Rattus norvegicus

0 known processes

Sh2d4a

SH2 domain containing 4A

Sh2d4a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular localization GO:0060341 263 0.107
positive regulation of transport GO:0051050 245 0.107
regulation of nucleic acid templated transcription GO:1903506 380 0.095
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.090
response to mineralocorticoid GO:0051385 49 0.081
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.080
positive regulation of biosynthetic process GO:0009891 319 0.077
wnt signaling pathway calcium modulating pathway GO:0007223 1 0.070
regulation of rna metabolic process GO:0051252 391 0.068
cellular metal ion homeostasis GO:0006875 172 0.068
cation homeostasis GO:0055080 195 0.068
macromolecule localization GO:0033036 252 0.068
regulation of ion transport GO:0043269 245 0.067
cation transport GO:0006812 382 0.064
cellular cation homeostasis GO:0030003 180 0.064
secretion by cell GO:0032940 248 0.061
positive regulation of cellular biosynthetic process GO:0031328 295 0.059
regulation of cellular component organization GO:0051128 368 0.058
macromolecular complex subunit organization GO:0043933 339 0.056
nitrogen compound transport GO:0071705 229 0.055
reproductive process GO:0022414 372 0.055
positive regulation of rna metabolic process GO:0051254 203 0.055
positive regulation of rna biosynthetic process GO:1902680 197 0.052
positive regulation of nucleic acid templated transcription GO:1903508 197 0.051
response to external biotic stimulus GO:0043207 221 0.049
positive regulation of gene expression GO:0010628 244 0.047
response to peptide hormone GO:0043434 278 0.047
regulation of hormone levels GO:0010817 187 0.046
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.046
negative regulation of gene expression GO:0010629 199 0.045
transcription dna templated GO:0006351 377 0.044
metal ion transport GO:0030001 289 0.044
regulation of transcription dna templated GO:0006355 374 0.043
regulation of stem cell differentiation GO:2000736 2 0.040
regulation of rna biosynthetic process GO:2001141 381 0.040
hepaticobiliary system development GO:0061008 90 0.040
response to bacterium GO:0009617 200 0.040
response to molecule of bacterial origin GO:0002237 194 0.040
oxoacid metabolic process GO:0043436 290 0.039
tissue development GO:0009888 252 0.038
cellular component assembly GO:0022607 360 0.038
gland development GO:0048732 155 0.037
intracellular signal transduction GO:0035556 314 0.037
cellular ion homeostasis GO:0006873 184 0.037
response to metal ion GO:0010038 253 0.037
transmembrane transport GO:0055085 412 0.036
rna metabolic process GO:0016070 406 0.036
nucleic acid templated transcription GO:0097659 379 0.036
regulation of response to wounding GO:1903034 69 0.035
amine metabolic process GO:0009308 38 0.035
protein phosphorylation GO:0006468 345 0.035
organic acid metabolic process GO:0006082 292 0.035
negative regulation of macromolecule metabolic process GO:0010605 260 0.035
negative regulation of metabolic process GO:0009892 331 0.035
Human
nucleobase containing small molecule metabolic process GO:0055086 316 0.034
cellular amino acid metabolic process GO:0006520 107 0.034
cellular amine metabolic process GO:0044106 38 0.032
response to estrogen GO:0043627 232 0.032
calcium ion homeostasis GO:0055074 162 0.031
rna biosynthetic process GO:0032774 380 0.030
negative regulation of cellular metabolic process GO:0031324 281 0.030
Human
response to nutrient GO:0007584 248 0.030
negative regulation of cell communication GO:0010648 158 0.030
cellular homeostasis GO:0019725 252 0.030
response to inorganic substance GO:0010035 377 0.029
negative regulation of multicellular organismal process GO:0051241 203 0.029
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.029
regulation of cellular ketone metabolic process GO:0010565 27 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
cellular divalent inorganic cation homeostasis GO:0072503 162 0.028
regulation of catalytic activity GO:0050790 304 0.027
Human
regulation of protein metabolic process GO:0051246 289 0.027
negative regulation of response to stimulus GO:0048585 155 0.027
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.027
circulatory system process GO:0003013 183 0.026
response to oxidative stress GO:0006979 186 0.026
lipid biosynthetic process GO:0008610 128 0.026
regulation of phosphorus metabolic process GO:0051174 349 0.026
Human
defense response GO:0006952 194 0.026
response to nutrient levels GO:0031667 370 0.026
regulation of programmed cell death GO:0043067 341 0.025
positive regulation of transcription dna templated GO:0045893 197 0.025
single organism intracellular transport GO:1902582 166 0.025
regulation of cell development GO:0060284 263 0.025
nucleotide metabolic process GO:0009117 279 0.025
positive regulation of molecular function GO:0044093 230 0.025
regulation of molecular function GO:0065009 398 0.025
Human
gonad development GO:0008406 104 0.024
carboxylic acid metabolic process GO:0019752 289 0.024
cellular chemical homeostasis GO:0055082 247 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.024
protein localization to organelle GO:0033365 57 0.024
response to hypoxia GO:0001666 231 0.024
organelle organization GO:0006996 266 0.023
positive regulation of developmental process GO:0051094 283 0.023
regulation of cell proliferation GO:0042127 359 0.023
head development GO:0060322 247 0.023
epithelial cell proliferation GO:0050673 54 0.023
cellular response to oxygen containing compound GO:1901701 386 0.023
ribonucleotide metabolic process GO:0009259 231 0.023
central nervous system development GO:0007417 311 0.023
female pregnancy GO:0007565 122 0.023
divalent inorganic cation homeostasis GO:0072507 165 0.023
transcription from rna polymerase ii promoter GO:0006366 252 0.023
ion homeostasis GO:0050801 212 0.023
calcium ion transport GO:0006816 131 0.022
regulation of growth GO:0040008 105 0.022
multi organism reproductive process GO:0044703 262 0.021
positive regulation of programmed cell death GO:0043068 157 0.021
positive regulation of response to stimulus GO:0048584 285 0.021
negative regulation of protein metabolic process GO:0051248 114 0.021
negative regulation of biosynthetic process GO:0009890 168 0.021
cellular response to endogenous stimulus GO:0071495 377 0.021
metal ion homeostasis GO:0055065 186 0.021
protein oligomerization GO:0051259 191 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
muscle contraction GO:0006936 88 0.020
response to acid chemical GO:0001101 222 0.020
jak stat cascade GO:0007259 26 0.020
immune system process GO:0002376 204 0.020
positive regulation of cell development GO:0010720 176 0.020
multi multicellular organism process GO:0044706 138 0.020
cellular ketone metabolic process GO:0042180 51 0.020
single organism organelle organization GO:1902589 180 0.020
g protein coupled receptor signaling pathway GO:0007186 242 0.020
protein localization GO:0008104 191 0.020
divalent inorganic cation transport GO:0072511 134 0.020
hepatocyte proliferation GO:0072574 3 0.020
single organism reproductive process GO:0044702 297 0.020
response to toxic substance GO:0009636 133 0.020
cellular response to stress GO:0033554 269 0.020
establishment of protein localization to organelle GO:0072594 44 0.019
cellular modified amino acid metabolic process GO:0006575 61 0.019
salivary gland development GO:0007431 3 0.019
positive regulation of nervous system development GO:0051962 178 0.019
intracellular transport GO:0046907 185 0.019
growth GO:0040007 165 0.019
positive regulation of secretion GO:0051047 140 0.019
synaptic transmission GO:0007268 235 0.019
response to wounding GO:0009611 254 0.019
cellular calcium ion homeostasis GO:0006874 160 0.019
peptidyl tyrosine modification GO:0018212 72 0.019
epithelial cell differentiation GO:0030855 71 0.018
positive regulation of ion transport GO:0043270 94 0.018
muscle system process GO:0003012 115 0.018
regulation of cell differentiation GO:0045595 320 0.018
secretion GO:0046903 307 0.018
organ regeneration GO:0031100 101 0.018
response to other organism GO:0051707 220 0.018
response to vitamin GO:0033273 131 0.018
liver development GO:0001889 90 0.018
regulation of secretion by cell GO:1903530 208 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
rhythmic process GO:0048511 156 0.017
cell projection organization GO:0030030 302 0.017
carbohydrate derivative metabolic process GO:1901135 346 0.017
chemical homeostasis GO:0048878 292 0.017
programmed cell death GO:0012501 392 0.017
negative regulation of signal transduction GO:0009968 83 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
negative regulation of transcription dna templated GO:0045892 116 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
purine nucleotide metabolic process GO:0006163 229 0.017
cytosolic calcium ion homeostasis GO:0051480 140 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
anion transport GO:0006820 178 0.017
organophosphate metabolic process GO:0019637 370 0.017
cellular nitrogen compound catabolic process GO:0044270 163 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
peptidyl tyrosine phosphorylation GO:0018108 72 0.016
peptide transport GO:0015833 97 0.016
single organism cellular localization GO:1902580 102 0.016
protein transport GO:0015031 132 0.016
oxidation reduction process GO:0055114 304 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
regulation of calcium ion transport GO:0051924 77 0.016
regulation of kinase activity GO:0043549 117 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
response to lipopolysaccharide GO:0032496 191 0.016
regulation of nervous system development GO:0051960 264 0.016
regulation of secretion GO:0051046 224 0.016
cellular component biogenesis GO:0044085 368 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
protein targeting GO:0006605 61 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
cell morphogenesis involved in differentiation GO:0000904 119 0.015
regulation of extracellular matrix constituent secretion GO:0003330 2 0.015
coagulation GO:0050817 28 0.015
cellular response to oxidative stress GO:0034599 76 0.015
developmental process involved in reproduction GO:0003006 159 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
potassium ion transport GO:0006813 97 0.014
divalent metal ion transport GO:0070838 132 0.014
regulation of immune system process GO:0002682 123 0.014
development of primary sexual characteristics GO:0045137 107 0.014
intracellular protein transport GO:0006886 79 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
negative regulation of nucleic acid templated transcription GO:1903507 117 0.014
response to corticosteroid GO:0031960 235 0.014
homeostatic process GO:0042592 331 0.014
protein complex biogenesis GO:0070271 263 0.014
response to oxygen levels GO:0070482 265 0.014
peptidyl amino acid modification GO:0018193 126 0.014
artery smooth muscle contraction GO:0014824 4 0.014
organic substance catabolic process GO:1901575 316 0.014
regulation of protein modification process GO:0031399 194 0.014
regulation of cellular amine metabolic process GO:0033238 8 0.014
purine containing compound metabolic process GO:0072521 253 0.014
multicellular organism reproduction GO:0032504 233 0.014
monocarboxylic acid metabolic process GO:0032787 152 0.014
reactive oxygen species metabolic process GO:0072593 37 0.014
male sex differentiation GO:0046661 64 0.014
immune response GO:0006955 104 0.013
regulation of body fluid levels GO:0050878 90 0.013
response to extracellular stimulus GO:0009991 380 0.013
response to glucocorticoid GO:0051384 223 0.013
negative regulation of signaling GO:0023057 157 0.013
dephosphorylation GO:0016311 98 0.013
Human
inorganic ion transmembrane transport GO:0098660 229 0.013
epithelium development GO:0060429 96 0.013
negative regulation of kidney development GO:0090185 2 0.013
sequestering of metal ion GO:0051238 9 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
anatomical structure morphogenesis GO:0009653 298 0.013
regulation of metal ion transport GO:0010959 118 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.013
cytoplasmic transport GO:0016482 115 0.013
behavior GO:0007610 205 0.013
cellular protein localization GO:0034613 122 0.013
multicellular organismal signaling GO:0035637 44 0.013
regulation of phosphorylation GO:0042325 248 0.013
response to corticosterone GO:0051412 40 0.013
regulation of multicellular organismal development GO:2000026 376 0.013
negative regulation of metanephros development GO:0072217 2 0.012
protein import into nucleus GO:0006606 35 0.012
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
spermatogenesis GO:0007283 99 0.012
gastrulation GO:0007369 2 0.012
response to carbohydrate GO:0009743 183 0.012
response to peptide GO:1901652 292 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
regulation of signal transduction GO:0009966 318 0.012
hormone biosynthetic process GO:0042446 25 0.012
regulation of jak stat cascade GO:0046425 21 0.012
ras protein signal transduction GO:0007265 29 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
regulation of system process GO:0044057 208 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
negative regulation of cell death GO:0060548 229 0.012
establishment of protein localization GO:0045184 141 0.012
positive regulation of signal transduction GO:0009967 175 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
neuronal action potential GO:0019228 35 0.012
cellular response to reactive oxygen species GO:0034614 55 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
sex differentiation GO:0007548 113 0.012
hormone secretion GO:0046879 115 0.012
nucleocytoplasmic transport GO:0006913 48 0.012
cellular response to external stimulus GO:0071496 118 0.012
catabolic process GO:0009056 351 0.012
negative regulation of developmental process GO:0051093 125 0.012
metanephric comma shaped body morphogenesis GO:0072278 2 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
protein localization to nucleus GO:0034504 39 0.011
male gonad development GO:0008584 59 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
protein targeting to nucleus GO:0044744 35 0.011
rho protein signal transduction GO:0007266 11 0.011
positive regulation of transferase activity GO:0051347 81 0.011
heart morphogenesis GO:0003007 3 0.011
cellular response to organic cyclic compound GO:0071407 202 0.011
steroid biosynthetic process GO:0006694 48 0.011
apoptotic process GO:0006915 381 0.011
chemotaxis GO:0006935 66 0.011
protein complex assembly GO:0006461 263 0.011
cell cell signaling GO:0007267 335 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
macromolecular complex assembly GO:0065003 273 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
tonic smooth muscle contraction GO:0014820 4 0.011
axis specification GO:0009798 4 0.011
positive regulation of signaling GO:0023056 270 0.011
single organism biosynthetic process GO:0044711 342 0.011
hormone metabolic process GO:0042445 69 0.010
regulation of neurogenesis GO:0050767 247 0.010
single organism nuclear import GO:1902593 35 0.010
cellular response to hypoxia GO:0071456 51 0.010
small molecule biosynthetic process GO:0044283 124 0.010
neuron projection development GO:0031175 273 0.010
ossification GO:0001503 70 0.010
ion transmembrane transport GO:0034220 365 0.010
energy derivation by oxidation of organic compounds GO:0015980 46 0.010
protein heterooligomerization GO:0051291 89 0.010
brain development GO:0007420 247 0.010
circadian rhythm GO:0007623 88 0.010
regulation of t cell migration GO:2000404 1 0.010
morphogenesis of a polarized epithelium GO:0001738 1 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.010
regulation of intracellular signal transduction GO:1902531 218 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.010

Sh2d4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.018
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.013
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013