Rattus norvegicus

0 known processes

Gzma

granzyme A

Gzma biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of rna metabolic process GO:0051252 391 0.155
immune response GO:0006955 104 0.147
positive regulation of biosynthetic process GO:0009891 319 0.137
apoptotic process GO:0006915 381 0.125
Human
rna biosynthetic process GO:0032774 380 0.120
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.117
positive regulation of response to stimulus GO:0048584 285 0.110
positive regulation of cellular biosynthetic process GO:0031328 295 0.105
cellular homeostasis GO:0019725 252 0.105
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.105
regulation of rna biosynthetic process GO:2001141 381 0.098
positive regulation of gene expression GO:0010628 244 0.094
chemical homeostasis GO:0048878 292 0.092
regulation of t cell chemotaxis GO:0010819 1 0.088
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.086
regulation of phosphorylation GO:0042325 248 0.085
programmed cell death GO:0012501 392 0.080
Human Rat
positive regulation of interleukin 1 alpha biosynthetic process GO:0050726 1 0.078
intracellular signal transduction GO:0035556 314 0.078
regulation of programmed cell death GO:0043067 341 0.077
Human Rat
transcription dna templated GO:0006351 377 0.076
immune system process GO:0002376 204 0.076
cellular chemical homeostasis GO:0055082 247 0.075
regulation of mast cell chemotaxis GO:0060753 1 0.069
cellular ion homeostasis GO:0006873 184 0.069
cellular amine metabolic process GO:0044106 38 0.067
amine metabolic process GO:0009308 38 0.065
interleukin 1 alpha biosynthetic process GO:0050719 1 0.065
regulation of cell differentiation GO:0045595 320 0.064
cell activation GO:0001775 97 0.064
cellular amino acid metabolic process GO:0006520 107 0.064
cell migration GO:0016477 197 0.063
regulation of multicellular organismal development GO:2000026 376 0.063
response to decreased oxygen levels GO:0036293 237 0.063
regulation of nucleic acid templated transcription GO:1903506 380 0.062
positive regulation of phosphorus metabolic process GO:0010562 262 0.062
regulation of hydrolase activity GO:0051336 143 0.062
Human
rna metabolic process GO:0016070 406 0.061
oxoacid metabolic process GO:0043436 290 0.060
regulation of cell proliferation GO:0042127 359 0.060
response to extracellular stimulus GO:0009991 380 0.060
regulation of cellular protein metabolic process GO:0032268 267 0.058
positive regulation of cell death GO:0010942 184 0.058
Human Rat
regulation of protein metabolic process GO:0051246 289 0.057
positive regulation of cellular amine metabolic process GO:0033240 3 0.057
reproductive process GO:0022414 372 0.056
cellular response to vitamin k GO:0071307 1 0.056
cellular response to oxygen containing compound GO:1901701 386 0.056
homeostatic process GO:0042592 331 0.055
positive regulation of cell communication GO:0010647 271 0.054
regulation of molecular function GO:0065009 398 0.054
Human
regulation of transcription dna templated GO:0006355 374 0.054
response to nutrient levels GO:0031667 370 0.051
negative regulation of metabolic process GO:0009892 331 0.051
Human
organic acid metabolic process GO:0006082 292 0.051
cation homeostasis GO:0055080 195 0.050
organic hydroxy compound metabolic process GO:1901615 115 0.050
calcium ion homeostasis GO:0055074 162 0.049
defense response GO:0006952 194 0.049
regulation of signal transduction GO:0009966 318 0.049
cellular cation homeostasis GO:0030003 180 0.048
positive regulation of protein metabolic process GO:0051247 178 0.048
regulation of immune system process GO:0002682 123 0.048
biological adhesion GO:0022610 110 0.047
positive regulation of phosphate metabolic process GO:0045937 262 0.046
regulation of cellular amino acid metabolic process GO:0006521 2 0.046
regulation of cellular ketone metabolic process GO:0010565 27 0.045
regulation of cellular amine metabolic process GO:0033238 8 0.045
negative regulation of gene expression GO:0010629 199 0.045
negative regulation of cellular metabolic process GO:0031324 281 0.044
Human
single organism reproductive process GO:0044702 297 0.043
wound healing GO:0042060 122 0.043
regulation of neurogenesis GO:0050767 247 0.042
cellular response to oxidative stress GO:0034599 76 0.042
cellular calcium ion homeostasis GO:0006874 160 0.041
inflammatory response GO:0006954 150 0.041
response to oxygen levels GO:0070482 265 0.040
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.040
response to glucocorticoid GO:0051384 223 0.039
response to external biotic stimulus GO:0043207 221 0.039
negative regulation of signal transduction GO:0009968 83 0.039
response to alkyl hydroperoxide GO:0033195 1 0.039
regulation of protein modification process GO:0031399 194 0.039
positive regulation of cell differentiation GO:0045597 217 0.039
organophosphate metabolic process GO:0019637 370 0.038
response to growth factor GO:0070848 189 0.038
regulation of catalytic activity GO:0050790 304 0.038
Human
regulation of nervous system development GO:0051960 264 0.038
regulation of cellular localization GO:0060341 263 0.038
cellular metal ion homeostasis GO:0006875 172 0.038
metal ion homeostasis GO:0055065 186 0.037
carboxylic acid metabolic process GO:0019752 289 0.036
cell cell signaling GO:0007267 335 0.036
nucleobase containing small molecule metabolic process GO:0055086 316 0.036
positive regulation of transcription dna templated GO:0045893 197 0.036
regulation of hormone levels GO:0010817 187 0.036
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.035
response to interleukin 13 GO:0035962 3 0.035
negative regulation of macromolecule metabolic process GO:0010605 260 0.035
Human
response to carbohydrate GO:0009743 183 0.035
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.034
peptidyl amino acid modification GO:0018193 126 0.033
regulation of apoptotic process GO:0042981 335 0.033
Human
negative regulation of programmed cell death GO:0043069 183 0.033
multi organism reproductive process GO:0044703 262 0.033
t cell extravasation GO:0072683 1 0.033
circulatory system process GO:0003013 183 0.032
regulation of phosphate metabolic process GO:0019220 349 0.032
regulation of neuron differentiation GO:0045664 208 0.032
gland development GO:0048732 155 0.032
positive regulation of immune system process GO:0002684 90 0.032
negative regulation of developmental process GO:0051093 125 0.031
positive regulation of developmental process GO:0051094 283 0.031
positive regulation of neurogenesis GO:0050769 165 0.030
response to hypoxia GO:0001666 231 0.030
intracellular transport GO:0046907 185 0.030
metal ion transport GO:0030001 289 0.030
response to cytokine GO:0034097 215 0.030
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.030
ion homeostasis GO:0050801 212 0.030
cation transport GO:0006812 382 0.030
positive regulation of cellular protein metabolic process GO:0032270 167 0.030
macromolecule localization GO:0033036 252 0.029
cellular ketone metabolic process GO:0042180 51 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
localization of cell GO:0051674 202 0.029
negative regulation of response to tumor cell GO:0002835 2 0.029
negative regulation of cell death GO:0060548 229 0.029
central nervous system development GO:0007417 311 0.028
multicellular organism reproduction GO:0032504 233 0.028
protein phosphorylation GO:0006468 345 0.028
regulation of necroptotic process GO:0060544 2 0.028
Rat
negative regulation of cellular biosynthetic process GO:0031327 161 0.028
negative regulation of rna biosynthetic process GO:1902679 118 0.028
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.028
t helper 1 cell extravasation GO:0035687 1 0.027
proteolysis GO:0006508 175 0.027
Human Mouse Rat
regulation of natural killer cell mediated immune response to tumor cell GO:0002855 1 0.027
cellular response to endogenous stimulus GO:0071495 377 0.027
transmembrane transport GO:0055085 412 0.027
regulation of intracellular signal transduction GO:1902531 218 0.027
purine containing compound metabolic process GO:0072521 253 0.027
single organism intracellular transport GO:1902582 166 0.027
cellular response to hydroperoxide GO:0071447 2 0.027
g protein coupled receptor signaling pathway GO:0007186 242 0.027
response to nutrient GO:0007584 248 0.027
positive regulation of cell proliferation GO:0008284 249 0.027
positive regulation of signaling GO:0023056 270 0.026
alcohol metabolic process GO:0006066 77 0.026
regulation of lymphocyte chemotaxis GO:1901623 1 0.026
acute inflammatory response GO:0002526 58 0.026
regulation of t cell migration GO:2000404 1 0.026
hematopoietic or lymphoid organ development GO:0048534 36 0.026
pseudopodium assembly GO:0031269 3 0.025
cell type specific apoptotic process GO:0097285 134 0.025
positive regulation of interleukin 1 biosynthetic process GO:0045362 1 0.025
nucleotide metabolic process GO:0009117 279 0.025
positive regulation of cell development GO:0010720 176 0.025
necroptotic process GO:0070266 2 0.025
Rat
reproduction GO:0000003 245 0.025
response to estrogen GO:0043627 232 0.025
negative regulation of innate immune response GO:0045824 4 0.024
regulation of cell killing GO:0031341 12 0.024
positive regulation of signal transduction GO:0009967 175 0.024
negative regulation of multicellular organismal process GO:0051241 203 0.024
aging GO:0007568 241 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
divalent inorganic cation homeostasis GO:0072507 165 0.024
positive regulation of phosphorylation GO:0042327 177 0.024
organelle organization GO:0006996 266 0.024
purine ribonucleotide metabolic process GO:0009150 227 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
positive regulation of nucleic acid templated transcription GO:1903508 197 0.024
regulation of cell development GO:0060284 263 0.023
hemopoiesis GO:0030097 34 0.023
secretion by cell GO:0032940 248 0.023
neuron projection development GO:0031175 273 0.023
single organism biosynthetic process GO:0044711 342 0.023
positive regulation of t cell migration GO:2000406 1 0.023
positive regulation of programmed cell death GO:0043068 157 0.023
Human Rat
positive regulation of neuron differentiation GO:0045666 126 0.023
positive regulation of rna biosynthetic process GO:1902680 197 0.023
regulation of protein phosphorylation GO:0001932 183 0.022
calcium ion transport GO:0006816 131 0.022
single organism organelle organization GO:1902589 180 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.022
Human
cellular response to alcohol GO:0097306 87 0.022
negative regulation of rna metabolic process GO:0051253 123 0.022
interleukin 1 biosynthetic process GO:0042222 1 0.022
negative regulation of signaling GO:0023057 157 0.022
response to inorganic substance GO:0010035 377 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
nucleoside phosphate metabolic process GO:0006753 283 0.021
transcription from rna polymerase ii promoter GO:0006366 252 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.021
Human
positive regulation of cellular component organization GO:0051130 200 0.021
locomotion GO:0040011 237 0.021
positive regulation of transport GO:0051050 245 0.021
hormone secretion GO:0046879 115 0.021
negative regulation of cell communication GO:0010648 158 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
protein complex subunit organization GO:0071822 302 0.020
cytosolic calcium ion homeostasis GO:0051480 140 0.020
helper t cell extravasation GO:0035684 1 0.020
myeloid leukocyte differentiation GO:0002573 20 0.020
negative regulation of immune response to tumor cell GO:0002838 2 0.020
cellular divalent inorganic cation homeostasis GO:0072503 162 0.020
cd8 positive alpha beta t cell extravasation GO:0035697 0 0.020
regulation of immune response to tumor cell GO:0002837 3 0.020
cellular component movement GO:0006928 248 0.020
cell adhesion GO:0007155 110 0.020
lipid metabolic process GO:0006629 283 0.020
cellular response to growth factor stimulus GO:0071363 162 0.020
head development GO:0060322 247 0.020
positive regulation of mast cell chemotaxis GO:0060754 1 0.020
helper t cell diapedesis GO:0035685 1 0.020
hormone transport GO:0009914 121 0.020
response to tumor cell GO:0002347 4 0.019
cell projection organization GO:0030030 302 0.019
mast cell migration GO:0097531 4 0.019
negative regulation of response to stimulus GO:0048585 155 0.019
regulation of cellular component organization GO:0051128 368 0.019
t cell migration GO:0072678 2 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
response to wounding GO:0009611 254 0.019
cellular response to stress GO:0033554 269 0.019
response to other organism GO:0051707 220 0.019
pseudopodium organization GO:0031268 3 0.019
regulation of secretion by cell GO:1903530 208 0.019
response to corticosteroid GO:0031960 235 0.019
positive regulation of hydrolase activity GO:0051345 86 0.019
regulation of anatomical structure morphogenesis GO:0022603 141 0.019
organic substance catabolic process GO:1901575 316 0.018
Human
eosinophil migration GO:0072677 3 0.018
divalent inorganic cation transport GO:0072511 134 0.018
positive regulation of protein phosphorylation GO:0001934 135 0.018
anatomical structure morphogenesis GO:0009653 298 0.018
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 1 0.018
regulation of neuron death GO:1901214 115 0.018
response to vitamin GO:0033273 131 0.018
nucleic acid templated transcription GO:0097659 379 0.018
positive regulation of molecular function GO:0044093 230 0.018
acute phase response GO:0006953 20 0.018
regulation of lymphocyte migration GO:2000401 1 0.018
leukocyte cell cell adhesion GO:0007159 4 0.018
positive regulation of rna metabolic process GO:0051254 203 0.018
regulation of ion transport GO:0043269 245 0.018
immune response to tumor cell GO:0002418 3 0.018
response to oxidative stress GO:0006979 186 0.017
response to acid chemical GO:0001101 222 0.017
immune effector process GO:0002252 53 0.017
cellular lipid metabolic process GO:0044255 208 0.017
cellular component assembly GO:0022607 360 0.017
t cell receptor signaling pathway GO:0050852 1 0.017
positive regulation of locomotion GO:0040017 102 0.017
negative regulation of transcription dna templated GO:0045892 116 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
positive regulation of lymphocyte migration GO:2000403 1 0.017
neuron death GO:0070997 127 0.017
immune system development GO:0002520 41 0.017
positive regulation of apoptotic process GO:0043065 154 0.017
Human
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.017
positive regulation of cellular component movement GO:0051272 102 0.017
cellular response to reactive oxygen species GO:0034614 55 0.017
response to activity GO:0014823 73 0.016
single organism cell adhesion GO:0098602 46 0.016
negative regulation of biosynthetic process GO:0009890 168 0.016
natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002420 1 0.016
response to peptide hormone GO:0043434 278 0.016
response to amino acid GO:0043200 75 0.016
divalent metal ion transport GO:0070838 132 0.016
smooth muscle cell proliferation GO:0048659 77 0.016
cytoplasmic transport GO:0016482 115 0.016
regulation of hormone secretion GO:0046883 106 0.016
response to biotic stimulus GO:0009607 226 0.016
response to peptide GO:1901652 292 0.016
innate immune response GO:0045087 35 0.016
membrane organization GO:0061024 94 0.016
regulation of leukocyte differentiation GO:1902105 20 0.016
negative regulation of neuron death GO:1901215 69 0.015
leukocyte mediated immunity GO:0002443 28 0.015
natural killer cell mediated immune response to tumor cell GO:0002423 1 0.015
signal release GO:0023061 145 0.015
secretion GO:0046903 307 0.015
lymphocyte migration GO:0072676 3 0.015
positive regulation of protein modification process GO:0031401 142 0.015
erk1 and erk2 cascade GO:0070371 48 0.015
negative regulation of viral process GO:0048525 4 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
peptidyl tyrosine phosphorylation GO:0018108 72 0.015
organic acid transport GO:0015849 116 0.015
muscle cell proliferation GO:0033002 84 0.015
response to vitamin k GO:0032571 4 0.015
negative regulation of cell differentiation GO:0045596 99 0.014
regulation of homeostatic process GO:0032844 101 0.014
negative regulation of natural killer cell mediated immune response to tumor cell GO:0002856 1 0.014
protein complex biogenesis GO:0070271 263 0.014
cell killing GO:0001906 13 0.014
t cell chemotaxis GO:0010818 2 0.014
sex differentiation GO:0007548 113 0.014
positive regulation of nervous system development GO:0051962 178 0.014
negative regulation of molecular function GO:0044092 133 0.014
Human
leukocyte differentiation GO:0002521 30 0.014
actin cytoskeleton organization GO:0030036 73 0.014
single organismal cell cell adhesion GO:0016337 42 0.014
positive regulation of intracellular signal transduction GO:1902533 138 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
regulation of neuron projection development GO:0010975 161 0.014
phospholipid metabolic process GO:0006644 61 0.014
cell motility GO:0048870 202 0.014
response to mineralocorticoid GO:0051385 49 0.014
gamete generation GO:0007276 124 0.014
mapk cascade GO:0000165 140 0.014
sexual reproduction GO:0019953 148 0.014
positive regulation of necroptotic process GO:0060545 2 0.014
Rat
signal transduction by phosphorylation GO:0023014 144 0.014
response to ketone GO:1901654 182 0.014
glucose homeostasis GO:0042593 75 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
Human
regulation of response to stress GO:0080134 126 0.013
anion transport GO:0006820 178 0.013
neuron differentiation GO:0030182 368 0.013
positive regulation of response to external stimulus GO:0032103 51 0.013
sensory perception of pain GO:0019233 73 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
developmental process involved in reproduction GO:0003006 159 0.013
response to lipopolysaccharide GO:0032496 191 0.013
regeneration GO:0031099 163 0.013
regulation of interferon gamma production GO:0032649 3 0.013
positive regulation of necrotic cell death GO:0010940 4 0.013
Rat
mast cell chemotaxis GO:0002551 4 0.012
response to interferon gamma GO:0034341 20 0.012
multicellular organism growth GO:0035264 1 0.012
ion transmembrane transport GO:0034220 365 0.012
blood circulation GO:0008015 183 0.012
sequestering of calcium ion GO:0051208 8 0.012
programmed necrotic cell death GO:0097300 2 0.012
Rat
small molecule biosynthetic process GO:0044283 124 0.012
antigen receptor mediated signaling pathway GO:0050851 1 0.012
development of primary sexual characteristics GO:0045137 107 0.012
regulation of anatomical structure size GO:0090066 135 0.012
multi multicellular organism process GO:0044706 138 0.012
leukocyte activation GO:0045321 76 0.012
t helper 1 cell diapedesis GO:0035688 1 0.012
nitrogen compound transport GO:0071705 229 0.012
dna metabolic process GO:0006259 96 0.012
Human
peptidyl tyrosine modification GO:0018212 72 0.012
response to ethanol GO:0045471 162 0.012
regulation of behavior GO:0050795 61 0.012
carbohydrate derivative metabolic process GO:1901135 346 0.012
regulation of locomotion GO:0040012 148 0.012
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 2 0.012
ras protein signal transduction GO:0007265 29 0.012
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
macromolecular complex assembly GO:0065003 273 0.012
gonad development GO:0008406 104 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.012
rho protein signal transduction GO:0007266 11 0.011
sequestering of metal ion GO:0051238 9 0.011
response to transforming growth factor beta GO:0071559 46 0.011
lymphocyte chemotaxis GO:0048247 3 0.011
hepatocyte proliferation GO:0072574 3 0.011
response to reactive oxygen species GO:0000302 120 0.011
cellular response to cytokine stimulus GO:0071345 127 0.011
vasculature development GO:0001944 70 0.011
reproductive system development GO:0061458 128 0.011
response to metal ion GO:0010038 253 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
cellular response to acid chemical GO:0071229 75 0.011
protein complex assembly GO:0006461 263 0.011
diapedesis GO:0050904 1 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
negative regulation of cell proliferation GO:0008285 119 0.011
cellular catabolic process GO:0044248 295 0.011
Human
response to osmotic stress GO:0006970 42 0.011
vascular process in circulatory system GO:0003018 96 0.011
reproductive structure development GO:0048608 128 0.011
positive regulation of myeloid leukocyte differentiation GO:0002763 7 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
response to insulin GO:0032868 133 0.011
regulation of protein localization GO:0032880 81 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
cytoskeleton organization GO:0007010 111 0.011
cellular response to organonitrogen compound GO:0071417 197 0.011
cytokine mediated signaling pathway GO:0019221 43 0.011
lymphocyte activation GO:0046649 43 0.010
jak stat cascade GO:0007259 26 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
behavior GO:0007610 205 0.010
cellular biogenic amine metabolic process GO:0006576 30 0.010
negative regulation of leukocyte mediated immunity GO:0002704 6 0.010
regulation of response to tumor cell GO:0002834 3 0.010
positive regulation of dna metabolic process GO:0051054 39 0.010
regulation of metal ion transport GO:0010959 118 0.010
spermatogenesis GO:0007283 99 0.010
hematopoietic progenitor cell differentiation GO:0002244 2 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
Human
inorganic ion transmembrane transport GO:0098660 229 0.010
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002858 1 0.010
b cell mediated immunity GO:0019724 4 0.010
response to organophosphorus GO:0046683 102 0.010
male gamete generation GO:0048232 99 0.010
regulation of nucleotide metabolic process GO:0006140 117 0.010
brain development GO:0007420 247 0.010
negative regulation of cell development GO:0010721 82 0.010
gliogenesis GO:0042063 93 0.010
cellular response to extracellular stimulus GO:0031668 73 0.010
response to lipoteichoic acid GO:0070391 1 0.010
positive regulation of t cell chemotaxis GO:0010820 1 0.010
regulation of smooth muscle cell proliferation GO:0048660 75 0.010

Gzma disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org