Rattus norvegicus

0 known processes

Pld4

phospholipase D family, member 4

Pld4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
metanephric glomerulus morphogenesis GO:0072275 1 0.325
cell activation GO:0001775 97 0.221
cellular amino acid metabolic process GO:0006520 107 0.166
platelet derived growth factor receptor alpha signaling pathway GO:0035790 1 0.140
b cell differentiation GO:0030183 2 0.137
organophosphate metabolic process GO:0019637 370 0.136
response to acid chemical GO:0001101 222 0.133
nucleic acid templated transcription GO:0097659 379 0.133
regulation of protein phosphorylation GO:0001932 183 0.131
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.128
regulation of cellular amine metabolic process GO:0033238 8 0.127
carbohydrate derivative metabolic process GO:1901135 346 0.126
response to ketone GO:1901654 182 0.119
amine metabolic process GO:0009308 38 0.119
cellular response to oxygen containing compound GO:1901701 386 0.118
regulation of b cell differentiation GO:0045577 1 0.117
peptidyl amino acid modification GO:0018193 126 0.113
response to other organism GO:0051707 220 0.111
positive regulation of chemotaxis GO:0050921 23 0.110
cellular amine metabolic process GO:0044106 38 0.106
cellular ketone metabolic process GO:0042180 51 0.104
regulation of cell proliferation GO:0042127 359 0.104
regulation of cellular amino acid metabolic process GO:0006521 2 0.101
protein phosphorylation GO:0006468 345 0.100
negative regulation of macromolecule metabolic process GO:0010605 260 0.100
carboxylic acid metabolic process GO:0019752 289 0.099
regulation of cellular ketone metabolic process GO:0010565 27 0.096
immune system process GO:0002376 204 0.094
Mouse
regulation of molecular function GO:0065009 398 0.090
negative regulation of apoptotic process GO:0043066 181 0.089
transcription from rna polymerase ii promoter GO:0006366 252 0.085
muscle system process GO:0003012 115 0.083
response to glucocorticoid GO:0051384 223 0.081
regulation of system process GO:0044057 208 0.081
regulation of cellular protein metabolic process GO:0032268 267 0.080
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.079
comma shaped body morphogenesis GO:0072049 2 0.075
positive regulation of cell proliferation GO:0008284 249 0.075
regulation of phosphorus metabolic process GO:0051174 349 0.074
glomerulus morphogenesis GO:0072102 1 0.073
s shaped body morphogenesis GO:0072050 2 0.073
regulation of intracellular signal transduction GO:1902531 218 0.071
response to peptide GO:1901652 292 0.069
cellular response to endogenous stimulus GO:0071495 377 0.068
regulation of nucleic acid templated transcription GO:1903506 380 0.068
oxoacid metabolic process GO:0043436 290 0.065
regulation of programmed cell death GO:0043067 341 0.064
defense response GO:0006952 194 0.063
regulation of catalytic activity GO:0050790 304 0.063
regulation of cellular component movement GO:0051270 150 0.060
organic acid metabolic process GO:0006082 292 0.059
cellular component assembly GO:0022607 360 0.059
negative regulation of programmed cell death GO:0043069 183 0.058
negative regulation of cell death GO:0060548 229 0.057
salivary gland morphogenesis GO:0007435 1 0.057
regulation of phosphate metabolic process GO:0019220 349 0.056
leukocyte activation GO:0045321 76 0.055
cation transport GO:0006812 382 0.055
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.053
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.053
cell migration GO:0016477 197 0.052
pro t cell differentiation GO:0002572 1 0.052
regulation of jak stat cascade GO:0046425 21 0.051
positive regulation of biosynthetic process GO:0009891 319 0.051
programmed cell death GO:0012501 392 0.051
negative regulation of lymphocyte activation GO:0051250 10 0.048
macromolecular complex assembly GO:0065003 273 0.048
rna biosynthetic process GO:0032774 380 0.048
positive regulation of molecular function GO:0044093 230 0.048
regulation of phosphorylation GO:0042325 248 0.047
myeloid progenitor cell differentiation GO:0002318 1 0.046
macromolecular complex subunit organization GO:0043933 339 0.045
regulation of protein metabolic process GO:0051246 289 0.045
response to wounding GO:0009611 254 0.045
positive regulation of protein metabolic process GO:0051247 178 0.045
wound healing GO:0042060 122 0.045
granulocyte migration GO:0097530 16 0.045
regulation of immune system process GO:0002682 123 0.044
regulation of leukocyte migration GO:0002685 24 0.044
central nervous system development GO:0007417 311 0.044
regulation of rna metabolic process GO:0051252 391 0.043
cellular response to growth factor stimulus GO:0071363 162 0.043
cell motility GO:0048870 202 0.043
transcription dna templated GO:0006351 377 0.043
positive regulation of cell communication GO:0010647 271 0.043
regulation of homeostatic process GO:0032844 101 0.043
positive regulation of cellular amine metabolic process GO:0033240 3 0.043
apoptotic process GO:0006915 381 0.043
intracellular signal transduction GO:0035556 314 0.042
response to toxic substance GO:0009636 133 0.042
positive regulation of cellular protein metabolic process GO:0032270 167 0.041
oxidation reduction process GO:0055114 304 0.041
cellular response to lipid GO:0071396 201 0.041
sequestering of metal ion GO:0051238 9 0.040
lipid metabolic process GO:0006629 283 0.040
regulation of signal transduction GO:0009966 318 0.039
regulation of protein modification process GO:0031399 194 0.039
cellular response to glucocorticoid stimulus GO:0071385 68 0.039
response to peptide hormone GO:0043434 278 0.039
cell migration involved in kidney development GO:0035787 2 0.038
regulation of muscle system process GO:0090257 79 0.037
positive regulation of response to stimulus GO:0048584 285 0.037
positive regulation of protein phosphorylation GO:0001934 135 0.037
granulocyte chemotaxis GO:0071621 15 0.037
positive regulation of catalytic activity GO:0043085 184 0.037
metanephric comma shaped body morphogenesis GO:0072278 2 0.036
response to external biotic stimulus GO:0043207 221 0.036
nucleobase containing small molecule metabolic process GO:0055086 316 0.035
regulation of cell differentiation GO:0045595 320 0.035
response to biotic stimulus GO:0009607 226 0.035
cellular response to hormone stimulus GO:0032870 247 0.035
behavior GO:0007610 205 0.035
regulation of rna biosynthetic process GO:2001141 381 0.035
positive regulation of cellular component movement GO:0051272 102 0.035
regulation of transferase activity GO:0051338 123 0.035
cell junction maintenance GO:0034331 1 0.034
regulation of protein kinase activity GO:0045859 105 0.034
nuclear transport GO:0051169 49 0.033
regulation of kinase activity GO:0043549 117 0.033
metanephric s shaped body morphogenesis GO:0072284 2 0.033
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.032
nucleoside phosphate metabolic process GO:0006753 283 0.032
salivary gland development GO:0007431 3 0.032
cellular lipid metabolic process GO:0044255 208 0.032
cellular response to organic cyclic compound GO:0071407 202 0.031
nucleotide metabolic process GO:0009117 279 0.031
positive regulation of immune system process GO:0002684 90 0.031
protein complex subunit organization GO:0071822 302 0.031
negative regulation of metabolic process GO:0009892 331 0.031
negative regulation of immune system process GO:0002683 39 0.031
positive regulation of multicellular organismal process GO:0051240 387 0.030
cellular ion homeostasis GO:0006873 184 0.030
hematopoietic progenitor cell differentiation GO:0002244 2 0.030
Mouse
organ regeneration GO:0031100 101 0.030
muscle contraction GO:0006936 88 0.030
glial cell differentiation GO:0010001 65 0.030
regulation of cell migration GO:0030334 128 0.029
positive regulation of phosphorus metabolic process GO:0010562 262 0.029
cellular chemical homeostasis GO:0055082 247 0.029
regulation of apoptotic process GO:0042981 335 0.029
rna metabolic process GO:0016070 406 0.029
negative regulation of multicellular organismal process GO:0051241 203 0.029
immunoglobulin mediated immune response GO:0016064 4 0.028
regulation of anatomical structure size GO:0090066 135 0.028
renal system development GO:0072001 67 0.028
regulation of cellular component organization GO:0051128 368 0.028
lymphoid progenitor cell differentiation GO:0002320 2 0.028
aging GO:0007568 241 0.027
neurological system process GO:0050877 219 0.027
positive regulation of protein modification process GO:0031401 142 0.027
positive regulation of signaling GO:0023056 270 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
positive regulation of leukocyte migration GO:0002687 21 0.026
divalent metal ion transport GO:0070838 132 0.025
negative regulation of cellular metabolic process GO:0031324 281 0.025
regulation of actin filament based process GO:0032970 42 0.025
regulation of neurogenesis GO:0050767 247 0.025
positive regulation of cell migration GO:0030335 96 0.025
negative regulation of protein metabolic process GO:0051248 114 0.025
regulation of secretion by cell GO:1903530 208 0.024
response to molecule of bacterial origin GO:0002237 194 0.024
divalent inorganic cation transport GO:0072511 134 0.024
cellular response to lipopolysaccharide GO:0071222 55 0.024
regulation of response to wounding GO:1903034 69 0.024
positive regulation of leukocyte chemotaxis GO:0002690 10 0.024
positive regulation of cell motility GO:2000147 97 0.024
b cell mediated immunity GO:0019724 4 0.024
intracellular transport GO:0046907 185 0.024
maintenance of location GO:0051235 17 0.024
protein complex assembly GO:0006461 263 0.024
positive regulation of macrophage chemotaxis GO:0010759 2 0.023
cellular cation homeostasis GO:0030003 180 0.023
purine containing compound metabolic process GO:0072521 253 0.023
regulation of cell activation GO:0050865 50 0.023
negative regulation of gene expression GO:0010629 199 0.023
regulation of ion transport GO:0043269 245 0.023
regulation of behavior GO:0050795 61 0.023
cellular homeostasis GO:0019725 252 0.023
positive regulation of behavior GO:0048520 38 0.023
regulation of cell motility GO:2000145 131 0.023
cellular component movement GO:0006928 248 0.023
establishment of protein localization GO:0045184 141 0.023
cellular response to steroid hormone stimulus GO:0071383 93 0.022
positive regulation of secretion by cell GO:1903532 128 0.022
reproductive process GO:0022414 372 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
peptidyl tyrosine phosphorylation GO:0018108 72 0.022
brain development GO:0007420 247 0.021
response to extracellular stimulus GO:0009991 380 0.021
regulation of leukocyte activation GO:0002694 45 0.021
ribose phosphate metabolic process GO:0019693 235 0.021
spindle organization GO:0007051 2 0.021
regulation of hydrolase activity GO:0051336 143 0.021
cellular response to nitrogen compound GO:1901699 210 0.021
glycosaminoglycan biosynthetic process GO:0006024 4 0.021
muscle cell proliferation GO:0033002 84 0.020
macrophage chemotaxis GO:0048246 2 0.020
cell projection organization GO:0030030 302 0.020
positive regulation of chemokine production GO:0032722 4 0.020
organelle organization GO:0006996 266 0.020
positive regulation of protein kinase activity GO:0045860 73 0.020
glycosyl compound catabolic process GO:1901658 126 0.020
regulation of nervous system development GO:0051960 264 0.020
regulation of cell morphogenesis GO:0022604 77 0.019
regulation of cytokine production GO:0001817 56 0.019
protein complex biogenesis GO:0070271 263 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
sensory perception of pain GO:0019233 73 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.018
chemical homeostasis GO:0048878 292 0.018
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.018
immune response GO:0006955 104 0.018
purine nucleoside metabolic process GO:0042278 169 0.018
regulation of myeloid cell differentiation GO:0045637 12 0.018
positive regulation of kinase activity GO:0033674 77 0.018
metanephric mesenchymal cell migration GO:0035789 2 0.018
positive regulation of cytokine production GO:0001819 42 0.018
response to ethanol GO:0045471 162 0.018
purine nucleotide metabolic process GO:0006163 229 0.018
cellular calcium ion homeostasis GO:0006874 160 0.018
regulation of response to external stimulus GO:0032101 106 0.018
response to vitamin GO:0033273 131 0.018
response to cytokine GO:0034097 215 0.018
triglyceride homeostasis GO:0070328 2 0.018
cellular response to corticosteroid stimulus GO:0071384 69 0.018
response to hexose GO:0009746 144 0.018
regulation of chemotaxis GO:0050920 29 0.018
positive regulation of cell death GO:0010942 184 0.017
positive regulation of gene expression GO:0010628 244 0.017
single organism organelle organization GO:1902589 180 0.017
regulation of metal ion transport GO:0010959 118 0.017
jak stat cascade GO:0007259 26 0.017
single organism intracellular transport GO:1902582 166 0.017
mononuclear cell proliferation GO:0032943 29 0.017
cytoplasmic transport GO:0016482 115 0.017
negative regulation of phosphorus metabolic process GO:0010563 80 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
response to nutrient GO:0007584 248 0.017
negative regulation of phosphate metabolic process GO:0045936 80 0.017
regulation of neuron differentiation GO:0045664 208 0.017
regulation of response to stress GO:0080134 126 0.016
positive regulation of phosphorylation GO:0042327 177 0.016
response to carbohydrate GO:0009743 183 0.016
response to retinoic acid GO:0032526 63 0.016
response to growth factor GO:0070848 189 0.016
cellular protein complex assembly GO:0043623 44 0.016
positive regulation of jak stat cascade GO:0046427 19 0.016
response to nutrient levels GO:0031667 370 0.016
nucleoside catabolic process GO:0009164 126 0.016
cytokine production GO:0001816 61 0.016
negative regulation of biosynthetic process GO:0009890 168 0.016
urogenital system development GO:0001655 78 0.016
camera type eye development GO:0043010 48 0.016
negative regulation of b cell differentiation GO:0045578 1 0.016
response to corticosteroid GO:0031960 235 0.016
cellular component maintenance GO:0043954 4 0.016
glycerolipid metabolic process GO:0046486 67 0.016
cellular response to alcohol GO:0097306 87 0.016
metal ion transport GO:0030001 289 0.016
positive regulation of hydrolase activity GO:0051345 86 0.015
neuron differentiation GO:0030182 368 0.015
mitotic spindle organization GO:0007052 2 0.015
response to insulin GO:0032868 133 0.015
response to inorganic substance GO:0010035 377 0.015
regulation of protein serine threonine kinase activity GO:0071900 64 0.015
metanephric glomerulus development GO:0072224 3 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.015
peptidyl tyrosine modification GO:0018212 72 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
single organism biosynthetic process GO:0044711 342 0.015
cellular response to insulin stimulus GO:0032869 81 0.015
sequestering of calcium ion GO:0051208 8 0.015
smooth muscle cell proliferation GO:0048659 77 0.015
reproduction GO:0000003 245 0.015
secretion by cell GO:0032940 248 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.014
organic anion transport GO:0015711 132 0.014
single organism catabolic process GO:0044712 283 0.014
positive regulation of phosphate metabolic process GO:0045937 262 0.014
locomotion GO:0040011 237 0.014
positive regulation of nervous system development GO:0051962 178 0.014
regulation of cytoskeleton organization GO:0051493 49 0.014
growth GO:0040007 165 0.014
single organism reproductive process GO:0044702 297 0.014
regulation of macrophage chemotaxis GO:0010758 2 0.014
cell cycle GO:0007049 101 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.014
regulation of neuron death GO:1901214 115 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
cellular response to stress GO:0033554 269 0.014
positive regulation of response to wounding GO:1903036 34 0.014
regulation of cellular localization GO:0060341 263 0.014
anterior posterior pattern specification GO:0009952 1 0.014
positive regulation of erk1 and erk2 cascade GO:0070374 29 0.014
cellular catabolic process GO:0044248 295 0.014
cytosolic calcium ion transport GO:0060401 39 0.014
positive regulation of transferase activity GO:0051347 81 0.014
response to oxidative stress GO:0006979 186 0.014
localization of cell GO:0051674 202 0.014
regulation of transcription dna templated GO:0006355 374 0.014
gland development GO:0048732 155 0.014
regulation of epithelial cell proliferation GO:0050678 49 0.014
regulation of organelle organization GO:0033043 80 0.014
monocarboxylic acid metabolic process GO:0032787 152 0.014
neuron death GO:0070997 127 0.014
cell growth GO:0016049 104 0.014
negative regulation of cell proliferation GO:0008285 119 0.013
regulation of calcium ion transport GO:0051924 77 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
response to lipopolysaccharide GO:0032496 191 0.013
negative regulation of lymphocyte differentiation GO:0045620 2 0.013
nitrogen compound transport GO:0071705 229 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
actin cytoskeleton organization GO:0030036 73 0.013
aromatic compound catabolic process GO:0019439 168 0.013
regulation of catabolic process GO:0009894 113 0.013
regulation of secretion GO:0051046 224 0.013
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.013
secretion GO:0046903 307 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
regulation of neuron apoptotic process GO:0043523 83 0.013
positive regulation of leukocyte degranulation GO:0043302 4 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
negative regulation of neuron death GO:1901215 69 0.013
regulation of cell development GO:0060284 263 0.013
kidney development GO:0001822 67 0.013
positive regulation of response to external stimulus GO:0032103 51 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
regulation of cell projection organization GO:0031344 175 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
positive regulation of rna metabolic process GO:0051254 203 0.013
regulation of multicellular organismal development GO:2000026 376 0.013
multi organism reproductive process GO:0044703 262 0.013
multicellular organism reproduction GO:0032504 233 0.013
gtp catabolic process GO:0006184 71 0.013
cytoskeleton organization GO:0007010 111 0.013
lymphocyte proliferation GO:0046651 29 0.013
nucleoside metabolic process GO:0009116 179 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 32 0.012
regulation of smooth muscle cell proliferation GO:0048660 75 0.012
neuron development GO:0048666 286 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
cellular component morphogenesis GO:0032989 155 0.012
mapk cascade GO:0000165 140 0.012
response to fatty acid GO:0070542 65 0.012
macromolecule localization GO:0033036 252 0.012
epithelial cell proliferation GO:0050673 54 0.012
response to glucose GO:0009749 136 0.012
regulation of growth GO:0040008 105 0.012
tissue development GO:0009888 252 0.012
regeneration GO:0031099 163 0.012
cellular response to biotic stimulus GO:0071216 59 0.012
regulation of muscle contraction GO:0006937 53 0.012
sensory perception GO:0007600 101 0.012
gamete generation GO:0007276 124 0.012
cellular response to vascular endothelial growth factor stimulus GO:0035924 6 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
regulation of locomotion GO:0040012 148 0.012
ribonucleotide metabolic process GO:0009259 231 0.011
glucose homeostasis GO:0042593 75 0.011
oligopeptide transport GO:0006857 4 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
anion transport GO:0006820 178 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
regulation of actin cytoskeleton organization GO:0032956 30 0.011
positive regulation of protein transport GO:0051222 41 0.011
rho protein signal transduction GO:0007266 11 0.011
lipid storage GO:0019915 1 0.011
lymphocyte activation GO:0046649 43 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 24 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
regulation of ion homeostasis GO:2000021 63 0.011
phospholipid metabolic process GO:0006644 61 0.011
positive regulation of gtpase activity GO:0043547 47 0.011
cytokine mediated signaling pathway GO:0019221 43 0.011
actin filament based process GO:0030029 86 0.011
positive regulation of immune response GO:0050778 42 0.011
calcium ion transport GO:0006816 131 0.011
actin filament organization GO:0007015 42 0.011
ion homeostasis GO:0050801 212 0.011
positive regulation of apoptotic process GO:0043065 154 0.010
cytosolic calcium ion homeostasis GO:0051480 140 0.010
cellular response to carbohydrate stimulus GO:0071322 72 0.010
cardiovascular system development GO:0072358 134 0.010
positive regulation of nucleotide metabolic process GO:0045981 91 0.010
negative regulation of cell cycle phase transition GO:1901988 4 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
positive regulation of intracellular signal transduction GO:1902533 138 0.010
reactive oxygen species metabolic process GO:0072593 37 0.010
mononuclear cell migration GO:0071674 3 0.010

Pld4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.056
musculoskeletal system disease DOID:17 0 0.056
connective tissue disease DOID:65 0 0.056