Rattus norvegicus

14 known processes

Adam15

a disintegrin and metallopeptidase domain 15 (metargidin)

(Aliases: tMDCVI,MDC15)

Adam15 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
catabolic process GO:0009056 351 0.095
apoptotic process GO:0006915 381 0.092
Rat
nucleobase containing small molecule metabolic process GO:0055086 316 0.088
cellular ketone metabolic process GO:0042180 51 0.078
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.075
single organism catabolic process GO:0044712 283 0.069
organic substance catabolic process GO:1901575 316 0.067
response to metal ion GO:0010038 253 0.067
regulation of apoptotic process GO:0042981 335 0.060
Rat
female pregnancy GO:0007565 122 0.058
reproductive process GO:0022414 372 0.057
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.057
carbohydrate derivative metabolic process GO:1901135 346 0.056
intracellular signal transduction GO:0035556 314 0.056
Human
regulation of cell motility GO:2000145 131 0.055
Human
organophosphate metabolic process GO:0019637 370 0.054
programmed cell death GO:0012501 392 0.054
Rat
response to peptide GO:1901652 292 0.051
purine nucleotide metabolic process GO:0006163 229 0.050
tissue development GO:0009888 252 0.050
regulation of phosphate metabolic process GO:0019220 349 0.049
nucleoside metabolic process GO:0009116 179 0.048
nucleoside phosphate metabolic process GO:0006753 283 0.048
organonitrogen compound catabolic process GO:1901565 179 0.048
organic acid metabolic process GO:0006082 292 0.047
purine containing compound metabolic process GO:0072521 253 0.047
ribose phosphate metabolic process GO:0019693 235 0.046
organelle organization GO:0006996 266 0.045
single organism biosynthetic process GO:0044711 342 0.044
carbohydrate derivative catabolic process GO:1901136 147 0.044
ribonucleotide metabolic process GO:0009259 231 0.042
g protein coupled receptor signaling pathway GO:0007186 242 0.041
single organism carbohydrate metabolic process GO:0044723 118 0.041
response to extracellular stimulus GO:0009991 380 0.041
protein complex subunit organization GO:0071822 302 0.041
response to nutrient levels GO:0031667 370 0.039
regulation of phosphorus metabolic process GO:0051174 349 0.035
cellular amine metabolic process GO:0044106 38 0.034
multi multicellular organism process GO:0044706 138 0.034
cellular amino acid metabolic process GO:0006520 107 0.033
nucleotide metabolic process GO:0009117 279 0.033
single organism reproductive process GO:0044702 297 0.033
Rat
rna metabolic process GO:0016070 406 0.032
regulation of signal transduction GO:0009966 318 0.032
negative regulation of cell death GO:0060548 229 0.032
Rat
oxoacid metabolic process GO:0043436 290 0.032
multi organism reproductive process GO:0044703 262 0.032
Rat
positive regulation of apoptotic process GO:0043065 154 0.032
aromatic compound catabolic process GO:0019439 168 0.031
positive regulation of biosynthetic process GO:0009891 319 0.031
response to growth factor GO:0070848 189 0.030
regulation of cellular amino acid metabolic process GO:0006521 2 0.030
negative regulation of signaling GO:0023057 157 0.030
cellular component assembly GO:0022607 360 0.029
regulation of multicellular organismal development GO:2000026 376 0.029
response to nutrient GO:0007584 248 0.029
organophosphate biosynthetic process GO:0090407 143 0.029
purine ribonucleotide metabolic process GO:0009150 227 0.028
brain development GO:0007420 247 0.027
amine metabolic process GO:0009308 38 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
regulation of protein metabolic process GO:0051246 289 0.025
negative regulation of response to stimulus GO:0048585 155 0.025
positive regulation of cell death GO:0010942 184 0.025
carbohydrate metabolic process GO:0005975 130 0.025
organic cyclic compound catabolic process GO:1901361 175 0.025
regulation of catalytic activity GO:0050790 304 0.025
regulation of purine nucleotide metabolic process GO:1900542 115 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
locomotion GO:0040011 237 0.024
Human
ribonucleoside catabolic process GO:0042454 126 0.024
regulation of hydrolase activity GO:0051336 143 0.024
nucleoside phosphate catabolic process GO:1901292 140 0.024
nucleoside triphosphate metabolic process GO:0009141 144 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.023
aging GO:0007568 241 0.023
negative regulation of gene expression GO:0010629 199 0.023
cellular nitrogen compound catabolic process GO:0044270 163 0.023
immune system process GO:0002376 204 0.022
Human
negative regulation of transport GO:0051051 136 0.022
regulation of phosphorylation GO:0042325 248 0.022
regulation of nucleic acid templated transcription GO:1903506 380 0.022
response to ketone GO:1901654 182 0.022
vesicle mediated transport GO:0016192 181 0.022
nucleoside phosphate biosynthetic process GO:1901293 102 0.022
cellular catabolic process GO:0044248 295 0.022
metal ion transport GO:0030001 289 0.022
transcription dna templated GO:0006351 377 0.022
nucleoside catabolic process GO:0009164 126 0.021
purine nucleotide catabolic process GO:0006195 136 0.021
organonitrogen compound biosynthetic process GO:1901566 167 0.021
ribonucleoside triphosphate metabolic process GO:0009199 141 0.021
response to estrogen GO:0043627 232 0.021
atp catabolic process GO:0006200 54 0.021
central nervous system development GO:0007417 311 0.021
macromolecular complex assembly GO:0065003 273 0.020
purine nucleoside triphosphate metabolic process GO:0009144 141 0.020
response to peptide hormone GO:0043434 278 0.020
response to ethanol GO:0045471 162 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.020
cellular component movement GO:0006928 248 0.020
Human
positive regulation of multicellular organismal process GO:0051240 387 0.020
growth GO:0040007 165 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
purine containing compound catabolic process GO:0072523 138 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
purine nucleotide biosynthetic process GO:0006164 83 0.019
negative regulation of cell communication GO:0010648 158 0.019
cellular component biogenesis GO:0044085 368 0.018
purine ribonucleotide biosynthetic process GO:0009152 81 0.018
response to inorganic substance GO:0010035 377 0.018
purine ribonucleoside catabolic process GO:0046130 124 0.018
positive regulation of programmed cell death GO:0043068 157 0.018
regulation of programmed cell death GO:0043067 341 0.018
Rat
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.018
nucleobase containing compound catabolic process GO:0034655 152 0.018
response to decreased oxygen levels GO:0036293 237 0.018
reproductive system development GO:0061458 128 0.017
protein phosphorylation GO:0006468 345 0.017
nucleotide catabolic process GO:0009166 139 0.017
regulation of nucleotide metabolic process GO:0006140 117 0.017
purine ribonucleotide catabolic process GO:0009154 136 0.017
regulation of secretion by cell GO:1903530 208 0.017
secretion GO:0046903 307 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
Rat
negative regulation of metabolic process GO:0009892 331 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
response to cytokine GO:0034097 215 0.017
carboxylic acid metabolic process GO:0019752 289 0.017
response to glucocorticoid GO:0051384 223 0.017
organophosphate catabolic process GO:0046434 148 0.017
icosanoid metabolic process GO:0006690 38 0.017
protein complex biogenesis GO:0070271 263 0.017
small molecule biosynthetic process GO:0044283 124 0.017
lipid metabolic process GO:0006629 283 0.016
macromolecular complex subunit organization GO:0043933 339 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
regulation of cellular catabolic process GO:0031329 101 0.016
regulation of molecular function GO:0065009 398 0.016
Human
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
neurological system process GO:0050877 219 0.016
response to radiation GO:0009314 137 0.016
regulation of cellular component movement GO:0051270 150 0.016
Human
regulation of neuron differentiation GO:0045664 208 0.016
positive regulation of developmental process GO:0051094 283 0.016
response to interleukin 1 GO:0070555 55 0.016
ribonucleoside metabolic process GO:0009119 174 0.016
wound healing GO:0042060 122 0.016
cellular lipid metabolic process GO:0044255 208 0.016
positive regulation of phosphorus metabolic process GO:0010562 262 0.016
neuron differentiation GO:0030182 368 0.015
positive regulation of gene expression GO:0010628 244 0.015
negative regulation of protein metabolic process GO:0051248 114 0.015
purine containing compound biosynthetic process GO:0072522 85 0.015
negative regulation of macromolecule metabolic process GO:0010605 260 0.015
ion transmembrane transport GO:0034220 365 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
nucleotide biosynthetic process GO:0009165 98 0.015
regulation of cellular localization GO:0060341 263 0.015
cellular response to abiotic stimulus GO:0071214 85 0.015
positive regulation of signaling GO:0023056 270 0.015
inorganic ion transmembrane transport GO:0098660 229 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
secretion by cell GO:0032940 248 0.015
purine nucleoside metabolic process GO:0042278 169 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
ribonucleotide catabolic process GO:0009261 136 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
developmental growth GO:0048589 100 0.014
positive regulation of signal transduction GO:0009967 175 0.014
response to temperature stimulus GO:0009266 94 0.014
proteolysis GO:0006508 175 0.014
Human Rat
ras protein signal transduction GO:0007265 29 0.014
enzyme linked receptor protein signaling pathway GO:0007167 116 0.014
regulation of neurogenesis GO:0050767 247 0.014
cyclic nucleotide metabolic process GO:0009187 80 0.014
ribose phosphate biosynthetic process GO:0046390 87 0.014
head development GO:0060322 247 0.014
single organism organelle organization GO:1902589 180 0.013
ion homeostasis GO:0050801 212 0.013
response to oxygen levels GO:0070482 265 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
positive regulation of hydrolase activity GO:0051345 86 0.013
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
cytoskeleton organization GO:0007010 111 0.013
regulation of protein modification process GO:0031399 194 0.013
response to wounding GO:0009611 254 0.013
developmental process involved in reproduction GO:0003006 159 0.013
transmembrane transport GO:0055085 412 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
cellular calcium ion homeostasis GO:0006874 160 0.013
negative regulation of signal transduction GO:0009968 83 0.013
homeostatic process GO:0042592 331 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
cellular response to endogenous stimulus GO:0071495 377 0.012
skeletal system development GO:0001501 41 0.012
connective tissue development GO:0061448 33 0.012
localization of cell GO:0051674 202 0.012
Human
transcription from rna polymerase ii promoter GO:0006366 252 0.012
positive regulation of nucleic acid templated transcription GO:1903508 197 0.012
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
regulation of cell differentiation GO:0045595 320 0.012
divalent inorganic cation transport GO:0072511 134 0.012
positive regulation of cell proliferation GO:0008284 249 0.012
behavior GO:0007610 205 0.012
cellular response to stress GO:0033554 269 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
ribonucleotide biosynthetic process GO:0009260 85 0.012
cellular chemical homeostasis GO:0055082 247 0.012
cell migration GO:0016477 197 0.012
Human
heterocycle catabolic process GO:0046700 167 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
regeneration GO:0031099 163 0.011
defense response GO:0006952 194 0.011
Human
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.011
positive regulation of cell communication GO:0010647 271 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
regulation of cell migration GO:0030334 128 0.011
Human
cellular response to oxygen containing compound GO:1901701 386 0.011
actin filament based process GO:0030029 86 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
single organism intracellular transport GO:1902582 166 0.011
cellular homeostasis GO:0019725 252 0.011
single organism cellular localization GO:1902580 102 0.011
potassium ion transport GO:0006813 97 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
blood vessel morphogenesis GO:0048514 58 0.011
regulation of homeostatic process GO:0032844 101 0.011
regulation of ion transport GO:0043269 245 0.011
organic acid biosynthetic process GO:0016053 83 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
regulation of hormone levels GO:0010817 187 0.011
hormone transport GO:0009914 121 0.011
multicellular organism growth GO:0035264 1 0.011
epithelial cell differentiation GO:0030855 71 0.011
protein oligomerization GO:0051259 191 0.011
metal ion homeostasis GO:0055065 186 0.010
positive regulation of nervous system development GO:0051962 178 0.010
inorganic cation transmembrane transport GO:0098662 202 0.010
tissue regeneration GO:0042246 36 0.010
chemical homeostasis GO:0048878 292 0.010
response to molecule of bacterial origin GO:0002237 194 0.010
cellular cation homeostasis GO:0030003 180 0.010
nucleoside triphosphate catabolic process GO:0009143 123 0.010
response to monosaccharide GO:0034284 159 0.010
peptide hormone secretion GO:0030072 84 0.010
neuron development GO:0048666 286 0.010
unsaturated fatty acid metabolic process GO:0033559 39 0.010
cell motility GO:0048870 202 0.010
Human

Adam15 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.058
nervous system disease DOID:863 0 0.058
central nervous system disease DOID:331 0 0.034
myopathy DOID:423 0 0.016
muscular disease DOID:0080000 0 0.016
muscular dystrophy DOID:9884 0 0.016
musculoskeletal system disease DOID:17 0 0.016
muscle tissue disease DOID:66 0 0.016
cerebral degeneration DOID:1443 0 0.016
brain disease DOID:936 0 0.016
disease of metabolism DOID:0014667 0 0.012