Rattus norvegicus

129 known processes

Atf4

activating transcription factor 4 (tax-responsive enhancer element B67)

Atf4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron death GO:0070997 127 0.170
cellular response to stress GO:0033554 269 0.165
programmed cell death GO:0012501 392 0.145
rna biosynthetic process GO:0032774 380 0.129
nucleic acid templated transcription GO:0097659 379 0.113
regulation of apoptotic process GO:0042981 335 0.106
apoptotic process GO:0006915 381 0.103
regulation of rna metabolic process GO:0051252 391 0.100
regulation of programmed cell death GO:0043067 341 0.088
regulation of neuron apoptotic process GO:0043523 83 0.088
cation transport GO:0006812 382 0.086
response to reactive oxygen species GO:0000302 120 0.085
regulation of cell differentiation GO:0045595 320 0.076
cell type specific apoptotic process GO:0097285 134 0.074
intracellular signal transduction GO:0035556 314 0.072
regulation of nucleic acid templated transcription GO:1903506 380 0.061
regulation of neuron death GO:1901214 115 0.059
response to extracellular stimulus GO:0009991 380 0.058
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.057
negative regulation of apoptotic process GO:0043066 181 0.055
transcription from rna polymerase ii promoter GO:0006366 252 0.054
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.052
regulation of protein metabolic process GO:0051246 289 0.052
proteolysis GO:0006508 175 0.051
negative regulation of macromolecule metabolic process GO:0010605 260 0.051
response to hydrogen peroxide GO:0042542 89 0.049
regulation of molecular function GO:0065009 398 0.049
negative regulation of nucleic acid templated transcription GO:1903507 117 0.047
regulation of cellular protein metabolic process GO:0032268 267 0.046
cellular response to oxidative stress GO:0034599 76 0.044
negative regulation of rna metabolic process GO:0051253 123 0.042
positive regulation of apoptotic process GO:0043065 154 0.040
organic substance catabolic process GO:1901575 316 0.040
cofactor metabolic process GO:0051186 95 0.040
response to nutrient levels GO:0031667 370 0.039
positive regulation of cell death GO:0010942 184 0.038
neuron apoptotic process GO:0051402 88 0.038
cellular catabolic process GO:0044248 295 0.037
negative regulation of metabolic process GO:0009892 331 0.037
regulation of fat cell differentiation GO:0045598 3 0.036
carbohydrate derivative metabolic process GO:1901135 346 0.036
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.036
single organism catabolic process GO:0044712 283 0.036
negative regulation of cell death GO:0060548 229 0.035
response to decreased oxygen levels GO:0036293 237 0.034
amino acid transport GO:0006865 70 0.033
cellular response to reactive oxygen species GO:0034614 55 0.033
nucleotide metabolic process GO:0009117 279 0.032
small gtpase mediated signal transduction GO:0007264 36 0.032
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 11 0.032
response to nutrient GO:0007584 248 0.032
nucleobase containing small molecule metabolic process GO:0055086 316 0.031
positive regulation of neuron apoptotic process GO:0043525 33 0.031
regulation of rna biosynthetic process GO:2001141 381 0.031
regulation of transcription dna templated GO:0006355 374 0.030
catabolic process GO:0009056 351 0.029
regulation of catalytic activity GO:0050790 304 0.029
regulation of cell development GO:0060284 263 0.029
cellular response to hormone stimulus GO:0032870 247 0.028
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.028
negative regulation of programmed cell death GO:0043069 183 0.027
mrna transcription from rna polymerase ii promoter GO:0042789 1 0.027
negative regulation of rna biosynthetic process GO:1902679 118 0.027
regulation of phosphate metabolic process GO:0019220 349 0.027
organic acid metabolic process GO:0006082 292 0.026
positive regulation of catalytic activity GO:0043085 184 0.026
negative regulation of cellular biosynthetic process GO:0031327 161 0.026
regulation of hydrolase activity GO:0051336 143 0.026
positive regulation of catabolic process GO:0009896 78 0.026
positive regulation of response to stimulus GO:0048584 285 0.026
negative regulation of molecular function GO:0044092 133 0.025
ribonucleoside catabolic process GO:0042454 126 0.025
negative regulation of cellular protein metabolic process GO:0032269 106 0.025
cellular response to oxygen containing compound GO:1901701 386 0.025
transcription dna templated GO:0006351 377 0.025
cation transmembrane transport GO:0098655 263 0.024
rna metabolic process GO:0016070 406 0.024
organonitrogen compound catabolic process GO:1901565 179 0.023
negative regulation of gene expression GO:0010629 199 0.023
negative regulation of cell differentiation GO:0045596 99 0.023
response to external biotic stimulus GO:0043207 221 0.023
positive regulation of multicellular organismal process GO:0051240 387 0.023
regulation of nucleotide metabolic process GO:0006140 117 0.023
regulation of gene expression epigenetic GO:0040029 10 0.022
positive regulation of molecular function GO:0044093 230 0.022
negative regulation of transcription dna templated GO:0045892 116 0.022
regulation of purine nucleotide metabolic process GO:1900542 115 0.022
organic cyclic compound catabolic process GO:1901361 175 0.022
cellular response to endogenous stimulus GO:0071495 377 0.021
protein heterooligomerization GO:0051291 89 0.021
carboxylic acid metabolic process GO:0019752 289 0.021
positive regulation of protein metabolic process GO:0051247 178 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
cellular amino acid biosynthetic process GO:0008652 32 0.020
cellular homeostasis GO:0019725 252 0.020
neuron differentiation GO:0030182 368 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
heterocycle catabolic process GO:0046700 167 0.020
cellular macromolecule catabolic process GO:0044265 29 0.019
cellular response to biotic stimulus GO:0071216 59 0.019
response to metal ion GO:0010038 253 0.019
ribonucleotide metabolic process GO:0009259 231 0.019
nitrogen compound transport GO:0071705 229 0.019
regulation of transferase activity GO:0051338 123 0.019
ribose phosphate metabolic process GO:0019693 235 0.019
negative regulation of biosynthetic process GO:0009890 168 0.019
multicellular organism reproduction GO:0032504 233 0.019
cellular protein catabolic process GO:0044257 19 0.019
organophosphate metabolic process GO:0019637 370 0.019
response to lipopolysaccharide GO:0032496 191 0.018
axis specification GO:0009798 4 0.018
response to other organism GO:0051707 220 0.018
positive regulation of nucleotide metabolic process GO:0045981 91 0.018
regulation of multicellular organismal development GO:2000026 376 0.018
divalent inorganic cation homeostasis GO:0072507 165 0.018
positive regulation of programmed cell death GO:0043068 157 0.018
single organism carbohydrate metabolic process GO:0044723 118 0.018
cellular ketone metabolic process GO:0042180 51 0.018
maintenance of location GO:0051235 17 0.018
response to molecule of bacterial origin GO:0002237 194 0.018
anterior posterior pattern specification GO:0009952 1 0.018
response to biotic stimulus GO:0009607 226 0.017
ion transmembrane transport GO:0034220 365 0.017
cellular protein localization GO:0034613 122 0.017
calcium ion transport GO:0006816 131 0.017
reproductive process GO:0022414 372 0.017
growth GO:0040007 165 0.016
purine containing compound metabolic process GO:0072521 253 0.016
cellular response to unfolded protein GO:0034620 2 0.016
organic anion transport GO:0015711 132 0.016
negative regulation of neuron apoptotic process GO:0043524 45 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
negative regulation of response to stimulus GO:0048585 155 0.016
cytoplasmic transport GO:0016482 115 0.015
carboxylic acid transport GO:0046942 115 0.015
small molecule biosynthetic process GO:0044283 124 0.015
positive regulation of nucleoside metabolic process GO:0045979 55 0.015
branched chain amino acid transport GO:0015803 2 0.015
intracellular transport GO:0046907 185 0.015
negative regulation of protein metabolic process GO:0051248 114 0.015
positive regulation of developmental process GO:0051094 283 0.015
response to acid chemical GO:0001101 222 0.015
cellular response to topologically incorrect protein GO:0035967 3 0.015
cellular divalent inorganic cation homeostasis GO:0072503 162 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
tissue development GO:0009888 252 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
regulation of intracellular signal transduction GO:1902531 218 0.014
cellular amino acid metabolic process GO:0006520 107 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 53 0.014
multi organism reproductive process GO:0044703 262 0.014
d amino acid transport GO:0042940 1 0.014
negative regulation of cellular metabolic process GO:0031324 281 0.014
inactivation of mapk activity GO:0000188 2 0.014
nucleoside metabolic process GO:0009116 179 0.014
response to hypoxia GO:0001666 231 0.014
purine containing compound biosynthetic process GO:0072522 85 0.014
regulation of cell proliferation GO:0042127 359 0.014
trna metabolic process GO:0006399 4 0.014
purine nucleotide metabolic process GO:0006163 229 0.013
response to oxygen levels GO:0070482 265 0.013
single organism intracellular transport GO:1902582 166 0.013
defense response GO:0006952 194 0.013
regulation of nucleotide catabolic process GO:0030811 65 0.013
ras protein signal transduction GO:0007265 29 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
positive regulation of neuron death GO:1901216 43 0.013
regeneration GO:0031099 163 0.013
nucleobase containing compound catabolic process GO:0034655 152 0.013
divalent metal ion transport GO:0070838 132 0.013
neuron projection development GO:0031175 273 0.013
calcium ion homeostasis GO:0055074 162 0.013
cellular response to hydrogen peroxide GO:0070301 42 0.012
transmembrane transport GO:0055085 412 0.012
cellular amine metabolic process GO:0044106 38 0.012
positive regulation of cellular biosynthetic process GO:0031328 295 0.012
negative regulation of transport GO:0051051 136 0.012
regulation of purine nucleotide catabolic process GO:0033121 65 0.012
regulation of phosphorus metabolic process GO:0051174 349 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
regulation of signal transduction GO:0009966 318 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
cardiovascular system development GO:0072358 134 0.012
reproduction GO:0000003 245 0.012
cellular chemical homeostasis GO:0055082 247 0.012
gastrulation GO:0007369 2 0.012
hepaticobiliary system development GO:0061008 90 0.012
regulation of homeostatic process GO:0032844 101 0.012
response to inorganic substance GO:0010035 377 0.012
positive regulation of signaling GO:0023056 270 0.012
regulation of phosphorylation GO:0042325 248 0.012
positive regulation of humoral immune response GO:0002922 2 0.012
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 17 0.012
regulation of kinase activity GO:0043549 117 0.012
aging GO:0007568 241 0.012
amine metabolic process GO:0009308 38 0.012
negative regulation of developmental process GO:0051093 125 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.011
inorganic cation transmembrane transport GO:0098662 202 0.011
regulation of response to stress GO:0080134 126 0.011
homeostatic process GO:0042592 331 0.011
response to bacterium GO:0009617 200 0.011
neuron development GO:0048666 286 0.011
response to estrogen GO:0043627 232 0.011
peptide biosynthetic process GO:0043043 3 0.011
single organism reproductive process GO:0044702 297 0.011
negative regulation of neuron death GO:1901215 69 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
stress activated protein kinase signaling cascade GO:0031098 37 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
anion transport GO:0006820 178 0.011
amide biosynthetic process GO:0043604 10 0.011
positive regulation of phosphate metabolic process GO:0045937 262 0.011
immune effector process GO:0002252 53 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
regulation of catabolic process GO:0009894 113 0.011
cellular macromolecule localization GO:0070727 122 0.011
protein targeting GO:0006605 61 0.011
sequestering of metal ion GO:0051238 9 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.011
protein localization GO:0008104 191 0.010
neuron projection regeneration GO:0031102 35 0.010
purine nucleoside triphosphate metabolic process GO:0009144 141 0.010
endochondral bone growth GO:0003416 3 0.010
positive regulation of cell proliferation GO:0008284 249 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.010
response to heat GO:0009408 60 0.010
macromolecular complex subunit organization GO:0043933 339 0.010
multicellular organism growth GO:0035264 1 0.010
regulation of anatomical structure size GO:0090066 135 0.010
organic acid transport GO:0015849 116 0.010
ion homeostasis GO:0050801 212 0.010
divalent inorganic cation transport GO:0072511 134 0.010
regulation of cellular localization GO:0060341 263 0.010

Atf4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
musculoskeletal system disease DOID:17 0 0.012
neuromuscular disease DOID:440 0 0.011
charcot marie tooth disease type 2 DOID:0050539 0 0.011
charcot marie tooth disease DOID:10595 0 0.011
neuropathy DOID:870 0 0.011