Rattus norvegicus

103 known processes

Btk

Bruton agammaglobulinemia tyrosine kinase

Btk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
immune response regulating signaling pathway GO:0002764 19 0.219
Rat
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.154
nucleoside metabolic process GO:0009116 179 0.129
lymphocyte migration GO:0072676 3 0.123
nucleoside catabolic process GO:0009164 126 0.118
cell activation GO:0001775 97 0.104
regulation of cellular ketone metabolic process GO:0010565 27 0.104
purine ribonucleoside catabolic process GO:0046130 124 0.102
organic acid metabolic process GO:0006082 292 0.101
response to molecule of bacterial origin GO:0002237 194 0.097
Rat
immune response activating signal transduction GO:0002757 15 0.093
Rat
immune response GO:0006955 104 0.090
cellular amino acid metabolic process GO:0006520 107 0.087
immune system process GO:0002376 204 0.087
positive regulation of response to stimulus GO:0048584 285 0.082
Rat
cellular calcium ion homeostasis GO:0006874 160 0.077
Rat
nucleoside phosphate metabolic process GO:0006753 283 0.076
response to biotic stimulus GO:0009607 226 0.076
regulation of immune system process GO:0002682 123 0.072
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.070
ribonucleoside catabolic process GO:0042454 126 0.069
cation homeostasis GO:0055080 195 0.068
Rat
purine containing compound metabolic process GO:0072521 253 0.068
t cell migration GO:0072678 2 0.068
purine ribonucleotide catabolic process GO:0009154 136 0.065
purine containing compound catabolic process GO:0072523 138 0.065
cellular amine metabolic process GO:0044106 38 0.065
organophosphate metabolic process GO:0019637 370 0.063
Rat
glycosyl compound metabolic process GO:1901657 182 0.061
regulation of cellular amine metabolic process GO:0033238 8 0.061
ribonucleoside metabolic process GO:0009119 174 0.060
regulation of phosphate metabolic process GO:0019220 349 0.060
Rat
oxoacid metabolic process GO:0043436 290 0.058
negative regulation of metabolic process GO:0009892 331 0.057
Rat
single organism intracellular transport GO:1902582 166 0.056
positive regulation of immune system process GO:0002684 90 0.054
Rat
atp metabolic process GO:0046034 72 0.053
ribonucleoside triphosphate metabolic process GO:0009199 141 0.052
positive regulation of biosynthetic process GO:0009891 319 0.051
Rat
amine metabolic process GO:0009308 38 0.050
carboxylic acid metabolic process GO:0019752 289 0.049
nucleobase containing small molecule metabolic process GO:0055086 316 0.048
regulation of phosphorus metabolic process GO:0051174 349 0.048
Rat
carbohydrate derivative catabolic process GO:1901136 147 0.047
behavior GO:0007610 205 0.047
Fly
carbohydrate derivative metabolic process GO:1901135 346 0.046
nucleoside triphosphate metabolic process GO:0009141 144 0.046
lipid metabolic process GO:0006629 283 0.046
Rat
organophosphate catabolic process GO:0046434 148 0.045
regulation of cellular localization GO:0060341 263 0.044
Rat
nucleotide metabolic process GO:0009117 279 0.043
organonitrogen compound catabolic process GO:1901565 179 0.042
macromolecule localization GO:0033036 252 0.042
Rat
regulation of locomotion GO:0040012 148 0.042
Rat
programmed cell death GO:0012501 392 0.041
Rat
cellular response to oxygen containing compound GO:1901701 386 0.041
response to other organism GO:0051707 220 0.041
antigen receptor mediated signaling pathway GO:0050851 1 0.041
regeneration GO:0031099 163 0.040
Rat
single organism membrane organization GO:0044802 74 0.040
ribonucleoside triphosphate catabolic process GO:0009203 122 0.040
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.040
chemical homeostasis GO:0048878 292 0.040
Rat
protein complex subunit organization GO:0071822 302 0.040
Fly
positive regulation of transcription factor import into nucleus GO:0042993 4 0.040
positive regulation of protein metabolic process GO:0051247 178 0.039
Rat
glycosyl compound catabolic process GO:1901658 126 0.039
nucleoside monophosphate catabolic process GO:0009125 56 0.039
macromolecular complex subunit organization GO:0043933 339 0.038
Fly
positive regulation of immune response GO:0050778 42 0.038
Rat
nucleobase containing compound catabolic process GO:0034655 152 0.038
divalent inorganic cation homeostasis GO:0072507 165 0.038
Rat
ribonucleotide catabolic process GO:0009261 136 0.037
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.037
Rat
regulation of secretion by cell GO:1903530 208 0.037
Rat
cytosolic calcium ion homeostasis GO:0051480 140 0.037
Rat
defense response GO:0006952 194 0.036
ion homeostasis GO:0050801 212 0.036
Rat
positive regulation of cellular component movement GO:0051272 102 0.036
Rat
nucleoside phosphate catabolic process GO:1901292 140 0.035
ribose phosphate metabolic process GO:0019693 235 0.034
nucleotide catabolic process GO:0009166 139 0.034
metal ion homeostasis GO:0055065 186 0.034
Rat
cellular chemical homeostasis GO:0055082 247 0.033
Rat
purine nucleoside triphosphate catabolic process GO:0009146 122 0.033
single organism catabolic process GO:0044712 283 0.033
heterocycle catabolic process GO:0046700 167 0.033
cellular nitrogen compound catabolic process GO:0044270 163 0.032
cytokine production GO:0001816 61 0.032
Rat
inflammatory response GO:0006954 150 0.032
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
Rat
cellular ketone metabolic process GO:0042180 51 0.032
protein phosphorylation GO:0006468 345 0.032
response to lipopolysaccharide GO:0032496 191 0.032
Rat
gland development GO:0048732 155 0.032
Fly
response to metal ion GO:0010038 253 0.031
Rat
g protein coupled receptor signaling pathway GO:0007186 242 0.031
regulation of molecular function GO:0065009 398 0.030
Rat
positive regulation of cellular amine metabolic process GO:0033240 3 0.030
cellular protein localization GO:0034613 122 0.030
response to inorganic substance GO:0010035 377 0.030
Rat
response to carbohydrate GO:0009743 183 0.029
Rat
cellular component movement GO:0006928 248 0.029
Rat
purine nucleoside metabolic process GO:0042278 169 0.029
secretion GO:0046903 307 0.029
positive regulation of signaling GO:0023056 270 0.029
Rat
calcium ion homeostasis GO:0055074 162 0.028
Rat
cellular divalent inorganic cation homeostasis GO:0072503 162 0.028
Rat
regulation of protein modification process GO:0031399 194 0.028
Rat
reproductive process GO:0022414 372 0.028
Fly
transcription dna templated GO:0006351 377 0.027
Rat
purine nucleotide catabolic process GO:0006195 136 0.027
purine ribonucleoside metabolic process GO:0046128 168 0.027
small molecule biosynthetic process GO:0044283 124 0.027
atp catabolic process GO:0006200 54 0.027
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.027
peptidyl amino acid modification GO:0018193 126 0.026
reactive oxygen species metabolic process GO:0072593 37 0.026
cellular homeostasis GO:0019725 252 0.026
Rat
response to growth factor GO:0070848 189 0.026
Rat
erk1 and erk2 cascade GO:0070371 48 0.026
Rat
purine nucleoside triphosphate metabolic process GO:0009144 141 0.026
intracellular signal transduction GO:0035556 314 0.025
Mouse Rat
vesicle mediated transport GO:0016192 181 0.025
negative regulation of cellular metabolic process GO:0031324 281 0.025
Rat
leukocyte activation GO:0045321 76 0.024
response to acid chemical GO:0001101 222 0.024
Rat
organic cyclic compound catabolic process GO:1901361 175 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
Fly
nucleoside monophosphate metabolic process GO:0009123 93 0.024
cellular response to lipopolysaccharide GO:0071222 55 0.024
Rat
homeostatic process GO:0042592 331 0.024
Rat
regulation of establishment of protein localization GO:0070201 69 0.023
Rat
catabolic process GO:0009056 351 0.023
purine nucleoside monophosphate metabolic process GO:0009126 84 0.023
regulation of lymphocyte migration GO:2000401 1 0.023
response to nutrient GO:0007584 248 0.023
response to peptide hormone GO:0043434 278 0.023
Rat
protein secretion GO:0009306 34 0.023
Rat
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.023
cellular response to endogenous stimulus GO:0071495 377 0.023
Rat
positive regulation of developmental process GO:0051094 283 0.023
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.023
Rat
intracellular transport GO:0046907 185 0.023
response to estrogen GO:0043627 232 0.023
neurological system process GO:0050877 219 0.023
Fly
regulation of metal ion transport GO:0010959 118 0.023
Rat
positive regulation of cellular biosynthetic process GO:0031328 295 0.023
Rat
regulation of catalytic activity GO:0050790 304 0.022
Rat
negative regulation of multicellular organismal process GO:0051241 203 0.022
protein complex assembly GO:0006461 263 0.022
Fly
circulatory system process GO:0003013 183 0.022
cellular response to peptide GO:1901653 133 0.022
Rat
localization of cell GO:0051674 202 0.022
Rat
membrane organization GO:0061024 94 0.022
positive regulation of transport GO:0051050 245 0.022
Rat
positive regulation of multicellular organismal process GO:0051240 387 0.022
Rat
cellular cation homeostasis GO:0030003 180 0.022
Rat
cellular catabolic process GO:0044248 295 0.022
cellular response to biotic stimulus GO:0071216 59 0.022
regulation of lymphocyte chemotaxis GO:1901623 1 0.022
purine nucleotide metabolic process GO:0006163 229 0.022
cellular macromolecule localization GO:0070727 122 0.021
positive regulation of cell death GO:0010942 184 0.021
Rat
ribonucleoside monophosphate metabolic process GO:0009161 88 0.021
nucleoside triphosphate catabolic process GO:0009143 123 0.021
response to nutrient levels GO:0031667 370 0.021
Rat
learning or memory GO:0007611 90 0.021
Fly
purine nucleoside catabolic process GO:0006152 124 0.021
reactive nitrogen species metabolic process GO:2001057 1 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
Rat
positive regulation of programmed cell death GO:0043068 157 0.021
Rat
regulation of apoptotic process GO:0042981 335 0.020
Rat
establishment of protein localization GO:0045184 141 0.020
Rat
purine nucleoside monophosphate catabolic process GO:0009128 55 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.020
Rat
response to reactive oxygen species GO:0000302 120 0.020
regulation of secretion GO:0051046 224 0.020
Rat
response to toxic substance GO:0009636 133 0.020
Rat
organic substance catabolic process GO:1901575 316 0.020
hormone secretion GO:0046879 115 0.020
regulation of defense response GO:0031347 68 0.020
negative regulation of molecular function GO:0044092 133 0.020
secretion by cell GO:0032940 248 0.020
receptor mediated endocytosis GO:0006898 42 0.019
innate immune response GO:0045087 35 0.019
regulation of protein phosphorylation GO:0001932 183 0.019
Rat
cytokine biosynthetic process GO:0042089 3 0.019
hematopoietic or lymphoid organ development GO:0048534 36 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
protein localization GO:0008104 191 0.019
Rat
cellular component biogenesis GO:0044085 368 0.019
Rat Fly
g protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 3 0.019
cellular ion homeostasis GO:0006873 184 0.019
Rat
regulation of transcription dna templated GO:0006355 374 0.019
Rat
response to extracellular stimulus GO:0009991 380 0.019
Rat
immunoglobulin mediated immune response GO:0016064 4 0.019
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.019
Rat
positive regulation of molecular function GO:0044093 230 0.019
Rat
response to cytokine GO:0034097 215 0.019
regulation of programmed cell death GO:0043067 341 0.019
Rat
negative regulation of transport GO:0051051 136 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.019
immune effector process GO:0002252 53 0.018
cellular lipid metabolic process GO:0044255 208 0.018
Rat
immune system development GO:0002520 41 0.018
cytoplasmic transport GO:0016482 115 0.018
Rat
positive regulation of nucleocytoplasmic transport GO:0046824 17 0.018
positive regulation of protein modification process GO:0031401 142 0.018
Rat
response to hypoxia GO:0001666 231 0.018
Rat
positive regulation of cell adhesion GO:0045785 30 0.018
Rat
aromatic compound catabolic process GO:0019439 168 0.018
cellular metal ion homeostasis GO:0006875 172 0.018
Rat
regulation of cytokine production GO:0001817 56 0.017
Rat
central nervous system development GO:0007417 311 0.017
Rat
negative regulation of macromolecule metabolic process GO:0010605 260 0.017
Rat
response to hydrogen peroxide GO:0042542 89 0.017
Rat
positive regulation of intracellular signal transduction GO:1902533 138 0.017
Rat
protein complex biogenesis GO:0070271 263 0.017
Fly
positive regulation of endothelial cell migration GO:0010595 4 0.017
regulation of ion homeostasis GO:2000021 63 0.017
Rat
cardiovascular system development GO:0072358 134 0.017
regulation of neurogenesis GO:0050767 247 0.017
Rat
protein transport GO:0015031 132 0.016
Rat
response to organophosphorus GO:0046683 102 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.016
Rat
small gtpase mediated signal transduction GO:0007264 36 0.016
regulation of anatomical structure size GO:0090066 135 0.016
Fly
blood coagulation GO:0007596 26 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
Rat
regulation of cellular extravasation GO:0002691 2 0.016
single organism cellular localization GO:1902580 102 0.016
cellular response to red or far red light GO:0071489 1 0.016
positive regulation of immunoglobulin mediated immune response GO:0002891 2 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.016
Rat
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.016
positive regulation of cell communication GO:0010647 271 0.015
Rat
developmental process involved in reproduction GO:0003006 159 0.015
Fly
single organism organelle organization GO:1902589 180 0.015
Fly
reactive oxygen species biosynthetic process GO:1903409 8 0.015
cation transport GO:0006812 382 0.015
rna metabolic process GO:0016070 406 0.015
Rat
positive regulation of protein phosphorylation GO:0001934 135 0.015
Rat
positive regulation of cell migration GO:0030335 96 0.015
Rat
response to bacterium GO:0009617 200 0.015
Rat
immune response regulating cell surface receptor signaling pathway GO:0002768 10 0.015
Rat
cellular response to oxidative stress GO:0034599 76 0.015
aging GO:0007568 241 0.015
Rat Fly
divalent inorganic cation transport GO:0072511 134 0.015
Rat
regulation of ion transport GO:0043269 245 0.015
Rat
alpha beta t cell activation GO:0046631 3 0.015
positive regulation of innate immune response GO:0045089 11 0.015
regulation of t cell chemotaxis GO:0010819 1 0.015
negative regulation of apoptotic process GO:0043066 181 0.015
Rat
regulation of t cell migration GO:2000404 1 0.015
protein oligomerization GO:0051259 191 0.014
sequestering of calcium ion GO:0051208 8 0.014
response to peptide GO:1901652 292 0.014
Rat
apoptotic process GO:0006915 381 0.014
Rat
positive regulation of t cell migration GO:2000406 1 0.014
cellular response to mechanical stimulus GO:0071260 48 0.014
response to oxygen levels GO:0070482 265 0.014
Rat
locomotion GO:0040011 237 0.014
Rat
cellular response to abiotic stimulus GO:0071214 85 0.014
signal release GO:0023061 145 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
positive regulation of neurogenesis GO:0050769 165 0.014
Rat
regulation of behavior GO:0050795 61 0.014
reproductive system development GO:0061458 128 0.014
Fly
alpha beta t cell differentiation GO:0046632 2 0.014
anatomical structure morphogenesis GO:0009653 298 0.014
Fly
regulation of catabolic process GO:0009894 113 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.014
histamine production involved in inflammatory response GO:0002349 3 0.014
negative regulation of signaling GO:0023057 157 0.014
Rat
biological adhesion GO:0022610 110 0.014
Rat
positive regulation of secretion by cell GO:1903532 128 0.014
Rat
negative regulation of phosphorus metabolic process GO:0010563 80 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
Rat
cellular response to insulin stimulus GO:0032869 81 0.014
Rat
positive regulation of defense response GO:0031349 37 0.014
multi organism reproductive process GO:0044703 262 0.014
Fly
hemopoiesis GO:0030097 34 0.014
positive regulation of protein localization to nucleus GO:1900182 15 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
Rat
regulation of cell motility GO:2000145 131 0.013
Rat
dna metabolic process GO:0006259 96 0.013
Rat Fly
regulation of cytokine biosynthetic process GO:0042035 3 0.013
response to oxidative stress GO:0006979 186 0.013
signal transduction by phosphorylation GO:0023014 144 0.013
Rat
regulation of protein metabolic process GO:0051246 289 0.013
Rat
positive regulation of rna biosynthetic process GO:1902680 197 0.013
Rat
icosanoid metabolic process GO:0006690 38 0.013
multicellular organism reproduction GO:0032504 233 0.013
Fly
monocarboxylic acid metabolic process GO:0032787 152 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
t cell extravasation GO:0072683 1 0.013
positive regulation of cytoplasmic transport GO:1903651 32 0.013
negative regulation of developmental process GO:0051093 125 0.013
single organism reproductive process GO:0044702 297 0.013
Fly
response to purine containing compound GO:0014074 126 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
Rat
negative regulation of ion transport GO:0043271 51 0.013
cellular response to external stimulus GO:0071496 118 0.013
Rat
regulation of membrane potential GO:0042391 110 0.013
regulation of dna metabolic process GO:0051052 60 0.013
Rat
regulation of blood circulation GO:1903522 110 0.013
regulation of system process GO:0044057 208 0.013
Rat
regulation of transferase activity GO:0051338 123 0.013
Rat
positive regulation of t cell chemotaxis GO:0010820 1 0.013
regulation of protein transport GO:0051223 68 0.012
Rat
response to external biotic stimulus GO:0043207 221 0.012
ras protein signal transduction GO:0007265 29 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
regulation of signal transduction GO:0009966 318 0.012
Rat
hepaticobiliary system development GO:0061008 90 0.012
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.012
ribonucleoside monophosphate catabolic process GO:0009158 55 0.012
organ regeneration GO:0031100 101 0.012
response to ethanol GO:0045471 162 0.012
divalent metal ion transport GO:0070838 132 0.012
Rat
b cell activation involved in immune response GO:0002312 1 0.012
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
neuron death GO:0070997 127 0.012
Rat
negative regulation of protein metabolic process GO:0051248 114 0.012
positive regulation of gene expression GO:0010628 244 0.012
Rat
regulation of nucleotide catabolic process GO:0030811 65 0.012
cell cell signaling GO:0007267 335 0.012
gtp catabolic process GO:0006184 71 0.012
sensory perception of bitter taste GO:0050913 4 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
sex differentiation GO:0007548 113 0.012
Fly
mapk cascade GO:0000165 140 0.012
Rat
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.012
Rat
cellular response to acid chemical GO:0071229 75 0.012
Rat
regulation of phosphorylation GO:0042325 248 0.012
Rat
regulation of blood vessel endothelial cell migration GO:0043535 4 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.011
positive regulation of nucleic acid templated transcription GO:1903508 197 0.011
Rat
negative regulation of cell proliferation GO:0008285 119 0.011
macromolecular complex assembly GO:0065003 273 0.011
Fly
positive regulation of neuron differentiation GO:0045666 126 0.011
sequestering of metal ion GO:0051238 9 0.011
positive regulation of protein import into nucleus GO:0042307 14 0.011
amine transport GO:0015837 57 0.011
gtp metabolic process GO:0046039 72 0.011
positive regulation of cell motility GO:2000147 97 0.011
Rat
response to radiation GO:0009314 137 0.011
regulation of hormone levels GO:0010817 187 0.011
neuron differentiation GO:0030182 368 0.011
leukocyte differentiation GO:0002521 30 0.011
positive regulation of protein kinase activity GO:0045860 73 0.011
Rat
positive regulation of mapk cascade GO:0043410 92 0.011
Rat
regulation of mapk cascade GO:0043408 116 0.011
Rat
response to wounding GO:0009611 254 0.011
Rat
cell motility GO:0048870 202 0.011
Rat
regulation of cellular catabolic process GO:0031329 101 0.011
regulation of cellular component size GO:0032535 51 0.011
Fly
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
nitrogen compound transport GO:0071705 229 0.011
cellular response to lipid GO:0071396 201 0.011
Rat
regulation of cell development GO:0060284 263 0.011
Rat
neuron development GO:0048666 286 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
Rat
regulation of rna biosynthetic process GO:2001141 381 0.011
Rat
response to glucose GO:0009749 136 0.010
single organism behavior GO:0044708 130 0.010
Fly
response to activity GO:0014823 73 0.010
response to monosaccharide GO:0034284 159 0.010
positive regulation of neuron projection development GO:0010976 99 0.010
reproductive structure development GO:0048608 128 0.010
Fly
blood circulation GO:0008015 183 0.010
positive regulation of intracellular protein transport GO:0090316 20 0.010
positive regulation of map kinase activity GO:0043406 46 0.010
Rat
regulation of leukocyte differentiation GO:1902105 20 0.010
organelle organization GO:0006996 266 0.010
Fly
positive regulation of secretion GO:0051047 140 0.010
Rat
positive regulation of angiogenesis GO:0045766 28 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
cellular response to molecule of bacterial origin GO:0071219 56 0.010
Rat

Btk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org