Rattus norvegicus

64 known processes

Lrp1

low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)

Lrp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
apoptotic process GO:0006915 381 0.241
intracellular signal transduction GO:0035556 314 0.139
myeloid progenitor cell differentiation GO:0002318 1 0.123
regulation of cellular component movement GO:0051270 150 0.114
positive regulation of developmental process GO:0051094 283 0.110
reproductive process GO:0022414 372 0.108
response to wounding GO:0009611 254 0.099
response to external biotic stimulus GO:0043207 221 0.093
regulation of cell motility GO:2000145 131 0.093
wound healing GO:0042060 122 0.088
regulation of hydrolase activity GO:0051336 143 0.082
programmed cell death GO:0012501 392 0.080
regulation of programmed cell death GO:0043067 341 0.078
positive regulation of multicellular organismal process GO:0051240 387 0.076
regulation of catalytic activity GO:0050790 304 0.073
regulation of apoptotic process GO:0042981 335 0.073
homeostatic process GO:0042592 331 0.072
response to inorganic substance GO:0010035 377 0.072
inflammatory response GO:0006954 150 0.071
enzyme linked receptor protein signaling pathway GO:0007167 116 0.070
response to growth factor GO:0070848 189 0.069
regulation of intracellular signal transduction GO:1902531 218 0.068
cellular response to endogenous stimulus GO:0071495 377 0.067
cell migration GO:0016477 197 0.067
positive regulation of cell differentiation GO:0045597 217 0.066
response to acid chemical GO:0001101 222 0.064
regulation of response to external stimulus GO:0032101 106 0.062
negative regulation of cell death GO:0060548 229 0.062
regulation of signal transduction GO:0009966 318 0.061
behavior GO:0007610 205 0.061
defense response GO:0006952 194 0.061
embryonic skeletal system development GO:0048706 3 0.060
response to other organism GO:0051707 220 0.059
response to corticosteroid GO:0031960 235 0.058
positive regulation of nervous system development GO:0051962 178 0.058
head development GO:0060322 247 0.058
neuron projection development GO:0031175 273 0.057
cellular response to platelet derived growth factor stimulus GO:0036120 7 0.057
regulation of molecular function GO:0065009 398 0.057
positive regulation of response to stimulus GO:0048584 285 0.057
positive regulation of cell projection organization GO:0031346 111 0.057
regeneration GO:0031099 163 0.056
positive regulation of neuron projection development GO:0010976 99 0.055
regulation of immune system process GO:0002682 123 0.054
heart morphogenesis GO:0003007 3 0.054
response to extracellular stimulus GO:0009991 380 0.053
positive regulation of neurogenesis GO:0050769 165 0.053
response to biotic stimulus GO:0009607 226 0.053
regulation of multicellular organismal development GO:2000026 376 0.051
metanephric glomerulus morphogenesis GO:0072275 1 0.051
response to glucocorticoid GO:0051384 223 0.050
regulation of growth GO:0040008 105 0.050
cell projection organization GO:0030030 302 0.050
metanephric s shaped body morphogenesis GO:0072284 2 0.049
positive regulation of apoptotic process GO:0043065 154 0.049
cell projection morphogenesis GO:0048858 123 0.049
central nervous system development GO:0007417 311 0.049
positive regulation of hydrolase activity GO:0051345 86 0.049
positive regulation of cell proliferation GO:0008284 249 0.048
cellular component assembly GO:0022607 360 0.047
cellular response to lipid GO:0071396 201 0.045
neuron apoptotic process GO:0051402 88 0.045
neuron differentiation GO:0030182 368 0.045
regulation of behavior GO:0050795 61 0.045
regulation of cell differentiation GO:0045595 320 0.045
immune system process GO:0002376 204 0.045
regulation of axonogenesis GO:0050770 37 0.045
salivary gland morphogenesis GO:0007435 1 0.044
regulation of cellular protein metabolic process GO:0032268 267 0.044
positive regulation of neuron differentiation GO:0045666 126 0.044
tissue development GO:0009888 252 0.043
positive regulation of intracellular signal transduction GO:1902533 138 0.043
reproduction GO:0000003 245 0.043
organ morphogenesis GO:0009887 75 0.042
regulation of cell projection organization GO:0031344 175 0.042
carbohydrate derivative metabolic process GO:1901135 346 0.042
regulation of response to stress GO:0080134 126 0.042
regulation of neuron differentiation GO:0045664 208 0.042
response to peptide GO:1901652 292 0.041
cell motility GO:0048870 202 0.041
tissue remodeling GO:0048771 40 0.041
positive regulation of signal transduction GO:0009967 175 0.041
single organism reproductive process GO:0044702 297 0.041
response to nutrient levels GO:0031667 370 0.041
cellular response to oxygen containing compound GO:1901701 386 0.040
response to metal ion GO:0010038 253 0.040
multi organism reproductive process GO:0044703 262 0.040
cellular lipid metabolic process GO:0044255 208 0.039
glycosaminoglycan biosynthetic process GO:0006024 4 0.039
response to lipopolysaccharide GO:0032496 191 0.039
cellular component movement GO:0006928 248 0.039
organonitrogen compound biosynthetic process GO:1901566 167 0.038
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.038
negative regulation of cell differentiation GO:0045596 99 0.038
regulation of cell migration GO:0030334 128 0.037
cellular response to glucocorticoid stimulus GO:0071385 68 0.036
negative regulation of developmental process GO:0051093 125 0.036
cellular response to nitrogen compound GO:1901699 210 0.036
positive regulation of catalytic activity GO:0043085 184 0.036
rna biosynthetic process GO:0032774 380 0.035
cell growth GO:0016049 104 0.035
regulation of neuron projection development GO:0010975 161 0.035
negative regulation of multicellular organismal process GO:0051241 203 0.035
pro t cell differentiation GO:0002572 1 0.035
salivary gland development GO:0007431 3 0.034
transcription dna templated GO:0006351 377 0.033
positive regulation of cell motility GO:2000147 97 0.033
anatomical structure morphogenesis GO:0009653 298 0.033
positive regulation of phosphorus metabolic process GO:0010562 262 0.033
regulation of cell proliferation GO:0042127 359 0.033
positive regulation of cellular component movement GO:0051272 102 0.032
cellular component morphogenesis GO:0032989 155 0.032
positive regulation of cellular protein metabolic process GO:0032270 167 0.032
carbohydrate derivative biosynthetic process GO:1901137 124 0.032
response to nutrient GO:0007584 248 0.032
positive regulation of protein phosphorylation GO:0001934 135 0.032
skeletal muscle tissue development GO:0007519 31 0.031
cellular calcium ion homeostasis GO:0006874 160 0.031
positive regulation of locomotion GO:0040017 102 0.031
multicellular organismal reproductive process GO:0048609 233 0.031
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.030
positive regulation of phosphorylation GO:0042327 177 0.030
chemotaxis GO:0006935 66 0.030
ras protein signal transduction GO:0007265 29 0.029
regulation of anatomical structure morphogenesis GO:0022603 141 0.029
cellular response to vascular endothelial growth factor stimulus GO:0035924 6 0.029
regulation of cellular component organization GO:0051128 368 0.029
positive regulation of phosphate metabolic process GO:0045937 262 0.028
cell part morphogenesis GO:0032990 123 0.028
positive regulation of cell migration GO:0030335 96 0.028
regulation of protein metabolic process GO:0051246 289 0.027
embryonic skeletal system morphogenesis GO:0048704 3 0.027
cytosolic calcium ion homeostasis GO:0051480 140 0.027
positive regulation of gene expression GO:0010628 244 0.027
embryonic cranial skeleton morphogenesis GO:0048701 2 0.027
cellular response to cytokine stimulus GO:0071345 127 0.027
sexual reproduction GO:0019953 148 0.026
negative regulation of macromolecule metabolic process GO:0010605 260 0.026
axonogenesis GO:0007409 71 0.026
positive regulation of protein metabolic process GO:0051247 178 0.026
growth GO:0040007 165 0.026
proteolysis GO:0006508 175 0.026
regulation of neuron death GO:1901214 115 0.025
nucleic acid templated transcription GO:0097659 379 0.025
cell adhesion GO:0007155 110 0.025
positive regulation of molecular function GO:0044093 230 0.025
regulation of stem cell differentiation GO:2000736 2 0.025
regulation of response to wounding GO:1903034 69 0.025
odontogenesis GO:0042476 32 0.025
signal transduction by phosphorylation GO:0023014 144 0.025
aminoglycan biosynthetic process GO:0006023 4 0.025
s shaped body morphogenesis GO:0072050 2 0.025
regulation of bmp signaling pathway GO:0030510 2 0.024
locomotion GO:0040011 237 0.024
multicellular organism reproduction GO:0032504 233 0.024
lipid metabolic process GO:0006629 283 0.024
positive regulation of programmed cell death GO:0043068 157 0.024
catabolic process GO:0009056 351 0.024
transcription from rna polymerase ii promoter GO:0006366 252 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.023
neuron development GO:0048666 286 0.023
brain development GO:0007420 247 0.023
response to molecule of bacterial origin GO:0002237 194 0.023
organophosphate metabolic process GO:0019637 370 0.023
osteoclast differentiation GO:0030316 11 0.023
positive regulation of cell development GO:0010720 176 0.023
cation homeostasis GO:0055080 195 0.023
regulation of nervous system development GO:0051960 264 0.023
cell morphogenesis involved in differentiation GO:0000904 119 0.023
positive regulation of cell death GO:0010942 184 0.023
regulation of homeostatic process GO:0032844 101 0.023
regulation of phosphorus metabolic process GO:0051174 349 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
developmental process involved in reproduction GO:0003006 159 0.022
regulation of rna biosynthetic process GO:2001141 381 0.022
regulation of phosphate metabolic process GO:0019220 349 0.022
regulation of locomotion GO:0040012 148 0.022
cellular chemical homeostasis GO:0055082 247 0.022
hemostasis GO:0007599 26 0.022
formation of primary germ layer GO:0001704 1 0.021
response to decreased oxygen levels GO:0036293 237 0.021
gastrulation GO:0007369 2 0.021
lymphoid progenitor cell differentiation GO:0002320 2 0.021
localization of cell GO:0051674 202 0.021
protein phosphorylation GO:0006468 345 0.021
spindle organization GO:0007051 2 0.021
digestive system development GO:0055123 41 0.021
regulation of neurogenesis GO:0050767 247 0.021
response to reactive oxygen species GO:0000302 120 0.021
oxoacid metabolic process GO:0043436 290 0.021
response to cytokine GO:0034097 215 0.021
metanephric comma shaped body morphogenesis GO:0072278 2 0.021
negative regulation of apoptotic process GO:0043066 181 0.020
cytokine mediated signaling pathway GO:0019221 43 0.020
cellular response to organonitrogen compound GO:0071417 197 0.020
cellular response to growth factor stimulus GO:0071363 162 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
metanephric mesenchymal cell migration GO:0035789 2 0.020
gliogenesis GO:0042063 93 0.020
neuron projection morphogenesis GO:0048812 122 0.020
protein maturation GO:0051604 68 0.020
bmp signaling pathway GO:0030509 4 0.020
cellular response to acid chemical GO:0071229 75 0.019
establishment of protein localization GO:0045184 141 0.019
regulation of cell growth GO:0001558 85 0.019
organic substance catabolic process GO:1901575 316 0.019
response to transforming growth factor beta GO:0071559 46 0.019
hematopoietic progenitor cell differentiation GO:0002244 2 0.019
regulation of anatomical structure size GO:0090066 135 0.019
axon extension GO:0048675 26 0.019
transmembrane transport GO:0055085 412 0.019
regulation of protein modification process GO:0031399 194 0.019
regulation of proteolysis GO:0030162 66 0.019
positive regulation of cellular component organization GO:0051130 200 0.019
purine containing compound metabolic process GO:0072521 253 0.019
skeletal muscle organ development GO:0060538 33 0.019
regulation of axon extension GO:0030516 24 0.019
axon development GO:0061564 96 0.019
aging GO:0007568 241 0.019
motor neuron axon guidance GO:0008045 1 0.018
mitotic spindle organization GO:0007052 2 0.018
chemical homeostasis GO:0048878 292 0.018
reproductive system development GO:0061458 128 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
response to ketone GO:1901654 182 0.018
response to estradiol GO:0032355 164 0.018
positive regulation of cell communication GO:0010647 271 0.018
nucleobase containing small molecule metabolic process GO:0055086 316 0.018
complement activation GO:0006956 11 0.018
regulation of cell development GO:0060284 263 0.018
regulation of chemotaxis GO:0050920 29 0.017
regulation of system process GO:0044057 208 0.017
muscle tissue development GO:0060537 58 0.017
neuron death GO:0070997 127 0.017
cell morphogenesis GO:0000902 142 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
cellular component biogenesis GO:0044085 368 0.017
positive regulation of cellular biosynthetic process GO:0031328 295 0.017
positive regulation of response to wounding GO:1903036 34 0.017
organ regeneration GO:0031100 101 0.017
comma shaped body morphogenesis GO:0072049 2 0.017
positive regulation of protein modification process GO:0031401 142 0.017
immune system development GO:0002520 41 0.017
regulation of cell morphogenesis GO:0022604 77 0.017
cellular response to corticosteroid stimulus GO:0071384 69 0.017
neurological system process GO:0050877 219 0.017
rna metabolic process GO:0016070 406 0.017
regulation of phosphorylation GO:0042325 248 0.017
urogenital system development GO:0001655 78 0.016
calcium ion homeostasis GO:0055074 162 0.016
reproductive structure development GO:0048608 128 0.016
positive regulation of blood coagulation GO:0030194 4 0.016
ribose phosphate metabolic process GO:0019693 235 0.016
single organism catabolic process GO:0044712 283 0.016
response to oxidative stress GO:0006979 186 0.016
positive regulation of biosynthetic process GO:0009891 319 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.016
positive regulation of response to external stimulus GO:0032103 51 0.016
response to insulin GO:0032868 133 0.016
cell activation GO:0001775 97 0.016
tissue regeneration GO:0042246 36 0.016
glomerulus morphogenesis GO:0072102 1 0.016
embryonic pattern specification GO:0009880 1 0.016
regulation of extent of cell growth GO:0061387 25 0.016
synaptic growth at neuromuscular junction GO:0051124 1 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.015
regulation of immunoglobulin production GO:0002637 4 0.015
cell type specific apoptotic process GO:0097285 134 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
regulation of neuron apoptotic process GO:0043523 83 0.015
regulation of rna metabolic process GO:0051252 391 0.015
response to hypoxia GO:0001666 231 0.015
learning or memory GO:0007611 90 0.015
single organism biosynthetic process GO:0044711 342 0.015
response to monosaccharide GO:0034284 159 0.015
cell migration involved in kidney development GO:0035787 2 0.015
negative regulation of cellular metabolic process GO:0031324 281 0.015
inorganic ion transmembrane transport GO:0098660 229 0.015
positive regulation of hemostasis GO:1900048 4 0.015
negative regulation of innate immune response GO:0045824 4 0.015
cellular cation homeostasis GO:0030003 180 0.015
amine metabolic process GO:0009308 38 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
metal ion homeostasis GO:0055065 186 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.015
response to hexose GO:0009746 144 0.015
cellular response to steroid hormone stimulus GO:0071383 93 0.015
peptidyl amino acid modification GO:0018193 126 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.014
cellular amine metabolic process GO:0044106 38 0.014
regulation of transcription dna templated GO:0006355 374 0.014
single organism behavior GO:0044708 130 0.014
blood coagulation GO:0007596 26 0.014
vascular process in circulatory system GO:0003018 96 0.014
b cell differentiation GO:0030183 2 0.014
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.014
gamete generation GO:0007276 124 0.014
negative regulation of cell communication GO:0010648 158 0.014
metanephric glomerulus development GO:0072224 3 0.014
regulation of cellular ketone metabolic process GO:0010565 27 0.014
odontogenesis of dentin containing tooth GO:0042475 18 0.014
cellular response to stress GO:0033554 269 0.014
cell projection assembly GO:0030031 21 0.014
cellular catabolic process GO:0044248 295 0.013
regulation of inflammatory response GO:0050727 48 0.013
response to carbohydrate GO:0009743 183 0.013
taxis GO:0042330 67 0.013
negative regulation of metabolic process GO:0009892 331 0.013
regulation of platelet activation GO:0010543 2 0.013
response to glucose GO:0009749 136 0.013
cellular response to metal ion GO:0071248 55 0.013
cellular homeostasis GO:0019725 252 0.013
biological adhesion GO:0022610 110 0.013
organic acid metabolic process GO:0006082 292 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
rho protein signal transduction GO:0007266 11 0.013
macromolecular complex subunit organization GO:0043933 339 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
axon midline choice point recognition GO:0016199 2 0.013
leukocyte differentiation GO:0002521 30 0.013
skeletal system development GO:0001501 41 0.013
regulation of muscle system process GO:0090257 79 0.013
smooth muscle contraction GO:0006939 37 0.013
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 5 0.013
negative regulation of gene expression GO:0010629 199 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
nucleotide metabolic process GO:0009117 279 0.013
neuron projection extension GO:1990138 26 0.013
positive regulation of immune system process GO:0002684 90 0.012
regulation of transferase activity GO:0051338 123 0.012
carboxylic acid metabolic process GO:0019752 289 0.012
regulation of peptidase activity GO:0052547 55 0.012
regulation of leukocyte differentiation GO:1902105 20 0.012
response to toxic substance GO:0009636 133 0.012
muscle contraction GO:0006936 88 0.012
regulation of wound healing GO:0061041 14 0.012
male gamete generation GO:0048232 99 0.012
lens fiber cell differentiation GO:0070306 3 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.012
myeloid leukocyte differentiation GO:0002573 20 0.012
angiogenesis GO:0001525 53 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
ion transmembrane transport GO:0034220 365 0.012
sex differentiation GO:0007548 113 0.012
muscle structure development GO:0061061 87 0.012
pro b cell differentiation GO:0002328 2 0.012
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
negative regulation of b cell differentiation GO:0045578 1 0.012
developmental growth involved in morphogenesis GO:0060560 33 0.012
regulation of organ formation GO:0003156 2 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
striated muscle tissue development GO:0014706 58 0.012
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 1 0.011
cytokine production GO:0001816 61 0.011
defense response to gram positive bacterium GO:0050830 2 0.011
single organism organelle organization GO:1902589 180 0.011
immune response GO:0006955 104 0.011
negative regulation of response to biotic stimulus GO:0002832 4 0.011
erk1 and erk2 cascade GO:0070371 48 0.011
cytoplasmic transport GO:0016482 115 0.011
actin cytoskeleton organization GO:0030036 73 0.011
rhythmic process GO:0048511 156 0.011
regulation of smooth muscle contraction GO:0006940 29 0.011
protein processing GO:0016485 68 0.011
female gonad development GO:0008585 53 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
adult locomotory behavior GO:0008344 4 0.011
cellular response to inorganic substance GO:0071241 65 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
response to bacterium GO:0009617 200 0.011
skin morphogenesis GO:0043589 2 0.011
single organismal cell cell adhesion GO:0016337 42 0.011
muscle system process GO:0003012 115 0.011
regulation of cellular amino acid metabolic process GO:0006521 2 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.011
ribonucleotide metabolic process GO:0009259 231 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
ovulation cycle GO:0042698 67 0.011
positive regulation of cell growth GO:0030307 44 0.011
forebrain development GO:0030900 98 0.011
negative regulation of response to external stimulus GO:0032102 37 0.011
single organism cell adhesion GO:0098602 46 0.011
muscle organ development GO:0007517 50 0.011
positive regulation of cytokine production GO:0001819 42 0.010
regulation of kinase activity GO:0043549 117 0.010
sensory perception of pain GO:0019233 73 0.010
negative regulation of cellular component organization GO:0051129 83 0.010
cellular response to alcohol GO:0097306 87 0.010
mapk cascade GO:0000165 140 0.010
response to oxygen levels GO:0070482 265 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
regulation of body fluid levels GO:0050878 90 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.010
positive regulation of jnk cascade GO:0046330 13 0.010
circulatory system development GO:0072359 134 0.010
cell cell signaling GO:0007267 335 0.010
dephosphorylation GO:0016311 98 0.010
cellular nitrogen compound catabolic process GO:0044270 163 0.010
macromolecular complex assembly GO:0065003 273 0.010

Lrp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.042
musculoskeletal system disease DOID:17 0 0.042
disease of metabolism DOID:0014667 0 0.024
inherited metabolic disorder DOID:655 0 0.022
nervous system disease DOID:863 0 0.021
bone disease DOID:0080001 0 0.015
connective tissue disease DOID:65 0 0.015
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
central nervous system disease DOID:331 0 0.012
gastrointestinal system cancer DOID:3119 0 0.011
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011