Rattus norvegicus

7 known processes

Gzmm

granzyme M (lymphocyte met-ase 1)

Gzmm biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.280
immune system process GO:0002376 204 0.270
regulation of natural killer cell mediated immune response to tumor cell GO:0002855 1 0.214
rna biosynthetic process GO:0032774 380 0.177
inflammatory response GO:0006954 150 0.158
negative regulation of multicellular organismal process GO:0051241 203 0.156
response to tumor cell GO:0002347 4 0.156
negative regulation of innate immune response GO:0045824 4 0.150
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 1 0.147
negative regulation of immune response to tumor cell GO:0002838 2 0.135
cellular response to organic cyclic compound GO:0071407 202 0.132
positive regulation of transport GO:0051050 245 0.126
cellular response to oxygen containing compound GO:1901701 386 0.115
negative regulation of nervous system development GO:0051961 79 0.114
negative regulation of natural killer cell mediated immune response to tumor cell GO:0002856 1 0.113
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002858 1 0.109
immune response to tumor cell GO:0002418 3 0.101
negative regulation of response to tumor cell GO:0002835 2 0.100
natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002420 1 0.099
positive regulation of lipid kinase activity GO:0090218 2 0.096
blood circulation GO:0008015 183 0.095
organophosphate metabolic process GO:0019637 370 0.088
cell activation GO:0001775 97 0.087
negative regulation of developmental process GO:0051093 125 0.086
positive regulation of multicellular organismal process GO:0051240 387 0.086
negative regulation of macromolecule metabolic process GO:0010605 260 0.085
regulation of immune response to tumor cell GO:0002837 3 0.080
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.078
cellular amine metabolic process GO:0044106 38 0.073
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.073
cellular response to lipid GO:0071396 201 0.073
programmed cell death GO:0012501 392 0.072
negative regulation of biosynthetic process GO:0009890 168 0.071
innate immune response GO:0045087 35 0.069
positive regulation of biosynthetic process GO:0009891 319 0.068
regulation of catalytic activity GO:0050790 304 0.068
apoptotic process GO:0006915 381 0.066
negative regulation of cellular metabolic process GO:0031324 281 0.065
metal ion transport GO:0030001 289 0.065
biological adhesion GO:0022610 110 0.064
natural killer cell mediated immune response to tumor cell GO:0002423 1 0.064
circulatory system process GO:0003013 183 0.064
proteolysis GO:0006508 175 0.063
intracellular signal transduction GO:0035556 314 0.063
cellular response to endogenous stimulus GO:0071495 377 0.062
cellular lipid metabolic process GO:0044255 208 0.062
response to insulin GO:0032868 133 0.059
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.059
cell type specific apoptotic process GO:0097285 134 0.058
organ morphogenesis GO:0009887 75 0.058
positive regulation of cellular amine metabolic process GO:0033240 3 0.057
ion transmembrane transport GO:0034220 365 0.056
cellular ketone metabolic process GO:0042180 51 0.056
cellular homeostasis GO:0019725 252 0.055
regulation of necroptotic process GO:0060544 2 0.055
regulation of purine nucleotide metabolic process GO:1900542 115 0.054
leukocyte cell cell adhesion GO:0007159 4 0.054
nucleoside phosphate metabolic process GO:0006753 283 0.052
cellular response to steroid hormone stimulus GO:0071383 93 0.052
negative regulation of cell development GO:0010721 82 0.052
cell chemotaxis GO:0060326 31 0.052
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.051
chemical homeostasis GO:0048878 292 0.050
negative regulation of immune system process GO:0002683 39 0.050
negative regulation of cell proliferation GO:0008285 119 0.048
negative regulation of response to stimulus GO:0048585 155 0.048
response to growth factor GO:0070848 189 0.047
regulation of cellular amino acid metabolic process GO:0006521 2 0.047
positive regulation of programmed cell death GO:0043068 157 0.047
amine metabolic process GO:0009308 38 0.046
regulation of hydrolase activity GO:0051336 143 0.046
regulation of phosphorus metabolic process GO:0051174 349 0.046
regulation of cellular localization GO:0060341 263 0.045
vesicle mediated transport GO:0016192 181 0.045
response to biotic stimulus GO:0009607 226 0.045
regulation of cell proliferation GO:0042127 359 0.045
muscle system process GO:0003012 115 0.044
positive regulation of molecular function GO:0044093 230 0.042
regulation of molecular function GO:0065009 398 0.042
positive regulation of necroptotic process GO:0060545 2 0.042
protein complex assembly GO:0006461 263 0.042
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.041
regulation of programmed cell death GO:0043067 341 0.041
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.041
negative regulation of neurogenesis GO:0050768 78 0.040
nucleotide metabolic process GO:0009117 279 0.040
purine ribonucleotide metabolic process GO:0009150 227 0.039
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.039
central nervous system development GO:0007417 311 0.037
response to extracellular stimulus GO:0009991 380 0.037
immune response GO:0006955 104 0.037
cellular response to cytokine stimulus GO:0071345 127 0.037
defense response GO:0006952 194 0.036
regulation of defense response GO:0031347 68 0.036
regulation of immune system process GO:0002682 123 0.035
cell adhesion GO:0007155 110 0.035
regulation of cellular protein metabolic process GO:0032268 267 0.035
response to lipopolysaccharide GO:0032496 191 0.035
negative regulation of gene expression GO:0010629 199 0.034
negative regulation of signaling GO:0023057 157 0.034
leukocyte activation GO:0045321 76 0.034
regulation of cellular amine metabolic process GO:0033238 8 0.033
positive regulation of cell proliferation GO:0008284 249 0.032
regulation of nucleic acid templated transcription GO:1903506 380 0.032
response to vitamin GO:0033273 131 0.032
transmembrane transport GO:0055085 412 0.032
positive regulation of phosphorylation GO:0042327 177 0.032
regulation of rna metabolic process GO:0051252 391 0.031
muscle contraction GO:0006936 88 0.031
regulation of neurogenesis GO:0050767 247 0.031
regulation of myeloid cell differentiation GO:0045637 12 0.031
epithelial cell differentiation GO:0030855 71 0.031
inorganic cation transmembrane transport GO:0098662 202 0.030
regulation of multicellular organismal development GO:2000026 376 0.030
cell projection organization GO:0030030 302 0.030
regulation of system process GO:0044057 208 0.030
regulation of ion transport GO:0043269 245 0.030
t cell activation GO:0042110 29 0.030
mast cell migration GO:0097531 4 0.029
head development GO:0060322 247 0.029
purine containing compound metabolic process GO:0072521 253 0.029
carboxylic acid metabolic process GO:0019752 289 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.029
positive regulation of phosphate metabolic process GO:0045937 262 0.029
protein complex subunit organization GO:0071822 302 0.029
positive regulation of gene expression GO:0010628 244 0.029
alcohol metabolic process GO:0006066 77 0.029
circulatory system development GO:0072359 134 0.028
enzyme linked receptor protein signaling pathway GO:0007167 116 0.028
regulation of response to stress GO:0080134 126 0.028
cellular response to organonitrogen compound GO:0071417 197 0.028
ribonucleotide metabolic process GO:0009259 231 0.028
cation transmembrane transport GO:0098655 263 0.028
cytokine production GO:0001816 61 0.028
regulation of hormone levels GO:0010817 187 0.028
single organism reproductive process GO:0044702 297 0.028
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.028
cellular response to alcohol GO:0097306 87 0.028
ribose phosphate metabolic process GO:0019693 235 0.027
cell motility GO:0048870 202 0.027
neuron differentiation GO:0030182 368 0.027
response to external biotic stimulus GO:0043207 221 0.027
regulation of signal transduction GO:0009966 318 0.027
anatomical structure morphogenesis GO:0009653 298 0.027
regulation of neuron differentiation GO:0045664 208 0.026
response to hexose GO:0009746 144 0.026
organic substance catabolic process GO:1901575 316 0.026
single organism intracellular transport GO:1902582 166 0.026
inorganic ion transmembrane transport GO:0098660 229 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.025
negative regulation of metabolic process GO:0009892 331 0.025
nitrogen compound transport GO:0071705 229 0.025
positive regulation of phosphorus metabolic process GO:0010562 262 0.025
lipid metabolic process GO:0006629 283 0.025
cellular amino acid metabolic process GO:0006520 107 0.025
cellular component assembly GO:0022607 360 0.025
cellular response to growth factor stimulus GO:0071363 162 0.025
cellular component biogenesis GO:0044085 368 0.025
ion homeostasis GO:0050801 212 0.024
cellular chemical homeostasis GO:0055082 247 0.024
regulation of rna biosynthetic process GO:2001141 381 0.024
cellular cation homeostasis GO:0030003 180 0.024
cellular response to nitrogen compound GO:1901699 210 0.024
localization of cell GO:0051674 202 0.024
temperature homeostasis GO:0001659 17 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.023
regulation of cell differentiation GO:0045595 320 0.023
ribose phosphate biosynthetic process GO:0046390 87 0.023
positive regulation of nucleotide metabolic process GO:0045981 91 0.023
regulation of protein phosphorylation GO:0001932 183 0.023
response to carbohydrate GO:0009743 183 0.023
intracellular transport GO:0046907 185 0.023
brain development GO:0007420 247 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.023
immune effector process GO:0002252 53 0.023
purine nucleotide metabolic process GO:0006163 229 0.022
response to ethanol GO:0045471 162 0.022
myeloid leukocyte activation GO:0002274 36 0.022
response to other organism GO:0051707 220 0.022
negative regulation of cell differentiation GO:0045596 99 0.022
response to inorganic substance GO:0010035 377 0.022
phospholipid metabolic process GO:0006644 61 0.022
negative regulation of signal transduction GO:0009968 83 0.022
cellular divalent inorganic cation homeostasis GO:0072503 162 0.022
regulation of immune response GO:0050776 55 0.022
nucleic acid templated transcription GO:0097659 379 0.022
response to monosaccharide GO:0034284 159 0.022
rna metabolic process GO:0016070 406 0.022
single organism biosynthetic process GO:0044711 342 0.021
epithelium development GO:0060429 96 0.021
homeostatic process GO:0042592 331 0.021
response to oxygen levels GO:0070482 265 0.021
regulation of secretion by cell GO:1903530 208 0.021
actin cytoskeleton organization GO:0030036 73 0.021
positive regulation of fever generation GO:0031622 5 0.021
cgmp biosynthetic process GO:0006182 15 0.021
positive regulation of cell death GO:0010942 184 0.021
cytoplasmic transport GO:0016482 115 0.021
response to nutrient levels GO:0031667 370 0.021
development of primary sexual characteristics GO:0045137 107 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
positive regulation of cellular component movement GO:0051272 102 0.021
negative regulation of neuron differentiation GO:0045665 62 0.021
response to reactive oxygen species GO:0000302 120 0.021
hematopoietic or lymphoid organ development GO:0048534 36 0.021
cell morphogenesis GO:0000902 142 0.021
carbohydrate derivative metabolic process GO:1901135 346 0.020
transcription dna templated GO:0006351 377 0.020
response to purine containing compound GO:0014074 126 0.020
regulation of neuron projection development GO:0010975 161 0.020
protein phosphorylation GO:0006468 345 0.020
forebrain development GO:0030900 98 0.020
eye morphogenesis GO:0048592 4 0.020
organic acid metabolic process GO:0006082 292 0.020
positive regulation of rna biosynthetic process GO:1902680 197 0.020
cellular response to molecule of bacterial origin GO:0071219 56 0.020
monocarboxylic acid metabolic process GO:0032787 152 0.019
catabolic process GO:0009056 351 0.019
regulation of peptide transport GO:0090087 87 0.019
response to corticosteroid GO:0031960 235 0.019
chemokine mediated signaling pathway GO:0070098 5 0.019
regulation of response to tumor cell GO:0002834 3 0.019
positive regulation of nervous system development GO:0051962 178 0.019
reproduction GO:0000003 245 0.019
eosinophil migration GO:0072677 3 0.019
carboxylic acid transport GO:0046942 115 0.019
cellular response to alkaloid GO:0071312 25 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.019
response to hydrogen peroxide GO:0042542 89 0.018
cellular potassium ion transport GO:0071804 72 0.018
response to hypoxia GO:0001666 231 0.018
necroptotic process GO:0070266 2 0.018
positive regulation of rna metabolic process GO:0051254 203 0.018
rhythmic process GO:0048511 156 0.018
response to estrogen GO:0043627 232 0.018
response to peptide GO:1901652 292 0.018
regulation of transcription dna templated GO:0006355 374 0.018
retinal ganglion cell axon guidance GO:0031290 1 0.018
response to cgmp GO:0070305 3 0.018
b cell activation involved in immune response GO:0002312 1 0.018
nucleobase containing small molecule metabolic process GO:0055086 316 0.018
response to oxidative stress GO:0006979 186 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.018
organophosphate biosynthetic process GO:0090407 143 0.018
alpha beta t cell activation GO:0046631 3 0.018
leukocyte mediated immunity GO:0002443 28 0.018
response to nutrient GO:0007584 248 0.017
positive regulation of response to stimulus GO:0048584 285 0.017
cellular response to oxidative stress GO:0034599 76 0.017
positive regulation of calcium ion transport GO:0051928 36 0.017
leukocyte migration GO:0050900 38 0.017
response to metal ion GO:0010038 253 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
positive regulation of hydrolase activity GO:0051345 86 0.017
gonad development GO:0008406 104 0.017
cellular catabolic process GO:0044248 295 0.017
lymphocyte activation GO:0046649 43 0.017
cellular component morphogenesis GO:0032989 155 0.017
protein oligomerization GO:0051259 191 0.017
regulation of muscle contraction GO:0006937 53 0.017
myeloid leukocyte migration GO:0097529 20 0.017
organic acid transport GO:0015849 116 0.016
t cell proliferation GO:0042098 19 0.016
sexual reproduction GO:0019953 148 0.016
regulation of cell development GO:0060284 263 0.016
response to organophosphorus GO:0046683 102 0.016
positive regulation of immune response GO:0050778 42 0.016
striated muscle contraction GO:0006941 44 0.016
positive regulation of necrotic cell death GO:0010940 4 0.016
cardiovascular system development GO:0072358 134 0.016
gastrulation GO:0007369 2 0.016
tumor necrosis factor mediated signaling pathway GO:0033209 4 0.016
cyclic nucleotide metabolic process GO:0009187 80 0.016
regulation of apoptotic process GO:0042981 335 0.016
regulation of natural killer cell mediated immunity GO:0002715 6 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
negative regulation of leukocyte mediated immunity GO:0002704 6 0.015
cellular component movement GO:0006928 248 0.015
protein complex biogenesis GO:0070271 263 0.015
sequestering of metal ion GO:0051238 9 0.015
oxoacid metabolic process GO:0043436 290 0.015
secretion GO:0046903 307 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
secretion by cell GO:0032940 248 0.015
response to activity GO:0014823 73 0.015
multicellular organism reproduction GO:0032504 233 0.015
amide transport GO:0042886 105 0.015
positive regulation of transcription dna templated GO:0045893 197 0.015
negative regulation of immune response GO:0050777 15 0.015
negative regulation of cellular biosynthetic process GO:0031327 161 0.015
b cell mediated immunity GO:0019724 4 0.014
cellular response to lipopolysaccharide GO:0071222 55 0.014
vascular process in circulatory system GO:0003018 96 0.014
smooth muscle cell proliferation GO:0048659 77 0.014
positive regulation of protein modification process GO:0031401 142 0.014
glycerolipid metabolic process GO:0046486 67 0.014
divalent inorganic cation transport GO:0072511 134 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
cellular response to tumor necrosis factor GO:0071356 46 0.014
multicellular organismal homeostasis GO:0048871 49 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
nucleotide biosynthetic process GO:0009165 98 0.014
regulation of homeostatic process GO:0032844 101 0.014
humoral immune response GO:0006959 12 0.014
sex differentiation GO:0007548 113 0.014
positive regulation of cell activation GO:0050867 34 0.013
negative regulation of molecular function GO:0044092 133 0.013
positive regulation of smooth muscle cell migration GO:0014911 27 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
positive regulation of cell development GO:0010720 176 0.013
glucose homeostasis GO:0042593 75 0.013
regulation of metal ion transport GO:0010959 118 0.013
transcription from rna polymerase ii promoter GO:0006366 252 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
response to acid chemical GO:0001101 222 0.013
gamete generation GO:0007276 124 0.013
cellular ion homeostasis GO:0006873 184 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
positive regulation of angiogenesis GO:0045766 28 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
response to cytokine GO:0034097 215 0.013
macromolecule localization GO:0033036 252 0.013
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
positive regulation of defense response GO:0031349 37 0.012
regulation of lymphocyte chemotaxis GO:1901623 1 0.012
regulation of vesicle mediated transport GO:0060627 81 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
regulation of nervous system development GO:0051960 264 0.012
regulation of synaptic transmission GO:0050804 141 0.012
myeloid leukocyte differentiation GO:0002573 20 0.012
response to glucocorticoid GO:0051384 223 0.012
regulation of hormone secretion GO:0046883 106 0.012
lipid catabolic process GO:0016042 46 0.012
negative regulation of secretion by cell GO:1903531 72 0.012
tissue development GO:0009888 252 0.012
regulation of cytokine production GO:0001817 56 0.012
neuron development GO:0048666 286 0.012
protein maturation GO:0051604 68 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
cyclic nucleotide biosynthetic process GO:0009190 63 0.012
regulation of cell motility GO:2000145 131 0.012
negative regulation of neuron projection development GO:0010977 46 0.012
immune system development GO:0002520 41 0.012
response to camp GO:0051591 91 0.012
protein processing GO:0016485 68 0.012
negative regulation of defense response GO:0031348 19 0.012
hemopoiesis GO:0030097 34 0.012
retina morphogenesis in camera type eye GO:0060042 1 0.012
regulation of muscle cell apoptotic process GO:0010660 26 0.012
response to bacterium GO:0009617 200 0.012
peptidyl amino acid modification GO:0018193 126 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
kidney development GO:0001822 67 0.011
regulation of acute inflammatory response GO:0002673 23 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
cellular macromolecule catabolic process GO:0044265 29 0.011
behavior GO:0007610 205 0.011
male sex differentiation GO:0046661 64 0.011
glial cell differentiation GO:0010001 65 0.011
viral genome replication GO:0019079 2 0.011
eosinophil chemotaxis GO:0048245 3 0.011
cellular response to glucocorticoid stimulus GO:0071385 68 0.011
reproductive process GO:0022414 372 0.011
positive regulation of protein kinase activity GO:0045860 73 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
negative regulation of leukocyte apoptotic process GO:2000107 4 0.011
monocarboxylic acid catabolic process GO:0072329 28 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
organic cyclic compound catabolic process GO:1901361 175 0.011
single organism organelle organization GO:1902589 180 0.011
positive regulation of neuron apoptotic process GO:0043525 33 0.011
macromolecular complex assembly GO:0065003 273 0.011
adult locomotory behavior GO:0008344 4 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
response to tumor necrosis factor GO:0034612 56 0.011
positive regulation of leukocyte activation GO:0002696 30 0.011
regulation of membrane potential GO:0042391 110 0.011
positive regulation of cell motility GO:2000147 97 0.011
single organism cell adhesion GO:0098602 46 0.011
developmental process involved in reproduction GO:0003006 159 0.011
cation transport GO:0006812 382 0.011
anterior posterior pattern specification GO:0009952 1 0.011
formation of primary germ layer GO:0001704 1 0.011
regulation of protein localization GO:0032880 81 0.011
regulation of anatomical structure morphogenesis GO:0022603 141 0.011
single organism cellular localization GO:1902580 102 0.011
transmission of nerve impulse GO:0019226 42 0.011
positive regulation of ion transport GO:0043270 94 0.011
regulation of peptide secretion GO:0002791 82 0.010
positive regulation of cell communication GO:0010647 271 0.010
positive regulation of immune system process GO:0002684 90 0.010
divalent metal ion transport GO:0070838 132 0.010
negative regulation of cell communication GO:0010648 158 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
morphogenesis of embryonic epithelium GO:0016331 3 0.010
alcohol biosynthetic process GO:0046165 38 0.010
rho protein signal transduction GO:0007266 11 0.010
lymphocyte proliferation GO:0046651 29 0.010
sensory perception GO:0007600 101 0.010
neuron projection development GO:0031175 273 0.010
smooth muscle contraction GO:0006939 37 0.010
cellular response to biotic stimulus GO:0071216 59 0.010
aging GO:0007568 241 0.010
negative regulation of cell death GO:0060548 229 0.010
regulation of apoptotic signaling pathway GO:2001233 13 0.010
divalent inorganic cation homeostasis GO:0072507 165 0.010
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
camera type eye morphogenesis GO:0048593 2 0.010
response to morphine GO:0043278 27 0.010
peptidyl tyrosine phosphorylation GO:0018108 72 0.010
antigen processing and presentation GO:0019882 2 0.010

Gzmm disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
musculoskeletal system disease DOID:17 0 0.035
connective tissue disease DOID:65 0 0.032
nervous system disease DOID:863 0 0.030
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.015
eye disease DOID:5614 0 0.015
immune system disease DOID:2914 0 0.014
lymphatic system disease DOID:75 0 0.014
retinal disease DOID:5679 0 0.013
retinal degeneration DOID:8466 0 0.013
bone disease DOID:0080001 0 0.010