.023
positive regulation of phosphorus metabolic process GO:0010562 262 0.023
ras protein signal transduction GO:0007265 29 0.023
rna metabolic process GO:0016070 406 0.023
regulation of intracellular signal transduction GO:1902531 218 0.023
regulation of cellular localization GO:0060341 263 0.023
purine ribonucleoside metabolic process GO:0046128 168 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
organic acid metabolic process GO:0006082 292 0.023
organic cyclic compound catabolic process GO:1901361 175 0.023
calcium ion transport GO:0006816 131 0.023
intracellular transport GO:0046907 185 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.022
divalent inorganic cation homeostasis GO:0072507 165 0.022
positive regulation of rna metabolic process GO:0051254 203 0.022
organelle organization GO:0006996 266 0.021
cellular calcium ion homeostasis GO:0006874 160 0.021
regulation of signal transduction GO:0009966 318 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
cation homeostasis GO:0055080 195 0.021
cellular component movement GO:0006928 248 0.020
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.020
regulation of hormone secretion GO:0046883 106 0.020
response to bacterium GO:0009617 200 0.020
regulation of neurogenesis GO:0050767 247 0.020
cellular catabolic process GO:0044248 295 0.020
regulation of protein modification process GO:0031399 194 0.020
metal ion homeostasis GO:0055065 186 0.020
divalent inorganic cation transport GO:0072511 134 0.020
response to lipopolysaccharide GO:0032496 191 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.020
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.020
regulation of blood vessel size GO:0050880 89 0.020
positive regulation of molecular function GO:0044093 230 0.020
regulation of apoptotic process GO:0042981 335 0.020
protein complex subunit organization GO:0071822 302 0.019
multi organism reproductive process GO:0044703 262 0.019
ribonucleotide metabolic process GO:0009259 231 0.019
sensory organ development GO:0007423 74 0.019
cytosolic calcium ion homeostasis GO:0051480 140 0.019
cellular amino acid metabolic process GO:0006520 107 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
neuron development GO:0048666 286 0.019
positive regulation of cell proliferation GO:0008284 249 0.019
multicellular organismal reproductive process GO:0048609 233 0.019
regulation of secretion by cell GO:1903530 208 0.019
regulation of transferase activity GO:0051338 123 0.019
cellular response to acid chemical GO:0071229 75 0.019
ribonucleotide catabolic process GO:0009261 136 0.019
positive regulation of response to stimulus GO:0048584 285 0.018
response to growth factor GO:0070848 189 0.018
positive regulation of cell development GO:0010720 176 0.018
regulation of secretion GO:0051046 224 0.018
apoptotic process GO:0006915 381 0.018
cell growth GO:0016049 104 0.018
nucleobase containing small molecule metabolic process GO:0055086 316 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.018
reproductive process GO:0022414 372 0.018
purine containing compound metabolic process GO:0072521 253 0.018
purine ribonucleotide metabolic process GO:0009150 227 0.018
positive regulation of phosphate metabolic process GO:0045937 262 0.018
protein localization GO:0008104 191 0.018
growth GO:0040007 165 0.018
regulation of rna biosynthetic process GO:2001141 381 0.017
positive regulation of cellular component movement GO:0051272 102 0.017
carbohydrate derivative catabolic process GO:1901136 147 0.017
peptide hormone secretion GO:0030072 84 0.017
nitrogen compound transport GO:0071705 229 0.017
regulation of rna metabolic process GO:0051252 391 0.017
regulation of cell proliferation GO:0042127 359 0.017
regulation of system process GO:0044057 208 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.017
positive regulation of biosynthetic process GO:0009891 319 0.017
cell cell signaling GO:0007267 335 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
regulation of metal ion transport GO:0010959 118 0.017
single organism catabolic process GO:0044712 283 0.016
response to nutrient GO:0007584 248 0.016
organonitrogen compound biosynthetic process GO:1901566 167 0.016
negative regulation of secretion GO:0051048 82 0.016
regulation of neuron projection development GO:0010975 161 0.016
nucleotide catabolic process GO:0009166 139 0.016
cytoplasmic transport GO:0016482 115 0.016
positive regulation of locomotion GO:0040017 102 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
brain development GO:0007420 247 0.016
negative regulation of cell differentiation GO:0045596 99 0.016
ribose phosphate metabolic process GO:0019693 235 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
response to glucocorticoid GO:0051384 223 0.015
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.015
negative regulation of cell communication GO:0010648 158 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
cellular response to stress GO:0033554 269 0.015
nucleoside metabolic process GO:0009116 179 0.015
single organism intracellular transport GO:1902582 166 0.015
protein transport GO:0015031 132 0.015
purine ribonucleotide catabolic process GO:0009154 136 0.015
lipid metabolic process GO:0006629 283 0.015
negative regulation of signaling GO:0023057 157 0.015
negative regulation of cellular biosynthetic process GO:0031327 161 0.015
ion homeostasis GO:0050801 212 0.015
negative regulation of biosynthetic process GO:0009890 168 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
single organism reproductive process GO:0044702 297 0.015
rna biosynthetic process GO:0032774 380 0.015
negative regulation of catalytic activity GO:0043086 103 0.015
nucleoside triphosphate catabolic process GO:0009143 123 0.014
central nervous system development GO:0007417 311 0.014
nucleoside phosphate catabolic process GO:1901292 140 0.014
organophosphate catabolic process GO:0046434 148 0.014
enzyme linked receptor protein signaling pathway GO:0007167 116 0.014
response to glucose GO:0009749 136 0.014
localization of cell GO:0051674 202 0.014
transmission of nerve impulse GO:0019226 42 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.014
negative regulation of molecular function GO:0044092 133 0.014
regulation of anatomical structure size GO:0090066 135 0.014
cellular lipid metabolic process GO:0044255 208 0.013
transmembrane transport GO:0055085 412 0.013
carbohydrate derivative metabolic process GO:1901135 346 0.013
divalent metal ion transport GO:0070838 132 0.013
catabolic process GO:0009056 351 0.013
regulation of cell migration GO:0030334 128 0.013
regulation of response to stress GO:0080134 126 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
organ morphogenesis GO:0009887 75 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
defense response GO:0006952 194 0.013
ribonucleoside triphosphate catabolic process GO:0009203 122 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
peptide transport GO:0015833 97 0.013
nucleotide metabolic process GO:0009117 279 0.013
circulatory system process GO:0003013 183 0.013
heterocycle catabolic process GO:0046700 167 0.013
response to vitamin GO:0033273 131 0.013
cellular response to endogenous stimulus GO:0071495 377 0.013
regulation of homeostatic process GO:0032844 101 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
gliogenesis GO:0042063 93 0.013
regeneration GO:0031099 163 0.013
organonitrogen compound catabolic process GO:1901565 179 0.013
macromolecular complex subunit organization GO:0043933 339 0.012
single organism organelle organization GO:1902589 180 0.012
protein complex biogenesis GO:0070271 263 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
positive regulation of signal transduction GO:0009967 175 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
single organism behavior GO:0044708 130 0.012
chemosensory behavior GO:0007635 2 0.012
amide transport GO:0042886 105 0.012
gastrulation GO:0007369 2 0.012
purine ribonucleoside catabolic process GO:0046130 124 0.012
glial cell differentiation GO:0010001 65 0.012
ribonucleoside catabolic process GO:0042454 126 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
response to oxidative stress GO:0006979 186 0.012
neuronal action potential GO:0019228 35 0.012
spermatogenesis GO:0007283 99 0.012
regulation of cell motility GO:2000145 131 0.012
cellular component morphogenesis GO:0032989 155 0.012
regulation of mapk cascade GO:0043408 116 0.012
positive regulation of secretion GO:0051047 140 0.012
regulation of cellular component movement GO:0051270 150 0.012
positive regulation of neuron differentiation GO:0045666 126 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
regulation of calcium ion transport GO:0051924 77 0.011
positive regulation of ion transport GO:0043270 94 0.011
gamete generation GO:0007276 124 0.011
regulation of phosphorylation GO:0042325 248 0.011
cell motility GO:0048870 202 0.011
regulation of behavior GO:0050795 61 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
cell part morphogenesis GO:0032990 123 0.011
response to purine containing compound GO:0014074 126 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
response to ethanol GO:0045471 162 0.011
regulation of membrane potential GO:0042391 110 0.011
response to decreased oxygen levels GO:0036293 237 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.011
axis specification GO:0009798 4 0.011
axon development GO:0061564 96 0.011
regulation of insulin secretion GO:0050796 65 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
regulation of response to wounding GO:1903034 69 0.011
regulation of programmed cell death GO:0043067 341 0.011
ribonucleoside triphosphate metabolic process GO:0009199 141 0.011
regulation of locomotion GO:0040012 148 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
multicellular organism growth GO:0035264 1 0.011
nucleoside catabolic process GO:0009164 126 0.011
peptide secretion GO:0002790 86 0.011
muscle system process GO:0003012 115 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
regulation of response to external stimulus GO:0032101 106 0.011
embryonic pattern specification GO:0009880 1 0.011
purine containing compound catabolic process GO:0072523 138 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
regulation of kinase activity GO:0043549 117 0.011
peptidyl amino acid modification GO:0018193 126 0.011
vascular process in circulatory system GO:0003018 96 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
retina morphogenesis in camera type eye GO:0060042 1 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
guanosine containing compound catabolic process GO:1901069 71 0.010
hematopoietic progenitor cell differentiation GO:0002244 2 0.010
macromolecular complex assembly GO:0065003 273 0.010
regulation of hydrolase activity GO:0051336 143 0.010
guanosine containing compound metabolic process GO:1901068 74 0.010
multicellular organism reproduction GO:0032504 233 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
response to cytokine GO:0034097 215 0.010
positive regulation of catalytic activity GO:0043085 184 0.010
monovalent inorganic cation transport GO:0015672 172 0.010
dna metabolic process GO:0006259 96 0.010
response to ketone GO:1901654 182 0.010
negative regulation of apoptotic process GO:0043066 181 0.010
negative regulation of transcription dna templated GO:0045892 116 0.010
camera type eye development GO:0043010 48 0.010
regulation of cell projection organization GO:0031344 175 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
aging GO:0007568 241 0.010
epithelium development GO:0060429 96 0.010
rho protein signal transduction GO:0007266 11 0.010

Spink4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017
sensory system disease DOID:0050155 0 0.012
disease of metabolism DOID:0014667 0 0.010