Rattus norvegicus

28 known processes

Pola2

polymerase (DNA directed), alpha 2

Pola2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic substance catabolic process GO:1901575 316 0.129
secretion GO:0046903 307 0.123
oxoacid metabolic process GO:0043436 290 0.120
carboxylic acid metabolic process GO:0019752 289 0.105
response to estrogen GO:0043627 232 0.094
catabolic process GO:0009056 351 0.092
cellular catabolic process GO:0044248 295 0.090
organic acid metabolic process GO:0006082 292 0.087
protein complex assembly GO:0006461 263 0.087
single organism biosynthetic process GO:0044711 342 0.077
intracellular signal transduction GO:0035556 314 0.075
response to oxygen levels GO:0070482 265 0.072
macromolecular complex subunit organization GO:0043933 339 0.070
programmed cell death GO:0012501 392 0.070
regulation of molecular function GO:0065009 398 0.068
response to inorganic substance GO:0010035 377 0.068
response to extracellular stimulus GO:0009991 380 0.066
cellular component biogenesis GO:0044085 368 0.064
regulation of phosphate metabolic process GO:0019220 349 0.062
response to nutrient levels GO:0031667 370 0.062
protein phosphorylation GO:0006468 345 0.060
macromolecular complex assembly GO:0065003 273 0.060
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.059
regulation of programmed cell death GO:0043067 341 0.059
cellular response to stress GO:0033554 269 0.058
organophosphate metabolic process GO:0019637 370 0.058
protein complex subunit organization GO:0071822 302 0.058
regulation of apoptotic process GO:0042981 335 0.057
cellular component assembly GO:0022607 360 0.056
regulation of phosphorus metabolic process GO:0051174 349 0.055
regulation of cellular component organization GO:0051128 368 0.055
single organism catabolic process GO:0044712 283 0.055
chemical homeostasis GO:0048878 292 0.055
rna metabolic process GO:0016070 406 0.054
cellular amino acid metabolic process GO:0006520 107 0.053
regulation of phosphorylation GO:0042325 248 0.053
regulation of cellular localization GO:0060341 263 0.051
nitrogen compound transport GO:0071705 229 0.051
protein oligomerization GO:0051259 191 0.051
nucleoside phosphate metabolic process GO:0006753 283 0.050
cell cell signaling GO:0007267 335 0.050
response to growth factor GO:0070848 189 0.050
protein complex biogenesis GO:0070271 263 0.049
anatomical structure morphogenesis GO:0009653 298 0.049
response to nutrient GO:0007584 248 0.049
regulation of cell proliferation GO:0042127 359 0.048
response to decreased oxygen levels GO:0036293 237 0.048
single organism reproductive process GO:0044702 297 0.048
negative regulation of metabolic process GO:0009892 331 0.046
carbohydrate derivative metabolic process GO:1901135 346 0.045
response to estradiol GO:0032355 164 0.044
rhythmic process GO:0048511 156 0.044
regulation of catalytic activity GO:0050790 304 0.044
response to metal ion GO:0010038 253 0.043
response to biotic stimulus GO:0009607 226 0.042
nucleic acid templated transcription GO:0097659 379 0.042
regulation of intracellular signal transduction GO:1902531 218 0.041
regulation of secretion GO:0051046 224 0.041
homeostatic process GO:0042592 331 0.041
regulation of rna biosynthetic process GO:2001141 381 0.041
apoptotic process GO:0006915 381 0.040
response to peptide GO:1901652 292 0.040
positive regulation of phosphate metabolic process GO:0045937 262 0.040
positive regulation of cell communication GO:0010647 271 0.040
ion transmembrane transport GO:0034220 365 0.039
response to hypoxia GO:0001666 231 0.039
reproduction GO:0000003 245 0.038
neuron differentiation GO:0030182 368 0.038
cation transport GO:0006812 382 0.038
regulation of cell differentiation GO:0045595 320 0.038
regulation of protein metabolic process GO:0051246 289 0.037
reproductive process GO:0022414 372 0.037
transcription dna templated GO:0006351 377 0.037
proteolysis GO:0006508 175 0.037
positive regulation of transcription dna templated GO:0045893 197 0.037
response to other organism GO:0051707 220 0.037
ion homeostasis GO:0050801 212 0.036
regulation of multicellular organismal development GO:2000026 376 0.035
response to external biotic stimulus GO:0043207 221 0.035
regulation of rna metabolic process GO:0051252 391 0.035
cellular amine metabolic process GO:0044106 38 0.035
cellular response to oxygen containing compound GO:1901701 386 0.035
locomotion GO:0040011 237 0.035
transmembrane transport GO:0055085 412 0.035
positive regulation of cellular biosynthetic process GO:0031328 295 0.034
cellular response to growth factor stimulus GO:0071363 162 0.034
response to vitamin GO:0033273 131 0.034
multicellular organismal reproductive process GO:0048609 233 0.034
secretion by cell GO:0032940 248 0.033
cardiovascular system development GO:0072358 134 0.033
reproductive system development GO:0061458 128 0.033
regulation of cellular ketone metabolic process GO:0010565 27 0.033
regulation of cellular protein metabolic process GO:0032268 267 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.033
negative regulation of cellular metabolic process GO:0031324 281 0.032
regulation of nucleic acid templated transcription GO:1903506 380 0.032
response to amino acid GO:0043200 75 0.032
metal ion transport GO:0030001 289 0.032
positive regulation of gene expression GO:0010628 244 0.032
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
carbohydrate metabolic process GO:0005975 130 0.032
amine metabolic process GO:0009308 38 0.032
dna metabolic process GO:0006259 96 0.032
response to glucose GO:0009749 136 0.032
response to monosaccharide GO:0034284 159 0.031
multi organism reproductive process GO:0044703 262 0.031
response to peptide hormone GO:0043434 278 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.031
positive regulation of biosynthetic process GO:0009891 319 0.031
tissue development GO:0009888 252 0.031
cellular ketone metabolic process GO:0042180 51 0.030
cellular response to lipid GO:0071396 201 0.030
response to wounding GO:0009611 254 0.029
neurological system process GO:0050877 219 0.029
response to hexose GO:0009746 144 0.029
cellular chemical homeostasis GO:0055082 247 0.029
positive regulation of cellular component organization GO:0051130 200 0.029
response to acid chemical GO:0001101 222 0.029
aromatic compound catabolic process GO:0019439 168 0.028
multicellular organism reproduction GO:0032504 233 0.028
purine containing compound metabolic process GO:0072521 253 0.028
macromolecule localization GO:0033036 252 0.028
Mouse
response to carbohydrate GO:0009743 183 0.028
regulation of transcription dna templated GO:0006355 374 0.028
regulation of cell development GO:0060284 263 0.028
positive regulation of programmed cell death GO:0043068 157 0.028
positive regulation of molecular function GO:0044093 230 0.027
cellular response to organic cyclic compound GO:0071407 202 0.027
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
cellular homeostasis GO:0019725 252 0.027
positive regulation of developmental process GO:0051094 283 0.027
defense response GO:0006952 194 0.027
lipid metabolic process GO:0006629 283 0.026
regulation of secretion by cell GO:1903530 208 0.026
positive regulation of phosphorylation GO:0042327 177 0.026
brain development GO:0007420 247 0.026
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.026
positive regulation of secretion by cell GO:1903532 128 0.026
response to corticosteroid GO:0031960 235 0.026
positive regulation of cellular protein metabolic process GO:0032270 167 0.025
regulation of membrane potential GO:0042391 110 0.025
positive regulation of apoptotic process GO:0043065 154 0.025
small molecule biosynthetic process GO:0044283 124 0.025
positive regulation of response to stimulus GO:0048584 285 0.025
aging GO:0007568 241 0.025
response to ethanol GO:0045471 162 0.025
cellular ion homeostasis GO:0006873 184 0.025
developmental process involved in reproduction GO:0003006 159 0.025
regulation of signal transduction GO:0009966 318 0.025
response to bacterium GO:0009617 200 0.025
regulation of cellular amine metabolic process GO:0033238 8 0.025
neuron development GO:0048666 286 0.025
cellular response to endogenous stimulus GO:0071495 377 0.025
regeneration GO:0031099 163 0.024
rna biosynthetic process GO:0032774 380 0.024
regulation of protein modification process GO:0031399 194 0.024
positive regulation of cell proliferation GO:0008284 249 0.024
response to lipopolysaccharide GO:0032496 191 0.024
cellular lipid metabolic process GO:0044255 208 0.024
oxidation reduction process GO:0055114 304 0.024
negative regulation of gene expression GO:0010629 199 0.024
response to toxic substance GO:0009636 133 0.024
positive regulation of signaling GO:0023056 270 0.024
response to oxidative stress GO:0006979 186 0.024
cell motility GO:0048870 202 0.024
reproductive structure development GO:0048608 128 0.024
response to molecule of bacterial origin GO:0002237 194 0.023
nucleobase containing compound catabolic process GO:0034655 152 0.023
neuron projection development GO:0031175 273 0.023
cation homeostasis GO:0055080 195 0.023
positive regulation of rna metabolic process GO:0051254 203 0.023
glycosyl compound metabolic process GO:1901657 182 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
transcription from rna polymerase ii promoter GO:0006366 252 0.023
circadian regulation of gene expression GO:0032922 3 0.023
regulation of hormone levels GO:0010817 187 0.023
nucleotide metabolic process GO:0009117 279 0.023
positive regulation of secretion GO:0051047 140 0.022
head development GO:0060322 247 0.022
amide transport GO:0042886 105 0.022
central nervous system development GO:0007417 311 0.022
regulation of proteasomal protein catabolic process GO:0061136 4 0.022
immune system process GO:0002376 204 0.022
regulation of response to stress GO:0080134 126 0.022
nucleoside metabolic process GO:0009116 179 0.022
gland development GO:0048732 155 0.022
positive regulation of multicellular organismal process GO:0051240 387 0.022
single organism carbohydrate metabolic process GO:0044723 118 0.021
chromosome segregation GO:0007059 2 0.021
negative regulation of cell death GO:0060548 229 0.021
purine nucleotide metabolic process GO:0006163 229 0.021
regulation of neurogenesis GO:0050767 247 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.020
small molecule catabolic process GO:0044282 59 0.020
cell migration GO:0016477 197 0.020
protein localization GO:0008104 191 0.020
Mouse
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
positive regulation of cell death GO:0010942 184 0.020
lipid oxidation GO:0034440 30 0.020
hormone transport GO:0009914 121 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.019
cellular nitrogen compound catabolic process GO:0044270 163 0.019
cell adhesion GO:0007155 110 0.019
ras protein signal transduction GO:0007265 29 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
stress activated protein kinase signaling cascade GO:0031098 37 0.019
cellular response to organonitrogen compound GO:0071417 197 0.019
cellular cation homeostasis GO:0030003 180 0.019
ribonucleoside metabolic process GO:0009119 174 0.019
positive regulation of protein modification process GO:0031401 142 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.019
regulation of cell motility GO:2000145 131 0.019
regulation of nervous system development GO:0051960 264 0.019
gamete generation GO:0007276 124 0.019
anion transport GO:0006820 178 0.019
organonitrogen compound catabolic process GO:1901565 179 0.019
growth GO:0040007 165 0.019
response to cytokine GO:0034097 215 0.019
response to temperature stimulus GO:0009266 94 0.019
cation transmembrane transport GO:0098655 263 0.019
negative regulation of apoptotic process GO:0043066 181 0.018
response to hydrogen peroxide GO:0042542 89 0.018
organic cyclic compound catabolic process GO:1901361 175 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
positive regulation of signal transduction GO:0009967 175 0.018
circulatory system development GO:0072359 134 0.018
response to ketone GO:1901654 182 0.018
carboxylic acid transport GO:0046942 115 0.018
cell morphogenesis GO:0000902 142 0.018
positive regulation of transport GO:0051050 245 0.018
positive regulation of protein metabolic process GO:0051247 178 0.018
development of primary sexual characteristics GO:0045137 107 0.018
negative regulation of response to stimulus GO:0048585 155 0.018
eye morphogenesis GO:0048592 4 0.018
organelle organization GO:0006996 266 0.018
muscle system process GO:0003012 115 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.017
glycosyl compound catabolic process GO:1901658 126 0.017
female gonad development GO:0008585 53 0.017
heterocycle catabolic process GO:0046700 167 0.017
renal system development GO:0072001 67 0.017
positive regulation of rna biosynthetic process GO:1902680 197 0.017
intracellular transport GO:0046907 185 0.017
Mouse
cellular response to external stimulus GO:0071496 118 0.017
behavior GO:0007610 205 0.017
negative regulation of rna metabolic process GO:0051253 123 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
signal release GO:0023061 145 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
organ regeneration GO:0031100 101 0.016
epithelium development GO:0060429 96 0.016
coenzyme metabolic process GO:0006732 86 0.016
alpha amino acid metabolic process GO:1901605 71 0.016
tube development GO:0035295 89 0.016
negative regulation of cell communication GO:0010648 158 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
metal ion homeostasis GO:0055065 186 0.016
mapk cascade GO:0000165 140 0.016
muscle structure development GO:0061061 87 0.016
carboxylic acid catabolic process GO:0046395 49 0.016
lipid catabolic process GO:0016042 46 0.016
urogenital system development GO:0001655 78 0.016
purine nucleoside metabolic process GO:0042278 169 0.015
regulation of ion transport GO:0043269 245 0.015
biological adhesion GO:0022610 110 0.015
protein homooligomerization GO:0051260 91 0.015
negative regulation of transport GO:0051051 136 0.015
cell cycle checkpoint GO:0000075 2 0.015
sexual reproduction GO:0019953 148 0.015
regulation of protein kinase activity GO:0045859 105 0.015
response to purine containing compound GO:0014074 126 0.015
gonad development GO:0008406 104 0.015
regulation of system process GO:0044057 208 0.015
single organism intracellular transport GO:1902582 166 0.015
Mouse
cellular component morphogenesis GO:0032989 155 0.015
regulation of catabolic process GO:0009894 113 0.015
peptidyl amino acid modification GO:0018193 126 0.015
sex differentiation GO:0007548 113 0.015
negative regulation of innate immune response GO:0045824 4 0.015
cellular lipid catabolic process GO:0044242 37 0.015
regulation of homeostatic process GO:0032844 101 0.015
peptide transport GO:0015833 97 0.015
response to radiation GO:0009314 137 0.015
regulation of mapk cascade GO:0043408 116 0.014
circadian rhythm GO:0007623 88 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
mitotic sister chromatid separation GO:0051306 1 0.014
organophosphate catabolic process GO:0046434 148 0.014
alcohol metabolic process GO:0006066 77 0.014
cellular response to nutrient levels GO:0031669 60 0.014
cell projection organization GO:0030030 302 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
cellular response to hormone stimulus GO:0032870 247 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
negative regulation of chromosome organization GO:2001251 1 0.014
negative regulation of molecular function GO:0044092 133 0.014
response to reactive oxygen species GO:0000302 120 0.014
fatty acid oxidation GO:0019395 29 0.014
synaptic transmission GO:0007268 235 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
muscle contraction GO:0006936 88 0.014
organonitrogen compound biosynthetic process GO:1901566 167 0.014
negative regulation of transcription dna templated GO:0045892 116 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
ribonucleoside catabolic process GO:0042454 126 0.014
response to alkaloid GO:0043279 132 0.014
organophosphate biosynthetic process GO:0090407 143 0.013
regulation of cell projection organization GO:0031344 175 0.013
protein targeting GO:0006605 61 0.013
Mouse
cell cell signaling involved in cell fate commitment GO:0045168 2 0.013
epithelial cell differentiation GO:0030855 71 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
regulation of transferase activity GO:0051338 123 0.013
cellular response to peptide GO:1901653 133 0.013
regulation of hormone secretion GO:0046883 106 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
wound healing GO:0042060 122 0.013
regulation of dna metabolic process GO:0051052 60 0.013
regulation of locomotion GO:0040012 148 0.013
regulation of neuron projection development GO:0010975 161 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
organic anion transport GO:0015711 132 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
regulation of fat cell differentiation GO:0045598 3 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.013
kidney development GO:0001822 67 0.013
glycerolipid metabolic process GO:0046486 67 0.013
heart development GO:0007507 72 0.013
double strand break repair GO:0006302 1 0.013
negative regulation of signaling GO:0023057 157 0.013
signal transduction by phosphorylation GO:0023014 144 0.013
nucleoside triphosphate metabolic process GO:0009141 144 0.013
hexose metabolic process GO:0019318 58 0.013
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.012
lipid biosynthetic process GO:0008610 128 0.012
establishment of protein localization GO:0045184 141 0.012
Mouse
spermatogenesis GO:0007283 99 0.012
gastrulation GO:0007369 2 0.012
calcium ion homeostasis GO:0055074 162 0.012
regulation of sister chromatid segregation GO:0033045 1 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
regulation of lipid metabolic process GO:0019216 68 0.012
cofactor metabolic process GO:0051186 95 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
cellular macromolecule localization GO:0070727 122 0.012
Mouse
reactive oxygen species metabolic process GO:0072593 37 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
positive regulation of transferase activity GO:0051347 81 0.012
axis specification GO:0009798 4 0.012
purine ribonucleotide catabolic process GO:0009154 136 0.012
negative regulation of cell cycle phase transition GO:1901988 4 0.012
spindle organization GO:0007051 2 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
regulation of kinase activity GO:0043549 117 0.012
cytoskeleton organization GO:0007010 111 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
regulation of anatomical structure size GO:0090066 135 0.011
cytoplasmic transport GO:0016482 115 0.011
Mouse
localization of cell GO:0051674 202 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
regulation of mitotic sister chromatid separation GO:0010965 1 0.011
inorganic cation transmembrane transport GO:0098662 202 0.011
appendage morphogenesis GO:0035107 4 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
regulation of metal ion transport GO:0010959 118 0.011
cellular component movement GO:0006928 248 0.011
cellular protein localization GO:0034613 122 0.011
Mouse
ribonucleotide catabolic process GO:0009261 136 0.011
regulation of growth GO:0040008 105 0.011
regulation of hydrolase activity GO:0051336 143 0.011
action potential GO:0001508 54 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
meiotic cell cycle process GO:1903046 3 0.011
regulation of peptide transport GO:0090087 87 0.011
monosaccharide metabolic process GO:0005996 61 0.011
protein heterooligomerization GO:0051291 89 0.011
single organism organelle organization GO:1902589 180 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
rho protein signal transduction GO:0007266 11 0.011
regulation of chromosome segregation GO:0051983 1 0.011
organic acid transport GO:0015849 116 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
positive regulation of cell development GO:0010720 176 0.011
regulation of peptide secretion GO:0002791 82 0.011
immune response GO:0006955 104 0.011
cell activation GO:0001775 97 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.010
regulation of organelle organization GO:0033043 80 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.010
monovalent inorganic cation transport GO:0015672 172 0.010
regulation of ion transmembrane transport GO:0034765 121 0.010
cellular amino acid biosynthetic process GO:0008652 32 0.010
regulation of synaptic transmission GO:0050804 141 0.010
metaphase anaphase transition of cell cycle GO:0044784 1 0.010
dephosphorylation GO:0016311 98 0.010
nucleoside phosphate biosynthetic process GO:1901293 102 0.010
organic acid catabolic process GO:0016054 49 0.010
regulation of neuron differentiation GO:0045664 208 0.010
regulation of reactive oxygen species metabolic process GO:2000377 26 0.010
regulation of cell morphogenesis GO:0022604 77 0.010
embryonic appendage morphogenesis GO:0035113 4 0.010
muscle cell proliferation GO:0033002 84 0.010
nucleoside phosphate catabolic process GO:1901292 140 0.010
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 1 0.010
peptide hormone secretion GO:0030072 84 0.010
organ morphogenesis GO:0009887 75 0.010

Pola2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.024
gastrointestinal system cancer DOID:3119 0 0.020
intestinal cancer DOID:10155 0 0.020
cancer DOID:162 0 0.020
disease of cellular proliferation DOID:14566 0 0.020
organ system cancer DOID:0050686 0 0.020
inherited metabolic disorder DOID:655 0 0.016
disease of anatomical entity DOID:7 0 0.015
musculoskeletal system disease DOID:17 0 0.015
nervous system disease DOID:863 0 0.014