Rattus norvegicus

91 known processes

Lrp6

low density lipoprotein receptor-related protein 6

Lrp6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transcription dna templated GO:0006351 377 0.152
organic acid metabolic process GO:0006082 292 0.119
cell projection organization GO:0030030 302 0.090
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.089
Human
reproductive process GO:0022414 372 0.073
multi organism reproductive process GO:0044703 262 0.070
multicellular organism reproduction GO:0032504 233 0.067
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.066
Human
positive regulation of signaling GO:0023056 270 0.065
Human
regulation of rna biosynthetic process GO:2001141 381 0.064
positive regulation of cellular biosynthetic process GO:0031328 295 0.062
Human
central nervous system development GO:0007417 311 0.062
positive regulation of rna biosynthetic process GO:1902680 197 0.062
Human
gland development GO:0048732 155 0.060
cell cell signaling GO:0007267 335 0.060
single organism reproductive process GO:0044702 297 0.060
cellular component biogenesis GO:0044085 368 0.058
regulation of transcription dna templated GO:0006355 374 0.053
carboxylic acid metabolic process GO:0019752 289 0.052
brain development GO:0007420 247 0.050
motor neuron axon guidance GO:0008045 1 0.049
sexual reproduction GO:0019953 148 0.048
response to nutrient levels GO:0031667 370 0.048
taxis GO:0042330 67 0.048
neuron differentiation GO:0030182 368 0.048
neuron death GO:0070997 127 0.047
heart morphogenesis GO:0003007 3 0.046
negative regulation of multicellular organismal process GO:0051241 203 0.046
cellular response to hormone stimulus GO:0032870 247 0.046
homeostatic process GO:0042592 331 0.045
monocarboxylic acid metabolic process GO:0032787 152 0.044
positive regulation of transcription dna templated GO:0045893 197 0.044
Human
regulation of cell proliferation GO:0042127 359 0.043
protein phosphorylation GO:0006468 345 0.042
Human
regulation of cellular amino acid metabolic process GO:0006521 2 0.042
cellular component assembly GO:0022607 360 0.042
regulation of neuron differentiation GO:0045664 208 0.042
regulation of protein phosphorylation GO:0001932 183 0.042
Human
multicellular organismal reproductive process GO:0048609 233 0.041
oxoacid metabolic process GO:0043436 290 0.041
response to peptide GO:1901652 292 0.041
negative regulation of osteoblast differentiation GO:0045668 2 0.040
regulation of phosphate metabolic process GO:0019220 349 0.040
Human
positive regulation of biosynthetic process GO:0009891 319 0.040
Human
regulation of rna metabolic process GO:0051252 391 0.039
regulation of nucleic acid templated transcription GO:1903506 380 0.038
hepaticobiliary system development GO:0061008 90 0.038
cellular amino acid metabolic process GO:0006520 107 0.038
cellular response to organonitrogen compound GO:0071417 197 0.038
reproduction GO:0000003 245 0.037
negative regulation of macromolecule metabolic process GO:0010605 260 0.036
Human
regulation of cellular ketone metabolic process GO:0010565 27 0.036
ribose phosphate metabolic process GO:0019693 235 0.035
regulation of cell development GO:0060284 263 0.035
purine nucleoside metabolic process GO:0042278 169 0.034
response to extracellular stimulus GO:0009991 380 0.034
locomotion GO:0040011 237 0.034
blood circulation GO:0008015 183 0.034
response to inorganic substance GO:0010035 377 0.034
positive regulation of signal transduction GO:0009967 175 0.034
Human
cellular response to oxygen containing compound GO:1901701 386 0.033
Human
regulation of signal transduction GO:0009966 318 0.033
Human
cellular ketone metabolic process GO:0042180 51 0.032
response to estrogen GO:0043627 232 0.032
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.032
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.032
Human
negative regulation of cellular component organization GO:0051129 83 0.031
regulation of molecular function GO:0065009 398 0.031
Human
negative regulation of nervous system development GO:0051961 79 0.031
positive regulation of cell communication GO:0010647 271 0.030
Human
synaptic transmission GO:0007268 235 0.030
regulation of phosphorus metabolic process GO:0051174 349 0.030
Human
response to purine containing compound GO:0014074 126 0.030
negative regulation of apoptotic process GO:0043066 181 0.030
Human
cell type specific apoptotic process GO:0097285 134 0.029
Human
nucleotide metabolic process GO:0009117 279 0.029
response to organophosphorus GO:0046683 102 0.029
neuromuscular synaptic transmission GO:0007274 2 0.029
neuron projection development GO:0031175 273 0.029
rna biosynthetic process GO:0032774 380 0.029
regulation of multicellular organismal development GO:2000026 376 0.029
Human
negative regulation of molecular function GO:0044092 133 0.028
Human
response to acid chemical GO:0001101 222 0.028
gamete generation GO:0007276 124 0.028
intracellular transport GO:0046907 185 0.028
purine ribonucleoside metabolic process GO:0046128 168 0.028
negative regulation of gene expression GO:0010629 199 0.027
mesoderm development GO:0007498 2 0.027
regulation of neuron death GO:1901214 115 0.027
positive regulation of molecular function GO:0044093 230 0.027
Human
response to hexose GO:0009746 144 0.027
negative regulation of cell proliferation GO:0008285 119 0.026
organic substance catabolic process GO:1901575 316 0.026
regulation of cellular protein metabolic process GO:0032268 267 0.026
Human
amine metabolic process GO:0009308 38 0.026
regulation of catalytic activity GO:0050790 304 0.026
Human
cytoplasmic transport GO:0016482 115 0.025
organelle organization GO:0006996 266 0.025
cation transport GO:0006812 382 0.025
purine ribonucleotide metabolic process GO:0009150 227 0.025
negative regulation of developmental process GO:0051093 125 0.025
cell motility GO:0048870 202 0.025
response to nutrient GO:0007584 248 0.025
multi multicellular organism process GO:0044706 138 0.025
positive regulation of response to stimulus GO:0048584 285 0.025
Human
positive regulation of transport GO:0051050 245 0.024
cellular response to endogenous stimulus GO:0071495 377 0.024
regulation of phosphorylation GO:0042325 248 0.024
Human
axonogenesis GO:0007409 71 0.024
positive regulation of gene expression GO:0010628 244 0.024
Human
nucleic acid templated transcription GO:0097659 379 0.024
neuron apoptotic process GO:0051402 88 0.024
negative regulation of nucleic acid templated transcription GO:1903507 117 0.024
negative regulation of metabolic process GO:0009892 331 0.024
Human
axis specification GO:0009798 4 0.023
Human
anterior posterior pattern specification GO:0009952 1 0.023
protein complex subunit organization GO:0071822 302 0.023
multicellular organismal signaling GO:0035637 44 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
positive regulation of nucleic acid templated transcription GO:1903508 197 0.022
Human
cellular response to nitrogen compound GO:1901699 210 0.022
positive regulation of cellular catabolic process GO:0031331 71 0.022
organ formation GO:0048645 3 0.022
lipid biosynthetic process GO:0008610 128 0.022
regulation of cellular amine metabolic process GO:0033238 8 0.022
regulation of cell motility GO:2000145 131 0.022
protein complex biogenesis GO:0070271 263 0.022
negative regulation of cellular biosynthetic process GO:0031327 161 0.022
head development GO:0060322 247 0.021
regulation of cell differentiation GO:0045595 320 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
Human
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.021
liver development GO:0001889 90 0.021
carbohydrate metabolic process GO:0005975 130 0.021
response to vitamin GO:0033273 131 0.021
positive regulation of intracellular signal transduction GO:1902533 138 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
reproductive system development GO:0061458 128 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
cellular response to lipid GO:0071396 201 0.020
Human
cellular response to stress GO:0033554 269 0.020
establishment of tissue polarity GO:0007164 2 0.020
protein complex assembly GO:0006461 263 0.020
gastrulation GO:0007369 2 0.020
ribonucleotide metabolic process GO:0009259 231 0.020
anatomical structure morphogenesis GO:0009653 298 0.020
Human
cell migration GO:0016477 197 0.020
single organism biosynthetic process GO:0044711 342 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
cell morphogenesis GO:0000902 142 0.019
Human
muscle system process GO:0003012 115 0.019
nucleoside monophosphate metabolic process GO:0009123 93 0.019
developmental process involved in reproduction GO:0003006 159 0.019
cellular component movement GO:0006928 248 0.019
negative regulation of neuron death GO:1901215 69 0.019
positive regulation of catabolic process GO:0009896 78 0.019
purine nucleoside triphosphate metabolic process GO:0009144 141 0.019
regulation of programmed cell death GO:0043067 341 0.019
Human
regulation of canonical wnt signaling pathway GO:0060828 4 0.019
Human
negative regulation of cellular metabolic process GO:0031324 281 0.019
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.019
Human
nucleoside phosphate metabolic process GO:0006753 283 0.019
regulation of protein modification process GO:0031399 194 0.019
Human
positive regulation of phosphate metabolic process GO:0045937 262 0.018
negative regulation of signaling GO:0023057 157 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
Human
negative regulation of cell communication GO:0010648 158 0.018
regulation of mapk cascade GO:0043408 116 0.018
regulation of membrane potential GO:0042391 110 0.018
tube development GO:0035295 89 0.018
formation of primary germ layer GO:0001704 1 0.018
cellular response to acid chemical GO:0071229 75 0.018
rhythmic process GO:0048511 156 0.018
regulation of cellular carbohydrate metabolic process GO:0010675 39 0.018
response to monosaccharide GO:0034284 159 0.018
cellular response to organic cyclic compound GO:0071407 202 0.018
Human
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.018
rna metabolic process GO:0016070 406 0.018
female pregnancy GO:0007565 122 0.017
regulation of body fluid levels GO:0050878 90 0.017
intracellular signal transduction GO:0035556 314 0.017
glucose metabolic process GO:0006006 52 0.017
single organism carbohydrate metabolic process GO:0044723 118 0.017
protein heterooligomerization GO:0051291 89 0.017
cation transmembrane transport GO:0098655 263 0.017
cardiovascular system development GO:0072358 134 0.017
maintenance of location GO:0051235 17 0.017
ribonucleoside monophosphate metabolic process GO:0009161 88 0.017
response to camp GO:0051591 91 0.017
cellular carbohydrate metabolic process GO:0044262 72 0.017
neuron development GO:0048666 286 0.017
cell projection morphogenesis GO:0048858 123 0.016
negative regulation of cell development GO:0010721 82 0.016
protein oligomerization GO:0051259 191 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
regulation of anatomical structure size GO:0090066 135 0.016
organophosphate metabolic process GO:0019637 370 0.016
chemical homeostasis GO:0048878 292 0.016
reproductive structure development GO:0048608 128 0.016
enzyme linked receptor protein signaling pathway GO:0007167 116 0.016
apoptotic process GO:0006915 381 0.016
Human
single organism catabolic process GO:0044712 283 0.016
cellular amine metabolic process GO:0044106 38 0.016
regulation of apoptotic process GO:0042981 335 0.016
Human
cellular chemical homeostasis GO:0055082 247 0.016
catabolic process GO:0009056 351 0.016
response to decreased oxygen levels GO:0036293 237 0.016
nucleocytoplasmic transport GO:0006913 48 0.016
positive regulation of cell development GO:0010720 176 0.015
regulation of cellular component movement GO:0051270 150 0.015
circulatory system process GO:0003013 183 0.015
programmed cell death GO:0012501 392 0.015
Human
regulation of blood vessel size GO:0050880 89 0.015
regulation of carbohydrate metabolic process GO:0006109 41 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
cellular catabolic process GO:0044248 295 0.015
regulation of locomotion GO:0040012 148 0.015
epithelium development GO:0060429 96 0.015
dendrite development GO:0016358 72 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
negative regulation of cell differentiation GO:0045596 99 0.015
lipid storage GO:0019915 1 0.015
transmission of nerve impulse GO:0019226 42 0.015
monosaccharide metabolic process GO:0005996 61 0.015
positive regulation of protein phosphorylation GO:0001934 135 0.015
coenzyme metabolic process GO:0006732 86 0.015
response to ethanol GO:0045471 162 0.014
lipid metabolic process GO:0006629 283 0.014
positive regulation of transferase activity GO:0051347 81 0.014
response to growth factor GO:0070848 189 0.014
cytosolic calcium ion homeostasis GO:0051480 140 0.014
ion transmembrane transport GO:0034220 365 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
regulation of neuron apoptotic process GO:0043523 83 0.014
macromolecular complex assembly GO:0065003 273 0.014
response to hypoxia GO:0001666 231 0.014
ribonucleoside triphosphate catabolic process GO:0009203 122 0.014
mesenchymal cell proliferation GO:0010463 4 0.014
biological adhesion GO:0022610 110 0.014
circadian rhythm GO:0007623 88 0.014
cell cycle GO:0007049 101 0.014
Human
neuron projection guidance GO:0097485 24 0.014
inorganic cation transmembrane transport GO:0098662 202 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
secretion GO:0046903 307 0.014
mammary gland development GO:0030879 38 0.014
positive regulation of rna metabolic process GO:0051254 203 0.014
Human
response to mechanical stimulus GO:0009612 134 0.013
regulation of catabolic process GO:0009894 113 0.013
regulation of neuron projection development GO:0010975 161 0.013
intracellular protein transport GO:0006886 79 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
neuron neuron synaptic transmission GO:0007270 60 0.013
spermatogenesis GO:0007283 99 0.013
response to insulin GO:0032868 133 0.013
response to corticosteroid GO:0031960 235 0.013
cellular ion homeostasis GO:0006873 184 0.013
development of primary sexual characteristics GO:0045137 107 0.013
neuron projection morphogenesis GO:0048812 122 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
response to glucose GO:0009749 136 0.013
localization of cell GO:0051674 202 0.013
nitrogen compound transport GO:0071705 229 0.013
eye morphogenesis GO:0048592 4 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
ras protein signal transduction GO:0007265 29 0.013
peptidyl tyrosine phosphorylation GO:0018108 72 0.013
vascular process in circulatory system GO:0003018 96 0.013
inflammatory response GO:0006954 150 0.013
action potential GO:0001508 54 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.013
behavior GO:0007610 205 0.013
response to oxygen levels GO:0070482 265 0.013
regeneration GO:0031099 163 0.013
mesoderm formation GO:0001707 1 0.012
aging GO:0007568 241 0.012
autonomic nervous system development GO:0048483 3 0.012
protein homooligomerization GO:0051260 91 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
response to carbohydrate GO:0009743 183 0.012
regulation of protein metabolic process GO:0051246 289 0.012
Human
growth GO:0040007 165 0.012
developmental induction GO:0031128 2 0.012
cell adhesion GO:0007155 110 0.012
regulation of transferase activity GO:0051338 123 0.012
Human
negative regulation of neuron differentiation GO:0045665 62 0.012
regulation of hormone levels GO:0010817 187 0.012
regulation of nervous system development GO:0051960 264 0.012
anion transport GO:0006820 178 0.012
erythrocyte differentiation GO:0030218 1 0.012
multicellular organism growth GO:0035264 1 0.012
response to alkaloid GO:0043279 132 0.012
chemotaxis GO:0006935 66 0.012
positive regulation of phagocytosis engulfment GO:0060100 4 0.012
vesicle mediated transport GO:0016192 181 0.012
Human
negative regulation of response to stimulus GO:0048585 155 0.012
positive regulation of developmental process GO:0051094 283 0.012
Human
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
heterocycle catabolic process GO:0046700 167 0.012
positive regulation of nervous system development GO:0051962 178 0.012
cerebellar granule cell precursor proliferation GO:0021930 1 0.012
response to osmotic stress GO:0006970 42 0.012
negative regulation of neuron apoptotic process GO:0043524 45 0.012
hair follicle development GO:0001942 2 0.012
cellular lipid metabolic process GO:0044255 208 0.012
single organism intracellular transport GO:1902582 166 0.012
regulation of establishment of planar polarity GO:0090175 2 0.012
transmembrane transport GO:0055085 412 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
ion homeostasis GO:0050801 212 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
response to estradiol GO:0032355 164 0.011
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.011
hexose metabolic process GO:0019318 58 0.011
response to peptide hormone GO:0043434 278 0.011
regulation of organ formation GO:0003156 2 0.011
divalent inorganic cation transport GO:0072511 134 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
male gamete generation GO:0048232 99 0.011
sequestering of calcium ion GO:0051208 8 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
telencephalon development GO:0021537 62 0.011
regulation of cellular component organization GO:0051128 368 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
Human
skin morphogenesis GO:0043589 2 0.011
rab protein signal transduction GO:0032482 1 0.011
purine containing compound metabolic process GO:0072521 253 0.011
nucleoside metabolic process GO:0009116 179 0.011
defense response GO:0006952 194 0.011
positive regulation of locomotion GO:0040017 102 0.011
regulation of embryonic development GO:0045995 2 0.011
heart development GO:0007507 72 0.011
response to glucocorticoid GO:0051384 223 0.011
neurotransmitter uptake GO:0001504 3 0.011
regulation of anatomical structure morphogenesis GO:0022603 141 0.011
regulation of system process GO:0044057 208 0.011
regulation of secretion GO:0051046 224 0.011
regulation of neurogenesis GO:0050767 247 0.011
regulation of kinase activity GO:0043549 117 0.011
Human
ribonucleoside monophosphate catabolic process GO:0009158 55 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
regulation of cellular localization GO:0060341 263 0.011
salivary gland development GO:0007431 3 0.010
negative regulation of transcription dna templated GO:0045892 116 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.010
synaptic vesicle endocytosis GO:0048488 4 0.010
neuronal action potential GO:0019228 35 0.010
muscle contraction GO:0006936 88 0.010
ribonucleoside metabolic process GO:0009119 174 0.010
heart contraction GO:0060047 57 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.010
peptidyl tyrosine modification GO:0018212 72 0.010
single organism cell adhesion GO:0098602 46 0.010
cell part morphogenesis GO:0032990 123 0.010
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.010
mesoderm morphogenesis GO:0048332 1 0.010
positive regulation of cell differentiation GO:0045597 217 0.010
molting cycle process GO:0022404 2 0.010
cellular component morphogenesis GO:0032989 155 0.010
Human
mechanoreceptor differentiation GO:0042490 2 0.010
digestive system development GO:0055123 41 0.010

Lrp6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
neuromuscular disease DOID:440 0 0.014
charcot marie tooth disease DOID:10595 0 0.014
neuropathy DOID:870 0 0.014