Rattus norvegicus

0 known processes

Akr1cl1

aldo-keto reductase family 1, member C-like 1

Akr1cl1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell proliferation GO:0042127 359 0.097
Rat
single organism biosynthetic process GO:0044711 342 0.095
Rat
response to estrogen GO:0043627 232 0.088
Rat
oxidation reduction process GO:0055114 304 0.083
Rat
organic acid metabolic process GO:0006082 292 0.079
response to inorganic substance GO:0010035 377 0.075
Rat
oxoacid metabolic process GO:0043436 290 0.062
reproductive process GO:0022414 372 0.059
Rat
cellular response to oxygen containing compound GO:1901701 386 0.057
Rat
regulation of multicellular organismal development GO:2000026 376 0.055
regulation of apoptotic process GO:0042981 335 0.055
response to nutrient GO:0007584 248 0.050
single organism reproductive process GO:0044702 297 0.050
Rat
carboxylic acid metabolic process GO:0019752 289 0.048
response to nutrient levels GO:0031667 370 0.047
positive regulation of multicellular organismal process GO:0051240 387 0.045
nucleobase containing small molecule metabolic process GO:0055086 316 0.045
cation homeostasis GO:0055080 195 0.044
response to decreased oxygen levels GO:0036293 237 0.043
response to acid chemical GO:0001101 222 0.043
Rat
programmed cell death GO:0012501 392 0.043
positive regulation of cell proliferation GO:0008284 249 0.042
Rat
aging GO:0007568 241 0.042
protein complex subunit organization GO:0071822 302 0.041
protein complex biogenesis GO:0070271 263 0.041
regulation of signal transduction GO:0009966 318 0.041
Rat
cellular lipid metabolic process GO:0044255 208 0.041
Rat
response to extracellular stimulus GO:0009991 380 0.040
regulation of molecular function GO:0065009 398 0.040
response to oxygen levels GO:0070482 265 0.039
circulatory system development GO:0072359 134 0.039
multicellular organism reproduction GO:0032504 233 0.039
Rat
negative regulation of metabolic process GO:0009892 331 0.039
response to hypoxia GO:0001666 231 0.038
cardiovascular system development GO:0072358 134 0.038
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.038
transcription from rna polymerase ii promoter GO:0006366 252 0.037
intracellular signal transduction GO:0035556 314 0.037
Rat
response to corticosteroid GO:0031960 235 0.036
positive regulation of phosphorus metabolic process GO:0010562 262 0.036
positive regulation of signal transduction GO:0009967 175 0.035
Rat
organophosphate metabolic process GO:0019637 370 0.035
regulation of phosphate metabolic process GO:0019220 349 0.035
organic acid biosynthetic process GO:0016053 83 0.035
apoptotic process GO:0006915 381 0.034
cellular chemical homeostasis GO:0055082 247 0.034
catabolic process GO:0009056 351 0.034
monocarboxylic acid metabolic process GO:0032787 152 0.034
fatty acid metabolic process GO:0006631 99 0.033
response to wounding GO:0009611 254 0.033
regulation of cellular protein metabolic process GO:0032268 267 0.033
response to cytokine GO:0034097 215 0.033
response to estradiol GO:0032355 164 0.032
response to metal ion GO:0010038 253 0.032
cellular response to stress GO:0033554 269 0.031
Rat
single organism carbohydrate metabolic process GO:0044723 118 0.031
Rat
lipid metabolic process GO:0006629 283 0.031
Rat
macromolecular complex subunit organization GO:0043933 339 0.031
cellular response to endogenous stimulus GO:0071495 377 0.031
Rat
regulation of programmed cell death GO:0043067 341 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
positive regulation of developmental process GO:0051094 283 0.030
nucleoside phosphate metabolic process GO:0006753 283 0.030
macromolecular complex assembly GO:0065003 273 0.030
regulation of nervous system development GO:0051960 264 0.030
regulation of cell differentiation GO:0045595 320 0.029
response to glucocorticoid GO:0051384 223 0.029
cellular ketone metabolic process GO:0042180 51 0.029
cellular homeostasis GO:0019725 252 0.029
regulation of rna metabolic process GO:0051252 391 0.029
protein complex assembly GO:0006461 263 0.029
amine metabolic process GO:0009308 38 0.029
positive regulation of protein metabolic process GO:0051247 178 0.028
cellular component biogenesis GO:0044085 368 0.028
ion homeostasis GO:0050801 212 0.028
response to oxidative stress GO:0006979 186 0.028
Rat
response to mechanical stimulus GO:0009612 134 0.027
regulation of neurogenesis GO:0050767 247 0.027
carbohydrate derivative metabolic process GO:1901135 346 0.027
positive regulation of biosynthetic process GO:0009891 319 0.027
chemical homeostasis GO:0048878 292 0.027
regulation of rna biosynthetic process GO:2001141 381 0.027
regulation of smooth muscle cell proliferation GO:0048660 75 0.027
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.027
response to peptide hormone GO:0043434 278 0.026
renal system development GO:0072001 67 0.026
Rat
nucleotide metabolic process GO:0009117 279 0.026
response to vitamin GO:0033273 131 0.026
purine containing compound metabolic process GO:0072521 253 0.026
carbohydrate metabolic process GO:0005975 130 0.026
Rat
negative regulation of cell death GO:0060548 229 0.026
positive regulation of response to stimulus GO:0048584 285 0.026
Rat
cellular component assembly GO:0022607 360 0.025
muscle cell proliferation GO:0033002 84 0.025
Rat
multi multicellular organism process GO:0044706 138 0.025
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.024
positive regulation of signaling GO:0023056 270 0.024
Rat
regulation of cellular component organization GO:0051128 368 0.024
regulation of catalytic activity GO:0050790 304 0.024
central nervous system development GO:0007417 311 0.024
Rat
protein phosphorylation GO:0006468 345 0.024
single organism catabolic process GO:0044712 283 0.024
regulation of homeostatic process GO:0032844 101 0.024
calcium ion homeostasis GO:0055074 162 0.024
cellular divalent inorganic cation homeostasis GO:0072503 162 0.024
cellular response to nitrogen compound GO:1901699 210 0.023
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.023
cellular amine metabolic process GO:0044106 38 0.023
positive regulation of molecular function GO:0044093 230 0.023
circulatory system process GO:0003013 183 0.023
negative regulation of macromolecule metabolic process GO:0010605 260 0.022
response to carbohydrate GO:0009743 183 0.022
negative regulation of multicellular organismal process GO:0051241 203 0.022
metal ion homeostasis GO:0055065 186 0.022
tissue development GO:0009888 252 0.022
positive regulation of cell communication GO:0010647 271 0.022
Rat
regulation of phosphorylation GO:0042325 248 0.022
lipid biosynthetic process GO:0008610 128 0.022
purine nucleotide metabolic process GO:0006163 229 0.022
transmembrane transport GO:0055085 412 0.021
organic substance catabolic process GO:1901575 316 0.021
cellular response to organic cyclic compound GO:0071407 202 0.021
reproduction GO:0000003 245 0.021
Rat
rna metabolic process GO:0016070 406 0.021
organ regeneration GO:0031100 101 0.021
cellular cation homeostasis GO:0030003 180 0.021
macromolecule localization GO:0033036 252 0.021
small molecule biosynthetic process GO:0044283 124 0.020
Rat
response to peptide GO:1901652 292 0.020
Rat
ribonucleotide metabolic process GO:0009259 231 0.020
positive regulation of cell death GO:0010942 184 0.020
cytosolic calcium ion homeostasis GO:0051480 140 0.020
neuron differentiation GO:0030182 368 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
kidney development GO:0001822 67 0.020
Rat
carbohydrate derivative biosynthetic process GO:1901137 124 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.020
nucleic acid templated transcription GO:0097659 379 0.020
secretion by cell GO:0032940 248 0.020
cellular component movement GO:0006928 248 0.020
cation transport GO:0006812 382 0.020
positive regulation of cell differentiation GO:0045597 217 0.019
cellular response to hormone stimulus GO:0032870 247 0.019
cellular ion homeostasis GO:0006873 184 0.019
positive regulation of programmed cell death GO:0043068 157 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.019
cellular amino acid metabolic process GO:0006520 107 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
inflammatory response GO:0006954 150 0.019
cellular response to lipid GO:0071396 201 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
negative regulation of cell proliferation GO:0008285 119 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.018
carboxylic acid biosynthetic process GO:0046394 83 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
regulation of nucleotide metabolic process GO:0006140 117 0.018
regulation of phosphorus metabolic process GO:0051174 349 0.018
proteolysis GO:0006508 175 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
cellular catabolic process GO:0044248 295 0.018
myeloid leukocyte differentiation GO:0002573 20 0.018
metal ion transport GO:0030001 289 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
multicellular organismal reproductive process GO:0048609 233 0.018
Rat
positive regulation of apoptotic process GO:0043065 154 0.018
negative regulation of rna biosynthetic process GO:1902679 118 0.017
cell type specific apoptotic process GO:0097285 134 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.017
organelle organization GO:0006996 266 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.017
reproductive system development GO:0061458 128 0.017
blood circulation GO:0008015 183 0.017
regulation of transcription dna templated GO:0006355 374 0.017
ion transmembrane transport GO:0034220 365 0.017
positive regulation of immune system process GO:0002684 90 0.017
response to growth factor GO:0070848 189 0.017
regulation of protein modification process GO:0031399 194 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.016
response to ethanol GO:0045471 162 0.016
smooth muscle cell proliferation GO:0048659 77 0.016
Rat
vesicle mediated transport GO:0016192 181 0.016
rna biosynthetic process GO:0032774 380 0.016
positive regulation of protein modification process GO:0031401 142 0.016
positive regulation of rna metabolic process GO:0051254 203 0.016
multi organism reproductive process GO:0044703 262 0.016
Rat
regulation of cell development GO:0060284 263 0.016
single organism organelle organization GO:1902589 180 0.016
protein oligomerization GO:0051259 191 0.016
positive regulation of nervous system development GO:0051962 178 0.016
regulation of protein metabolic process GO:0051246 289 0.016
defense response GO:0006952 194 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
regulation of lipid metabolic process GO:0019216 68 0.016
neuron projection development GO:0031175 273 0.016
response to monosaccharide GO:0034284 159 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.016
regulation of response to stress GO:0080134 126 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
negative regulation of innate immune response GO:0045824 4 0.015
negative regulation of gene expression GO:0010629 199 0.015
regulation of hormone levels GO:0010817 187 0.015
Rat
amide transport GO:0042886 105 0.015
cell cell signaling GO:0007267 335 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
growth GO:0040007 165 0.015
immune system process GO:0002376 204 0.015
positive regulation of cellular component organization GO:0051130 200 0.015
developmental process involved in reproduction GO:0003006 159 0.015
ras protein signal transduction GO:0007265 29 0.015
negative regulation of developmental process GO:0051093 125 0.015
reproductive structure development GO:0048608 128 0.015
organic hydroxy compound metabolic process GO:1901615 115 0.015
Rat
organonitrogen compound catabolic process GO:1901565 179 0.015
cellular protein localization GO:0034613 122 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
vascular process in circulatory system GO:0003018 96 0.015
homeostatic process GO:0042592 331 0.015
Rat
inner medullary collecting duct development GO:0072061 1 0.015
Rat
response to hydrogen peroxide GO:0042542 89 0.015
Rat
positive regulation of endothelial cell migration GO:0010595 4 0.015
positive regulation of nucleic acid templated transcription GO:1903508 197 0.015
regulation of neuron differentiation GO:0045664 208 0.014
regulation of blood circulation GO:1903522 110 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
maternal process involved in female pregnancy GO:0060135 38 0.014
Rat
response to lipopolysaccharide GO:0032496 191 0.014
negative regulation of cellular biosynthetic process GO:0031327 161 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
negative regulation of transport GO:0051051 136 0.014
rhythmic process GO:0048511 156 0.014
response to bacterium GO:0009617 200 0.014
head development GO:0060322 247 0.014
Rat
response to molecule of bacterial origin GO:0002237 194 0.014
response to purine containing compound GO:0014074 126 0.014
regulation of secretion by cell GO:1903530 208 0.014
cellular response to external stimulus GO:0071496 118 0.014
regulation of secretion GO:0051046 224 0.014
sex differentiation GO:0007548 113 0.014
positive regulation of cell development GO:0010720 176 0.014
regulation of tube size GO:0035150 89 0.014
regulation of cell motility GO:2000145 131 0.014
purine ribonucleotide biosynthetic process GO:0009152 81 0.014
gonad development GO:0008406 104 0.014
response to other organism GO:0051707 220 0.014
alcohol metabolic process GO:0006066 77 0.014
Rat
nitrogen compound transport GO:0071705 229 0.014
positive regulation of neurogenesis GO:0050769 165 0.014
secretion GO:0046903 307 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
muscle system process GO:0003012 115 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.014
negative regulation of rna metabolic process GO:0051253 123 0.014
response to calcium ion GO:0051592 59 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
hormone transport GO:0009914 121 0.013
lipid storage GO:0019915 1 0.013
regulation of cellular component movement GO:0051270 150 0.013
localization of cell GO:0051674 202 0.013
intracellular transport GO:0046907 185 0.013
sorbitol metabolic process GO:0006060 1 0.013
Rat
endocytosis GO:0006897 84 0.013
urogenital system development GO:0001655 78 0.013
Rat
response to glucose GO:0009749 136 0.013
female pregnancy GO:0007565 122 0.013
Rat
positive regulation of gene expression GO:0010628 244 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
regulation of intracellular signal transduction GO:1902531 218 0.013
Rat
negative regulation of molecular function GO:0044092 133 0.013
response to external biotic stimulus GO:0043207 221 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
purine ribonucleotide metabolic process GO:0009150 227 0.013
regulation of catabolic process GO:0009894 113 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
response to ketone GO:1901654 182 0.013
Rat
brain development GO:0007420 247 0.013
Rat
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
negative regulation of transcription dna templated GO:0045892 116 0.012
negative regulation of biosynthetic process GO:0009890 168 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
regulation of phagocytosis engulfment GO:0060099 4 0.012
cellular response to peptide GO:1901653 133 0.012
Rat
angiogenesis GO:0001525 53 0.012
response to insulin GO:0032868 133 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
maintenance of location GO:0051235 17 0.012
organic acid transport GO:0015849 116 0.012
single organism intracellular transport GO:1902582 166 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
ribose phosphate biosynthetic process GO:0046390 87 0.012
icosanoid metabolic process GO:0006690 38 0.012
regulation of vasculature development GO:1901342 44 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
protein homooligomerization GO:0051260 91 0.012
cell projection organization GO:0030030 302 0.012
blood vessel development GO:0001568 69 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
Rat
retinal metabolic process GO:0042574 3 0.012
Rat
regulation of reactive oxygen species metabolic process GO:2000377 26 0.012
response to organophosphorus GO:0046683 102 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
synaptic transmission GO:0007268 235 0.011
divalent metal ion transport GO:0070838 132 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
regulation of locomotion GO:0040012 148 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
sexual reproduction GO:0019953 148 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
neuron development GO:0048666 286 0.011
response to ammonium ion GO:0060359 71 0.011
transcription dna templated GO:0006351 377 0.011
mesenchymal cell proliferation GO:0010463 4 0.011
regulation of blood vessel size GO:0050880 89 0.011
response to alkaloid GO:0043279 132 0.011
cellular response to oxidative stress GO:0034599 76 0.011
Rat
cell migration GO:0016477 197 0.011
regeneration GO:0031099 163 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
response to hexose GO:0009746 144 0.011
organic hydroxy compound biosynthetic process GO:1901617 51 0.011
Rat
cellular response to cytokine stimulus GO:0071345 127 0.011
regulation of organelle organization GO:0033043 80 0.011
sequestering of calcium ion GO:0051208 8 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
action potential GO:0001508 54 0.011
response to interleukin 1 GO:0070555 55 0.011
forebrain development GO:0030900 98 0.011
Rat
regulation of mesenchymal cell proliferation GO:0010464 4 0.011
sorbitol biosynthetic process GO:0006061 1 0.011
Rat
regulation of system process GO:0044057 208 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
regulation of membrane potential GO:0042391 110 0.011
cellular response to acid chemical GO:0071229 75 0.010
cell cycle checkpoint GO:0000075 2 0.010
response to radiation GO:0009314 137 0.010
positive regulation of rna biosynthetic process GO:1902680 197 0.010
regulation of fat cell differentiation GO:0045598 3 0.010
blood vessel morphogenesis GO:0048514 58 0.010
monosaccharide metabolic process GO:0005996 61 0.010
Rat
regulation of anatomical structure size GO:0090066 135 0.010
vasculature development GO:0001944 70 0.010
cellular response to growth factor stimulus GO:0071363 162 0.010
calcium ion transport GO:0006816 131 0.010
positive regulation of nucleotide metabolic process GO:0045981 91 0.010
regulation of hydrolase activity GO:0051336 143 0.010
peptide transport GO:0015833 97 0.010
regulation of kinase activity GO:0043549 117 0.010
regulation of cellular catabolic process GO:0031329 101 0.010
regulation of endocytosis GO:0030100 42 0.010

Akr1cl1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.024
inherited metabolic disorder DOID:655 0 0.016
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
musculoskeletal system disease DOID:17 0 0.013
integumentary system disease DOID:16 0 0.012