Rattus norvegicus

0 known processes

Nup188

nucleoporin 188

Nup188 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
protein complex subunit organization GO:0071822 302 0.140
macromolecular complex subunit organization GO:0043933 339 0.139
rna biosynthetic process GO:0032774 380 0.128
rna metabolic process GO:0016070 406 0.127
nucleic acid templated transcription GO:0097659 379 0.097
programmed cell death GO:0012501 392 0.092
regulation of transcription dna templated GO:0006355 374 0.089
cellular component assembly GO:0022607 360 0.088
protein complex assembly GO:0006461 263 0.087
macromolecular complex assembly GO:0065003 273 0.085
organelle organization GO:0006996 266 0.084
positive regulation of nucleic acid templated transcription GO:1903508 197 0.080
regulation of nucleic acid templated transcription GO:1903506 380 0.077
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.075
protein complex biogenesis GO:0070271 263 0.074
positive regulation of rna biosynthetic process GO:1902680 197 0.070
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.069
cellular component biogenesis GO:0044085 368 0.068
cellular response to stress GO:0033554 269 0.068
regulation of rna metabolic process GO:0051252 391 0.061
cellular response to endogenous stimulus GO:0071495 377 0.059
transcription dna templated GO:0006351 377 0.059
regulation of signal transduction GO:0009966 318 0.058
positive regulation of neurogenesis GO:0050769 165 0.056
positive regulation of rna metabolic process GO:0051254 203 0.054
positive regulation of biosynthetic process GO:0009891 319 0.054
regulation of cell differentiation GO:0045595 320 0.053
positive regulation of transcription dna templated GO:0045893 197 0.053
protein phosphorylation GO:0006468 345 0.051
histone h3 acetylation GO:0043966 2 0.050
regulation of molecular function GO:0065009 398 0.049
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.048
regulation of phosphate metabolic process GO:0019220 349 0.047
positive regulation of nervous system development GO:0051962 178 0.047
reproductive process GO:0022414 372 0.046
positive regulation of molecular function GO:0044093 230 0.046
regulation of rna biosynthetic process GO:2001141 381 0.045
transcription from rna polymerase ii promoter GO:0006366 252 0.044
single organism organelle organization GO:1902589 180 0.042
regulation of catalytic activity GO:0050790 304 0.042
positive regulation of gene expression GO:0010628 244 0.042
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.041
cellular response to oxygen containing compound GO:1901701 386 0.041
protein oligomerization GO:0051259 191 0.039
macromolecule localization GO:0033036 252 0.039
intracellular signal transduction GO:0035556 314 0.038
locomotion GO:0040011 237 0.038
positive regulation of response to stimulus GO:0048584 285 0.038
regulation of cell proliferation GO:0042127 359 0.037
positive regulation of cell development GO:0010720 176 0.037
positive regulation of phosphate metabolic process GO:0045937 262 0.037
neuron development GO:0048666 286 0.037
regulation of cell development GO:0060284 263 0.036
protein localization GO:0008104 191 0.036
negative regulation of metabolic process GO:0009892 331 0.036
signal transduction by phosphorylation GO:0023014 144 0.036
regulation of phosphorylation GO:0042325 248 0.036
negative regulation of cell death GO:0060548 229 0.036
anatomical structure morphogenesis GO:0009653 298 0.035
cytoskeleton organization GO:0007010 111 0.035
regulation of phosphorus metabolic process GO:0051174 349 0.035
positive regulation of cell differentiation GO:0045597 217 0.035
positive regulation of phosphorylation GO:0042327 177 0.034
cell projection organization GO:0030030 302 0.034
regulation of cellular localization GO:0060341 263 0.033
positive regulation of protein metabolic process GO:0051247 178 0.033
purine containing compound metabolic process GO:0072521 253 0.033
positive regulation of cellular component organization GO:0051130 200 0.033
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
regulation of cellular protein metabolic process GO:0032268 267 0.032
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
neuron projection development GO:0031175 273 0.031
regulation of programmed cell death GO:0043067 341 0.031
positive regulation of cellular biosynthetic process GO:0031328 295 0.031
nucleobase containing small molecule metabolic process GO:0055086 316 0.030
response to cytokine GO:0034097 215 0.030
regulation of protein metabolic process GO:0051246 289 0.030
neuron differentiation GO:0030182 368 0.030
negative regulation of signaling GO:0023057 157 0.029
gastrulation GO:0007369 2 0.029
cellular component morphogenesis GO:0032989 155 0.029
negative regulation of cell communication GO:0010648 158 0.029
positive regulation of signaling GO:0023056 270 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
negative regulation of biosynthetic process GO:0009890 168 0.028
positive regulation of cell communication GO:0010647 271 0.028
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.028
nucleoside triphosphate catabolic process GO:0009143 123 0.028
central nervous system development GO:0007417 311 0.028
negative regulation of cellular biosynthetic process GO:0031327 161 0.028
catabolic process GO:0009056 351 0.027
negative regulation of cellular metabolic process GO:0031324 281 0.027
apoptotic process GO:0006915 381 0.027
brain development GO:0007420 247 0.027
tissue development GO:0009888 252 0.027
asymmetric protein localization GO:0008105 2 0.027
nucleocytoplasmic transport GO:0006913 48 0.026
regulation of nervous system development GO:0051960 264 0.026
multi organism reproductive process GO:0044703 262 0.026
positive regulation of transport GO:0051050 245 0.026
purine nucleotide metabolic process GO:0006163 229 0.026
small gtpase mediated signal transduction GO:0007264 36 0.025
mapk cascade GO:0000165 140 0.025
positive regulation of neuron differentiation GO:0045666 126 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.025
cellular ketone metabolic process GO:0042180 51 0.025
heterocycle catabolic process GO:0046700 167 0.024
aromatic compound catabolic process GO:0019439 168 0.024
cellular response to nitrogen compound GO:1901699 210 0.024
cell cell signaling GO:0007267 335 0.024
response to growth factor GO:0070848 189 0.023
regulation of mapk cascade GO:0043408 116 0.023
negative regulation of gene expression GO:0010629 199 0.023
response to peptide hormone GO:0043434 278 0.023
regulation of protein phosphorylation GO:0001932 183 0.023
cell cycle GO:0007049 101 0.023
positive regulation of developmental process GO:0051094 283 0.023
organic acid metabolic process GO:0006082 292 0.023
reproduction GO:0000003 245 0.023
cell migration GO:0016477 197 0.023
negative regulation of transcription dna templated GO:0045892 116 0.023
regulation of neurogenesis GO:0050767 247 0.023
single organism catabolic process GO:0044712 283 0.022
positive regulation of neuron projection development GO:0010976 99 0.022
regulation of cell projection organization GO:0031344 175 0.022
positive regulation of protein modification process GO:0031401 142 0.022
response to metal ion GO:0010038 253 0.022
regulation of proteasomal protein catabolic process GO:0061136 4 0.022
regulation of cellular component organization GO:0051128 368 0.022
purine ribonucleotide catabolic process GO:0009154 136 0.022
carboxylic acid metabolic process GO:0019752 289 0.022
oxoacid metabolic process GO:0043436 290 0.021
secretion GO:0046903 307 0.021
single organism reproductive process GO:0044702 297 0.021
positive regulation of cellular protein metabolic process GO:0032270 167 0.021
purine nucleoside triphosphate metabolic process GO:0009144 141 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
regulation of transferase activity GO:0051338 123 0.021
cell morphogenesis involved in differentiation GO:0000904 119 0.021
neurological system process GO:0050877 219 0.021
dna metabolic process GO:0006259 96 0.021
negative regulation of response to stimulus GO:0048585 155 0.020
cell cycle checkpoint GO:0000075 2 0.020
regulation of apoptotic process GO:0042981 335 0.020
organophosphate metabolic process GO:0019637 370 0.020
regulation of canonical wnt signaling pathway GO:0060828 4 0.020
nucleoside catabolic process GO:0009164 126 0.020
negative regulation of developmental process GO:0051093 125 0.020
purine nucleotide catabolic process GO:0006195 136 0.020
cellular component movement GO:0006928 248 0.020
behavior GO:0007610 205 0.020
immune response GO:0006955 104 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
positive regulation of intracellular signal transduction GO:1902533 138 0.020
ras protein signal transduction GO:0007265 29 0.020
positive regulation of signal transduction GO:0009967 175 0.019
response to lipopolysaccharide GO:0032496 191 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
regulation of multicellular organismal development GO:2000026 376 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
nucleoside metabolic process GO:0009116 179 0.019
organic cyclic compound catabolic process GO:1901361 175 0.019
regulation of protein modification process GO:0031399 194 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.019
cellular amine metabolic process GO:0044106 38 0.019
peptidyl amino acid modification GO:0018193 126 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.019
carbohydrate derivative metabolic process GO:1901135 346 0.019
response to heat GO:0009408 60 0.019
positive regulation of protein phosphorylation GO:0001934 135 0.018
regulation of catabolic process GO:0009894 113 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.018
negative regulation of apoptotic process GO:0043066 181 0.018
response to nutrient levels GO:0031667 370 0.018
chromosome organization GO:0051276 36 0.018
purine nucleoside catabolic process GO:0006152 124 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.018
cell morphogenesis GO:0000902 142 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
amine metabolic process GO:0009308 38 0.018
response to inorganic substance GO:0010035 377 0.018
chromosome segregation GO:0007059 2 0.017
cellular amino acid metabolic process GO:0006520 107 0.017
protein homooligomerization GO:0051260 91 0.017
nucleotide catabolic process GO:0009166 139 0.017
ribonucleoside catabolic process GO:0042454 126 0.017
glycosyl compound metabolic process GO:1901657 182 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
negative regulation of signal transduction GO:0009968 83 0.017
ribonucleotide catabolic process GO:0009261 136 0.017
cellular nitrogen compound catabolic process GO:0044270 163 0.017
cellular response to organonitrogen compound GO:0071417 197 0.017
cell part morphogenesis GO:0032990 123 0.017
nuclear transport GO:0051169 49 0.017
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.017
purine ribonucleoside catabolic process GO:0046130 124 0.017
chromatin assembly or disassembly GO:0006333 1 0.017
cellular macromolecular complex assembly GO:0034622 58 0.017
purine ribonucleoside metabolic process GO:0046128 168 0.017
aging GO:0007568 241 0.016
regulation of kinase activity GO:0043549 117 0.016
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.016
ribonucleoside metabolic process GO:0009119 174 0.016
nucleotide metabolic process GO:0009117 279 0.016
spindle organization GO:0007051 2 0.016
response to bacterium GO:0009617 200 0.016
organonitrogen compound catabolic process GO:1901565 179 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
regulation of neuron projection development GO:0010975 161 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
regulation of mrna splicing via spliceosome GO:0048024 3 0.016
ribonucleoside triphosphate catabolic process GO:0009203 122 0.016
regulation of neuron differentiation GO:0045664 208 0.016
intracellular transport GO:0046907 185 0.015
growth GO:0040007 165 0.015
glycosyl compound catabolic process GO:1901658 126 0.015
regulation of protein kinase activity GO:0045859 105 0.015
cellular catabolic process GO:0044248 295 0.015
purine nucleoside triphosphate catabolic process GO:0009146 122 0.015
cellular response to oxidative stress GO:0034599 76 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
carbohydrate derivative catabolic process GO:1901136 147 0.015
nitrogen compound transport GO:0071705 229 0.015
organophosphate catabolic process GO:0046434 148 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
nucleoside triphosphate metabolic process GO:0009141 144 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
establishment of protein localization GO:0045184 141 0.015
purine containing compound catabolic process GO:0072523 138 0.015
nucleoside phosphate catabolic process GO:1901292 140 0.014
homeostatic process GO:0042592 331 0.014
single organism intracellular transport GO:1902582 166 0.014
wound healing GO:0042060 122 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
ion homeostasis GO:0050801 212 0.014
multicellular organism reproduction GO:0032504 233 0.014
alternative mrna splicing via spliceosome GO:0000380 4 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.014
dna integrity checkpoint GO:0031570 2 0.014
regulation of response to stress GO:0080134 126 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
regulation of cell morphogenesis GO:0022604 77 0.014
head development GO:0060322 247 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
cellular protein complex assembly GO:0043623 44 0.013
response to oxygen levels GO:0070482 265 0.013
axon midline choice point recognition GO:0016199 2 0.013
negative regulation of rna metabolic process GO:0051253 123 0.013
cell motility GO:0048870 202 0.013
organic substance catabolic process GO:1901575 316 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
response to ketone GO:1901654 182 0.013
cytoplasmic transport GO:0016482 115 0.013
single organism biosynthetic process GO:0044711 342 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
axis specification GO:0009798 4 0.013
negative regulation of molecular function GO:0044092 133 0.013
negative regulation of cell cycle phase transition GO:1901988 4 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
cellular protein localization GO:0034613 122 0.013
localization of cell GO:0051674 202 0.013
carbohydrate metabolic process GO:0005975 130 0.013
positive regulation of apoptotic process GO:0043065 154 0.012
regulation of hydrolase activity GO:0051336 143 0.012
mitotic spindle organization GO:0007052 2 0.012
proteolysis GO:0006508 175 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
response to estrogen GO:0043627 232 0.012
response to peptide GO:1901652 292 0.012
defense response GO:0006952 194 0.012
cell adhesion GO:0007155 110 0.012
cell cycle process GO:0022402 57 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
actin cytoskeleton organization GO:0030036 73 0.012
response to biotic stimulus GO:0009607 226 0.012
positive regulation of transferase activity GO:0051347 81 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
double strand break repair GO:0006302 1 0.012
heart morphogenesis GO:0003007 3 0.012
chemical homeostasis GO:0048878 292 0.012
glucose metabolic process GO:0006006 52 0.012
positive regulation of protein kinase activity GO:0045860 73 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
tube formation GO:0035148 3 0.012
cellular response to cytokine stimulus GO:0071345 127 0.011
cellular response to tumor necrosis factor GO:0071356 46 0.011
chromatin remodeling GO:0006338 3 0.011
response to decreased oxygen levels GO:0036293 237 0.011
response to radiation GO:0009314 137 0.011
tumor necrosis factor mediated signaling pathway GO:0033209 4 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
response to other organism GO:0051707 220 0.011
actin filament based process GO:0030029 86 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.011
response to extracellular stimulus GO:0009991 380 0.011
positive regulation of kinase activity GO:0033674 77 0.011
regulation of body fluid levels GO:0050878 90 0.011
cellular macromolecule localization GO:0070727 122 0.011
regulation of membrane potential GO:0042391 110 0.011
regulation of growth GO:0040008 105 0.011
protein transport GO:0015031 132 0.011
activation of protein kinase activity GO:0032147 47 0.011
immune system process GO:0002376 204 0.011
sensory organ development GO:0007423 74 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
sexual reproduction GO:0019953 148 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
regulation of anatomical structure size GO:0090066 135 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
cellular calcium ion homeostasis GO:0006874 160 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.010
reproductive structure development GO:0048608 128 0.010
response to external biotic stimulus GO:0043207 221 0.010
positive regulation of cell death GO:0010942 184 0.010
rna localization GO:0006403 4 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
cellular homeostasis GO:0019725 252 0.010
developmental process involved in reproduction GO:0003006 159 0.010
regulation of protein transport GO:0051223 68 0.010
regulation of cell motility GO:2000145 131 0.010
regulation of purine nucleotide metabolic process GO:1900542 115 0.010
biological adhesion GO:0022610 110 0.010
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.010
gamete generation GO:0007276 124 0.010
reproductive system development GO:0061458 128 0.010
guanosine containing compound catabolic process GO:1901069 71 0.010
regulation of protein targeting GO:1903533 28 0.010
gliogenesis GO:0042063 93 0.010
response to estradiol GO:0032355 164 0.010

Nup188 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
nervous system disease DOID:863 0 0.019
sensory system disease DOID:0050155 0 0.016
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
myopathy DOID:423 0 0.012
muscular disease DOID:0080000 0 0.012
musculoskeletal system disease DOID:17 0 0.012
muscle tissue disease DOID:66 0 0.012
gastrointestinal system cancer DOID:3119 0 0.012
organ system cancer DOID:0050686 0 0.012
cardiovascular system disease DOID:1287 0 0.012