Rattus norvegicus

28 known processes

Pola1

polymerase (DNA directed), alpha 1

Pola1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna biosynthetic process GO:0032774 380 0.129
rna metabolic process GO:0016070 406 0.125
regulation of cell proliferation GO:0042127 359 0.102
neuron differentiation GO:0030182 368 0.090
nucleic acid templated transcription GO:0097659 379 0.087
response to ethanol GO:0045471 162 0.083
single organism reproductive process GO:0044702 297 0.080
regulation of transcription dna templated GO:0006355 374 0.079
cell migration GO:0016477 197 0.078
cellular component movement GO:0006928 248 0.078
organ regeneration GO:0031100 101 0.075
coenzyme metabolic process GO:0006732 86 0.070
regulation of nucleic acid templated transcription GO:1903506 380 0.067
tetrahydrofolate metabolic process GO:0046653 9 0.066
head development GO:0060322 247 0.066
cellular component biogenesis GO:0044085 368 0.065
response to estrogen GO:0043627 232 0.063
cellular catabolic process GO:0044248 295 0.058
regulation of molecular function GO:0065009 398 0.058
response to corticosteroid GO:0031960 235 0.056
regulation of rna metabolic process GO:0051252 391 0.055
deoxyribonucleoside monophosphate biosynthetic process GO:0009157 4 0.055
response to estradiol GO:0032355 164 0.054
nucleoside phosphate metabolic process GO:0006753 283 0.054
carbohydrate derivative metabolic process GO:1901135 346 0.053
rhythmic process GO:0048511 156 0.052
response to other organism GO:0051707 220 0.052
regeneration GO:0031099 163 0.051
purine containing compound metabolic process GO:0072521 253 0.051
cellular response to organic cyclic compound GO:0071407 202 0.050
single organism biosynthetic process GO:0044711 342 0.050
central nervous system development GO:0007417 311 0.050
response to ketone GO:1901654 182 0.050
reproduction GO:0000003 245 0.048
tissue development GO:0009888 252 0.048
apoptotic process GO:0006915 381 0.048
cell motility GO:0048870 202 0.048
positive regulation of cellular biosynthetic process GO:0031328 295 0.047
response to metal ion GO:0010038 253 0.047
transcription dna templated GO:0006351 377 0.047
cellular response to oxygen containing compound GO:1901701 386 0.046
regulation of rna biosynthetic process GO:2001141 381 0.045
cellular response to stress GO:0033554 269 0.045
positive regulation of cell proliferation GO:0008284 249 0.045
pyrimidine nucleobase metabolic process GO:0006206 8 0.044
positive regulation of rna metabolic process GO:0051254 203 0.044
response to acid chemical GO:0001101 222 0.044
brain development GO:0007420 247 0.043
secretion GO:0046903 307 0.043
response to nutrient GO:0007584 248 0.042
nucleobase containing small molecule metabolic process GO:0055086 316 0.042
programmed cell death GO:0012501 392 0.042
sexual reproduction GO:0019953 148 0.041
response to glucocorticoid GO:0051384 223 0.041
macromolecule localization GO:0033036 252 0.040
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.040
locomotion GO:0040011 237 0.040
response to nutrient levels GO:0031667 370 0.040
aging GO:0007568 241 0.039
pteridine containing compound metabolic process GO:0042558 14 0.039
reproductive process GO:0022414 372 0.039
positive regulation of multicellular organismal process GO:0051240 387 0.038
positive regulation of rna biosynthetic process GO:1902680 197 0.038
organic acid metabolic process GO:0006082 292 0.038
defense response GO:0006952 194 0.037
nucleotide metabolic process GO:0009117 279 0.037
cellular response to hormone stimulus GO:0032870 247 0.037
macromolecular complex subunit organization GO:0043933 339 0.037
positive regulation of cell differentiation GO:0045597 217 0.036
response to extracellular stimulus GO:0009991 380 0.036
organophosphate metabolic process GO:0019637 370 0.036
regulation of catalytic activity GO:0050790 304 0.036
response to decreased oxygen levels GO:0036293 237 0.035
positive regulation of biosynthetic process GO:0009891 319 0.035
cellular response to endogenous stimulus GO:0071495 377 0.035
regulation of programmed cell death GO:0043067 341 0.035
cellular response to lipid GO:0071396 201 0.035
positive regulation of developmental process GO:0051094 283 0.035
multi organism reproductive process GO:0044703 262 0.034
multicellular organismal reproductive process GO:0048609 233 0.034
response to wounding GO:0009611 254 0.033
epithelium development GO:0060429 96 0.033
negative regulation of cellular metabolic process GO:0031324 281 0.033
response to toxic substance GO:0009636 133 0.033
aromatic compound catabolic process GO:0019439 168 0.033
negative regulation of apoptotic process GO:0043066 181 0.033
purine ribonucleotide metabolic process GO:0009150 227 0.032
positive regulation of transport GO:0051050 245 0.032
oxoacid metabolic process GO:0043436 290 0.032
organophosphate catabolic process GO:0046434 148 0.032
regulation of apoptotic process GO:0042981 335 0.032
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.032
regulation of phosphorus metabolic process GO:0051174 349 0.032
dna metabolic process GO:0006259 96 0.032
localization of cell GO:0051674 202 0.032
carboxylic acid metabolic process GO:0019752 289 0.031
transcription from rna polymerase ii promoter GO:0006366 252 0.031
cellular component assembly GO:0022607 360 0.031
positive regulation of nucleic acid templated transcription GO:1903508 197 0.031
female gonad development GO:0008585 53 0.030
response to amino acid GO:0043200 75 0.030
regulation of multicellular organismal development GO:2000026 376 0.030
deoxyribonucleotide biosynthetic process GO:0009263 6 0.030
pyrimidine deoxyribonucleotide metabolic process GO:0009219 5 0.030
cell projection organization GO:0030030 302 0.030
alpha amino acid metabolic process GO:1901605 71 0.030
purine nucleoside triphosphate metabolic process GO:0009144 141 0.030
carbohydrate derivative catabolic process GO:1901136 147 0.030
negative regulation of response to stimulus GO:0048585 155 0.029
regulation of signal transduction GO:0009966 318 0.029
protein complex assembly GO:0006461 263 0.029
homeostatic process GO:0042592 331 0.029
ribose phosphate metabolic process GO:0019693 235 0.029
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.029
development of primary sexual characteristics GO:0045137 107 0.029
regulation of cell differentiation GO:0045595 320 0.029
chemical homeostasis GO:0048878 292 0.029
purine nucleoside metabolic process GO:0042278 169 0.029
purine nucleotide metabolic process GO:0006163 229 0.029
response to external biotic stimulus GO:0043207 221 0.029
organonitrogen compound catabolic process GO:1901565 179 0.029
response to vitamin GO:0033273 131 0.028
multicellular organism reproduction GO:0032504 233 0.028
ovulation cycle process GO:0022602 50 0.028
protein transport GO:0015031 132 0.027
positive regulation of apoptotic process GO:0043065 154 0.027
regulation of cellular localization GO:0060341 263 0.027
inflammatory response GO:0006954 150 0.027
ribonucleotide catabolic process GO:0009261 136 0.027
cellular amine metabolic process GO:0044106 38 0.027
response to hypoxia GO:0001666 231 0.026
cofactor metabolic process GO:0051186 95 0.026
cation transport GO:0006812 382 0.026
cellular response to nitrogen compound GO:1901699 210 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.026
anatomical structure morphogenesis GO:0009653 298 0.026
positive regulation of cell death GO:0010942 184 0.026
forebrain development GO:0030900 98 0.026
nucleoside metabolic process GO:0009116 179 0.025
organic cyclic compound catabolic process GO:1901361 175 0.025
negative regulation of macromolecule metabolic process GO:0010605 260 0.025
cellular response to steroid hormone stimulus GO:0071383 93 0.025
response to lipopolysaccharide GO:0032496 191 0.025
ribonucleoside catabolic process GO:0042454 126 0.025
anatomical structure formation involved in morphogenesis GO:0048646 83 0.025
protein localization GO:0008104 191 0.025
positive regulation of response to stimulus GO:0048584 285 0.024
transformation of host cell by virus GO:0019087 4 0.024
response to molecule of bacterial origin GO:0002237 194 0.024
purine nucleotide catabolic process GO:0006195 136 0.024
response to bacterium GO:0009617 200 0.024
development of primary female sexual characteristics GO:0046545 56 0.024
regulation of secretion GO:0051046 224 0.024
positive regulation of catabolic process GO:0009896 78 0.024
glycosyl compound metabolic process GO:1901657 182 0.024
reproductive system development GO:0061458 128 0.023
positive regulation of molecular function GO:0044093 230 0.023
response to alkaloid GO:0043279 132 0.023
regulation of protein metabolic process GO:0051246 289 0.023
ribonucleoside triphosphate catabolic process GO:0009203 122 0.023
single organism catabolic process GO:0044712 283 0.023
catabolic process GO:0009056 351 0.023
ribonucleoside metabolic process GO:0009119 174 0.023
organic substance catabolic process GO:1901575 316 0.022
positive regulation of protein metabolic process GO:0051247 178 0.022
regulation of cellular component movement GO:0051270 150 0.022
ovulation cycle GO:0042698 67 0.022
female sex differentiation GO:0046660 59 0.022
protein complex subunit organization GO:0071822 302 0.022
response to oxygen levels GO:0070482 265 0.022
circadian rhythm GO:0007623 88 0.022
regulation of anatomical structure morphogenesis GO:0022603 141 0.022
response to peptide hormone GO:0043434 278 0.022
nucleobase containing compound catabolic process GO:0034655 152 0.022
protein complex biogenesis GO:0070271 263 0.022
intracellular signal transduction GO:0035556 314 0.021
regulation of protein localization GO:0032880 81 0.021
positive regulation of immune system process GO:0002684 90 0.021
cellular response to organonitrogen compound GO:0071417 197 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
intracellular transport GO:0046907 185 0.021
folic acid containing compound metabolic process GO:0006760 10 0.021
negative regulation of metabolic process GO:0009892 331 0.021
negative regulation of transcription dna templated GO:0045892 116 0.021
response to biotic stimulus GO:0009607 226 0.021
developmental process involved in reproduction GO:0003006 159 0.021
positive regulation of phosphate metabolic process GO:0045937 262 0.021
pyrimidine nucleotide biosynthetic process GO:0006221 9 0.020
camera type eye development GO:0043010 48 0.020
purine ribonucleotide catabolic process GO:0009154 136 0.020
response to inorganic substance GO:0010035 377 0.020
positive regulation of catalytic activity GO:0043085 184 0.020
immune system process GO:0002376 204 0.020
gamete generation GO:0007276 124 0.020
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.020
response to transition metal nanoparticle GO:1990267 122 0.020
negative regulation of signaling GO:0023057 157 0.020
nucleoside phosphate catabolic process GO:1901292 140 0.020
muscle structure development GO:0061061 87 0.020
purine ribonucleoside metabolic process GO:0046128 168 0.020
organonitrogen compound biosynthetic process GO:1901566 167 0.020
response to cytokine GO:0034097 215 0.020
tube development GO:0035295 89 0.020
regulation of neurogenesis GO:0050767 247 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
nucleoside triphosphate catabolic process GO:0009143 123 0.019
purine nucleoside triphosphate catabolic process GO:0009146 122 0.019
regulation of cell development GO:0060284 263 0.019
heterocycle catabolic process GO:0046700 167 0.019
positive regulation of gene expression GO:0010628 244 0.019
organ morphogenesis GO:0009887 75 0.019
organophosphate biosynthetic process GO:0090407 143 0.019
positive regulation of secretion GO:0051047 140 0.019
developmental growth GO:0048589 100 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.019
positive regulation of programmed cell death GO:0043068 157 0.018
regulation of response to stress GO:0080134 126 0.018
female pregnancy GO:0007565 122 0.018
response to insulin GO:0032868 133 0.018
neurological system process GO:0050877 219 0.018
negative regulation of cellular biosynthetic process GO:0031327 161 0.018
cerebellar purkinje cell layer development GO:0021680 2 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.018
regulation of protein phosphorylation GO:0001932 183 0.018
ribonucleoside triphosphate metabolic process GO:0009199 141 0.018
purine ribonucleoside catabolic process GO:0046130 124 0.018
cellular protein localization GO:0034613 122 0.018
single organism intracellular transport GO:1902582 166 0.018
regulation of neuron differentiation GO:0045664 208 0.018
deoxyribonucleoside monophosphate metabolic process GO:0009162 6 0.017
negative regulation of biosynthetic process GO:0009890 168 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
amine metabolic process GO:0009308 38 0.017
cell cycle checkpoint GO:0000075 2 0.017
negative regulation of cell communication GO:0010648 158 0.017
double strand break repair GO:0006302 1 0.017
skeletal system development GO:0001501 41 0.017
nucleoside monophosphate metabolic process GO:0009123 93 0.017
spermatogenesis GO:0007283 99 0.017
ion transmembrane transport GO:0034220 365 0.017
eye morphogenesis GO:0048592 4 0.017
regulation of cell projection organization GO:0031344 175 0.017
cellular amino acid metabolic process GO:0006520 107 0.017
regulation of establishment of protein localization GO:0070201 69 0.017
establishment of protein localization GO:0045184 141 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.017
cardiovascular system development GO:0072358 134 0.016
heart morphogenesis GO:0003007 3 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
negative regulation of gene expression GO:0010629 199 0.016
secretion by cell GO:0032940 248 0.016
metal ion homeostasis GO:0055065 186 0.016
sex differentiation GO:0007548 113 0.016
nucleoside triphosphate metabolic process GO:0009141 144 0.016
multicellular organism growth GO:0035264 1 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
sensory organ development GO:0007423 74 0.015
growth GO:0040007 165 0.015
2 deoxyribonucleotide biosynthetic process GO:0009265 6 0.015
response to growth factor GO:0070848 189 0.015
male gamete generation GO:0048232 99 0.015
negative regulation of signal transduction GO:0009968 83 0.015
purine containing compound catabolic process GO:0072523 138 0.015
cellular chemical homeostasis GO:0055082 247 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
positive regulation of cell development GO:0010720 176 0.015
response to reactive oxygen species GO:0000302 120 0.015
transmembrane transport GO:0055085 412 0.015
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.015
atp metabolic process GO:0046034 72 0.015
regulation of protein modification process GO:0031399 194 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
actin filament based process GO:0030029 86 0.015
ion homeostasis GO:0050801 212 0.015
nucleotide catabolic process GO:0009166 139 0.015
chemotaxis GO:0006935 66 0.015
circulatory system process GO:0003013 183 0.014
vesicle mediated transport GO:0016192 181 0.014
neuron projection development GO:0031175 273 0.014
regulation of cell motility GO:2000145 131 0.014
positive regulation of cellular component movement GO:0051272 102 0.014
peptidyl amino acid modification GO:0018193 126 0.014
gland development GO:0048732 155 0.014
mitotic cell cycle checkpoint GO:0007093 1 0.014
proteolysis GO:0006508 175 0.014
wound healing GO:0042060 122 0.014
response to hexose GO:0009746 144 0.014
lipid metabolic process GO:0006629 283 0.014
organelle organization GO:0006996 266 0.014
regulation of membrane potential GO:0042391 110 0.014
cation transmembrane transport GO:0098655 263 0.014
regulation of ion transport GO:0043269 245 0.014
negative regulation of cell cycle phase transition GO:1901988 4 0.014
2 deoxyribonucleotide metabolic process GO:0009394 9 0.014
circulatory system development GO:0072359 134 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
protein autophosphorylation GO:0046777 66 0.014
regulation of secretion by cell GO:1903530 208 0.014
negative regulation of rna metabolic process GO:0051253 123 0.014
peptide biosynthetic process GO:0043043 3 0.014
response to oxidative stress GO:0006979 186 0.014
multi multicellular organism process GO:0044706 138 0.013
regulation of catabolic process GO:0009894 113 0.013
protein oligomerization GO:0051259 191 0.013
regulation of cellular amine metabolic process GO:0033238 8 0.013
cytokine production GO:0001816 61 0.013
positive regulation of protein modification process GO:0031401 142 0.013
inorganic cation transmembrane transport GO:0098662 202 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
regulation of hydrolase activity GO:0051336 143 0.013
monovalent inorganic cation transport GO:0015672 172 0.013
neuron development GO:0048666 286 0.013
positive regulation of signaling GO:0023056 270 0.013
regulation of fat cell differentiation GO:0045598 3 0.013
purine nucleoside monophosphate catabolic process GO:0009128 55 0.013
response to monosaccharide GO:0034284 159 0.013
single organism organelle organization GO:1902589 180 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.013
regulation of phosphorylation GO:0042325 248 0.013
cellular cation homeostasis GO:0030003 180 0.013
macromolecular complex assembly GO:0065003 273 0.013
apoptotic signaling pathway GO:0097190 27 0.013
cellular response to alcohol GO:0097306 87 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
regulation of cell migration GO:0030334 128 0.012
cellular response to peptide hormone stimulus GO:0071375 120 0.012
axis specification GO:0009798 4 0.012
cellular ketone metabolic process GO:0042180 51 0.012
regulation of cellular amino acid metabolic process GO:0006521 2 0.012
response to organophosphorus GO:0046683 102 0.012
sensory perception GO:0007600 101 0.012
activation of cysteine type endopeptidase activity GO:0097202 4 0.012
response to carbohydrate GO:0009743 183 0.012
cytoplasmic transport GO:0016482 115 0.012
positive regulation of cell communication GO:0010647 271 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
negative regulation of cell differentiation GO:0045596 99 0.012
regulation of neuron projection development GO:0010975 161 0.012
regulation of immune system process GO:0002682 123 0.012
regulation of hormone levels GO:0010817 187 0.012
eye development GO:0001654 50 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
anterior posterior pattern specification GO:0009952 1 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
regulation of growth GO:0040008 105 0.012
regulation of intracellular transport GO:0032386 65 0.012
protein heterooligomerization GO:0051291 89 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
deoxyribose phosphate biosynthetic process GO:0046385 6 0.011
maintenance of location GO:0051235 17 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
regulation of neuron death GO:1901214 115 0.011
pyrimidine nucleotide metabolic process GO:0006220 9 0.011
negative regulation of cell death GO:0060548 229 0.011
single organism cellular localization GO:1902580 102 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
regulation of homeostatic process GO:0032844 101 0.011
heart development GO:0007507 72 0.011
epithelial cell differentiation GO:0030855 71 0.011
chromosome segregation GO:0007059 2 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
response to glucose GO:0009749 136 0.011
uracil metabolic process GO:0019860 3 0.011
telencephalon development GO:0021537 62 0.011
inorganic ion transmembrane transport GO:0098660 229 0.011
urogenital system development GO:0001655 78 0.011
pyrimidine containing compound biosynthetic process GO:0072528 10 0.011
gliogenesis GO:0042063 93 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
regulation of nervous system development GO:0051960 264 0.011
regulation of protein transport GO:0051223 68 0.011
reproductive structure development GO:0048608 128 0.011
response to purine containing compound GO:0014074 126 0.011
response to light stimulus GO:0009416 52 0.011
limbic system development GO:0021761 38 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
anion transport GO:0006820 178 0.011
negative regulation of transport GO:0051051 136 0.011
positive regulation of nervous system development GO:0051962 178 0.011
cellular macromolecule localization GO:0070727 122 0.011
deoxyribose phosphate metabolic process GO:0019692 9 0.011
taxis GO:0042330 67 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
ras protein signal transduction GO:0007265 29 0.010
protein phosphorylation GO:0006468 345 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.010
organic anion transport GO:0015711 132 0.010
cellular response to abiotic stimulus GO:0071214 85 0.010
respiratory system development GO:0060541 45 0.010
negative regulation of organ growth GO:0046621 3 0.010
response to radiation GO:0009314 137 0.010
cell adhesion GO:0007155 110 0.010
divalent inorganic cation homeostasis GO:0072507 165 0.010
positive regulation of signal transduction GO:0009967 175 0.010
cell morphogenesis GO:0000902 142 0.010

Pola1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.010
sensory system disease DOID:0050155 0 0.010